Abstract：
:The aims of the study were to evaluate long-term outcomes after autologous matrix-induced chondrogenesis (AMIC) in the treatment of focal chondral lesions and to assess the possible improvements given by the combination of this technique with bone marrow aspirate concentrate (BMAC). Twenty-four patients (age range 18⁻55 years) affected by focal knee chondral lesions were treated with standard AMIC or AMIC enhanced by BMAC (AMIC+). Pain (Visual Analogue Scale (VAS)) and functional scores (Lysholm, International Knee Documentation Committee (IKDC), Tegner, Knee injury and Osteoarthritis Outcome Score (KOOS)) were collected pre-operatively and then at 6, 12, 24, 60, and 100 months after treatment. Magnetic resonance imaging (MRI) evaluation was performed pre-operatively and at 6, 12, and 24 months follow-ups. Patients treated with AMIC+ showed higher Lysholm scores (p = 0.015) and lower VAS (p = 0.011) in comparison with patients in the standard AMIC group at the 12 months follow-up. Both treatments allowed for functional and pain improvements with respect to pre-operative levels lasting up to 100 months. MRI revealed consistent cartilage repair at 24 months in both groups. This study shows that AMIC and AMIC+ are effective treatments for focal chondral lesions with beneficial effect lasting up to 9 years. AMIC+ allows for faster recovery from injury, and is thus more indicated for patients requiring a prompt return to activity. Level of evidence: II, randomized controlled trial in an explorative cohort.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
de Girolamo L,Schönhuber H,Viganò M,Bait C,Quaglia A,Thiebat G,Volpi Pdoi
10.3390/jcm8030392subject
Has Abstractpub_date
2019-03-21 00:00:00issue
3issn
2077-0383pii
jcm8030392journal_volume
8pub_type
杂志文章abstract：:Differing beliefs about the acceptability of living-donor kidney transplants (LDKTs) have been proposed as explaining age, ethnic and socioeconomic disparities in their uptake. We investigated whether certain patient groups hold beliefs incompatible with LDKTs. This questionnaire-based case-control study was based at ...
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更新日期：2020-08-11 00:00:00
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更新日期：2020-11-05 00:00:00
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更新日期：2020-12-28 00:00:00
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更新日期：2019-09-05 00:00:00
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更新日期：2020-08-13 00:00:00
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更新日期：2019-10-03 00:00:00
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更新日期：2020-09-27 00:00:00
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更新日期：2019-03-27 00:00:00
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