Abstract：
:Schizophrenia is a multifactorial disease associated with widespread cognitive impairment. Although cognitive deficits are one of the factors most strongly associated with functional impairment in schizophrenia (SZ), current treatment strategies hardly tackle these impairments. To develop more efficient treatment strategies in patients, a better understanding of their pathogenesis is needed. Recent progress in genetics, driven by large genome-wide association studies (GWAS) and the use of polygenic risk scores (PRS), has provided new insights about the genetic architecture of complex human traits, including cognition and SZ. Here, we review the recent findings examining the genetic links between SZ and cognitive functions in population-based samples as well as in participants with SZ. The performed meta-analysis showed a negative correlation between the polygenetic risk score of schizophrenia and global cognition (p < 0.001) when the samples rely on general and healthy participants, while no significant correlation was detected when the three studies devoted to schizophrenia patients were meta-analysed (p > 0.05). Our review and meta-analysis therefore argues against universal pleiotropy for schizophrenia alleles and cognition, since cognition in SZ patients would be underpinned by the same genetic factors than in the general population, and substantially independent of common variant liability to the disorder.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Mallet J,Le Strat Y,Dubertret C,Gorwood Pdoi
10.3390/jcm9020341subject
Has Abstractpub_date
2020-01-25 00:00:00issue
2issn
2077-0383pii
jcm9020341journal_volume
9pub_type
杂志文章abstract：BACKGROUND AND OBJECTIVE:Elderly and/or frail women with ovarian cancer are often undertreated. The aim of the study is to compare the effects of age and frailty on surgical approaches, postoperative complications, and prognosis in elderly women with ovarian cancer. METHODS:A retrospective multicenter study of women ≥...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9051339
更新日期：2020-05-04 00:00:00
abstract：BACKGROUND:Psoriasis is a chronic inflammatory disease which affects the body far beyond the skin. Whereas there is solid evidence that chronic skin inflammation in psoriasis drives cardiovascular disease, the impact on renal impairment and acute kidney injury (AKI) is still unclear. We aimed to analyze the impact of p...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9093004
更新日期：2020-09-17 00:00:00
abstract：BACKGROUND:Bioelectrical impedance analysis (BIA) is a simple and rapid technique to measure body composition (BC). Validity of BIA in patients with low body mass index (BMI) remains controversial. We assessed the validity of several BIA equations to evaluate fat-free mass (FFM), fat mass (FM) and muscle mass in patien...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9113664
更新日期：2020-11-14 00:00:00
abstract：:Abnormalities in body composition are associated with poor prognosis in cancer patients. We investigated the association between body composition and 90-day mortality in cancer patients who developed septic shock. We included consecutive septic shock patients with active cancer from 2010 to 2017. The muscle area at th...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8101583
更新日期：2019-10-02 00:00:00
abstract：:Improving transgender people's quality of life (QoL) is the most important goal of gender-affirming care. Prospective changes in affect can influence QoL. We aim to assess the impact of initiating gender-affirming hormonal treatment (HT) on affect. In the European Network for the Investigation of Gender Incongruence (...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm10020296
更新日期：2021-01-14 00:00:00
abstract：:Additive manufacturing (AM) of patient-specific implants (PSIs) is gradually moving towards in-house or point-of-care (POC) manufacturing. Polyetheretherketone (PEEK) has been used in cranioplasty cases as a reliable alternative to other alloplastic materials. As only a few fused filament fabrication (FFF) printers ar...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9092818
更新日期：2020-08-31 00:00:00
abstract：:The burden of illness related to diabetes and its complications is exceedingly high and growing globally. Systematic approaches to managing chronic care are needed to address the complex nature of the disease, taking into account health system structures. This study presents data collected from interviews with physici...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7110451
更新日期：2018-11-20 00:00:00
abstract：:Significant others are often crucial for suicidal persons or suicide attempters' access to care, yet little is known about their efforts to seek help. This article presents the findings of a qualitative pilot study carried out in Switzerland on the help-seeking process of 18 significant others, their perception of the...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm6020017
更新日期：2017-02-13 00:00:00
abstract：:Our study aimed to clarify the neuroimaging correlates of suicide attempt by comparing differences in functional magnetic resonance imaging (fMRI) among depressed suicide attempters, depressed patients without suicide attempt history, and healthy controls through comprehensive and novel fMRI analyses and methods in th...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8111966
更新日期：2019-11-14 00:00:00
abstract：:Propionibacterium are anaerobic/aero-tolerant rod Gram-positive bacteria, and numerous studies are associated with primary and secondary endodontic infections. The data in the literature on the prevalence of Propionibacterium are conflicting, and there are studies that report conflicting data on the prevalence in prim...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9030739
更新日期：2020-03-09 00:00:00
abstract：:Gastric cancer (GC) remains one of the major causes of cancer-related mortality worldwide. As for other types of cancers, several limitations to the success of current therapeutic GC treatments may be due to cancer drug resistance that leads to tumor recurrence and metastasis. Increasing evidence suggests that cancer ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8050639
更新日期：2019-05-09 00:00:00
abstract：:Dihydrofolate reductase (DHFR) is an essential cellular enzyme and thereby catalyzes thereduction of dihydrofolate to tetrahydrofolate (THF). In cancer medication, inhibition of humanDHFR (hDHFR) remains a promising strategy, as it depletes THF and slows DNA synthesis and cellproliferation. In the current study, ligan...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8020233
更新日期：2019-02-11 00:00:00
abstract：:We aimed to evaluate the effects of ultrasound-assisted wound (UAW) debridement on cellular proliferation and dermal repair in complicated diabetic foot ulcers as compared to diabetic foot ulcers receiving surgical/sharp wound debridement. A randomized controlled trial was performed involving 51 outpatients with compl...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9124032
更新日期：2020-12-13 00:00:00
abstract：:The innate immunity has evolved during millions of years, and thus, equivalent or comparable components are found in most vertebrates, invertebrates, and even plants. It constitutes the first line of defense against molecules, which are either pathogen-derived or a danger signal themselves, and not seldom both. These ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8111981
更新日期：2019-11-14 00:00:00
abstract：:Clinically-relevant pituitary adenomas occur in about 1:1000 of the general population, but only about 5% occur in a known genetic or familial setting. Familial isolated pituitary adenomas (FIPA) are one of the most important inherited settings for pituitary adenomas and the most frequent genetic cause is a germline m...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9062003
更新日期：2020-06-26 00:00:00
abstract：:Ocular surgery is one of the most performed medical procedures in the world. Its limitation or suspension, recursively extended over time, could be associated with a significant increase in the number of blind people worldwide. Indeed, cataract causes more than half of all cases of visual impairment in those countries...
journal_title：Journal of clinical medicine
pub_type： 社论
doi：10.3390/jcm9051403
更新日期：2020-05-09 00:00:00
abstract：:Exercise has health benefits and prevents a range of chronic diseases caused by physiological and biological changes in the whole body. Generally, the metabolic regulation of skeletal muscle through exercise is known to have a protective effect on the pathogenesis of metabolic syndrome, non-alcoholic fatty liver disea...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm10030385
更新日期：2021-01-20 00:00:00
abstract：:The use of sugammadex can reduce post-operative residual neuromuscular blockade, which is known to increase the risk of post-operative respiratory events. However, its effect on post-operative pulmonary complications is not obvious. This study was performed to evaluate the effects of sugammadex on post-operative pulmo...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9041232
更新日期：2020-04-24 00:00:00
abstract：:Conventional 3D multicellular tumor spheroids of head and neck squamous cell carcinoma (HNSCC) consisting exclusively of cancer cells have some limitations. They are compact cell aggregates that do not interact with their extracellular milieu, thus suffering from both insufficient extracellular matrix (ECM) deposition...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8101686
更新日期：2019-10-15 00:00:00
abstract：:Bronchopulmonary dysplasia (BPD) is a chronic lung disease most commonly seen in premature infants who required mechanical ventilation and oxygen therapy for acute respiratory distress. While advances in neonatal care have resulted in improved survival rates of premature infants, limited progress has been made in redu...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm6010004
更新日期：2017-01-06 00:00:00
abstract：:Fetal exposure to particulate matter (PM) is associated with infant developmental delay likely via neuroinflammation and prefrontal cortex lesions; however, whether air-purifier usage, which can reduce indoor PM levels, is related to infant developmental delay remains unknown. We therefore examined the prospective rel...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9061924
更新日期：2020-06-19 00:00:00
abstract：:Both vasculature and myocardium in the heart are excessively damaged following myocardial infarction (MI), hence therapeutic strategies for treating MI hearts should concurrently aim for true cardiac repair by introducing new cardiomyocytes to replace lost or injured ones. Of them, mesenchymal stem cells (MSCs) have l...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9051277
更新日期：2020-04-28 00:00:00
abstract：OBJECTIVE:To analyse the published evidence of the validity of DIAGNDOdent and VistaProof in diagnosing carious depths in pre-cavitated lesions. Material and methods: A systematic review was carried out after identifying a total of 184 articles, including 27 concerning the qualitative review and a subsequent meta-analy...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9010020
更新日期：2019-12-19 00:00:00
abstract：:The use of artificial intelligence (AI) to support clinical medical decisions is a rather promising concept. There are two important factors that have driven these advances: the availability of data from electronic health records (EHR) and progress made in computational performance. These two concepts are interrelated...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9010248
更新日期：2020-01-17 00:00:00
abstract：BACKGROUND:In hemodialysis patients, extracellular water (ECW) overload predicts all-cause and cardiovascular mortality. The primary aim of the present study was to analyze changes in post-dialysis (i.e., following removal of excess ECW) ECW, intracellular water (ICW), and the overhydration (OH) parameter over time. Ad...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9113616
更新日期：2020-11-10 00:00:00
abstract：:Spinal disorders and associated interventions are costly in the United States, putting them in the limelight of economic analyses. The Patient-Reported Outcomes Measurement Information System Global Health Survey (PROMIS-GHS) requires mapping to other surveys for economic investigation. Previous studies have proposed ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8101506
更新日期：2019-09-20 00:00:00
abstract：:(1) Background: Endoscopic management of hilar biliary obstruction is still challenging. Compared with unilateral drainage, bilateral drainage could preserve larger functional liver volume and potentially improve clinical outcomes. To evaluate the effectiveness of bilateral drainage, we conducted this multicenter rand...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm10020206
更新日期：2021-01-08 00:00:00
abstract：:Sarcoidosis is a systemic disease of unknown etiology characterized by the presence of noncaseating granulomas that can occur in any organ, most commonly the lungs. Early and accurate diagnosis of sarcoidosis remains challenging because initial presentations may vary, many patients are asymptomatic, and there is no si...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9082363
更新日期：2020-07-24 00:00:00
abstract：BACKGROUND:Current therapeutic options in the course of metastatic castration-resistant prostate cancers (mCRPC) reinforce the need for reliable tools to characterize the tumor in a dynamic way. Circulating tumor cells (CTCs) have emerged as a viable solution to the problem, whereby patients with a variety of solid tum...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9072066
更新日期：2020-07-01 00:00:00
abstract：:Elevated blood pressure (BP) is a major cause of death, yet hypertension commonly goes undetected. Owing to its nature, it is typically asymptomatic until later in its progression when the vessel or organ structure has already been compromised. Therefore, noninvasive and continuous BP measurement methods are needed to...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9041203
更新日期：2020-04-22 00:00:00
