Abstract：
:Endometriosis concerns more than 10% of women of reproductive age, frequently leading to chronic pelvic pain. Repetitive transcranial magnetic stimulation (rTMS) over the primary motor cortex (M1) induces an analgesic effect. This effect on chronic pelvic pain is yet to be evaluated. The objective of this study was to assess the feasibility and effect of rTMS to reduce pain and improve quality of life (QoL) in patients with chronic pelvic pain due to endometriosis. This pilot, open-labelled prospective trial examined treatment by neuronavigated rTMS over M1, one session per day for 5 consecutive days. Each session consisted of 1.500 pulses at 10 Hz. We assessed tolerance, pain change and QoL until 4 weeks post treatment with a primary endpoint at day 8. Twelve women were included. No patients experienced serious adverse effects or a significant increase in pain. Nine women reported improvement on the Patient Global Impression of Change with a reduction in both pain intensity and pain interference (5.1 ± 1.4 vs. 4.1 ± 1.6, p = 0.01 and 6.2 ± 2.1 vs. 4.2 ± 1.5, p = 0.004, respectively). rTMS appears well tolerated and might be of interest for patients suffering from chronic pelvic pain for whom other treatments have failed. A randomized controlled trial is mandatory before proposing such treatment.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Pinot-Monange A,Moisset X,Chauvet P,Gremeau AS,Comptour A,Canis M,Pereira B,Bourdel Ndoi
10.3390/jcm8040508subject
Has Abstractpub_date
2019-04-13 00:00:00issue
4issn
2077-0383pii
jcm8040508journal_volume
8pub_type
杂志文章abstract：BACKGROUND:We aimed to build a model using machine learning for the prediction of survival in trauma patients and compared these model predictions to those predicted by the most commonly used algorithm, the Trauma and Injury Severity Score (TRISS). METHODS:Enrolled hospitalized trauma patients from 2009 to 2016 were d...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
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更新日期：2019-06-05 00:00:00
abstract：:The diagnosis of small-bowel tumors is challenging due to their low incidence, nonspecific presentation, and limitations of traditional endoscopic techniques. In our study, we examined the utility of the mucosal protrusion angle in differentiating between true submucosal masses and bulges of the small bowel on video c...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
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更新日期：2019-03-27 00:00:00
abstract：:(1) Background: To evaluate women's satisfaction with the care received during childbirth undergoing labour and how this changes over time. (2) Methods: An observational, multicentre and longitudinal study in two public hospitals of Spain with a convenience sample of 248 women during the post-partum period. Satisfacti...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8040434
更新日期：2019-03-29 00:00:00
abstract：:Pulmonary vein (PV) enlargement is associated with atrial fibrillation (AF). However, the predictive value of PV volume for new-onset AF has not been determined. We retrospectively assessed and enrolled non-AF subjects who underwent echocardiography and cardiac CT angiography (CCTA) around the same time and evaluated ...
journal_title：Journal of clinical medicine
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更新日期：2020-02-02 00:00:00
abstract：:This study assessed the efficacy of intraoperative high-dose intravenous iron therapy in facilitating recovery from postoperative anemia and reducing the transfusion rate in patients with total knee and total hip arthroplasty. This prospective randomized controlled study involved 58 subjects. Group F received 1000 mg ...
journal_title：Journal of clinical medicine
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更新日期：2019-10-13 00:00:00
abstract：:Diabetes mellitus is one of the most prevalent chronic diseases worldwide. Diabetic patients are at risk of developing cataract and present for surgery at an earlier age than non-diabetics. The aim of this study was to review the problems associated with cataract surgery in a diabetic patient. Corneal complications in...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
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更新日期：2019-05-20 00:00:00
abstract：:The widespread epidemic of obesity and type 2 diabetes (T2D), suggests that both disorders are closely linked. Several pre-clinical and clinical studies have showed that adipose-derived mesenchymal stem cells (ASC) transplantation is efficient and safe. Moreover, scientists have already highlighted the therapeutic cap...
journal_title：Journal of clinical medicine
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更新日期：2019-05-30 00:00:00
abstract：:The ongoing coronavirus disease 2019 (COVID-19) pandemic has resulted in efforts to identify therapies to ameliorate adverse clinical outcomes. The recognition of the key role for increased inflammation in COVID-19 has led to a proliferation of clinical trials targeting inflammation. The purpose of this review is to c...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
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更新日期：2020-09-11 00:00:00
abstract：:Women affected by autoimmune diseases, organ transplantation, or neoplasia need to continue immunosuppressive treatment during pregnancy. In this setting, not only a careful planning of pregnancy, but also the choice of drugs is critical to preventing maternal complications and minimizing the fetal risks. Some immunos...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
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更新日期：2018-12-15 00:00:00
abstract：:This study of parents in Romania explores how perceptions of their couple relationship quality and of factors associated with it (such as sexual communication anxiety and sexual perfectionism) were related to their perception of aspects describing parenting dimensions relevant to the sexual education and sexual health...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
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更新日期：2019-03-19 00:00:00
abstract：:The evolution of implant dentistry since the discovery of the osseointegration concept has been remarkable [...]. ...
journal_title：Journal of clinical medicine
pub_type： 社论
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更新日期：2020-05-22 00:00:00
abstract：:Nocturnal (night) eating syndrome and sleep-related eating disorder have common characteristics, but are considered to differ in their level of consciousness during eating behavior and recallability. To date, there have been no large population-based studies determining their similarities and differences. We conducted...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9041243
更新日期：2020-04-24 00:00:00
abstract：:(1) Background: Focal chondral defects of the knee can significantly impair patient quality of life. Although different options are available, they are still not conclusive and have several limitations. The aim of this study was to evaluate the role of autologous cartilage micrografts in the treatment of knee chondrop...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm10020322
更新日期：2021-01-17 00:00:00
abstract：:This study reports the integrated analysis of two phase III studies of meropenem-vaborbactam in the treatment of acute bacterial infections. Targeting Antibiotic Non-Susceptible Gram-Negative Organisms (TANGO) I compared the clinical efficacy and tolerability of meropenem-vaborbactam and piperacillin-tazobactam in the...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8101650
更新日期：2019-10-11 00:00:00
abstract：BACKGROUND:Although aldosterone has been demonstrated to induce left ventricular (LV) hypertrophy not only in primary aldosteronism but also in primary hypertension (HT), it can be affected by multiple factors, including age, and the effect of aldosterone on LV function is controversial. This study was to investigate t...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8071045
更新日期：2019-07-17 00:00:00
abstract：:The purpose of this study was to investigate the effect of high molecular weight hyaluronan (HMWHA) eye drops on subbasal corneal nerves in patients suffering from severe dry eye disease (DED) and to evaluate the damage of subbasal corneal nerves associated with severe DED. Designed as an international, multicenter st...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9123799
更新日期：2020-11-24 00:00:00
abstract：:Paraneoplastic neurological syndromes (PNSs) are a heterogeneous group of rare immune-mediated diseases associated with cancer. The aim of this study was to investigate the prevalence of PNSs in the province of Brescia. PNS prevalence was calculated using the Lombardy regional hospital admission records from 1998 to 2...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9103105
更新日期：2020-09-25 00:00:00
abstract：:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the global coronavirus disease 2019 (COVID-19) outbreak. Along with the respiratory tract, the gastrointestinal (GI) tract is one of the main extra-pulmonary targets of SARS-CoV-2 with respect to symptom occurrence and is a potential route fo...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9113630
更新日期：2020-11-11 00:00:00
abstract：:The ultrasound (US) pattern of intrathyroidal ectopic thymus (IET) can resemble papillary thyroid carcinoma (PTC) while the extrathyroidal ectopic thymus (EET) can mimic pathological lymph nodes. Recently, the usefulness of strain elastography (SE) was demonstrated in the differential diagnosis, however this method ha...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9123816
更新日期：2020-11-25 00:00:00
abstract：:CD73, a cell-surface protein encoded by the gene NT5E, is overexpressed in glioblastoma (GBM), where it contributes to the tumor's pathophysiology via the generation of immunosuppressive adenosine. Adenosinergic signaling, in turn, drives immunosuppression of natural killer (NK) cells through metabolic and functional ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8101526
更新日期：2019-09-23 00:00:00
abstract：:This study evaluated the efficacy of Lactobacillus acidophilus YT1 (MENOLACTO) for alleviating menopausal symptoms. This study was a multi-center, randomized, double-blinded, placebo-controlled clinical trial involving female subjects (ages: 40-60 years) with menopausal symptoms and a Kupperman index (KMI) score ≥ 20....
journal_title：Journal of clinical medicine
pub_type： 杂志文章
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更新日期：2020-07-09 00:00:00
abstract：:Post-transplant diabetes mellitus (PTDM) is a serious complication in renal transplant recipients. Branched-chain amino acids (BCAAs) are involved in the pathogenesis of insulin resistance. We determined the association of plasma BCAAs with PTDM and included adult renal transplant recipients (≥18 y) with a functioning...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
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更新日期：2020-02-13 00:00:00
abstract：:This phase II randomized controlled trial tested whether intracoronary autologous CD34+ cell therapy could further improve left ventricular (LV) systolic function in patients with diffuse coronary artery disease (CAD) with relatively preserved LV ejection fraction (defined as LVEF >40%) unsuitable for coronary interve...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
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更新日期：2020-04-07 00:00:00
abstract：:Congenital lactic acidosis (CLA) is a rare condition in most instances due to a range of inborn errors of metabolism that result in defective mitochondrial function. Even though the implementation of next generation sequencing has been rapid, the diagnosis rate for this highly heterogeneous allelic condition remains l...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
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更新日期：2019-11-01 00:00:00
abstract：:Objectives: One of the challenges of spine surgery is the need for adequate exposure of the anterolateral spinal column. Improved retractor systems with integrated lighting minimize the need for large thoracotomy, flank, or abdominal incisions. In 2013, we began using the NuVasive MaXcess® system via a minimal-access ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
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更新日期：2020-09-27 00:00:00
abstract：:Endoscopic resection is recommended for gastric neoplasms confined to mucosa or superficial submucosa. The determination of invasion depth is based on gross morphology assessed in endoscopic images, or on endoscopic ultrasound. These methods have limited accuracy and pose an inter-observer variability. Several studies...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9061858
更新日期：2020-06-15 00:00:00
abstract：BACKGROUND:Invasive fungal disease (IFD) is common in solid organ transplant (SOT) recipients and contributes to high morbidity and mortality. Although kidney transplantation (KT) is a commonly performed SOT, data on the risk factors for IFD-related mortality are limited. METHODS:A 1:2 retrospective case-control study...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
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更新日期：2020-06-11 00:00:00
abstract：:Brain-derived neurotrophic factor (BDNF) facilitates neuronal growth and plasticity, and is crucial for learning and memory. Contactin-1 (CNTN1) is a member of the subfamily of neural immunoglobulin and is involved in the formation of axon connections in the developing nervous system. This cross-sectional study invest...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
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更新日期：2019-09-02 00:00:00
abstract：:Although remote ischemic preconditioning (RIPC) has been shown to have renoprotective effects, few studies have assessed the effects of RIPC on renal function in living kidney donors. This study investigated whether RIPC performed in living kidney donors could improve residual renal function in donors and outcomes in ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8050713
更新日期：2019-05-20 00:00:00
abstract：:The aim of this study was to investigate the prescribing cascade phenomenon of dopaminergic drugs such as levodopa in the management of gastroprokinetic drugs induced parkinsonism. Based on the Korea National Health Insurance Service (NHIS)-Senior Cohort Database, we analyzed patients aged ≥65 years, between 2009 and ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
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更新日期：2019-09-19 00:00:00
