Abstract:
:Inflammatory bowel diseases (IBD) are characterized by chronic inflammation of the intestinal mucosa and unknown etiology. In this review, we identified three main eras in the IBD history. Between the 19th and the 20th century, the primary task had been the definition of the diagnostic criteria in order to differentiate the new entity from intestinal tuberculosis. In the 20th century, an intense and prolific therapeutic research prevailed, culminating in the introduction of biological drugs in the clinical setting. Since the beginning of the 21st century, traditional definition criteria have been challenged by holistic criteria in an effort to seek a still unattained cure. Centuries of worldwide efforts on IBD etiology and therapy search have culminated in this novel strategy.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Actis GC,Pellicano R,Fagoonee S,Ribaldone DGdoi
10.3390/jcm8111970subject
Has Abstractpub_date
2019-11-14 00:00:00issue
11issn
2077-0383pii
jcm8111970journal_volume
8pub_type
杂志文章,评审abstract::Maternal and pediatric delivery outcomes may vary in patients who underwent open fetal myelomeningocele repair and elected to deliver at the fetal center where their fetal intervention was performed versus at the referring physician's hospital. A prospective cohort study of 88 patients were evaluated following in uter...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9113443
更新日期:2020-10-27 00:00:00
abstract::Tadalafil 5 mg represents the standard for men with Erectile dysfunction (ED) and lower urinary tract symptoms (LUTS)/benign prostatic enlargement (BPE). We carried out an observational trial aiming to assess the efficacy and safety of Tadalafil compared with Tadalafil plus Tamsulosin. Seventy-five patients complainin...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8081126
更新日期:2019-07-29 00:00:00
abstract::The ongoing coronavirus disease 2019 (COVID-19) pandemic has resulted in efforts to identify therapies to ameliorate adverse clinical outcomes. The recognition of the key role for increased inflammation in COVID-19 has led to a proliferation of clinical trials targeting inflammation. The purpose of this review is to c...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9092935
更新日期:2020-09-11 00:00:00
abstract::Primary Sjögren's Syndrome (pSS) is an autoimmune disease mainly affecting salivary and lacrimal glands. Previous pSS studies have relied on primary cell culture models or cancer cell lines with limited relevance to the disease. Our objective was to generate and characterize immortalized salivary gland epithelial cell...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9123820
更新日期:2020-11-25 00:00:00
abstract::One in every four deaths is due to cancer in Europe. In view of its increasing incidence, cancer became the leading cause of death and disease burden in Denmark, France, the Netherlands, and the UK. Without essential improvements in cancer prevention, an additional 775,000 cases of annual incidence have been prognosed...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9092749
更新日期:2020-08-25 00:00:00
abstract::Research examining associations between objectively-measured napping time and type 2 diabetes (T2D) is lacking. This study aimed to evaluate daytime napping in relation to T2D and adiposity measures in elderly individuals from the Mediterranean region. A cross-sectional analysis of baseline data from 2190 elderly part...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8071053
更新日期:2019-07-19 00:00:00
abstract::Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the global coronavirus disease 2019 (COVID-19) outbreak. Along with the respiratory tract, the gastrointestinal (GI) tract is one of the main extra-pulmonary targets of SARS-CoV-2 with respect to symptom occurrence and is a potential route fo...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9113630
更新日期:2020-11-11 00:00:00
abstract:BACKGROUND:Prostate cancer (PCa) is characterized by significant heterogeneity in its molecular, genomic, and immunologic characteristics. METHODS:Whole transcriptome RNAseq data from The Cancer Genome Atlas of prostate adenocarcinomas (n = 492) was utilized. The immune microenvironment was characterized using the CIB...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9061973
更新日期:2020-06-24 00:00:00
abstract::With the expanded legalization of marijuana, its medical and recreational use have sharply increased over the past decade. A wide array of new forms of cannabis is available on the market today, and the potencies are ten times those of forms previously tested, meaning that the true impact of marijuana on the cardiovas...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9061925
更新日期:2020-06-19 00:00:00
abstract::Social media enables the public sharing of information. With the recent emphasis on transparency and the open sharing of information between doctors and patients, the intersection of social media and healthcare is of particular interest. Twitter is currently the most popular form of social media used for healthcare co...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm7060121
更新日期:2018-05-28 00:00:00
abstract::Endometriosis concerns more than 10% of women of reproductive age, frequently leading to chronic pelvic pain. Repetitive transcranial magnetic stimulation (rTMS) over the primary motor cortex (M1) induces an analgesic effect. This effect on chronic pelvic pain is yet to be evaluated. The objective of this study was to...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8040508
更新日期:2019-04-13 00:00:00
abstract:OBJECTIVE:To investigate the risk and risk factors for suicide attempt by patients with regular migraines (RM) and status migrainosus (SM) in Taiwan. METHODS:We analyzed a subset of the National Health Insurance Research Database of Taiwan and enrolled patients (≥20 years old) who had ever received a diagnosis of RM o...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm7090269
更新日期:2018-09-11 00:00:00
abstract::Neovascular age related macular degeneration (nAMD) leads to severe vision loss worldwide and is characterized by the formation of choroidal neovascularization (CNV) and fibrosis. In the current study, we aimed to investigate the effect of blockade for platelet derived growth factor receptor-β (PDGFR-β) on the formati...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9072242
更新日期:2020-07-15 00:00:00
abstract::Background: We decided to investigate whether aneurysm wall enhancement (AWE) on high-resolution vessel wall magnetic resonance imaging (HR VW-MRI) coexists with the conventional risk factors for aneurysm rupture. Methods: We performed HR VW-MRI in 46 patients with 64 unruptured small intracranial aneurysms. Patient d...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm10020225
更新日期:2021-01-10 00:00:00
abstract:INTRODUCTION:The inherent immunosuppression of uremia increases the susceptibility of hemodialysis patients to infection. There is still limited evidence on hemodialysis patients and COVID-19. The clinical and analytical spectrum and treatment responses and mortality are poorly characterized. MATERIAL AND METHODS:Clin...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9072264
更新日期:2020-07-16 00:00:00
abstract::Epileptic seizures in critically ill patients represent a major source of concern, because they are associated with significant mortality and morbidity rates. Despite recent advances that have enabled a better understanding of the global epidemiology of this entity, epileptic seizures in critically ill patients remain...
journal_title:Journal of clinical medicine
pub_type: 社论
doi:10.3390/jcm9072218
更新日期:2020-07-13 00:00:00
abstract::Background. Accumulating evidence suggests that inflammation plays a key role in acute kidney injury (AKI) pathogenesis. We explored the relationship between high-sensitivity C-reactive protein (hs-CRP) and AKI in acute myocardial infarction (AMI). Methods. We prospectively included 2,063 AMI patients in whom hs-CRP w...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8122192
更新日期:2019-12-12 00:00:00
abstract::Chronic stress is thought to be involved in the occurrence and progression of multiple diseases, via mechanisms that still remain largely unknown. Interestingly, key regulators of the stress response, such as members of the corticotropin-releasing-hormone (CRH) family of neuropeptides and receptors, are now known to b...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm8101669
更新日期:2019-10-12 00:00:00
abstract::Bioimpedance spectroscopy (BIS) is a noninvasive method used to evaluate body fluid volume status in dialysis patients, but reports on its effectiveness in pediatrics are scarce. We investigated the correlation between BIS and clinical characteristics and identified the changes in patients whose dialysis prescription ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm10010079
更新日期:2020-12-28 00:00:00
abstract::Decompensated cirrhosis predisposes to infectious diseases and acute-on-chronic liver failure (ACLF) in critically ill patients. Infections like spontaneous bacterial peritonitis (SBP) are frequently associated with multi-organ failure and increased mortality. Consequently, reliable predictors of outcome and early dia...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9092865
更新日期:2020-09-04 00:00:00
abstract::Hemorrhagic strokes account for half of all strokes seen in children, and the etiologies of these hemorrhagic strokes differ greatly from those seen in adult patients. This review gives an overview about incidence and etiologies as well as presentation of children with intracerebral hemorrhage and with differential di...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9051518
更新日期:2020-05-18 00:00:00
abstract::Hepatocellular carcinoma (HCC) is a poor-prognosis cancer due to its high rate of recurrence. microRNAs (miRNAs) are a class of small non-coding RNA molecules that affect crucial processes in cancer development. The objective of this study is to identify the role of miRNAs in patient bone marrow (BM) and explore the f...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm4081600
更新日期:2015-08-14 00:00:00
abstract::Immune thrombocytopenia (ITP) is an acquired autoimmune disorder characterized by isolated thrombocytopenia defined as platelet count in peripheral blood <100 × 109/L. Hypovitaminosis D is very common in children with autoimmune diseases. To analyze whether hypovitaminosis D is associated with the clinical presentatio...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8111861
更新日期:2019-11-03 00:00:00
abstract::Right ventricular failure (RVF) is a major risk factor for end organ morbidity and mortality following cardiac surgery. Perioperative RVF is difficult to predict and detect, and to date, no convenient, accurate, or reproducible measure of right ventricular (RV) function is available. Few studies have examined the use ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm8040559
更新日期:2019-04-25 00:00:00
abstract::High-frequency near-infrared diode laser provides a high-peak output, low-heat accumulation, and efficient biostimulation. Although these characteristics are considered suitable for osteoarthritis (OA) treatment, the effect of high-frequency near-infrared diode laser irradiation in in vitro or in vivo OA models has no...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9030881
更新日期:2020-03-24 00:00:00
abstract:BACKGROUND:The clinical outcome of patients affected by dilated cardiomyopathy (DCM) is heterogeneous, since its pathophysiology is only partially understood. Interleukin 1β levels could predict the mortality and necessity of cardiac transplantation of DCM patients. OBJECTIVE:To investigate mechanisms triggering steri...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8101519
更新日期:2019-09-21 00:00:00
abstract:BACKGROUND:The heat produced during implant site osteotomy can potentially interfere with and influence the osseointegration process of a dental implant. The objective of this in vitro investigation was to measure the temperature changes during simulated osteotomies in bovine rib bone. The measurements were made at the...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9010148
更新日期:2020-01-05 00:00:00
abstract::(1) Background: Focal chondral defects of the knee can significantly impair patient quality of life. Although different options are available, they are still not conclusive and have several limitations. The aim of this study was to evaluate the role of autologous cartilage micrografts in the treatment of knee chondrop...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm10020322
更新日期:2021-01-17 00:00:00
abstract::The identification of biomarkers predicting disease severity and outcomes is the focus of intense research in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 infection). Ideally, such biomarkers should be easily derivable from routine tests. We conducted a systematic review and meta-analysis ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm10020286
更新日期:2021-01-14 00:00:00
abstract::To date, studies have highlighted cross-sectional and unidirectional prospective relationships between problem gambling and mental health symptoms or substance use. The current study aims to: (1) examine the reciprocal relationships between problem gambling and mental health symptoms (depression, generalized anxiety)/...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8111888
更新日期:2019-11-06 00:00:00