Abstract：
:Sarcoidosis is a systemic disease of unknown etiology characterized by the presence of noncaseating granulomas that can occur in any organ, most commonly the lungs. Early and accurate diagnosis of sarcoidosis remains challenging because initial presentations may vary, many patients are asymptomatic, and there is no single reliable diagnostic test. Prognosis is variable and depends on epidemiologic factors, mode of onset, initial clinical course, and specific organ involvement. From a pathobiological standpoint, sarcoidosis represents an immune paradox, where an excessive spread of both the innate and the adaptive immune arms of the immune system is accompanied by a state of partial immune anergy. For all these reasons, the optimal treatment for sarcoidosis remains unclear, with corticosteroid therapy being the current gold standard for those patients with significantly symptomatic or progressive pulmonary disease or serious extrapulmonary disease. This review is a state of the art of clinical presentations and immunological features of sarcoidosis, and the current therapeutic approaches used to treat the disease.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Polverino F,Balestro E,Spagnolo Pdoi
10.3390/jcm9082363subject
Has Abstractpub_date
2020-07-24 00:00:00issue
8issn
2077-0383pii
jcm9082363journal_volume
9pub_type
杂志文章,评审abstract：:Uric acid urolithiasis constitutes approximately 7-10% of all urinary stones. Previous studies have revealed that patients with gout do not equally have uric acid stones. Instead, the risk of gout in patients with uric acid stones remains controversial. This study aimed to investigate whether there is different associ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8101536
更新日期：2019-09-25 00:00:00
abstract：PURPOSE:The risk of epiphora after medial maxillectomy with lacrimal duct transection is difficult to assess. The data available in the literature are inconclusive due to various operating techniques used by the authors of medical publications, different additional procedures aimed at improving tear drainage after maxi...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm10020245
更新日期：2021-01-12 00:00:00
abstract：:: Pulmonary fibrosis (PF) is a very rare condition in children, which may be observed in specific forms of interstitial lung disease. None of the clinical, radiological, or histological descriptions used for PF diagnosis in adult patients, especially in situations of idiopathic PF, can apply to pediatric situations. T...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8091312
更新日期：2019-08-26 00:00:00
abstract：BACKGROUND:No dural substitute has proven to be complication-free in a large clinical trial, even suggesting some benefit during watertight closure. However, primary dural closure is not always possible due to dural shrinkage from electrocautery for dural bleeding. OBJECTIVE:This study is performed to analyze the clin...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9040902
更新日期：2020-03-25 00:00:00
abstract：:Although skin manifestations are quite common in systemic sclerosis (SSc), a link between SSc and psoriasis (PsO) has been poorly investigated. We assessed the Clalit medical database in a cohort study to compare the prevalence of PsO between SSc-patients and SSc-free controls. We also evaluated the SSc-related autoan...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8040521
更新日期：2019-04-16 00:00:00
abstract：:The aim of this study was to assess the efficacy of anti-endomysium antibodies (EMA) as a serological marker for celiac disease (CD) diagnosis in a pediatric population. A retrospective study of pediatric patients who underwent a CD serological markers study: EMA and anti-tissue transglutaminase antibodies (anti-TG2)....
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8122179
更新日期：2019-12-11 00:00:00
abstract：INTRODUCTION:Exposure to cumulative environmental risk factors across development has been linked to a host of adverse health/functional outcomes. This perspective incorporating information regarding exposure at differing developmental periods is lacking in research surrounding individuals at Clinical High Risk (CHR) f...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8070994
更新日期：2019-07-09 00:00:00
abstract：:Novel strategies are needed to address vaccine hesitancy (VH), which correlates with complementary and alternative medicine (CAM). In Switzerland, CAM providers play important roles in vaccine counseling of vaccine hesitant (VH) parents, and traditional vaccination messaging tends to overlook CAM provider perspectives...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9020592
更新日期：2020-02-21 00:00:00
abstract：BACKGROUND:Congenital factor (F) VII deficiency is a rare coagulation factor deficiency with an estimated incidence of 1 per 500,000 individuals. Patients with severe FVII deficiency present a broad range of clinical presentations. Alloimmunization against exogenous FVII, as the main challenge of replacement therapy, i...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm10020211
更新日期：2021-01-08 00:00:00
abstract：BACKGROUND:Patients with Crohn's disease are at increased risk for fractures due to low bone mineral density (BMD). Real-world data are necessary to optimize surveillance and treatment strategies. METHODS:Patients with Crohn's disease who underwent at least one dual-energy X-ray absorptiometry (DXA) scans were recruit...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8122178
更新日期：2019-12-10 00:00:00
abstract：:Torsional abnormalities of the femur represent a significant risk factor for patellar instability or patellofemoral complaints. Although their clinical implication has been demonstrated, there is still a debate going on about different aspects. These include, especially, the various methods of measurements with a wide...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm10030474
更新日期：2021-01-27 00:00:00
abstract：:Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer and affects millions worldwide. Due to the lack of effective systemic therapies for HCC, researchers have been investigating the use of locoregional tumor control with Yttrium-90 (Y90) radioembolization since the 1960s. Following the develo...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8010055
更新日期：2019-01-07 00:00:00
abstract：:Background. Accumulating evidence suggests that inflammation plays a key role in acute kidney injury (AKI) pathogenesis. We explored the relationship between high-sensitivity C-reactive protein (hs-CRP) and AKI in acute myocardial infarction (AMI). Methods. We prospectively included 2,063 AMI patients in whom hs-CRP w...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8122192
更新日期：2019-12-12 00:00:00
abstract：BACKGROUND AND AIMS:The markers of renal damage defining subclinical AKI are not widely used in children undergoing allogeneic hematopoietic stem cell transplantation (alloHSCT). The aim of the study was to evaluate serum and urinary clusterin as indices of kidney injury after alloHSCT in relation to damage (kidney inj...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9082599
更新日期：2020-08-11 00:00:00
abstract：:Diabetic nephropathy (DN) often develops in patients suffering from type 1 or type 2 diabetes mellitus. DN is characterized by renal injury resulting in proteinuria. Neuropilin-1 (NRP-1) is a single-pass transmembrane receptor protein devoid of enzymatic activity. Its large extracellular tail is structured in several ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm4061293
更新日期：2015-06-17 00:00:00
abstract：:In the last decade, it has been well-established that tumor-infiltrating myeloid cells fuel not only the process of carcinogenesis through cancer-related inflammation mechanisms, but also tumor progression, invasion, and metastasis. In particular, tumor-associated macrophages (TAMs) are the most abundant leucocyte sub...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9103226
更新日期：2020-10-08 00:00:00
abstract：:We aimed to explore the accuracy of physical examination (PE) to detect the synovial and extra-synovial pathologies in psoriatic arthritis (PsA) in comparison to ultrasonography (US). Twenty-nine PsA patients with hand pain were included in the study. A detailed PE of the hands was performed and US scans were performe...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9092929
更新日期：2020-09-10 00:00:00
abstract：BACKGROUND:Peri-interventional myocardial injury occurs frequently during transcatheter aortic valve implantation (TAVI). We assessed the effect of remote ischemic preconditioning (RIPC) on myocardial injury, acute kidney injury (AKIN) and 6-month mortality in patients undergoing TAVI. METHODS:We performed a prospecti...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9010160
更新日期：2020-01-07 00:00:00
abstract：:Randomized controlled trials (RCTs) have eligibility criteria for the inclusion of participants. Ideally, the RCT sample would be representative for the patient population that will use the drug under investigation. However, external validity may be at stake when applying too many or too restrictive eligibility criter...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7080206
更新日期：2018-08-08 00:00:00
abstract：:(1) Background: To evaluate women's satisfaction with the care received during childbirth undergoing labour and how this changes over time. (2) Methods: An observational, multicentre and longitudinal study in two public hospitals of Spain with a convenience sample of 248 women during the post-partum period. Satisfacti...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8040434
更新日期：2019-03-29 00:00:00
abstract：:Background: We performed this prospective double-blind randomized controlled trial to identify the effect of a preoperative prophylactic transdermal scopolamine (TDS) patch on postoperative nausea and vomiting (PONV) after retromastoid craniectomy with microvascular decompression (RMC-MVD). Methods: We recruited 38 pa...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9010156
更新日期：2020-01-07 00:00:00
abstract：:In addition to its regulatory function in the formation of red blood cells (erythropoiesis) in vertebrates, Erythropoietin (Epo) contributes to beneficial functions in a variety of non-hematopoietic tissues including the nervous system. Epo protects cells from apoptosis, reduces inflammatory responses and supports re-...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm7020024
更新日期：2018-02-02 00:00:00
abstract：:Diabetes in pregnancy, both preexisting type 1 or type 2 and gestational diabetes, is a highly prevalent condition, which has a great impact on maternal and fetal health, with short and long-term implications. Gestational Diabetes Mellitus (GDM) is a condition triggered by metabolic adaptation, which occurs during the...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm7020011
更新日期：2018-01-25 00:00:00
abstract：INTRODUCTION:Dementia is a group of disorders that causes dysfunctions in human cognitive and operating functions. Currently, it is not possible to conduct a fast, low-invasive dementia diagnostic process with the use of peripheral blood biomarkers, however, there is a great deal of research in progress covering this s...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9113452
更新日期：2020-10-27 00:00:00
abstract：:This study aimed at evaluating the clinical relevance of glycoprotein profiles during the earliest phases of rheumatoid arthritis (RA) as biomarkers of cardiovascular (CV) risk and treatment response. Then, GlycA and GlycB serum levels were measured using 1H-nuclear magnetic resonance in 82 early RA patients, 14 clini...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9082472
更新日期：2020-08-01 00:00:00
abstract：:Our aim was to illustrate our technique of sex-sparing (SS)-robot-assisted radical cystectomy (RARC) in female patients receiving an intracorporeal neobladder (iN). From January 2013 to June 2018, 11 female patients underwent SS-RARC-iN at a single tertiary referral center. Inclusion criteria were a cT ≤ 2 N0 M0 bladd...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9020577
更新日期：2020-02-20 00:00:00
abstract：:(1) Background: Little is known about the impact of pathophysiological mechanisms that underlie the enhancement of excitotoxicity and the neuronal consequences of status epilepticus (SE), as well as the clinical consequences of secondary brain insults (SBI) in patients with SE on outcome; (2) Methods: Electronic searc...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9082521
更新日期：2020-08-05 00:00:00
abstract：BACKGROUND:In mildly to moderately malnourished adolescent patients with anorexia nervosa (AN), accelerated refeeding protocols using higher initial calory supply coupled with phosphate supplements were not associated with a higher incidence of refeeding syndrome (RS). It is unclear whether this is also a feasible appr...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9051535
更新日期：2020-05-19 00:00:00
abstract：:Photodynamic therapy (PDT) has become an effective treatment for certain types of solid tumors. The combination of PDT with other therapies has been extensively investigated in recent years to improve its effectiveness and expand its applications. This focused review summarizes the development of a prodrug system in w...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8122198
更新日期：2019-12-13 00:00:00
abstract：:Hyperglycemia is a common occurrence in hospitalized patients receiving parenteral and/or enteral nutrition. Although there are several approaches to manage hyperglycemia, there is no consensus on the best practice. We systematically searched PubMed, Embase, Cochrane Central, and ClinicalTrials.gov to identify records...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8070935
更新日期：2019-06-28 00:00:00
