Abstract：
:Mixed neuroendocrine non-neuroendocrine neoplasms (MiNENs) represent a rare diagnosis of the gastro-entero-pancreatic tract. Evidence from the current literature regarding their epidemiology, biology, and management is of variable quality and conflicting. Based on available data, the MiNEN has an aggressive biological behaviour, mostly driven by its (often high-grade) neuroendocrine component, and a dismal prognosis. In most cases, the non-neuroendocrine component is of adenocarcinoma histology. Due to limitations in diagnostic methods and poor awareness within the scientific community, the incidence of MiNENs may be underestimated. In the absence of data from clinical trials, MiNENs are commonly treated according to the standard of care for pure neuroendocrine carcinomas or adenocarcinomas from the same sites of origin, based on the assumption of a biological similarity to their pure counterparts. However, little is known about the molecular aberrations of MiNENs, and their pathogenesis remains controversial; molecular/genetic studies conducted so far point towards a common monoclonal origin of the two components. In addition, mutations in tumour-associated genes, including TP53, BRAF, and KRAS, and microsatellite instability have emerged as potential drivers of MiNENs. This systematic review (91 full manuscripts or abstracts in English language) summarises the current reported literature on clinical, pathological, survival, and molecular/genetic data on MiNENs.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Frizziero M,Chakrabarty B,Nagy B,Lamarca A,Hubner RA,Valle JW,McNamara MGdoi
10.3390/jcm9010273subject
Has Abstractpub_date
2020-01-19 00:00:00issue
1issn
2077-0383pii
jcm9010273journal_volume
9pub_type
杂志文章,评审abstract：:Helicobacter pylori, responsible for chronic ulcers and most stomach cancers, infects half of the world's population. The Urea Breath Test (UBT) is one of the most accurate and reliable non-invasive methods for diagnosing active H. pylori infection. The objective was to use longitudinal, population-wide UBT data for W...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8111821
更新日期：2019-11-01 00:00:00
abstract：PURPOSE:Evasion of the immune system by cancer cells allows for the progression of tumors. Antitumor immunotherapy has shown remarkable effects in a diverse range of cancers. The aim of this study was to determine the clinicopathological significance of human epidermal growth factor receptor 2 (HER2), indoleamine 2,3-d...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9051265
更新日期：2020-04-27 00:00:00
abstract：:The new allocation criteria classify patients on veno-arterial extracorporeal membranous oxygenation (VA-ECMO) as the highest priority for receiving orthotopic heart transplantation (OHT) especially if they are considered not candidates for ventricular assist devices. The outcomes of patients who receive ventricular a...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8050572
更新日期：2019-04-26 00:00:00
abstract：:We prospectively evaluated the relationship between meibomian gland dysfunction (MGD) and Graves' ophthalmopathy (GO) in 19 patients (38 eyes) with subjective dry eye symptoms, compared to 14 age-matched normal participants (14 eyes). Extraocular muscle and lacrimal gland enlargement were evaluated by magnetic resonan...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9092814
更新日期：2020-08-31 00:00:00
abstract：:Arterial stiffness has been shown to be a subclinical marker associated with cardiovascular disease. Meanwhile, long-term exercise has been demonstrated to reduce arterial stiffness, providing a decrease in cardiovascular risk. However, the acute effect of exercise on arterial stiffness is unclear. This systematic rev...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm10020291
更新日期：2021-01-14 00:00:00
abstract：OBJECTIVE:To review the current published literature on the use of procalcitonin as a diagnostic and prognostic marker in adult patients with meningitis. METHODS:We conducted a PubMed search to identify all relevant publications regarding the diagnostic and prognostic value of serum procalcitonin in patients with a kn...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm7060148
更新日期：2018-06-11 00:00:00
abstract：:Patient-reported outcome measures (PROMs) are used to assess satisfaction after total hip arthroplasty (THA); however, the factors that determine these PROMs remain unclear. This study aimed to identify the patient- and surgery-related factors that affect patient satisfaction after THA as indicated by the Oxford Hip S...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7100358
更新日期：2018-10-15 00:00:00
abstract：:The aim of this study was to determine the prevalence of early chronic kidney disease (EKD) (stages 1 and 2) and the factors associated. This was a populational study including individuals from 18-75 years randomly selected from 18 Primary Healthcare centers in the area of Barcelonès Nord and Maresme (Catalunya, Spain...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8091384
更新日期：2019-09-04 00:00:00
abstract：:To analyse the predictive ability and incremental value of left ventricular longitudinal axis strain (LAS) and late gadolinium enhancement (LGE) using standard cardiovascular magnetic resonance (CMR) imaging for the diagnosis and prognosis of severe aortic stenosis (AS) in patients with an indication for aortic valve ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8020165
更新日期：2019-02-01 00:00:00
abstract：:Interstitial lung disease (ILD) seems to be associated with an increased risk of lung cancer (LC) and to have a poorer prognosis than LC without ILD. The frequency of ILD in an LC cohort and its prognosis implication need to be better elucidated. This retrospective, observational, cohort study evaluated the frequency ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9030700
更新日期：2020-03-05 00:00:00
abstract：:Acute retinal necrosis (ARN) is a rare viral endophthalmitis, and human herpesvirus is the principal pathogen. Early diagnosis and treatment are critical to avoid visual impairment by ARN, and pars plana vitrectomy (PPV) is required in advanced cases. In this study, we evaluated the transition of viral load in ocular ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9041204
更新日期：2020-04-22 00:00:00
abstract：:We aimed to investigate the cross-sectional and longitudinal associations of electrocardiogram (ECG)-based QT, QTc, JT, JTc, and QRS intervals with cognitive function and brain magnetic resonance imaging (MRI) measurements in a cohort of older individuals at increased risk for cardiovascular disease, but free of known...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9040911
更新日期：2020-03-26 00:00:00
abstract：BACKGROUND:The assessment of ovarian reserve in the case of endometrioma is of pivotal importance for planning a tailored management. However, both the antral follicle count (AFC) and the antimüllerian hormone (AMH) dosage are subject to a fair degree of variability in ovarian endometriosis. This study aimed to identif...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9124076
更新日期：2020-12-17 00:00:00
abstract：OBJECTIVES:Non-alcoholic fatty liver disease (NAFLD) is considered a well-known pathology that is determined without using alcohol and has emerged as a growing public health problem. Lipotoxicity is known to promote hepatocyte death, which, in the context of NAFLD, is termed lipoapoptosis. The severity of NAFLD correla...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9051294
更新日期：2020-05-01 00:00:00
abstract：:Methotrexate (MTX) is a remarkable drug with a key role in the management of rheumatoid arthritis (RA) at every stage of its evolution. Its attributes include good overall efficacy for signs and symptoms, inhibition of structural damage and preservation of function with acceptable and manageable safety, a large dose-t...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8040515
更新日期：2019-04-15 00:00:00
abstract：:The 14-3-3 protein family are molecular chaperones involved in several biological functions and neurological diseases. We previously pinpointed YWHAZ (encoding 14-3-3ζ) as a candidate gene for autism spectrum disorder (ASD) through a whole-exome sequencing study, which identified a frameshift variant within the gene (...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9061851
更新日期：2020-06-13 00:00:00
abstract：:Fetal exposure to particulate matter (PM) is associated with infant developmental delay likely via neuroinflammation and prefrontal cortex lesions; however, whether air-purifier usage, which can reduce indoor PM levels, is related to infant developmental delay remains unknown. We therefore examined the prospective rel...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9061924
更新日期：2020-06-19 00:00:00
abstract：BACKGROUND:Loss of peripheral muscle oxidative phenotype, cognitive impairment, and depression are well-recognized systemic manifestations of chronic obstructive pulmonary disease (COPD). Kynurenine (KYN), known to be associated with disturbed mental health, can be metabolized in muscle by kynurenine aminotransferases ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8070915
更新日期：2019-06-26 00:00:00
abstract：BACKGROUND:Standard clinical imaging of the acute respiratory distress syndrome (ARDS) lung lacks resolution and offers limited possibilities in the exploration of the structure-function relationship, and therefore cannot provide an early and clear discrimination of patients with unexpected diagnosis and unrepair profi...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8081197
更新日期：2019-08-11 00:00:00
abstract：:Proteasome inhibitor bortezomib has been used in the treatment of refractory cases of acute and chronic antibody-mediated rejection (AMR) in kidney transplant recipients. However, its efficacy and safety as a primary treatment for early AMR has been scarcely investigated. We herein present our preliminary experience w...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9020529
更新日期：2020-02-15 00:00:00
abstract：PURPOSE:To compare the reliability of five different intraoral scanners (IOSs) in the capture of implant scanbodies (SBs) and to verify the dimensional congruence between the meshes (MEs) of the SBs and the corresponding library file (LF). METHODS:A gypsum cast of a fully edentulous maxilla with six implant analogues ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9072174
更新日期：2020-07-09 00:00:00
abstract：:The development of new HER2-directed therapies has resulted in a significant prolongation of survival for women with metastatic HER2-positive breast cancer. Discoveries in the laboratory inform clinical trials which are the basis for improving the standard of care and are also the backbone for quality improvement. Cli...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9061984
更新日期：2020-06-24 00:00:00
abstract：:Torsional abnormalities of the femur represent a significant risk factor for patellar instability or patellofemoral complaints. Although their clinical implication has been demonstrated, there is still a debate going on about different aspects. These include, especially, the various methods of measurements with a wide...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm10030474
更新日期：2021-01-27 00:00:00
abstract：:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the global coronavirus disease 2019 (COVID-19) outbreak. Along with the respiratory tract, the gastrointestinal (GI) tract is one of the main extra-pulmonary targets of SARS-CoV-2 with respect to symptom occurrence and is a potential route fo...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9113630
更新日期：2020-11-11 00:00:00
abstract：:This study explored the perspectives and experiences of breast cancer patients and medical oncologists with regards to participation in a lifestyle intervention at a tertiary cancer treatment center. A thematic approach was used to understand the context within which a lifestyle intervention was recommended and experi...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9092815
更新日期：2020-08-31 00:00:00
abstract：:Photodynamic therapy (PDT) is an anticancer strategy utilizing light-mediated activation of a photosensitizer (PS) which has accumulated in tumor and/or surrounding vasculature. Upon activation, the PS mediates tumor destruction through the generation of reactive oxygen species and tumor-associated vasculature damage,...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9020333
更新日期：2020-01-24 00:00:00
abstract：BACKGROUND:Although aldosterone has been demonstrated to induce left ventricular (LV) hypertrophy not only in primary aldosteronism but also in primary hypertension (HT), it can be affected by multiple factors, including age, and the effect of aldosterone on LV function is controversial. This study was to investigate t...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8071045
更新日期：2019-07-17 00:00:00
abstract：:A recent study suggested mortality benefits using vitamin C, hydrocortisone, and thiamine combination therapy (triple therapy) in addition to standard care in patients with severe sepsis and septic shock. In order to further evaluate the effects of triple therapy in real-world clinical practice, we conducted a retrosp...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8040478
更新日期：2019-04-09 00:00:00
abstract：:Most human papillomavirus (HPV) antiviral strategies have focused upon inhibiting viral DNA replication, but it is increasingly apparent that viral DNA levels can be chemically controlled by approaches that promote its instability. HPVs and other DNA viruses have a tenuous relationship with their hosts. They must repl...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm4020204
更新日期：2015-01-01 00:00:00
abstract：:Maternal and pediatric delivery outcomes may vary in patients who underwent open fetal myelomeningocele repair and elected to deliver at the fetal center where their fetal intervention was performed versus at the referring physician's hospital. A prospective cohort study of 88 patients were evaluated following in uter...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9113443
更新日期：2020-10-27 00:00:00
