Abstract：
:Pain in Sickle Cell Disease (SCD) is a major comorbidity and unique with acute pain due to recurrent and episodic vaso-occlusive crises as well as chronic pain, which can span an individual's entire life. Opioids are the mainstay treatment for pain in SCD. Due to recent health crises raised by adverse effects including deaths from opioid use, pain management in SCD is adversely affected. Cannabis and its products are most widely used for pain in multiple conditions and also by patients with SCD on their own. With the availability of "Medical Cannabis" and approval to use cannabis as medicine across majority of States in the United States as well as over-the-counter preparations, cannabis products are being used increasingly for SCD. The reliability of many of these products remains questionable, which poses a major health risk to the vulnerable individuals seeking pain relief. Therefore, this review provides up to date insights into available categories of cannabis-based treatment strategies, their mechanism of action and pre-clinical and clinical outcomes in SCD. It provides evidence for the benefits and risks of cannabis use in SCD and cautions about the unreliable and unvalidated products that may be adulterated with life-threatening non-cannabis compounds.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Argueta DA,Aich A,Muqolli F,Cherukury H,Sagi V,DiPatrizio NV,Gupta Kdoi
10.3390/jcm9123902subject
Has Abstractpub_date
2020-12-01 00:00:00issue
12issn
2077-0383pii
jcm9123902journal_volume
9pub_type
杂志文章,评审abstract：OBJECTIVE:To analyze the difference in the prevalence of sexually transmitted infections (STIs) between two time periods (2000⁻2007 and 2008⁻2014, with the latter period characterized by the economic crisis), as well as determine differences in sociodemographic factors, clinical care, and risk indicators. METHODS:This...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8020277
更新日期：2019-02-25 00:00:00
abstract：:Fluorescence imaging is a well-known method for both the in vivo and in vitro identification of specific cells or tissues. This imaging tool is gaining importance in the intraoperative detection and preservation of parathyroid glands during endocrine surgery owing to the intrinsic properties of parathyroid tissue. The...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9030830
更新日期：2020-03-18 00:00:00
abstract：BACKGROUND:A hierarchical symptoms-based diagnostic strategy relying on the presence of five main symptoms (chest pain, acute dyspnea, neurological symptoms, headache, visual impairment) was recently proposed to diagnose patients with hypertensive emergency. However, poor scientific evidence is available about the role...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9072201
更新日期：2020-07-12 00:00:00
abstract：BACKGROUND AND AIM:Although head and/or neck pain attributed to orthostatic hypotension is included in international guidelines, its mechanisms and relevance remain unknown. This study examined the term's relevance and aimed to elucidate the associated clinical features. METHODS:An active stand test was performed to e...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9124125
更新日期：2020-12-21 00:00:00
abstract：:Nasal deformity is associated with congenital cleft lip and palate. Primary rhinoplasty for reconstruction of the nasal deformity at the time of bilateral cleft lip repair is a controversial issue in cleft care due to traditional teaching concerning the potential impairment of nasal growth. This study assessed long-te...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8050602
更新日期：2019-05-01 00:00:00
abstract：:Corneal grafts interact with their hosts via complex immunobiological processes that sometimes lead to graft failure. Prediction of graft failure is often a tedious task due to the genetic and nongenetic heterogeneity of patients. As in other areas of medicine, a reliable prediction method would impact therapeutic dec...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9020586
更新日期：2020-02-21 00:00:00
abstract：:Hemophilia is the most common of the severe bleeding disorders and if not properly managed since early infancy can lead to chronic disease and lifelong disabilities. However, it enjoys the most efficacious and safe treatment among the most prevalent monogenic disorders. Hemophilia should be considered in the neonatal ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm6050054
更新日期：2017-05-19 00:00:00
abstract：:Apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APEX1) has been known to play key roles in DNA repair, the regulation of diverse transcriptional activity, and cellular responses to redox activity. This study aimed to examine serum APEX1 (s-APEX1) expression as a possible screening biomarker for clear cel...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8081151
更新日期：2019-08-01 00:00:00
abstract：:Periodontal ligament-derived mesenchymal stem cells (hPDLSCs) possess immunomodulatory abilities which are strongly enhanced by various inflammatory cytokines. Vitamin D3 has anti-inflammatory effects on hPDLSCs and immune cells. However, no study to date has directly compared the influence of 1,25(OH)2D3 on the immun...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8122211
更新日期：2019-12-14 00:00:00
abstract：:Drug-induced immune thrombocytopenia (DITP) is a life-threatening clinical syndrome that is under-recognized and difficult to diagnose. Many drugs can cause immune-mediated thrombocytopenia, but the most commonly implicated are abciximab, carbamazepine, ceftriaxone, eptifibatide, heparin, ibuprofen, mirtazapine, oxali...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9072212
更新日期：2020-07-13 00:00:00
abstract：:Background: Urinary calprotectin is a novel biomarker that distinguishes between intrinsic or prerenal acute kidney injury (AKI) in different studies. However, these studies were based on different populations and different AKI criteria. We evaluated the diagnostic accuracy of urinary calprotectin and compared its dia...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8010074
更新日期：2019-01-10 00:00:00
abstract：:The innate immunity has evolved during millions of years, and thus, equivalent or comparable components are found in most vertebrates, invertebrates, and even plants. It constitutes the first line of defense against molecules, which are either pathogen-derived or a danger signal themselves, and not seldom both. These ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8111981
更新日期：2019-11-14 00:00:00
abstract：:The aim of this study was to evaluate the ability of a PIPS (photon-induced photoacoustic streaming) Er:YAG laser to reduce the root canal system bacterial count in vivo in comparison to the traditional irrigation technique. The post-operative patients' quality of life (QoL) after endodontic therapy was evaluated thro...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9123915
更新日期：2020-12-02 00:00:00
abstract：BACKGROUND:Prevalence estimates for sarcopenia vary depending on the ascertainment criteria and thresholds applied. We aimed to estimate the prevalence of sarcopenia using two international definitions but employing Australian population-specific cut-points. METHODS:Participants (n = 665; 323 women) aged 60-96 years o...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm10020343
更新日期：2021-01-18 00:00:00
abstract：:Anemia is a common feature of liver and bowel diseases. Although the main causes of anemia in these conditions are represented by gastrointestinal bleeding and iron deficiency, autoimmune hemolytic anemia should be considered in the differential diagnosis. Due to the epidemiological association, autoimmune hemolytic a...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm10030423
更新日期：2021-01-22 00:00:00
abstract：:Preterm infants are at higher risk for both symmetrical and asymmetrical head molding. This study involved 3D stereophotogrammetry to assess the cranial growth, molding, and incidence of deformational plagiocephaly (DP) in preterm children compared to term born children. Thirty-four preterm infants and 34 term born co...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8101665
更新日期：2019-10-11 00:00:00
abstract：:Central serous chorioretinopathy (CSC) is a complex and not entirely understood retinal disease. The aim of our research was to describe a novel optical coherence tomography (OCT) finding named "choroidal rift", which may be identified in the choroid of eyes with CSC. We collected data from 357 patients (488 eyes) wit...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9072260
更新日期：2020-07-16 00:00:00
abstract：:Numerous studies over the years have shown that oxidative stress plays a major role in the development of the disease. Oxidative stress involvement in COPD opens up the possibility of using antioxidant therapies in the treatment of the disease. However, so far, these therapies have shown no clinical benefit indicating...
journal_title：Journal of clinical medicine
pub_type： 社论
doi：10.3390/jcm8111953
更新日期：2019-11-13 00:00:00
abstract：:Pharmacogenetic testing (PGT) is increasingly being used as a tool to guide clinical decisions. This article describes the development of an outpatient, pharmacist-led, pharmacogenetics consult clinic within internal medicine, its workflow, and early results, along with successes and challenges. A pharmacogenetics-tra...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9072274
更新日期：2020-07-17 00:00:00
abstract：:A major challenge of cell-based therapy for cartilage lesions is the preservation of the chondrogenic phenotype during ex vivo cell cultivation. In this in vitro study, the chondro-inductive capacity of two different hyaline cartilage-conditioned cell culture media on human chondrocytes in 3D spheroids was determined....
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9092798
更新日期：2020-08-30 00:00:00
abstract：:The authors wish to make the following corrections to this paper [...]. ...
journal_title：Journal of clinical medicine
pub_type： 已发布勘误
doi：10.3390/jcm8030389
更新日期：2019-03-20 00:00:00
abstract：BACKGROUND:Postoperative Acute Kidney Injury (AKI) is a common and serious complication associated with significant morbidity and mortality. While several pre- and intra-operative risk factors for AKI have been recognized in cardiac surgery patients, relatively few data are available regarding the incidence and risk fa...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7110431
更新日期：2018-11-09 00:00:00
abstract：:Contemporary minimally invasive surgical (MIS) treatment options of patients with male Lower Urinary Tract Symptoms (LUTS) in men with prostate glands >80 mL include Holmium Laser Enucleation Prostate (HoLEP), Thulium laser VapoEnucleation Prostate (ThuVEP), and Laparoscopic (LSP) or Robotic-Assisted Simple Prostatect...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9061798
更新日期：2020-06-09 00:00:00
abstract：:CANTOS reported reduced secondary atherothrombotic events in patients with residual inflammatory risk treated with the inhibitory anti-IL-1β antibody, Canakinumab. Yet, mechanisms that underlie this benefit remain elusive. Recent work has implicated formation of neutrophil extracellular traps (NETosis) in arterial thr...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8122072
更新日期：2019-11-26 00:00:00
abstract：:Joint bleeding represents the most commonly reported type of hemorrhage in patients affected by hemophilia. Although the widespread use of prophylaxis has been able to significantly reduce the onset of arthropathy, it has been shown that a non-negligible percentage of patients develop degenerative changes in their joi...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm6080077
更新日期：2017-07-31 00:00:00
abstract：:A higher incidence rate of nocturia in patients with obstructive sleep apnea (OSA) has been observed. We investigated the differences in clinical examinations between OSA patients with and without nocturia, and further compared those with successful and unsuccessful uvulopalatopharyngoplasty (UPPP). This retrospective...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9103089
更新日期：2020-09-25 00:00:00
abstract：:There are differences in the incidence, clinical presentation, molecular pathogenesis, and outcome of colorectal cancer (CRC) based on tumor location. Emerging research suggests that the perioperative carcinoembryonic antigen (CEA) ratio (post-op/pre-op CEA) is a prognostic factor for CRC patients. We aimed to determi...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9123848
更新日期：2020-11-27 00:00:00
abstract：:The aim of this article is to investigate pathological subjects from a population through different physical factors. To achieve this, particle swarm optimization (PSO) and K-means (KM) clustering algorithms have been combined (PSO-KM). Datasets provided by the literature were divided into three clusters based on age ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7040065
更新日期：2018-03-28 00:00:00
abstract：:Permanent hypoparathyroidism, a feared thyroidectomy complication, leads to significant patient morbidity, medical treatment, and monitoring. This study explores whether preoperative high-dose vitamin D loading decreases the incidence of permanent hypoparathyroidism. In a subgroup analysis, the study examines the pred...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm10030442
更新日期：2021-01-24 00:00:00
abstract：:The aim of this study was to determine whether elevated serum level of uric acid (sUA) could predict renal outcome after contrast-enhanced computerized tomography (CCT). We used a historical cohort of 58,106 non-dialysis adult patients who received non-ionic iso-osmolar CCT from 1 June 2008 to 31 March 2015 to evaluat...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8071003
更新日期：2019-07-10 00:00:00
