Abstract:
:Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer and affects millions worldwide. Due to the lack of effective systemic therapies for HCC, researchers have been investigating the use of locoregional tumor control with Yttrium-90 (Y90) radioembolization since the 1960s. Following the development of glass and resin Y90 microspheres in the early 1990s, Y90 radioembolization has been shown to be a safe and efficacious treatment for patients with HCC across Barcelona Clinic Liver Cancer (BCLC) stages. By demonstrating durable local control, good long term outcomes, and equivalent if not superior tumor responses and tolerability when compared to alternative therapies including transarterial chemoembolization (TACE) and sorafenib, Y90 radioembolization is being increasingly used in HCC treatment. More recently, investigations into variations in Y90 radioembolization technique including radiation segmentectomy and radiation lobectomy have further expanded its clinical utility. Here, we discuss the history and evolution of Y90 use in HCC. We outline key clinical trials that have established the safety and efficacy of Y90 radioembolization, and also summarize trials comparing its efficacy to existing HCC treatments. We conclude by reviewing the techniques of radiation segmentectomy and lobectomy, and by discussing dosimetry.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Saini A,Wallace A,Alzubaidi S,Knuttinen MG,Naidu S,Sheth R,Albadawi H,Oklu Rdoi
10.3390/jcm8010055subject
Has Abstractpub_date
2019-01-07 00:00:00issue
1issn
2077-0383pii
jcm8010055journal_volume
8pub_type
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journal_title:Journal of clinical medicine
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journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9113671
更新日期:2020-11-16 00:00:00
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journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9103104
更新日期:2020-09-25 00:00:00
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