Abstract:
:Creatinine is produced in muscle metabolism as the end-product of creatine phosphate and is subsequently excreted principally by way of the kidneys, predominantly by glomerular filtration. Blood creatinine assays constitute the most common clinically relevant measure of renal function. The use of individual patient-level real-time serum creatinine trajectories provides a very attractive and tantalizing methodology in nephrology practice. Topics covered in this review include acute kidney injury (AKI) with its multifarious rainbow spectrum of renal outcomes; the stimulating vicissitudes of the diverse patterns of chronic kidney disease (CKD) to end-stage renal disease (ESRD) progression, including the syndrome of rapid onset end stage renal disease (SORO-ESRD); the syndrome of late onset renal failure from angiotensin blockade (LORFFAB); and post-operative AKI linked with the role of intra-operative hypotension in patients with diabetes mellitus and suspected diabetic nephropathy with CKD. We conclude that the study of individual patient-level serum creatinine trajectories, albeit a neglected and forgotten diagnostic methodology for diabetic CKD prognostication and prediction, is a most useful diagnostic tool, both in the short-term and in the long-term practice of nephrology. The analysis of serum creatinine trajectories, both in real time and retrospectively, indeed provides supplementary superior diagnostic and prognostic insights in the management of the nephrology patient.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Onuigbo MA,Agbasi Ndoi
10.3390/jcm4071348subject
Has Abstractpub_date
2015-06-26 00:00:00pages
1348-68issue
7issn
2077-0383pii
jcm4071348journal_volume
4pub_type
杂志文章,评审abstract::Survivors of colorectal cancer (CRC) may experience a range of physical, psychosocial, and practical challenges as a consequence of their diagnosis. We assessed the patterns and documented content of follow-up visits within the first three years following treatment, in comparison to survivorship care guidelines. Survi...
journal_title:Journal of clinical medicine
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更新日期:2020-08-24 00:00:00
abstract::The worldwide epidemiology of inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), still shows an increasing trend in Asia and Iran. Despite an improvement in the treatment landscape focused on symptomatic control, long-term colectomies have not decreased over the last 10-year ...
journal_title:Journal of clinical medicine
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journal_title:Journal of clinical medicine
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更新日期:2020-06-29 00:00:00
abstract::Robust early prediction of clinical outcomes in Parkinson's disease (PD) is paramount for implementing appropriate management interventions. We propose a method that uses the baseline MRI, measuring diffusion parameters from multiple parcellated brain regions, to predict the 2-year clinical outcome in Parkinson's dise...
journal_title:Journal of clinical medicine
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abstract::Injury is a major cause of worldwide child mortality. This retrospective nationwide study aimed to evaluate the characteristics of paediatric injured patients in Japan and their in-hospital mortality trends from 2009 to 2018. Injured patients aged <17 years were enrolled. Data were extracted from the Japan Trauma Data...
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abstract:BACKGROUND AND AIMS:The Multidimensional Prognostic Index (MPI), an objective and quantifiable tool based on the Comprehensive Geriatric Assessment, has been shown to predict adverse outcomes in European cohorts. We conducted a validation study of the original MPI, and of adapted versions that accounted for the use of ...
journal_title:Journal of clinical medicine
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更新日期:2019-11-01 00:00:00
abstract::Active vision therapy using perceptual learning and/or dichoptic or binocular environments has shown its potential effectiveness in amblyopia, but some doubts remain about the type of stimuli and the mode and sequence of presentation that should be used. A search was performed in PubMed, obtaining 143 articles with in...
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journal_title:Journal of clinical medicine
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更新日期:2020-06-02 00:00:00
abstract::Conventional 3D multicellular tumor spheroids of head and neck squamous cell carcinoma (HNSCC) consisting exclusively of cancer cells have some limitations. They are compact cell aggregates that do not interact with their extracellular milieu, thus suffering from both insufficient extracellular matrix (ECM) deposition...
journal_title:Journal of clinical medicine
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更新日期:2019-10-15 00:00:00
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更新日期:2020-07-08 00:00:00
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journal_title:Journal of clinical medicine
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更新日期:2019-09-02 00:00:00
abstract:BACKGROUND:Oral and enteral mucositis due to high-dose cytostatic treatment administered during autologous and allogeneic stem-cell transplantation increases mortality. Salivary secretory immunoglobulin A (sIgA) is a basic pillar of local immunity in the first line of defense. Altered salivary sialoglycoprotein carbohy...
journal_title:Journal of clinical medicine
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更新日期:2020-06-05 00:00:00
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journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
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更新日期:2019-09-13 00:00:00
abstract::Immune checkpoint inhibitors (ICI) have revolutionised cancer therapy. However, they have been effective in only a small subset of patients and a principal mechanism underlying immune-refractoriness is a 'cold' tumour microenvironment, that is, lack of a T-cell-rich, spontaneously inflamed phenotype. As such, there is...
journal_title:Journal of clinical medicine
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更新日期:2020-10-16 00:00:00
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journal_title:Journal of clinical medicine
pub_type: 杂志文章
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更新日期:2020-05-16 00:00:00
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journal_title:Journal of clinical medicine
pub_type: 杂志文章
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更新日期:2020-06-19 00:00:00
abstract:BACKGROUND:In-depth knowledge about potential predictors of mortality in transcatheter aortic valve replacement (TAVR) is still warranted. Currently used risk stratification models for TAVR often fail to reach a holistic approach. We, therefore, aimed to create a new staged risk model for 1-year mortality including sev...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
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更新日期:2019-10-08 00:00:00
abstract::The widely varying therapeutic response of patients with inflammatory bowel disease (IBD) continues to raise questions regarding the unclarified heterogeneity of pathological mechanisms promoting disease progression. While biomarkers for the differentiation of Crohn's disease (CD) versus ulcerative colitis (UC) have b...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
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更新日期:2020-05-06 00:00:00
abstract::The ultrasound (US) pattern of intrathyroidal ectopic thymus (IET) can resemble papillary thyroid carcinoma (PTC) while the extrathyroidal ectopic thymus (EET) can mimic pathological lymph nodes. Recently, the usefulness of strain elastography (SE) was demonstrated in the differential diagnosis, however this method ha...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
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更新日期:2020-11-25 00:00:00
abstract:BACKGROUND AND AIMS:The markers of renal damage defining subclinical AKI are not widely used in children undergoing allogeneic hematopoietic stem cell transplantation (alloHSCT). The aim of the study was to evaluate serum and urinary clusterin as indices of kidney injury after alloHSCT in relation to damage (kidney inj...
journal_title:Journal of clinical medicine
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更新日期:2020-08-11 00:00:00
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journal_title:Journal of clinical medicine
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journal_title:Journal of clinical medicine
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journal_title:Journal of clinical medicine
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更新日期:2020-06-01 00:00:00
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journal_title:Journal of clinical medicine
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更新日期:2020-02-14 00:00:00
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更新日期:2019-05-24 00:00:00
abstract:BACKGROUND AND AIMS:Data from clinical trials suggest that biological drugs may improve the outcomes in Crohn's disease (CD) by reducing the need for surgery or hospitalization. The aim of this study is to evaluate the time-trends of the use of biological drugs and other treatments for CD, and its relationship with out...
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journal_title:Journal of clinical medicine
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更新日期:2020-07-13 00:00:00