当前位置： SCI文献检索 > Journal of Clinical Medicine期刊下所有文献 > Differential Expression and Clinicopathological Significance of HER2, Indoleamine 2,3-Dioxygenase and PD-L1 in Urothelial Carcinoma of the Bladder.

Differential Expression and Clinicopathological Significance of HER2, Indoleamine 2,3-Dioxygenase and PD-L1 in Urothelial Carcinoma of the Bladder.

Abstract：

PURPOSE:Evasion of the immune system by cancer cells allows for the progression of tumors. Antitumor immunotherapy has shown remarkable effects in a diverse range of cancers. The aim of this study was to determine the clinicopathological significance of human epidermal growth factor receptor 2 (HER2), indoleamine 2,3-dioxygenase (IDO), and programmed death ligand-1 (PD-L1) expression in urothelial carcinoma of the bladder (UCB). MATERIALS AND METHODS:We retrospectively studied 97 patients with UCB. We performed an immunohistochemical study to measure the expression levels of HER2, IDO, and PD-L1 in UCB tissue from these 97 patients. RESULTS:In all 97 cases, the PD-L1 expression of tumor-infiltrating immune cells (ICs) was significantly correlated with higher pathologic tumor stage (pT). In pT2-pT4 cases (n = 69), higher levels of HER2 and IDO expression in invasive tumor cells (TCs) were associated with shorter periods of disease-free survival (DFS). CONCLUSION:These results imply that the expression of PD-L1 in ICs of the UCB microenvironment is associated with cancer invasion and the expression of HER2 or IDO in the invasive cancer cell and suggestive of the potential for cancer recurrence. We suggest that the expression levels of IDO, HER2, and PD-L1 could be useful as targets in the development of combined cancer immunotherapeutic strategies.

journal_name

J Clin Med

journal_title

Journal of clinical medicine

authors

Kim D,Kim JM,Kim JS,Kim S,Kim KH

doi

10.3390/jcm9051265

subject

Has Abstract

pub_date

2020-04-27 00:00:00

issue

5

issn

2077-0383

pii

jcm9051265

journal_volume

9

pub_type

杂志文章

相关文献

Journal of Clinical Medicine文献大全
  • Vitamin C, Hydrocortisone, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Analysis of Real-World Application.

    abstract：:A recent study suggested mortality benefits using vitamin C, hydrocortisone, and thiamine combination therapy (triple therapy) in addition to standard care in patients with severe sepsis and septic shock. In order to further evaluate the effects of triple therapy in real-world clinical practice, we conducted a retrosp...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm8040478

    authors： Litwak JJ,Cho N,Nguyen HB,Moussavi K,Bushell T

    更新日期：2019-04-09 00:00:00

  • Considerations for Cannabis Use to Treat Pain in Sickle Cell Disease.

    abstract：:Pain in Sickle Cell Disease (SCD) is a major comorbidity and unique with acute pain due to recurrent and episodic vaso-occlusive crises as well as chronic pain, which can span an individual's entire life. Opioids are the mainstay treatment for pain in SCD. Due to recent health crises raised by adverse effects includin...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章,评审

    doi：10.3390/jcm9123902

    authors： Argueta DA,Aich A,Muqolli F,Cherukury H,Sagi V,DiPatrizio NV,Gupta K

    更新日期：2020-12-01 00:00:00

  • Could Mesenchymal Stem Cell-Derived Exosomes Be a Therapeutic Option for Critically Ill COVID-19 Patients?

    abstract：:Coronavirus disease 2019 (COVID-19) is a pandemic viral disease originated in Wuhan, China, in December 2019, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The severe form of the disease is often associated with acute respiratory distress syndrome (ARDS), and most critically ill patients ...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章,评审

    doi：10.3390/jcm9092762

    authors： Gardin C,Ferroni L,Chachques JC,Zavan B

    更新日期：2020-08-26 00:00:00

  • Low Serum Branched-Chain Amino Acid and Insulin-Like Growth Factor-1 Levels Are Associated with Sarcopenia and Slow Gait Speed in Patients with Liver Cirrhosis.

    abstract：:Branched-chain amino acid (BCAA) and insulin-like growth factor 1 (IGF-1) are essential for muscle protein synthesis. We investigated the association of serum BCAA and IGF-1 levels with sarcopenia and gait speed in 192 patients with liver cirrhosis (LC). Sarcopenia was diagnosed according to the Japan Society of Hepat...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9103239

    authors： Saeki C,Kanai T,Nakano M,Oikawa T,Torisu Y,Saruta M,Tsubota A

    更新日期：2020-10-10 00:00:00

  • A Clinical Efficacy of PRRT in Patients with Advanced, Nonresectable, Paraganglioma-Pheochromocytoma, Related to SDHx Gene Mutation.

    abstract：:Paragangliomas and pheochromytomas (PPGLs) exhibit variable malignancy, advanced/hormonally active/progressive need therapy. PRRT (Peptide Receptor Radionuclide Therapy) could be an option for these patients. To evaluate the effectiveness of PRRT (90Y DOTATATE), based on overall survival (OS) and progression-free surv...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm8070952

    authors： Kolasinska-Ćwikła A,Pęczkowska M,Ćwikła JB,Michałowska I,Pałucki JM,Bodei L,Lewczuk-Myślicka A,Januszewicz A

    更新日期：2019-06-30 00:00:00

  • Possible Role of Mitochondrial DNA Mutations in Chronification of Inflammation: Focus on Atherosclerosis.

    abstract：:Chronification of inflammation is the process that lies at the basis of several human diseases that make up to 80% of morbidity and mortality worldwide. It can also explain a great deal of processes related to aging. Atherosclerosis is an example of the most important chronic inflammatory pathology in terms of public ...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章,评审

    doi：10.3390/jcm9040978

    authors： Orekhov AN,Nikiforov NN,Ivanova EA,Sobenin IA

    更新日期：2020-04-01 00:00:00

  • Systemic Redox Imbalance in Patients with Chronic Granulomatous Disease.

    abstract：:The aim of our study was to evaluate redox status, enzymatic and non-enzymatic antioxidant barriers, oxidative damage of proteins, lipids and DNA, as well as concentration of coenzyme Q10 and vitamins A and E in patients with chronic granulomatous disease (CGD). The study was performed on fifteen Caucasian individuals...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9051397

    authors： Heropolitanska-Pliszka E,Berk K,Maciejczyk M,Sawicka-Powierza J,Bernatowska E,Wolska-Kusnierz B,Pac M,Dabrowska-Leonik N,Piatosa B,Lewandowicz-Uszynska A,Karpinska J,Zalewska A,Mikoluc B

    更新日期：2020-05-09 00:00:00

  • Genetic Modifiers at the Crossroads of Personalised Medicine for Haemoglobinopathies.

    abstract：:Haemoglobinopathies are common monogenic disorders with diverse clinical manifestations, partly attributed to the influence of modifier genes. Recent years have seen enormous growth in the amount of genetic data, instigating the need for ranking methods to identify candidate genes with strong modifying effects. Here, ...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm8111927

    authors： Stephanou C,Tamana S,Minaidou A,Papasavva P,Kleanthous M,Kountouris P

    更新日期：2019-11-09 00:00:00

  • A Nomogram to Predict the Outcome of Fine Needle Aspiration Cytology in Head and Neck Masses.

    abstract：:Fine needle aspiration cytology (FNAC) is an important diagnostic tool for tumors of the head and neck. However, non-diagnostic or inconclusive results may occur and lead to delay in treatment. The aim of this study was to evaluate the factors that predict a successful FNAC. A retrospective search was performed to ide...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm8122050

    authors： Kotowski U,Brkic FF,Koperek O,Pablik E,Grasl S,Grasl MC,Erovic BM

    更新日期：2019-11-22 00:00:00

  • Machine Learning of Infant Spontaneous Movements for the Early Prediction of Cerebral Palsy: A Multi-Site Cohort Study.

    abstract：BACKGROUND:Early identification of cerebral palsy (CP) during infancy will provide opportunities for early therapies and treatments. The aim of the present study was to present a novel machine-learning model, the Computer-based Infant Movement Assessment (CIMA) model, for clinically feasible early CP prediction based o...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9010005

    authors： Ihlen EAF,Støen R,Boswell L,Regnier RA,Fjørtoft T,Gaebler-Spira D,Labori C,Loennecken MC,Msall ME,Möinichen UI,Peyton C,Schreiber MD,Silberg IE,Songstad NT,Vågen RT,Øberg GK,Adde L

    更新日期：2019-12-18 00:00:00

  • Epigenetic Regulation of Alternative mRNA Splicing in Dilated Cardiomyopathy.

    abstract：:In recent years, the genetic architecture of dilated cardiomyopathy (DCM) has been more thoroughly elucidated. However, there is still insufficient knowledge on the modifiers and regulatory principles that lead to the failure of myocardial function. The current study investigates the association of epigenome-wide DNA ...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9051499

    authors： Gi WT,Haas J,Sedaghat-Hamedani F,Kayvanpour E,Tappu R,Lehmann DH,Shirvani Samani O,Wisdom M,Keller A,Katus HA,Meder B

    更新日期：2020-05-16 00:00:00

  • Challenges to the Application of Integrated, Personalized Care for Patients with COPD-A Vision for the Role of Clinical Information.

    abstract：:Chronic Obstructive Pulmonary Disease (COPD) is a complex disease defined by airflow limitation and characterized by a spectrum of treatable and untreatable pulmonary and extra-pulmonary disease characteristics. Nonpharmacological management related to physical activity, physical capacity, body composition, breathing ...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章,评审

    doi：10.3390/jcm9051311

    authors： Vanfleteren LEGW,van 't Hul AJ,Kulbacka-Ortiz K,Andersson A,Ullman A,Ingvar M

    更新日期：2020-05-02 00:00:00

  • Ultrasound Tissue Characterization of Carotid Plaques Differs Between Patients with Type 1 Diabetes and Subjects without Diabetes.

    abstract：:The aim of the study was to investigate ultrasound tissue characterization of carotid plaques in subjects with and without diabetes type 1 (T1D). B-mode carotid ultrasound was performed to assess the presence and type of plaque in a group of 340 subjects with and 304 without T1D, all of them without cardiovascular dis...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm8040424

    authors： Castelblanco E,Betriu À,Hernández M,Granado-Casas M,Ortega E,Soldevila B,Ramírez-Morros A,Franch-Nadal J,Puig-Domingo M,Fernández E,Avogaro A,Alonso N,Mauricio D

    更新日期：2019-03-28 00:00:00

  • Machine Learning Models of Survival Prediction in Trauma Patients.

    abstract：BACKGROUND:We aimed to build a model using machine learning for the prediction of survival in trauma patients and compared these model predictions to those predicted by the most commonly used algorithm, the Trauma and Injury Severity Score (TRISS). METHODS:Enrolled hospitalized trauma patients from 2009 to 2016 were d...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm8060799

    authors： Rau CS,Wu SC,Chuang JF,Huang CY,Liu HT,Chien PC,Hsieh CH

    更新日期：2019-06-05 00:00:00

  • Cardiogenic Shock Clinical Presentation, Management, and In-Hospital Outcomes in Patients Admitted to the Acute Cardiac Care Unit of a Tertiary Hospital: Does Gender Play a Role?

    abstract：:Cardiogenic shock (CS), as the most severe form of heart failure, is associated with very high mortality rates despite therapeutic advances in the last decades. Gender differences in outcomes have been widely reported regarding several cardiovascular diseases. The aim of our study was to evaluate potential gender disp...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9103117

    authors： Jerónimo A,Ferrández-Escarabajal M,Ferrera C,Noriega FJ,Diz-Díaz J,Fernández-Jiménez R,McInerney A,Fernández-Ortiz A,Viana-Tejedor A

    更新日期：2020-09-27 00:00:00

  • COVID-19: Specific and Non-Specific Clinical Manifestations and Symptoms: The Current State of Knowledge.

    abstract：:Coronavirus disease 2019 (COVID-19), due to the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has become an epidemiological threat and a worldwide concern. SARS-CoV-2 has spread to 210 countries worldwide and more than 6,500,000 confirmed cases and 384,643 deaths have been reported, while the number of...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章,评审

    doi：10.3390/jcm9061753

    authors： Baj J,Karakuła-Juchnowicz H,Teresiński G,Buszewicz G,Ciesielka M,Sitarz E,Forma A,Karakuła K,Flieger W,Portincasa P,Maciejewski R

    更新日期：2020-06-05 00:00:00

  • Characteristics of Trauma Mortality in Patients with Aortic Injury in Harris County, Texas.

    abstract：BACKGROUND:The National Academies of Science have issued a call for zero preventable trauma deaths. The mortality characteristics in all patients with aortic injury are not well described. METHODS:All prehospital and hospital medical examiner records for deaths occurring in Harris County, Texas in 2014 were retrospect...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9092965

    authors： Chang R,Drake SA,Holcomb JB,Phillips G,Wade CE,Charlton-Ouw KM

    更新日期：2020-09-14 00:00:00

  • Organ Transplantation in Iran; Current State and Challenges with a View on Ethical Consideration.

    abstract：:Organ transplantation is a new issue in medical science. It is an important achievement and a sign of the progression and ability of medical centers around the world. Governments, populations, the medical community and people involved in culture, art, and media all have a decisive role in the culture of organ donation...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章,评审

    doi：10.3390/jcm7030045

    authors： Kiani M,Abbasi M,Ahmadi M,Salehi B

    更新日期：2018-03-05 00:00:00

  • Hepatic Stellate Cells and microRNAs in Pathogenesis of Liver Fibrosis.

    abstract：:microRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by either blocking translation or inducing degradation of target mRNA. miRNAs play essential roles in diverse biological and pathological processes, including development of hepatic fibrosis. Hepatic stellate cells (HSCs) play a central role in...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章,评审

    doi：10.3390/jcm5030038

    authors： Kitano M,Bloomston PM

    更新日期：2016-03-16 00:00:00

  • The Role of Protein SUMOylation in the Pathogenesis of Atherosclerosis.

    abstract：:Atherosclerosis is a progressive, inflammatory cardiovascular disorder characterized by the development of lipid-filled plaques within arteries. Endothelial cell dysfunction in the walls of blood vessels results in an increase in vascular permeability, alteration of the components of the extracellular matrix, and rete...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章,评审

    doi：10.3390/jcm8111856

    authors： Dehnavi S,Sadeghi M,Penson PE,Banach M,Jamialahmadi T,Sahebkar A

    更新日期：2019-11-02 00:00:00

  • Omega-3 Fatty Acids in Modern Parenteral Nutrition: A Review of the Current Evidence.

    abstract：:Intravenous lipid emulsions are an essential component of parenteral nutrition regimens. Originally employed as an efficient non-glucose energy source to reduce the adverse effects of high glucose intake and provide essential fatty acids, lipid emulsions have assumed a larger therapeutic role due to research demonstra...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章,评审

    doi：10.3390/jcm5030034

    authors： Klek S

    更新日期：2016-03-07 00:00:00

  • Obesity Does Not Increase the Risk of Asthma Readmissions.

    abstract：:The relationship between obesity and asthma exacerbations is still under debate. The aim of our work is to analyse the relationship between obesity and hospital re-admissions in asthmatics. A review was retrospectively performed on all hospital admissions of adult patients due to asthma exacerbation occurring in our h...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9010221

    authors： Gonzalez-Barcala FJ,Nieto-Fontarigo JJ,Lourido-Cebreiro T,Rodríguez-García C,San-Jose ME,Carreira JM,Calvo-Alvarez U,Cruz MJ,Facal D,Garcia-Sanz MT,Valdes-Cuadrado L,Salgado FJ

    更新日期：2020-01-14 00:00:00

  • Rheumatoid Meningitis a Rare Extra-Articular Manifestation of Rheumatoid Arthritis: Report of 6 Cases and Literature Review.

    abstract：OBJECTIVES:Central neurological manifestations of rheumatoid arthritis (RA) like rheumatoid meningitis (RM) are rare, little known and have a high rate of morbi-mortality. METHODS:We described six cases of RM that were directly related to RA activity after exhaustive assessment. RESULTS:They were mainly women, aged o...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9061625

    authors： Trabelsi M,Romand X,Gilson M,Vaillant M,Guerne PA,Hayem G,Bertolini E,Baillet A,Gaudin P

    更新日期：2020-05-27 00:00:00

  • Gender Differences in the Levels of Periodontal Destruction, Behavioral Risk Factors and Systemic Oxidative Stress in Ischemic Stroke Patients: A Cohort Pilot Study.

    abstract：:Background: Due to the higher frequency of ischemic stroke in men compared to women, we aimed to determine if gender differences exist regarding periodontal status and several plasma biomarkers in patients with a recent large artery atherosclerosis ischemic stroke (IS). Material and methods: Patients with their first ...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9061744

    authors： Stănescu I,Bulboacă AE,Micu IC,Bolboacă SD,Feștilă DG,Bulboacă AC,Bodizs G,Dogaru G,Boarescu PM,Popa-Wagner A,Roman A

    更新日期：2020-06-04 00:00:00

  • Influence of Overcrowding in the Emergency Department on Return Visit within 72 Hours.

    abstract：:This study was conducted to determine whether overcrowding in the emergency department (ED) affects the occurrence of a return visit (RV) within 72 hours. The crowding indicator of index visit was the average number of total patients, patients under observation, and boarding patients during the first 1 and 4 hours fro...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9051406

    authors： Kim DU,Park YS,Park JM,Brown NJ,Chu K,Lee JH,Kim JH,Kim MJ

    更新日期：2020-05-09 00:00:00

  • Incidence and Cost of Acute Kidney Injury in Hospitalized Patients with Infective Endocarditis.

    abstract：:Acute kidney injury (AKI) is a frequent complication of hospitalized patients with infective endocarditis (IE). Further, AKI in the setting of IE is associated with high morbidity and mortality. We aimed to examine the incidence, clinical parameters, and hospital costs associated with AKI in hospitalized patients with...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章,评审

    doi：10.3390/jcm8070927

    authors： Ortiz-Soriano V,Donaldson K,Du G,Li Y,Lambert J,Cleland D,Thornton A,Fanucchi LC,Huaman MA,Neyra JA

    更新日期：2019-06-27 00:00:00

  • Comparison between Adult Patients with Sickle Cell Disease of Sub-Saharan African Origin Born in Metropolitan France and in Sub-Saharan Africa.

    abstract：:Sickle cell disease (SCD) prevalence has increased rapidly in Europe as a result of an increase in the life expectancy of these patients and the arrival of SCD migrants from Africa. The aim of our study was to compare the phenotypes of adult patients born in Sub-Saharan Africa (SSA) who migrated to France with those o...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm8122173

    authors： Honsel V,Khimoud D,Ranque B,Offredo L,Joseph L,Pouchot J,Arlet JB

    更新日期：2019-12-09 00:00:00

  • APEX1 Expression as a Potential Diagnostic Biomarker of Clear Cell Renal Cell Carcinoma and Hepatobiliary Carcinomas.

    abstract：:Apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APEX1) has been known to play key roles in DNA repair, the regulation of diverse transcriptional activity, and cellular responses to redox activity. This study aimed to examine serum APEX1 (s-APEX1) expression as a possible screening biomarker for clear cel...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm8081151

    authors： Kim JM,Yeo MK,Lim JS,Song IS,Chun K,Kim KH

    更新日期：2019-08-01 00:00:00

  • The Value of Adding Surveillance Cultures to Fluoroquinolone Prophylaxis in the Management of Multiresistant Gram Negative Bacterial Infections in Acute Myeloid Leukemia.

    abstract：:Multidrug resistant Gram-Negative Bacterial Infections (MR-GNBI) are an increasing cause of mortality in acute myeloid leukemia (AML), compromising the success of antineoplastic therapy. We prospectively explored a novel strategy, including mandatory fluoroquinolone prophylaxis, weekly surveillance cultures (SC) and t...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm8111985

    authors： Castañón C,Fernández Moreno A,Fernández Verdugo AM,Fernández J,Martínez Ortega C,Alaguero M,Nicolás C,Vilorio Marqués L,Bernal T

    更新日期：2019-11-15 00:00:00

  • Accuracy of Different Indexes of Body Composition and Adiposity in Identifying Metabolic Syndrome in Adult Subjects with Prader-Willi Syndrome.

    abstract：:(1) Objective: To compare the accuracy of different indexes of adiposity and/or body composition in identifying metabolic syndrome (MetS) in adult patients suffering from Prader‒Willi syndrome (PWS). (2) Study Design: One hundred and twenty PWS patients (69 females and 51 males), aged 29.1 ± 9.4 years, body mass index...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9061646

    authors： Radetti G,Fanolla A,Lupi F,Sartorio A,Grugni G

    更新日期：2020-05-30 00:00:00