Abstract：
:Histological evaluation of renal biopsies is currently the gold standard for acquiring important diagnostic and prognostic information in diabetic nephropathy (DN) patients. Nevertheless, there is an unmet clinical need for new biomarkers that allow earlier diagnosis and risk stratification. As biochemical changes in tissues must precede any symptomatic or morphological expression of a disease, we explored the potential of near-infrared (NIR) spectroscopy in the detection of a biochemical signature associated with DN. Kidney tissue sections were investigated using NIR spectroscopy, followed by principal component analysis and soft independent modelling of class analogy. A biochemical signature indicative of DN was detected, which enabled perfect discrimination between tissue sections with normal histological findings (n = 27) and sections obtained from DN patients (n = 26). Some spectral changes related to carbamoylation and glycation reactions appeared to be similar to the ones obtained in patients with DN. In addition, treatment with the deglycating enzyme fructosamine-3-kinase resulted in partial to pronounced restorations of the spectral pattern. Significant relationships were found between spectral features and laboratory parameters indicative of glycemic and uremic load, such as hemoglobin A1c, urea, creatinine, estimated glomerular filtration rate, and proteinuria. The presented method could be a useful tool to complement histopathological analysis in order to prevent or delay further disease progression, especially in the setting of post-transplant surveillance kidney biopsies.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
De Bruyne S,Van Dorpe J,Himpe J,Van Biesen W,Delanghe S,Speeckaert MM,Delanghe JRdoi
10.3390/jcm8071022subject
Has Abstractpub_date
2019-07-12 00:00:00issue
7issn
2077-0383pii
jcm8071022journal_volume
8pub_type
杂志文章abstract：BACKGROUND:Psoriasis is a chronic inflammatory disease which affects the body far beyond the skin. Whereas there is solid evidence that chronic skin inflammation in psoriasis drives cardiovascular disease, the impact on renal impairment and acute kidney injury (AKI) is still unclear. We aimed to analyze the impact of p...
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更新日期：2020-09-17 00:00:00
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更新日期：2020-08-30 00:00:00
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journal_title：Journal of clinical medicine
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abstract：:A key criterion for the most common chronic liver disease-non-alcoholic fatty liver disease (NAFLD)-is an intrahepatic fat content above 5% in individuals who are not using steatogenic agents or having significant alcohol intake. Subjects with NAFLD have increased plasma concentrations of glucagon, and emerging eviden...
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更新日期：2020-12-15 00:00:00
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journal_title：Journal of clinical medicine
pub_type： 社论
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更新日期：2019-05-08 00:00:00
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journal_title：Journal of clinical medicine
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更新日期：2020-07-21 00:00:00
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更新日期：2019-12-16 00:00:00
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journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
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更新日期：2019-11-15 00:00:00
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journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
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更新日期：2019-09-22 00:00:00
abstract：BACKGROUND:This study aims to evaluate if children with temporal arachnoid cysts (AC) have cognitive symptoms and if neurosurgery improves these. METHODS:A prospective case series study including consecutive pediatric patients with temporal AC. The children underwent neuroradiology, neuroopthalmologic evaluation, and ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
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更新日期：2020-03-20 00:00:00
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journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8060842
更新日期：2019-06-12 00:00:00
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journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9010236
更新日期：2020-01-16 00:00:00
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journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm10010145
更新日期：2021-01-04 00:00:00
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journal_title：Journal of clinical medicine
pub_type： 杂志文章
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更新日期：2019-06-19 00:00:00
abstract：:Cardiogenic shock (CS), as the most severe form of heart failure, is associated with very high mortality rates despite therapeutic advances in the last decades. Gender differences in outcomes have been widely reported regarding several cardiovascular diseases. The aim of our study was to evaluate potential gender disp...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9103117
更新日期：2020-09-27 00:00:00
abstract：:Sepsis is a major cause of death in intensive care units worldwide. The acute phase of sepsis is often accompanied by sepsis-associated encephalopathy, which is highly associated with increased mortality. Moreover, in the chronic phase, more than 50% of surviving patients suffer from severe and long-term cognitive def...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9030703
更新日期：2020-03-05 00:00:00
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pub_type： 杂志文章
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更新日期：2020-09-23 00:00:00
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更新日期：2019-03-01 00:00:00
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更新日期：2020-03-16 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2020-01-28 00:00:00
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journal_title：Journal of clinical medicine
pub_type： 杂志文章
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更新日期：2019-10-08 00:00:00
abstract：:This study aimed to investigate the periodontal health of patients with established rheumatoid arthritis (RA) in relation to oral microbiota, systemic and oral inflammatory mediators, and RA disease activity. Forty patients underwent full-mouth dental/periodontal and rheumatological examination, including collection o...
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pub_type： 杂志文章
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更新日期：2019-05-08 00:00:00
abstract：:Atrial fibrillation (AF) is the most common type of cardiac arrhythmia and is associated with significant morbidity and mortality. The autonomic nervous system (ANS) plays an important role in the initiation and development of AF, causing alterations in atrial structure and electrophysiological defects. The intrinsic ...
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pub_type： 杂志文章,评审
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更新日期：2020-09-24 00:00:00
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更新日期：2020-06-03 00:00:00
abstract：:Androgen/androgen receptor (AR) signaling is a significant driver of prostate cancer progression, therefore androgen-deprivation therapy (ADT) is often used as a standard form of treatment for advanced and metastatic prostate cancer patients. However, after several years of ADT, prostate cancer progresses to castratio...
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更新日期：2019-03-13 00:00:00
abstract：:The core conception of sepsis-that it is a dysregulated state-is a powerful and durable idea that has inspired decades of research. But is it true that the body's response to sepsis is dysregulated? To answer that question, this review surveyed the history of trials of experimental sepsis treatments targeting the host...
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pub_type： 杂志文章,评审
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更新日期：2018-08-29 00:00:00
