Abstract:
INTRODUCTION:Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are an increasing tumor entity. Since many patients are diagnosed at an advanced stage, treatment is still challenging and dependent on many tumor and patient specific factors. Therefore, the aim of the present study was to elucidate the expression rates and the prognostic value of vascular endothelial growth factor receptor (VEGFR) 1-3 in GEP-NENs. A potential association to immune checkpoint markers was further investigated. MATERIAL AND METHODS:The expression levels of VEGFR 1-3 were analyzed by immunohistochemistry and correlated with the expression of the checkpoint markers PD-1 and PD-L1. Furthermore, the tumor samples of 249 GEP-NEN patients were studied and correlated with overall survival rates and clinicopathological features. Kaplan-Meier analyses and the log rank test were used for survival analyses. Categorical variables were compared by the χ2 test. RESULTS:The most common primary tumor site was the small intestine (50.6%), followed by the pancreas (25.7%). VEGFR 1 was highly expressed in 59%, VEGFR 2 in 6.4%, and VEGFR 3 in 61.8% of the analyzed samples. The expression of VEGFR 1-3 was not significantly associated with survival rates. Pancreatic NENs had the highest expression of VEGFR 1 and 3 in 80% of the cases. VEGFR 1-3 positivity correlated with the expression levels of immune checkpoint markers. DISCUSSION:VEGFR 1-3 show a distinct expression pattern in different subgroups of neuroendocrine neoplasias indicating a conceivable target. Moreover, there was a substantial association between VEGFRs and immune checkpoint markers. Taken together, anti-VEGFR therapy represents a promising therapeutic approach in GEP-NEN patients and should be addressed in future studies.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Bösch F,Altendorf-Hofmann A,Jacob S,Auernhammer CJ,Spitzweg C,Boeck S,Schubert-Fritschle G,Werner J,Kirchner T,Angele MK,Knösel Tdoi
10.3390/jcm9103368subject
Has Abstractpub_date
2020-10-21 00:00:00issue
10issn
2077-0383pii
jcm9103368journal_volume
9pub_type
杂志文章abstract::Ly75 (also known as DEC-205 or CD205) is expressed in immune cells and cancers and involved in tumor immunity. However, clinical relevance of Ly75 expression in skin cutaneous melanoma (SKCM) have not been comprehensively studied. This study analyzed the correlation between Ly75 mRNA expression and patient survival us...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9051383
更新日期:2020-05-08 00:00:00
abstract::The aim of the study was to examine the usefulness of targeted musculoskeletal ultrasonography (MSUS) in assessing the disease activity of patients with early inflammatory arthritis (EIA). Twenty-eight patients with EIA were enrolled. The MSUS examination of joints with arthritic signs (tenderness or swelling), measur...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm10020283
更新日期:2021-01-14 00:00:00
abstract::Effective behavior change approaches are necessary to help individuals avoid or mitigate risk factors, engage in behavioral patterns that lead to better health, and consequently, prevent several chronic diseases. Physical inactivity is considered one of the most harmful risk factors for chronic medical conditions, and...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8030295
更新日期:2019-03-01 00:00:00
abstract::Epistaxis is a common debilitating manifestation in hereditary hemorrhagic telangiectasia (HHT), due to mucocutaneous telangiectases. The epistaxis can be difficult to control despite available treatments. Dysregulated angiogenesis has been shown to be associated with telangiectases formation. Topical propranolol has ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9103130
更新日期:2020-09-28 00:00:00
abstract::Pancreatic pathology, comprising acute and chronic pancreatitis, autoimmune pancreatitis and pancreatic neoplasms, primarily presents with gastrointestinal symptoms and signs; however, it is well recognized that it can also associate a wide range of extra-digestive features. Among these systemic manifestations, cutane...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9082611
更新日期:2020-08-12 00:00:00
abstract:OBJECTIVE:To investigate the risk and risk factors for suicide attempt by patients with regular migraines (RM) and status migrainosus (SM) in Taiwan. METHODS:We analyzed a subset of the National Health Insurance Research Database of Taiwan and enrolled patients (≥20 years old) who had ever received a diagnosis of RM o...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm7090269
更新日期:2018-09-11 00:00:00
abstract::Most human papillomavirus (HPV) antiviral strategies have focused upon inhibiting viral DNA replication, but it is increasingly apparent that viral DNA levels can be chemically controlled by approaches that promote its instability. HPVs and other DNA viruses have a tenuous relationship with their hosts. They must repl...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm4020204
更新日期:2015-01-01 00:00:00
abstract::The use of artificial intelligence (AI) to support clinical medical decisions is a rather promising concept. There are two important factors that have driven these advances: the availability of data from electronic health records (EHR) and progress made in computational performance. These two concepts are interrelated...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9010248
更新日期:2020-01-17 00:00:00
abstract::Microbial contamination could compromise the stability of dental implants increasing the risk of inflammatory reactions in the surrounding soft tissues. In this human, randomized, double-blind, clinical study, the presence of Porphyromonas gingivalis on the healing abutment and the inflammatory infiltrate surrounding ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9010284
更新日期:2020-01-20 00:00:00
abstract::Two doses of propiverine ER (30 and 45 mg/d) are available for the treatment of overactive bladder (OAB) syndrome. We have explored factors associated with the initial dosing choice (allocation bias), the decision to adapt dosing (escalation bias) and how dosing relative to other factors affects treatment outcomes. Da...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm10020311
更新日期:2021-01-15 00:00:00
abstract::Patients diagnosed with traumatic or non-traumatic spinal pain and idiopathic scoliosis frequently suffer from imbalance. The evaluation of the perception of verticality by means of visual tests emerges as a quick and easy tool for clinical management of the balance disorders. Several studies have assessed the visual ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9061725
更新日期:2020-06-03 00:00:00
abstract::While satisfactory results have been reported during short-to mid-term follow-up assessments of hemophilic patients who have undergone total knee arthroplasty (TKA), limited literature focusing on long-term survival following TKA exists to date. As part of this investigation, a consecutive series of 78 TKAs in 56 pati...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9103247
更新日期:2020-10-11 00:00:00
abstract::Ovarian endometrioma are found in up to 40% of women with endometriosis and 50% of infertile women. The best surgical approach for endometrioma and its impact on pregnancy rates is still controversial. Therefore, we conducted a literature review on surgical management of ovarian endometrioma and its impact on pregnanc...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm10030414
更新日期:2021-01-22 00:00:00
abstract::The pathogenesis of an increasing number of chronic diseases is being attributed to effects of the immune system. However, its role in the development and maintenance of anorexia nervosa is seemingly under-appreciated. Yet, in examining the available research on the immune system and genetic studies in anorexia nervos...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm8111915
更新日期:2019-11-08 00:00:00
abstract::Mitochondrial respiratory chain (MRC) disorders have a multifaceted clinical presentation and genetic origin[...]. ...
journal_title:Journal of clinical medicine
pub_type: 社论
doi:10.3390/jcm7040066
更新日期:2018-03-29 00:00:00
abstract::Clinical trials in attention-deficit/hyperactivity disorder (ADHD) have typically measured outcome using clinician ratings on the Attention-Deficit/Hyperactivity Disorder Rating Scale, Fourth Edition (ADHD-RS-IV) and the Clinical Global Impression-Improvement (CGI-I) scale. Remission has been defined as an endpoint sc...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8040461
更新日期:2019-04-05 00:00:00
abstract::The geographic spread of 2019 novel coronavirus (COVID-19) infections from the epicenter of Wuhan, China, has provided an opportunity to study the natural history of the recently emerged virus. Using publicly available event-date data from the ongoing epidemic, the present study investigated the incubation period and ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9020538
更新日期:2020-02-17 00:00:00
abstract::Sex differences among patients with complement-gene-variant-mediated thrombotic microangiopathy (cTMA) are not well established. We examined demographic and clinical data from female and male patients with a history of cTMA enrolled in the Vienna thrombotic microangiopathy (TMA) cohort. Follow-up was three years after...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9040964
更新日期:2020-03-31 00:00:00
abstract::Ticagrelor, an antiplatelet adenosine diphosphate (ADP)-P2Y12 receptor antagonist, increases the risk of bleeding. Its management is challenging because platelet transfusion is ineffective and no specific antidote is currently available. Epinephrine, a vasopressor catecholamine prescribed during shock, restores platel...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9030809
更新日期:2020-03-16 00:00:00
abstract::The aim of this study was to investigate whether early intermittent electroencephalography (EEG) could be used to predict neurological prognosis of patients who underwent extracorporeal cardiopulmonary resuscitation (ECPR). This was a retrospective and observational study of adult patients who were evaluated by EEG sc...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9061745
更新日期:2020-06-04 00:00:00
abstract::We prospectively evaluated the relationship between meibomian gland dysfunction (MGD) and Graves' ophthalmopathy (GO) in 19 patients (38 eyes) with subjective dry eye symptoms, compared to 14 age-matched normal participants (14 eyes). Extraocular muscle and lacrimal gland enlargement were evaluated by magnetic resonan...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9092814
更新日期:2020-08-31 00:00:00
abstract::Antibiotic treatment in paediatric rhinosinusitis is still a matter of debate, as the current guidelines have been drafted mainly based on clinical studies published before 2013. Recent modifications in the epidemiological basis of the disease might mean that current treatments are not completely adequate considering ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm8081162
更新日期:2019-08-03 00:00:00
abstract::We examined the association between self-rated health (SRH), a subjective measure of an individual's health status, and the incidence of metabolic abnormalities, as well as the effect of obesity on this association in metabolically healthy individuals. The cohort study included 85,377 metabolically healthy men and wom...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8010034
更新日期:2019-01-01 00:00:00
abstract::Ventilator-associated pneumonia (VAP) is a well-known complication of patients on invasive mechanical ventilation. The main cause of acute respiratory distress syndrome (ARDS) is pneumonia. ARDS can occur in patients with community-acquired or nosocomial pneumonia. Data regarding ARDS incidence, related pathogens, and...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9113508
更新日期:2020-10-29 00:00:00
abstract::Contemporary minimally invasive surgical (MIS) treatment options of patients with male Lower Urinary Tract Symptoms (LUTS) in men with prostate glands >80 mL include Holmium Laser Enucleation Prostate (HoLEP), Thulium laser VapoEnucleation Prostate (ThuVEP), and Laparoscopic (LSP) or Robotic-Assisted Simple Prostatect...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9061798
更新日期:2020-06-09 00:00:00
abstract:BACKGROUND:Loss of peripheral muscle oxidative phenotype, cognitive impairment, and depression are well-recognized systemic manifestations of chronic obstructive pulmonary disease (COPD). Kynurenine (KYN), known to be associated with disturbed mental health, can be metabolized in muscle by kynurenine aminotransferases ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8070915
更新日期:2019-06-26 00:00:00
abstract:BACKGROUND:The National Academies of Science have issued a call for zero preventable trauma deaths. The mortality characteristics in all patients with aortic injury are not well described. METHODS:All prehospital and hospital medical examiner records for deaths occurring in Harris County, Texas in 2014 were retrospect...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9092965
更新日期:2020-09-14 00:00:00
abstract::Immune checkpoint inhibitors (ICI) have revolutionised cancer therapy. However, they have been effective in only a small subset of patients and a principal mechanism underlying immune-refractoriness is a 'cold' tumour microenvironment, that is, lack of a T-cell-rich, spontaneously inflamed phenotype. As such, there is...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9103323
更新日期:2020-10-16 00:00:00
abstract::Mixed neuroendocrine non-neuroendocrine neoplasms (MiNENs) represent a rare diagnosis of the gastro-entero-pancreatic tract. Evidence from the current literature regarding their epidemiology, biology, and management is of variable quality and conflicting. Based on available data, the MiNEN has an aggressive biological...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9010273
更新日期:2020-01-19 00:00:00
abstract::There is a large body of research showing that psychological treatment can be effectively delivered via the internet, and Digital Mental Health Services (DMHS) are now delivering those interventions in routine care. However, not all attempts to translate these research outcomes into routine care have been successful. ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8081239
更新日期:2019-08-17 00:00:00