Abstract:
:Cancer cells can acquire a spectrum of stable hybrid epithelial/mesenchymal (E/M) states during epithelial-mesenchymal transition (EMT). Cells in these hybrid E/M phenotypes often combine epithelial and mesenchymal features and tend to migrate collectively commonly as small clusters. Such collectively migrating cancer cells play a pivotal role in seeding metastases and their presence in cancer patients indicates an adverse prognostic factor. Moreover, cancer cells in hybrid E/M phenotypes tend to be more associated with stemness which endows them with tumor-initiation ability and therapy resistance. Most recently, cells undergoing EMT have been shown to promote immune suppression for better survival. A systematic understanding of the emergence of hybrid E/M phenotypes and the connection of EMT with stemness and immune suppression would contribute to more effective therapeutic strategies. In this review, we first discuss recent efforts combining theoretical and experimental approaches to elucidate mechanisms underlying EMT multi-stability (i.e., the existence of multiple stable phenotypes during EMT) and the properties of hybrid E/M phenotypes. Following we discuss non-cell-autonomous regulation of EMT by cell cooperation and extracellular matrix. Afterwards, we discuss various metrics that can be used to quantify EMT spectrum. We further describe possible mechanisms underlying the formation of clusters of circulating tumor cells. Last but not least, we summarize recent systems biology analysis of the role of EMT in the acquisition of stemness and immune suppression.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Jia D,Li X,Bocci F,Tripathi S,Deng Y,Jolly MK,Onuchic JN,Levine Hdoi
10.3390/jcm8050725subject
Has Abstractpub_date
2019-05-22 00:00:00issue
5issn
2077-0383pii
jcm8050725journal_volume
8pub_type
杂志文章,评审abstract::Internet gaming disorder (IGD) is a new disease proposed by the Diagnostic and Statistical Manual of Mental Disorders-Fifth Edition (DSM-5), and has been studied extensively in relation to depression and impulsivity. The relationship between resilience and disease has been found in a variety of addictive disorders, bu...
journal_title:Journal of clinical medicine
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abstract::Prolonged oligohydramnios following extreme preterm prelabour rupture of membranes (EPPROM) is traditionally associated with a high morbidity and mortality to both the mother and the baby. The clinical maternal evaluation and fetal ultrasound assessment may provide important prognostic information for the clinicians a...
journal_title:Journal of clinical medicine
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abstract::Mesalamine (5-ASA) is the mainstay therapy in patients with mild-to-moderate active ulcerative colitis (UC). However, non-adherence to therapy and practice variability among gastroenterologists represent long-standing barriers, leading to poor outcomes. Additionally, targets to treat in UC are increasingly evolving fr...
journal_title:Journal of clinical medicine
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更新日期:2020-09-08 00:00:00
abstract::Elevated blood pressure (BP) is a major cause of death, yet hypertension commonly goes undetected. Owing to its nature, it is typically asymptomatic until later in its progression when the vessel or organ structure has already been compromised. Therefore, noninvasive and continuous BP measurement methods are needed to...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9041203
更新日期:2020-04-22 00:00:00
abstract::Air composition influences Dry Eye (DE) symptoms as demonstrated by studies that have linked the outdoor environment to DE. However, there is insufficient data on the effect of short-term exposure to indoor environments on DE symptoms. We conducted a prospective experimental research, in which an older building served...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9051316
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abstract:BACKGROUND:Psoriasis is a chronic inflammatory disease which affects the body far beyond the skin. Whereas there is solid evidence that chronic skin inflammation in psoriasis drives cardiovascular disease, the impact on renal impairment and acute kidney injury (AKI) is still unclear. We aimed to analyze the impact of p...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9093004
更新日期:2020-09-17 00:00:00
abstract::Mitochondrial respiratory chain (MRC) disorders have a multifaceted clinical presentation and genetic origin[...]. ...
journal_title:Journal of clinical medicine
pub_type: 社论
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abstract::Posttraumatic stress disorder (PTSD) is a chronic psychological disorder that can develop after exposure to a traumatic event. This review summarizes the literature on the epidemiology, assessment, and treatment of PTSD. We provide a review of the characteristics of PTSD along with associated risk factors, and describ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
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更新日期:2016-11-22 00:00:00
abstract::This study evaluated whether inter-hospital transfer (IHT) after the return of spontaneous circulation (ROSC) was associated with poor neurological outcomes after 6 months in post-cardiac-arrest patients treated with targeted temperature management (TTM). We used data from the Korean Hypothermia Network prospective re...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9061979
更新日期:2020-06-24 00:00:00
abstract::Background: Urinary calprotectin is a novel biomarker that distinguishes between intrinsic or prerenal acute kidney injury (AKI) in different studies. However, these studies were based on different populations and different AKI criteria. We evaluated the diagnostic accuracy of urinary calprotectin and compared its dia...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm8010074
更新日期:2019-01-10 00:00:00
abstract::The nociceptive withdrawal reflex (NWR) is used to probe spinal cord excitability in chronic pain states. Here, we used an automated and unbiased procedure for determining the NWR threshold and compared the reflex thresholds and corresponding pain ratings in a well-characterized cohort of fibromyalgia (n = 29) and mat...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
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更新日期:2020-06-25 00:00:00
abstract::Patient-reported outcome measures (PROMs) are used to assess satisfaction after total hip arthroplasty (THA); however, the factors that determine these PROMs remain unclear. This study aimed to identify the patient- and surgery-related factors that affect patient satisfaction after THA as indicated by the Oxford Hip S...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm7100358
更新日期:2018-10-15 00:00:00
abstract::Although skin manifestations are quite common in systemic sclerosis (SSc), a link between SSc and psoriasis (PsO) has been poorly investigated. We assessed the Clalit medical database in a cohort study to compare the prevalence of PsO between SSc-patients and SSc-free controls. We also evaluated the SSc-related autoan...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8040521
更新日期:2019-04-16 00:00:00
abstract:BACKGROUND:Thyroid hormone modulation of cardiovascular function has been associated with cardiovascular disease. Recent evidence suggests that free thyroxine (FT4) levels are associated with an increase in systemic arterial stiffness, but little is known about the effects of FT4 at the local level of the common caroti...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm10030420
更新日期:2021-01-22 00:00:00
abstract::Sickle cell disease (SCD) prevalence has increased rapidly in Europe as a result of an increase in the life expectancy of these patients and the arrival of SCD migrants from Africa. The aim of our study was to compare the phenotypes of adult patients born in Sub-Saharan Africa (SSA) who migrated to France with those o...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8122173
更新日期:2019-12-09 00:00:00
abstract::Hypertrophy of facet joints is associated with a high risk of central lumbar spinal stenosis (CLSS). However, no research has reported the effect of inferior articular process hypertrophy in CLSS. We hypothesize that the inferior articular process's cross-sectional area (IAPCSA) is larger in patients with CLSS compare...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9010214
更新日期:2020-01-13 00:00:00
abstract::In the grey zone of testosterone levels between 8 and 12 nmol/L, the usefulness of therapy is controversial; as such, markers of tissue action of androgens may be helpful in adjusting clinical decisions. To better understand the effect of the hypothalamic-pituitary-testicular axis on male accessory secretion, we perfo...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8122128
更新日期:2019-12-03 00:00:00
abstract::Neovascular age related macular degeneration (nAMD) leads to severe vision loss worldwide and is characterized by the formation of choroidal neovascularization (CNV) and fibrosis. In the current study, we aimed to investigate the effect of blockade for platelet derived growth factor receptor-β (PDGFR-β) on the formati...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9072242
更新日期:2020-07-15 00:00:00
abstract:BACKGROUND:Anemia of Chronic Disease (ACD) can negatively influence the clinical course of Inflammatory Bowel Disease (IBD) patients. The aim of this study was to evaluate the effect of Vedolizumab on ACD in IBD. METHODS:Clinical data of 75 IBD patients (25 Crohn's disease (CD) and 50 Ulcerative Colitis (UC)) receivin...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9072126
更新日期:2020-07-06 00:00:00
abstract::Diabetic foot ulcers (DFUs) and diabetic foot infections (DFIs) are associated with reduced patient quality of life, lower-extremity amputation, hospitalization, and high morbidity and mortality. Diverse bacterial communities have been identified in DFUs/DFIs, playing a significant role in infection prognosis. However...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm8111935
更新日期:2019-11-10 00:00:00
abstract:INTRODUCTION:Traumatic cervical artery dissections are associated with high mortality and morbidity in severely injured patients. After finding even higher incidences than reported before, we decided to incorporate a dedicated head-and-neck computed tomography angiogram (CT-A) in our imaging routine for patients who ha...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9082568
更新日期:2020-08-08 00:00:00
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journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm10020286
更新日期:2021-01-14 00:00:00
abstract::Insomnia is a prevalent disorder and it leads to relevant impairment in health-related quality of life. Recent clinical guidelines pointed out that Cognitive-Behavior Therapy for Insomnia (CBT-I) should be considered as first-line intervention. Nevertheless, many other interventions are commonly used by patients or ha...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9061949
更新日期:2020-06-22 00:00:00
abstract:BACKGROUND:Daily management to shield chronic dialysis patients from SARS-CoV-2 contamination makes patient care cumbersome. There are no screening methods to date and a molecular biology platform is essential to perform RT-PCR for SARS-CoV-2; however, accessibility remains poor. Our goal was to assess whether the tool...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm10010004
更新日期:2020-12-22 00:00:00
abstract::In excess of three quarters of patients with psoriatic arthritis (PsA) have preceding psoriasis (PsO), which offers a clinical biomarker for the recognition of early PsA. Numerous surveys have shown a remarkably high frequency of clinically occult musculoskeletal symptoms in psoriasis patients. Imaging studies, partic...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9103262
更新日期:2020-10-12 00:00:00
abstract::The aim of this paper was to provide insights into alcohol misuse within UK veterans to inform as to whether their presentations differ from the general public. This was done by exploring differences in the severity of alcohol misuse between UK veterans and the general public admitted to a general NHS hospital over an...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm5110095
更新日期:2016-11-02 00:00:00
abstract::Both nuclear and mitochondrial DNA defects can cause isolated cytochrome c oxidase (COX; complex IV) deficiency, leading to the development of the mitochondrial disease. We report a 52-year-old female patient who presented with a late-onset, progressive cerebellar ataxia, tremor and axonal neuropathy. No family histor...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8060789
更新日期:2019-06-04 00:00:00
abstract::Risk assessment is relevant to predict outcomes in patients with gastric cancer. This systematic review aimed to investigate the predictive value of low muscle mass for postoperative complications in gastric cancer patients. A systematic literature search was performed to identify all articles reporting on muscle mass...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9010199
更新日期:2020-01-11 00:00:00
abstract::Spinal disorders and associated interventions are costly in the United States, putting them in the limelight of economic analyses. The Patient-Reported Outcomes Measurement Information System Global Health Survey (PROMIS-GHS) requires mapping to other surveys for economic investigation. Previous studies have proposed ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8101506
更新日期:2019-09-20 00:00:00
abstract::Irritable bowel syndrome (IBS) is one of the most common of all medical disorders worldwide and, while for some it represents no more than a nuisance, for others it imposes significant negative impacts on daily life and activities. IBS is a heterogeneous disorder and may well have a number of causes which may lie anyw...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm7010006
更新日期:2018-01-03 00:00:00