Abstract：
:Oral diseases are considered the most common noncommunicable diseases and are related to serious local and systemic disorders. Oral pathogens can grow and spread in the oral mucosae and frequently in biomaterials (e.g., dentures or prostheses) under polymicrobial biofilms, leading to several disorders such as dental caries and periodontal disease. Biofilms harbor a complex array of interacting microbes, increasingly unapproachable to antimicrobials and with dynamic processes key to disease pathogenicity, which partially explain the gradual loss of response towards conventional therapeutic regimens. New drugs (synthesized and natural) and other therapies that have revealed promising results for the treatment or control of these mixed biofilms are presented and discussed here. A structured search of bibliographic databases was applied to include recent research. There are several promising new approaches in the treatment of Candida spp.-Streptococcus mutans oral mixed biofilms that could be clinically applied in the near future. These findings confirm the importance of developing effective therapies for oral Candida-bacterial infections.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Salehi B,Kregiel D,Mahady G,Sharifi-Rad J,Martins N,Rodrigues CFdoi
10.3390/jcm9020517subject
Has Abstractpub_date
2020-02-14 00:00:00issue
2issn
2077-0383pii
jcm9020517journal_volume
9pub_type
杂志文章,评审abstract：INTRODUCTION:Immunoglobulin G4-related disease (IgG4-RD) is a systemic immune-mediated disease characterised pathologically by the infiltration of IgG4-bearing plasma cells into the involved organs. Autoimmune pancreatitis (AIP) is a form of chronic pancreatitis with a heavy lymphocytic infiltration and two distinct hi...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9020409
更新日期：2020-02-03 00:00:00
abstract：:The future hope of generated induced pluripotent stem cells (iPS cells) from Alzheimer's disease patients is multifold. Firstly, they may help to uncover novel mechanisms of the disease, which could lead to the development of new and unprecedented drugs for patients and secondly, they could also be directly used for s...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm3041402
更新日期：2014-12-12 00:00:00
abstract：BACKGROUND:Nine percent of all cases of tuberculosis are bone and joint tuberculosis (BJTB). BJTB occurs in two main forms: spinal (STB) and extraspinal (ESTB). The aim of this study was to compare STB with ESTB in terms of diagnosis, treatment and outcomes. METHODS:We collected demographic, clinical, microbiological,...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9082529
更新日期：2020-08-05 00:00:00
abstract：:Graves' orbitopathy (GO) is the most common extrathyroidal manifestation of Graves' disease (GD). Our aim was to assess the efficacy and safety of Tocilizumab (TCZ) in GO refractory to conventional therapy. This was an open-label multicenter study of glucocorticoid-resistant GO treated with TCZ. The main outcomes were...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9092816
更新日期：2020-08-31 00:00:00
abstract：:MicroRNAs (miRNAs) can provide insight into the pathophysiological states of ocular tissues such as proliferative diabetic retinopathy (PDR). In this study, differences in miRNA expression in vitreous from PDR patients with and without incidence of recurrent vitreous hemorrhage (RVH) after the initial pars-plana vitre...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8122217
更新日期：2019-12-15 00:00:00
abstract：:Hepatobiliary complications in children with sickle cell disease (SCD) are rarely reported but can be life-threatening. We retrospectively assessed their prevalence in a cohort of 616 children followed in a French university-hospital SCD reference center. Eligibility criteria were the following: age <18 years, seen at...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8091481
更新日期：2019-09-18 00:00:00
abstract：PURPOSE:Evasion of the immune system by cancer cells allows for the progression of tumors. Antitumor immunotherapy has shown remarkable effects in a diverse range of cancers. The aim of this study was to determine the clinicopathological significance of human epidermal growth factor receptor 2 (HER2), indoleamine 2,3-d...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9051265
更新日期：2020-04-27 00:00:00
abstract：:Although the use of oral administration of pharmacological all-trans retinoic acid (ATRA) concentration in acute promyelocytic leukaemia (APL) patients was approved for over 20 years and used as standard therapy still to date, the same use in solid cancers is still controversial. In the present review the literature a...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9020360
更新日期：2020-01-28 00:00:00
abstract：:Ocular surgery is one of the most performed medical procedures in the world. Its limitation or suspension, recursively extended over time, could be associated with a significant increase in the number of blind people worldwide. Indeed, cataract causes more than half of all cases of visual impairment in those countries...
journal_title：Journal of clinical medicine
pub_type： 社论
doi：10.3390/jcm9051403
更新日期：2020-05-09 00:00:00
abstract：:Bronchiectasis and asthma may share some characteristics and some patients may have both conditions. The present study aimed to examine the rationale of prophylactic inhaled corticosteroids (ICS) prescription in children with bronchiectasis. Data of children with radiologically established bronchiectasis were retrospe...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9124009
更新日期：2020-12-11 00:00:00
abstract：:The aim of this paper was to provide insights into alcohol misuse within UK veterans to inform as to whether their presentations differ from the general public. This was done by exploring differences in the severity of alcohol misuse between UK veterans and the general public admitted to a general NHS hospital over an...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm5110095
更新日期：2016-11-02 00:00:00
abstract：:* Correspondence: kasiajanda@op [...]. ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9061652
更新日期：2020-05-31 00:00:00
abstract：:With the improvement in survival rate, cardiotoxicity has emerged as a significant adverse effect of cancer therapy. Early diagnosis of subclinical cardiac injury may allow the initiation of cardioprotective therapy and preventing the interruption of optimal cancer therapy and the development of irreversible cardiac d...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm10010154
更新日期：2021-01-05 00:00:00
abstract：BACKGROUND:In-depth knowledge about potential predictors of mortality in transcatheter aortic valve replacement (TAVR) is still warranted. Currently used risk stratification models for TAVR often fail to reach a holistic approach. We, therefore, aimed to create a new staged risk model for 1-year mortality including sev...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8101642
更新日期：2019-10-08 00:00:00
abstract：:The non-consensual sharing of an intimate image is a serious breach of a person's right to privacy and can lead to severe psychosocial consequences. However, little research has been conducted on the reasons for consuming intimate pictures that have been shared non-consensually. This study aims to investigate how the ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8050706
更新日期：2019-05-17 00:00:00
abstract：BACKGROUND:The thyroid plays a key role in development and homeostasis, but it has been difficult to establish causality with diseases and phenotypic traits because of several potential confounders. METHODS:To determine the causal effect of euthyroid function, we conducted a two-sample Mendelian randomization study of...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7100296
更新日期：2018-09-21 00:00:00
abstract：:Inflammatory bowel diseases (IBD) are characterized by chronic inflammation of the intestinal mucosa and unknown etiology. In this review, we identified three main eras in the IBD history. Between the 19th and the 20th century, the primary task had been the definition of the diagnostic criteria in order to differentia...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8111970
更新日期：2019-11-14 00:00:00
abstract：:This study sought to determine whether the implementation of regular and structured follow-up of patients with chronic heart failure (CHF), combined with therapeutic education and remote monitoring solution, leads to better management. This was a single-center retrospective study conducted in a cohort of patients with...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9103106
更新日期：2020-09-25 00:00:00
abstract：:The prognostic significance of sarcopenia in unresectable advanced esophageal cancer remains unclear. Our study retrospectively evaluated 176 consecutive Japanese patients with esophageal squamous cell carcinoma who had been diagnosed with unresectable advanced cancer in Aichi Cancer Center Hospital between January 20...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8101647
更新日期：2019-10-09 00:00:00
abstract：:Nasal deformity is associated with congenital cleft lip and palate. Primary rhinoplasty for reconstruction of the nasal deformity at the time of bilateral cleft lip repair is a controversial issue in cleft care due to traditional teaching concerning the potential impairment of nasal growth. This study assessed long-te...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8050602
更新日期：2019-05-01 00:00:00
abstract：:Cancer cells can acquire a spectrum of stable hybrid epithelial/mesenchymal (E/M) states during epithelial-mesenchymal transition (EMT). Cells in these hybrid E/M phenotypes often combine epithelial and mesenchymal features and tend to migrate collectively commonly as small clusters. Such collectively migrating cancer...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8050725
更新日期：2019-05-22 00:00:00
abstract：:We aimed to test the association between low-density lipoprotein cholesterol (LDL-C) and cardiovascular disease (CVD), cancer, and all-cause mortality in non-statin users. A total of 347,971 subjects in Kangbuk Samsung Health Study (KSHS.57.4% men, mean follow up: 5.64 ± 3.27 years) were tested. To validate these asso...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8101571
更新日期：2019-10-01 00:00:00
abstract：BACKGROUND:Asthma patterns are not well established in epidemiological studies. AIM:To assess asthma patterns and risk factors in an adult general population sample. METHODS:In total, 452 individuals reporting asthma symptoms/diagnosis in previous surveys participated in the AGAVE survey (2011-2014). Latent transitio...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9113632
更新日期：2020-11-11 00:00:00
abstract：:Conventional angiography is used to evaluate and treat possible sources of intraabdominal bleeding, though it may cause complications such as contrast-induced nephropathy (CIN). The study's purpose was to identify factors predicting active extravasation and complications during angiography for acute intraabdominal ble...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm6040047
更新日期：2017-04-18 00:00:00
abstract：:The main objective was to assess the efficacy of botulinum toxin-based treatment for sialorrhea in adult patients with Parkinson's disease. The search was performed by using the Medline-PubMed, EMBASE and Cochrane Library databases from January 2000⁻December 2017, in English/Spanish in patients with Parkinson's diseas...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8030317
更新日期：2019-03-06 00:00:00
abstract：BACKGROUND:Heart failure with preserved ejection fraction (HFpEF) remains an ongoing therapeutic and diagnostic challenge to date. In this study we aimed for an analysis of the diagnostic potential of four novel cardiovascular biomarkers, GDF-15, H-FABP, sST2, and suPAR in HFpEF patients compared to controls as well as...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9041130
更新日期：2020-04-15 00:00:00
abstract：:Proteins have been demonstrated to reduce food intake in animals and humans via peripheral and central mechanisms. Supplementation of a dietetic regimen with single or mixed amino acids might represent an approach to improve the effectiveness of any body weight reduction program in obese subjects. The aim of the prese...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9093054
更新日期：2020-09-22 00:00:00
abstract：:Crohn's disease (CD) is characterized by compromised immune tolerance to the intestinal commensal microbiota, intestinal barrier inflammation, and hyperplasia of creeping fat (CF) and mesenteric adipose tissue (AT), which seems to be directly related to disease activity. Gut microbiota dysbiosis might be a determining...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9082448
更新日期：2020-07-31 00:00:00
abstract：:Studies have reported controversial findings on the association between fetal growth restriction (FGR) or intertwin weight discordance and the risk of hypertensive disorders of pregnancy (HDP) in twin pregnancies. The aim of this study was to investigate the association between twin growth disorders and HDP. Twin preg...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9103276
更新日期：2020-10-13 00:00:00
abstract：:The reliable prediction of cochlear implant (CI) speech perception outcomes is highly relevant and can facilitate the monitoring of postoperative hearing performance. To date, multiple audiometric, demographic, and surgical variables have shown some degree of correlation with CI speech perception outcomes. In the pres...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm10020324
更新日期：2021-01-17 00:00:00
