Abstract：
:The aim of this study was to evaluate the ability of a PIPS (photon-induced photoacoustic streaming) Er:YAG laser to reduce the root canal system bacterial count in vivo in comparison to the traditional irrigation technique. The post-operative patients' quality of life (QoL) after endodontic therapy was evaluated through a questionnaire. Fifty-four patients affected by pulp necrosis with or without apical periodontitis biofilm disease were selected for endodontic treatment and randomly assigned to Group A (n = 27) with traditional irrigation and Group B (n = 27), with PIPS irrigation applied according to the protocol. Shaping was performed with ProGlider and ProTaper Next, and irrigation was performed with 5% NaOCl and 10% EDTA. Intracanal samples for culture tests were collected before and after irrigation. The microbiological analysis was evaluated by the Kolmogorov-Smirnov normality and Mann-Whitney tests (p < 0.05). A self-assessment questionnaire was used to evaluate the QoL during the 7 days after treatment; differences were analysed with Student's t-test. Irrigation with the PIPS device was significantly effective in reducing bacterial counts, which were higher for facultative than obligate anaerobic strains, particularly for Gram-negative bacteria, without statistical significance (p > 0.05). There were no significant differences among the QoL indicators, except for the maximum pain (p = 0.02), eating difficulty (p = 0.03) and difficulty performing daily functions (p = 0.02) in the first few days post-treatment. PIPS may represent an aid to root canal disinfection not affecting the patients' QoL, particularly for the first day after treatment.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Mandras N,Pasqualini D,Roana J,Tullio V,Banche G,Gianello E,Bonino F,Cuffini AM,Berutti E,Alovisi Mdoi
10.3390/jcm9123915subject
Has Abstractpub_date
2020-12-02 00:00:00issue
12issn
2077-0383pii
jcm9123915journal_volume
9pub_type
杂志文章abstract：BACKGROUND:Compared to typically developing individuals, individuals with attention-deficit-hyperactivity disorder (ADHD) are on average more often exposed to stressful conditions (e.g., school failure, family conflicts, financial problems). We hypothesized that high exposure to stress relates to a more persistent and ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8111824
更新日期：2019-11-01 00:00:00
abstract：:The diagnosis of small-bowel tumors is challenging due to their low incidence, nonspecific presentation, and limitations of traditional endoscopic techniques. In our study, we examined the utility of the mucosal protrusion angle in differentiating between true submucosal masses and bulges of the small bowel on video c...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8040418
更新日期：2019-03-27 00:00:00
abstract：:Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE-MTDPS1) is a devastating autosomal recessive disorder due to mutations in TYMP, which cause a loss of function of thymidine phosphorylase (TP), nucleoside accumulation in plasma and tissues, and mitochondrial dysfunction. The clinical picture includes progre...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm7110389
更新日期：2018-10-26 00:00:00
abstract：:Maternal and pediatric delivery outcomes may vary in patients who underwent open fetal myelomeningocele repair and elected to deliver at the fetal center where their fetal intervention was performed versus at the referring physician's hospital. A prospective cohort study of 88 patients were evaluated following in uter...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9113443
更新日期：2020-10-27 00:00:00
abstract：:Exercise has health benefits and prevents a range of chronic diseases caused by physiological and biological changes in the whole body. Generally, the metabolic regulation of skeletal muscle through exercise is known to have a protective effect on the pathogenesis of metabolic syndrome, non-alcoholic fatty liver disea...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm10030385
更新日期：2021-01-20 00:00:00
abstract：:The widespread epidemic of obesity and type 2 diabetes (T2D), suggests that both disorders are closely linked. Several pre-clinical and clinical studies have showed that adipose-derived mesenchymal stem cells (ASC) transplantation is efficient and safe. Moreover, scientists have already highlighted the therapeutic cap...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8060765
更新日期：2019-05-30 00:00:00
abstract：:The aim of the study was to investigate ultrasound tissue characterization of carotid plaques in subjects with and without diabetes type 1 (T1D). B-mode carotid ultrasound was performed to assess the presence and type of plaque in a group of 340 subjects with and 304 without T1D, all of them without cardiovascular dis...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8040424
更新日期：2019-03-28 00:00:00
abstract：:Subungual osteochondroma (SO) is an infrequent and non-malignant bone tumour of the distal phalanx, especially prominent in paediatric populations. The aim of this research was to describe a case series of paediatric feet with SO which received surgical treatments. The secondary purpose was to compare these descriptiv...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9041122
更新日期：2020-04-14 00:00:00
abstract：:Social media enables the public sharing of information. With the recent emphasis on transparency and the open sharing of information between doctors and patients, the intersection of social media and healthcare is of particular interest. Twitter is currently the most popular form of social media used for healthcare co...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm7060121
更新日期：2018-05-28 00:00:00
abstract：:Limited information on the effect of antiretroviral treatment (ART) on vascular function in South Africans of African descent living with human immunodeficiency virus (HIV) is available. The relationship between ART, vascular function and cardiovascular risk factors in South Africans of African ancestry with HIV was t...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm10030392
更新日期：2021-01-20 00:00:00
abstract：:Major depression disorder (MDD) is the most prevalent psychiatric comorbid condition in cocaine use disorder (CUD). The comorbid MDD might be primary-MDD (CUD-primary-MDD) or cocaine-induced MDD (CUD-induced-MDD), and their accurate diagnoses and treatment is a challenge for improving prognoses. This study aimed to as...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9124103
更新日期：2020-12-19 00:00:00
abstract：:Sepsis is a major cause of death in intensive care units worldwide. The acute phase of sepsis is often accompanied by sepsis-associated encephalopathy, which is highly associated with increased mortality. Moreover, in the chronic phase, more than 50% of surviving patients suffer from severe and long-term cognitive def...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9030703
更新日期：2020-03-05 00:00:00
abstract：:Background: We performed this prospective double-blind randomized controlled trial to identify the effect of a preoperative prophylactic transdermal scopolamine (TDS) patch on postoperative nausea and vomiting (PONV) after retromastoid craniectomy with microvascular decompression (RMC-MVD). Methods: We recruited 38 pa...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9010156
更新日期：2020-01-07 00:00:00
abstract：:Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an ultra-rare autosomal recessive disorder of nucleoside metabolism that is caused by mutations in the nuclear thymidine phosphorylase gene (TYMP) gene, encoding for the enzyme thymidine phosphorylase. There are currently no approved treatments for MNGIE...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8040457
更新日期：2019-04-05 00:00:00
abstract：:Because of limitations caused by unique complications of free flap reconstruction, the Clavien-Dindo classification was modified to include grade "IIIc" for "partial or total free flap failure." From 2013 to 2018, 116 patients who had undergone free flap reconstruction for head and neck cancer with grade III or higher...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9113770
更新日期：2020-11-22 00:00:00
abstract：:The ongoing coronavirus disease 2019 (COVID-19) pandemic has resulted in efforts to identify therapies to ameliorate adverse clinical outcomes. The recognition of the key role for increased inflammation in COVID-19 has led to a proliferation of clinical trials targeting inflammation. The purpose of this review is to c...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9092935
更新日期：2020-09-11 00:00:00
abstract：:Pancreatic pathology, comprising acute and chronic pancreatitis, autoimmune pancreatitis and pancreatic neoplasms, primarily presents with gastrointestinal symptoms and signs; however, it is well recognized that it can also associate a wide range of extra-digestive features. Among these systemic manifestations, cutane...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9082611
更新日期：2020-08-12 00:00:00
abstract：:MicroRNAs (miRNAs) can provide insight into the pathophysiological states of ocular tissues such as proliferative diabetic retinopathy (PDR). In this study, differences in miRNA expression in vitreous from PDR patients with and without incidence of recurrent vitreous hemorrhage (RVH) after the initial pars-plana vitre...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8122217
更新日期：2019-12-15 00:00:00
abstract：:With the improvement in survival rate, cardiotoxicity has emerged as a significant adverse effect of cancer therapy. Early diagnosis of subclinical cardiac injury may allow the initiation of cardioprotective therapy and preventing the interruption of optimal cancer therapy and the development of irreversible cardiac d...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm10010154
更新日期：2021-01-05 00:00:00
abstract：:After decades of pioneering and improvement, kidney transplantation is now the renal replacement therapy of choice for most patients with end-stage kidney disease (ESKD). Where focus has traditionally been on surgical techniques and immunosuppressive treatment with prevention of rejection and infection in relation to ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9061911
更新日期：2020-06-18 00:00:00
abstract：:In the past two decades, multiple studies have been undertaken to elucidate the genetic cause of the predisposition to mismatch repair (MMR)-proficient nonpolyposis colorectal cancer (CRC). Here, we present the proposed candidate genes according to their involvement in specific pathways considered relevant in heredita...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9061954
更新日期：2020-06-23 00:00:00
abstract：BACKGROUND:Wolf-Hirschhorn syndrome (WHS) is a rare disease caused by deletion in the distal moiety of the short arm of chromosome 4. The objectives of this study were to report the most representative oral findings of WHS, relate them with other clinical characteristics of the disease, and establish possible phenotype...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9113556
更新日期：2020-11-04 00:00:00
abstract：:Differentiation syndrome (DS) is a potentially fatal adverse drug reaction caused by the so-called differentiating agents such as all-trans retinoic acid (ATRA) and arsenic trioxide (ATO), used for remission induction in the treatment of the M3 subtype of acute myeloid leukemia (AML), acute promyelocytic leukemia (APL...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9103342
更新日期：2020-10-18 00:00:00
abstract：INTRODUCTION:Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are an increasing tumor entity. Since many patients are diagnosed at an advanced stage, treatment is still challenging and dependent on many tumor and patient specific factors. Therefore, the aim of the present study was to elucidate the expression...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9103368
更新日期：2020-10-21 00:00:00
abstract：OBJECTIVES:The purpose of this study was to evaluate the effectiveness of the intraoral use of subperiosteally placed self-inflating tissue expanders for subsequent bone augmentation and implant integrity. MATERIAL AND METHODS:A prospective, multicenter, randomized controlled trial was performed on patients requiring ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9041143
更新日期：2020-04-16 00:00:00
abstract：:The incidence of acute and chronic pancreatitis is increasing in the United States. Rates of acute pancreatitis (AP) are similar in both sexes, but chronic pancreatitis (CP) is more common in males. When stratified by etiology, women have higher rates of gallstone AP, while men have higher rates of alcohol- and tobacc...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm10020300
更新日期：2021-01-15 00:00:00
abstract：BACKGROUND:Although the loop electrosurgical excision procedure (LEEP) is a brief procedure, it can cause severe pain and discomfort to patients in the absence of adequate sedation. An admixture of ketamine with propofol (ketofol), may reduce patient movement due to insufficient sedation while providing hemodynamic and...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8070943
更新日期：2019-06-28 00:00:00
abstract：:We aimed to develop a mathematical model to predict the progression of aortic stenosis (AS) and aortic dilatation (AD) in bicuspid aortic valve patients. Bicuspid AS patients who underwent at least two serial echocardiograms from 2005 to 2017 were enrolled. Mathematical modeling was undertaken to assess (1) the non-li...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8091302
更新日期：2019-08-24 00:00:00
abstract：:Pancreatic cancer is a lethal cancer with an increasing incidence. Despite improvements in chemotherapy, patients with pancreatic cancer continue to face poor prognoses. Endoscopic ultrasound-guided tissue acquisition (EUS-TA) is the primary method for obtaining tissue samples of pancreatic cancer. Due to advancements...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8081173
更新日期：2019-08-05 00:00:00
abstract：:Orf virus (OV) is a zoonotic parapoxvirus that causes highly proliferative skin lesions which resolve with minimal inflammation and scarring. OV encodes two immunomodulators, vascular endothelial growth factor (VEGF)-E and interleukin-10 (ovIL-10), which individually modulate skin repair and inflammation. This study e...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9041085
更新日期：2020-04-11 00:00:00
