Abstract：
:Tuberculosis (TB) remains a major health issue worldwide. In order to contain TB infections, improved vaccines as well as accurate and reliable diagnostic tools are desirable. Exosomes are employed for the diagnosis of various diseases. At present, research on exosomes in TB is still at the preliminary stage. Recent studies have described isolation and characterization of Mycobacterium tuberculosis (Mtb) derived exosomes in vivo and in vitro. Mtb-derived exosomes (Mtbexo) may be critical for TB pathogenesis by delivering mycobacterial-derived components to the recipient cells. Proteomic and transcriptomic analysis of Mtbexo have revealed a variety of proteins and miRNA, which are utilized by the TB bacteria for pathogenesis. Exosomes has been isolated in body fluids, are amenable for fast detection, and could contribute as diagnostic or prognostic biomarker to disease control. Extraction of exosomes from biological fluids is essential for the exosome research and requires careful standardization for TB. In this review, we summarized the different studies on Mtbexo molecules, including protein and miRNA and the method used to detect exosomes in biological fluids and cell culture supernatants. Thus, the detection of Mtbexo molecules in biological fluids may have a potential to expedite the diagnosis of TB infection. Moreover, the analysis of Mtbexo may generate new aspects in vaccine development.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Biadglegne F,König B,Rodloff AC,Dorhoi A,Sack Udoi
10.3390/jcm10010145subject
Has Abstractpub_date
2021-01-04 00:00:00issue
1issn
2077-0383pii
jcm10010145journal_volume
10pub_type
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更新日期：2018-05-10 00:00:00
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更新日期：2014-10-29 00:00:00
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journal_title：Journal of clinical medicine
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更新日期：2019-10-22 00:00:00
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更新日期：2020-08-01 00:00:00
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journal_title：Journal of clinical medicine
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更新日期：2018-12-02 00:00:00
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journal_title：Journal of clinical medicine
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doi：10.3390/jcm8030392
更新日期：2019-03-21 00:00:00
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pub_type： 杂志文章
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更新日期：2020-05-06 00:00:00
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journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9124094
更新日期：2020-12-18 00:00:00
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journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8040431
更新日期：2019-03-29 00:00:00
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journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8050741
更新日期：2019-05-24 00:00:00
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pub_type： 杂志文章
doi：10.3390/jcm8020233
更新日期：2019-02-11 00:00:00
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pub_type： 杂志文章
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更新日期：2018-04-10 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章,评审
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更新日期：2020-11-06 00:00:00
