Abstract:
:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the global coronavirus disease 2019 (COVID-19) outbreak. Along with the respiratory tract, the gastrointestinal (GI) tract is one of the main extra-pulmonary targets of SARS-CoV-2 with respect to symptom occurrence and is a potential route for virus transmission, most likely due to the presence of angiotensin-converting enzyme 2. Therefore, understanding the mechanisms of GI injury is crucial for a harmonized therapeutic strategy against COVID-19. This review summarizes the current evidence for the clinical features of and possible pathogenic mechanisms leading to GI injury in COVID-19.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Mitsuyama K,Tsuruta K,Takedatsu H,Yoshioka S,Morita M,Niwa M,Matsumoto Sdoi
10.3390/jcm9113630subject
Has Abstractpub_date
2020-11-11 00:00:00issue
11issn
2077-0383pii
jcm9113630journal_volume
9pub_type
杂志文章,评审abstract:OBJECTIVES:Non-alcoholic fatty liver disease (NAFLD) is considered a well-known pathology that is determined without using alcohol and has emerged as a growing public health problem. Lipotoxicity is known to promote hepatocyte death, which, in the context of NAFLD, is termed lipoapoptosis. The severity of NAFLD correla...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9051294
更新日期:2020-05-01 00:00:00
abstract::Tens of millions of patients are affected by liver disease worldwide. Many of these patients can benefit from cell therapy involving living metabolically active cells, either by treatment of their liver disease, or by prevention of their disease phenotype. Cell therapies, including hepatocyte transplantation and bioar...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm3030997
更新日期:2014-09-05 00:00:00
abstract::The purpose of this study was to investigate the relationship between the retinal pigment epithelium (RPE) and outer retina changes, expressed in terms of sub-RPE illumination (SRI) on optical-coherence tomography (OCT), and central retinal function, measured by visual acuity and focal electroretinogram (fERG), in pat...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9092973
更新日期:2020-09-15 00:00:00
abstract::This study aimed to investigate the periodontal health of patients with established rheumatoid arthritis (RA) in relation to oral microbiota, systemic and oral inflammatory mediators, and RA disease activity. Forty patients underwent full-mouth dental/periodontal and rheumatological examination, including collection o...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8050630
更新日期:2019-05-08 00:00:00
abstract::This study was conducted to determine whether overcrowding in the emergency department (ED) affects the occurrence of a return visit (RV) within 72 hours. The crowding indicator of index visit was the average number of total patients, patients under observation, and boarding patients during the first 1 and 4 hours fro...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9051406
更新日期:2020-05-09 00:00:00
abstract::Nasal deformity is associated with congenital cleft lip and palate. Primary rhinoplasty for reconstruction of the nasal deformity at the time of bilateral cleft lip repair is a controversial issue in cleft care due to traditional teaching concerning the potential impairment of nasal growth. This study assessed long-te...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8050602
更新日期:2019-05-01 00:00:00
abstract::Regional anesthesia (RA) is an anesthetic technique essential for the performance of ambulatory surgery. Failure rates range from 6% to 20%, and the consequences of these failures have been poorly investigated. We determined the incidence and the impact of regional block failure on patient management in the ambulatory...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9082453
更新日期:2020-07-31 00:00:00
abstract::Cholangiocarcinoma (CCA) arises from the biliary tract epithelium and accounts for 10-15% of all hepatobiliary malignancies. Depending on anatomic location, CCA is classified as intrahepatic (iCCA), perihilar (pCCA) and distal (dCCA). The best treatment option for pCCA is liver resection and when a radical oncological...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9051353
更新日期:2020-05-05 00:00:00
abstract::Acute cardiovascular disease after community-acquired pneumonia is a well-accepted complication for which definitive treatment strategies are lacking. These complications share some common features but have distinct diagnostic and treatment approaches. We therefore undertook an updated systematic review and meta-analy...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9020414
更新日期:2020-02-03 00:00:00
abstract::Active vision therapy using perceptual learning and/or dichoptic or binocular environments has shown its potential effectiveness in amblyopia, but some doubts remain about the type of stimuli and the mode and sequence of presentation that should be used. A search was performed in PubMed, obtaining 143 articles with in...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9123985
更新日期:2020-12-09 00:00:00
abstract::Many studies have shown a global efficacy of laparoscopic surgery for patients with endometriosis in reducing painful symptoms and improving quality of life (QoL) in the short and long-term. The aim of this study was to analyze the different trajectories of long-term evolution in QoL and symptoms following surgical tr...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9082461
更新日期:2020-07-31 00:00:00
abstract::Long noncoding RNAs (lncRNAs) are involved in diverse physiological and pathological processes by modulating gene expression. They have been found to be dysregulated in the brain and cerebrospinal fluid of patients with neurodegenerative diseases, and are considered promising therapeutic targets for treatment. Among t...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm7110461
更新日期:2018-11-21 00:00:00
abstract::Cognitive models of pain propose that catastrophic thinking is negatively associated with chronic pain. However, pain catastrophizing is a complex phenomenon requiring a multivariate examination. This study estimates the effects of mood variables (anxiety and depression) on pain catastrophizing in older adults with ch...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9072073
更新日期:2020-07-01 00:00:00
abstract::Creatinine is produced in muscle metabolism as the end-product of creatine phosphate and is subsequently excreted principally by way of the kidneys, predominantly by glomerular filtration. Blood creatinine assays constitute the most common clinically relevant measure of renal function. The use of individual patient-le...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm4071348
更新日期:2015-06-26 00:00:00
abstract:INTRODUCTION:Advances in the acute treatment of myocardial infarction (AMI) substantially reduced in-hospital mortality, but the post-discharge prognosis is still unacceptable. The Managed Care in Acute Myocardial Infarction (MC-AMI) is a program of Poland's National Health Fund that aims at comprehensive post-AMI care...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9103178
更新日期:2020-09-30 00:00:00
abstract::The aim of this study was to analyze the value of urine α- and π-GST in monitoring and predicting kidney graft function following transplantation. In addition, urine samples from corresponding organ donors was analyzed and compared with graft function after organ donation from brain-dead and living donors. Urine sampl...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8111899
更新日期:2019-11-07 00:00:00
abstract:OBJECTIVE:To investigate the risk and risk factors for suicide attempt by patients with regular migraines (RM) and status migrainosus (SM) in Taiwan. METHODS:We analyzed a subset of the National Health Insurance Research Database of Taiwan and enrolled patients (≥20 years old) who had ever received a diagnosis of RM o...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm7090269
更新日期:2018-09-11 00:00:00
abstract::This study explored the perspectives and experiences of breast cancer patients and medical oncologists with regards to participation in a lifestyle intervention at a tertiary cancer treatment center. A thematic approach was used to understand the context within which a lifestyle intervention was recommended and experi...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9092815
更新日期:2020-08-31 00:00:00
abstract::Hypertrophy of facet joints is associated with a high risk of central lumbar spinal stenosis (CLSS). However, no research has reported the effect of inferior articular process hypertrophy in CLSS. We hypothesize that the inferior articular process's cross-sectional area (IAPCSA) is larger in patients with CLSS compare...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9010214
更新日期:2020-01-13 00:00:00
abstract::In recent years, the genetic architecture of dilated cardiomyopathy (DCM) has been more thoroughly elucidated. However, there is still insufficient knowledge on the modifiers and regulatory principles that lead to the failure of myocardial function. The current study investigates the association of epigenome-wide DNA ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9051499
更新日期:2020-05-16 00:00:00
abstract:BACKGROUND:Depression is commonly treated with anti-depressant medication and/or psychological interventions. Patients with depression are common users of complementary therapies, such as acupuncture, either as a replacement for, or adjunct to, their conventional treatments. This systematic review and meta-analysis exa...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm8081140
更新日期:2019-07-31 00:00:00
abstract::An increasing number of studies implicates the NF-κB (Nuclear Factor of kappa light chain gene enhancer in B cells) alternative pathway in non-small-cell lung cancer (NSCLC). We assessed the clinical significance of CD40 (Tumor necrosis factor receptor superfamily member 5, TNFRSF5), BAFFR (B-cell activating factor re...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8050741
更新日期:2019-05-24 00:00:00
abstract:BACKGROUND:Mismatch of intramedullary nails with the bowing of femur is a frequent clinical finding. Previous studies showed inconsistent results. METHODS:We present an algorithm of region growing territory method to get the radii of the anterior bowing of femur. We also tested it on ten radiographs. Plain radiographs...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8101598
更新日期:2019-10-03 00:00:00
abstract::Psoriatic arthritis (PsA) is a chronic immune-mediated disease manifesting as joint inflammation with functional impairment associated with psoriasis. Recently, PsA has emerged as a systemic disease with several comorbidities, such as cardiovascular diseases and metabolic disorders. Apremilast is a targeted synthetic ...
journal_title:Journal of clinical medicine
pub_type:
doi:10.3390/jcm8030398
更新日期:2019-03-22 00:00:00
abstract:PURPOSE:To investigate the prognostic significance of diabetes mellitus (DM) in patients with high risk acute myocardial infarction (AMI) treated with primary percutaneous coronary intervention (pPCI) in the era of potent antithrombotics. METHODS:Data from 1230 ST-segment elevation myocardial infarction (STEMI) patien...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9082555
更新日期:2020-08-06 00:00:00
abstract:INTRODUCTION:Immunoglobulin G4-related disease (IgG4-RD) is a systemic immune-mediated disease characterised pathologically by the infiltration of IgG4-bearing plasma cells into the involved organs. Autoimmune pancreatitis (AIP) is a form of chronic pancreatitis with a heavy lymphocytic infiltration and two distinct hi...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9020409
更新日期:2020-02-03 00:00:00
abstract::Pain is the main impetus for osteoarthritis (OA) patients to seek healthcare including joint replacement. The pain experience in OA is heterogeneous and affected by factors across multiple domains-peripheral, psychological, and neurological. This indicates the existence of homogenous subgroups/phenotypes within OA pat...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9030632
更新日期:2020-02-27 00:00:00
abstract:BACKGROUND:To investigate the short-term effects of different types of anti-glaucoma eyedrop on sclero-conjunctival vasculatures and their associations with intraocular pressure (IOP) reduction. METHODS:This was a prospective study including 20 healthy subjects. A single instillation of ripasudil or bimatoprost was in...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9124016
更新日期:2020-12-11 00:00:00
abstract::Sex differences among patients with complement-gene-variant-mediated thrombotic microangiopathy (cTMA) are not well established. We examined demographic and clinical data from female and male patients with a history of cTMA enrolled in the Vienna thrombotic microangiopathy (TMA) cohort. Follow-up was three years after...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9040964
更新日期:2020-03-31 00:00:00
abstract::Rhinosinusitis (RS) is a common disease in children, significantly affecting their quality of life. Chronic rhinosinusitis (CRS) is frequently linked to other respiratory diseases, including asthma. Children affected by CRS may be candidates for surgery in the case of failure of maximal medical therapy comprising thre...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm8050684
更新日期:2019-05-15 00:00:00