Abstract：
:microRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by either blocking translation or inducing degradation of target mRNA. miRNAs play essential roles in diverse biological and pathological processes, including development of hepatic fibrosis. Hepatic stellate cells (HSCs) play a central role in development of hepatic fibrosis and there are intricate regulatory effects of miRNAs on their activation, proliferation, collagen production, migration, and apoptosis. There are multiple differentially expressed miRNAs in activated HSCs, and in this review we aim to summarize current data on miRNAs that participate in the development of hepatic fibrosis. Based on this review, miRNAs may serve as biomarkers for diagnosis of liver disease, as well as markers of disease progression. Most importantly, dysregulated miRNAs may potentially be targeted by novel therapies to treat and reverse progression of hepatic fibrosis.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Kitano M,Bloomston PMdoi
10.3390/jcm5030038subject
Has Abstractpub_date
2016-03-16 00:00:00issue
3issn
2077-0383pii
jcm5030038journal_volume
5pub_type
杂志文章,评审abstract：:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causal agent of coronavirus disease 2019 (COVID-19), first emerged in Wuhan, China. The clinical manifestations of patients infected with COVID-19 include fever, cough, and dyspnea, up to acute respiratory distress syndrome (ARDS) and acute cardiac inju...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9124057
更新日期：2020-12-15 00:00:00
abstract：:Graves' orbitopathy (GO) is the most common extrathyroidal manifestation of Graves' disease (GD). Our aim was to assess the efficacy and safety of Tocilizumab (TCZ) in GO refractory to conventional therapy. This was an open-label multicenter study of glucocorticoid-resistant GO treated with TCZ. The main outcomes were...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9092816
更新日期：2020-08-31 00:00:00
abstract：PURPOSE:To investigate the prognostic significance of diabetes mellitus (DM) in patients with high risk acute myocardial infarction (AMI) treated with primary percutaneous coronary intervention (pPCI) in the era of potent antithrombotics. METHODS:Data from 1230 ST-segment elevation myocardial infarction (STEMI) patien...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9082555
更新日期：2020-08-06 00:00:00
abstract：:Decompensated cirrhosis predisposes to infectious diseases and acute-on-chronic liver failure (ACLF) in critically ill patients. Infections like spontaneous bacterial peritonitis (SBP) are frequently associated with multi-organ failure and increased mortality. Consequently, reliable predictors of outcome and early dia...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9092865
更新日期：2020-09-04 00:00:00
abstract：:Atrial fibrillation (AF) is the most common type of cardiac arrhythmia and is associated with significant morbidity and mortality. The autonomic nervous system (ANS) plays an important role in the initiation and development of AF, causing alterations in atrial structure and electrophysiological defects. The intrinsic ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9103081
更新日期：2020-09-24 00:00:00
abstract：:Using the Taguchi method to narrow experimental parameters, the antimicrobial efficiency of a cold atmospheric plasma jet (CAPJ) treatment was investigated. An L9 array with four parameters of CAPJ treatments, including the application voltage, CAPJ-sample distance, argon (Ar) gas flow rate, and CAPJ treatment time, w...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8111930
更新日期：2019-11-09 00:00:00
abstract：:The limited number of available studies that examined the pathology of alcohol hangover focused on biomarkers of alcohol metabolism, oxidative stress and the inflammatory response to alcohol as potentially important determinants of hangover severity. The available literature on alcohol metabolism and oxidative stress ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9113421
更新日期：2020-10-25 00:00:00
abstract：:In excess of three quarters of patients with psoriatic arthritis (PsA) have preceding psoriasis (PsO), which offers a clinical biomarker for the recognition of early PsA. Numerous surveys have shown a remarkably high frequency of clinically occult musculoskeletal symptoms in psoriasis patients. Imaging studies, partic...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9103262
更新日期：2020-10-12 00:00:00
abstract：PURPOSE:To investigate the value of visual acuity and patient-perceived visual function test when subretinal drusenoid deposits (SDD) are incorporated into the classification of age-related macular degeneration (AMD). A total of 50 participants were recruited into the study in these groups: healthy ageing (n = 11), int...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9092832
更新日期：2020-09-01 00:00:00
abstract：:Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder, with the characteristic symptoms of chronic abdominal pain and altered bowel habits (diarrhea, constipation, or both). IBS is a highly prevalent condition, which negatively affects quality of life and is a significant burden on global healthcare...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm6110104
更新日期：2017-11-03 00:00:00
abstract：:Cutaneous nerve entrapment plays an important role in neuropathic pain syndrome. Due to the advancement of ultrasound technology, the cutaneous nerves can be visualized by high-resolution ultrasound. As the cutaneous nerves course superficially in the subcutaneous layer, they are vulnerable to entrapment or collateral...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm7110457
更新日期：2018-11-21 00:00:00
abstract：:In December 2019, a novel coronavirus, SARS-CoV-2, appeared, causing a wide range of symptoms, mainly respiratory infection. In March 2020, the World Health Organization (WHO) declared Coronavirus Disease 2019 (COVID-19) a pandemic, therefore the efforts of scientists around the world are focused on finding the right ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9061917
更新日期：2020-06-19 00:00:00
abstract：:Surgery, including minimally invasive surgery, and radiotherapy are key modalities in the treatment of gynecological malignancies. The aim of this review is to offer the multidisciplinary care team a comprehensive summary of the intersections of surgery and radiotherapy in the local treatment of gynecological malignan...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm10010093
更新日期：2020-12-29 00:00:00
abstract：BACKGROUND AND AIM:Although head and/or neck pain attributed to orthostatic hypotension is included in international guidelines, its mechanisms and relevance remain unknown. This study examined the term's relevance and aimed to elucidate the associated clinical features. METHODS:An active stand test was performed to e...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9124125
更新日期：2020-12-21 00:00:00
abstract：:The reliable prediction of cochlear implant (CI) speech perception outcomes is highly relevant and can facilitate the monitoring of postoperative hearing performance. To date, multiple audiometric, demographic, and surgical variables have shown some degree of correlation with CI speech perception outcomes. In the pres...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm10020324
更新日期：2021-01-17 00:00:00
abstract：BACKGROUND:Ocular involvement in Psoriatic Arthritis (PsA) patients is mainly associated with uveitis but there remains a paucity of data on dry eye and retinal abnormalities. We aimed to analyze dry eye and subclinical retinal abnormalities in a cohort of PsA patients sine-psoriasis (PsO). METHODS:PsA patients sine-P...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9030719
更新日期：2020-03-06 00:00:00
abstract：:Background: We decided to investigate whether aneurysm wall enhancement (AWE) on high-resolution vessel wall magnetic resonance imaging (HR VW-MRI) coexists with the conventional risk factors for aneurysm rupture. Methods: We performed HR VW-MRI in 46 patients with 64 unruptured small intracranial aneurysms. Patient d...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm10020225
更新日期：2021-01-10 00:00:00
abstract：:Eosinophilic granulomatosis with polyangiitis (EGPA) is a type of systemic vasculitis with eosinophilia in the peripheral blood, which is preceded by bronchial asthma or allergic disease. EGPA is pathologically characterized by microangiopathy granulomatosis vasculitis. Vasculitis can be exacerbated and cause central ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9123890
更新日期：2020-11-30 00:00:00
abstract：:The present Special Issue of Journal of Clinical Medicine includes a series of important papers that aim to further the evidence base of innovative technological advances in the screening and treatment of mental health, and to further our understanding of their implications for mental health care [...]. ...
journal_title：Journal of clinical medicine
pub_type： 社论
doi：10.3390/jcm9103075
更新日期：2020-09-24 00:00:00
abstract：:The integrated assessment of nutritional status and presence of sarcopenia would help improve clinical outcomes of in-hospital aged patients. We compared three common nutritional screening tools with the new Global Leadership Initiative on Malnutrition (GLIM) diagnostic criteria among hospitalized older patients. To t...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9061898
更新日期：2020-06-17 00:00:00
abstract：:Diabetic foot ulcers (DFUs) and diabetic foot infections (DFIs) are associated with reduced patient quality of life, lower-extremity amputation, hospitalization, and high morbidity and mortality. Diverse bacterial communities have been identified in DFUs/DFIs, playing a significant role in infection prognosis. However...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8111935
更新日期：2019-11-10 00:00:00
abstract：BACKGROUND:To investigate insulin sensitivity and glucose metabolism in pregnant lean and overweight polycystic ovary syndrome (PCOS) patients vs. lean and overweight controls without PCOS. METHODS:Prospective cohort study on 67 pregnant women (31 with PCOS and 36 controls, subdivided into overweight or obese and norm...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm10010035
更新日期：2020-12-24 00:00:00
abstract：:The burden of cardiovascular disease and death in chronic kidney disease (CKD) outpaces that of the other diseases and is not adequately described by traditional risk factors alone. Diminished activity of paraoxonase (PON)-1 is associated with increased oxidant stress, a common feature underlying the pathogenesis of C...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8071034
更新日期：2019-07-15 00:00:00
abstract：:Clinically-relevant pituitary adenomas occur in about 1:1000 of the general population, but only about 5% occur in a known genetic or familial setting. Familial isolated pituitary adenomas (FIPA) are one of the most important inherited settings for pituitary adenomas and the most frequent genetic cause is a germline m...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9062003
更新日期：2020-06-26 00:00:00
abstract：:This study aimed to understand whether the effect of non-metastatic cells 1 (NME1) on recurrence-free survival (RFS) in early stage non-small cell lung cancer (NSCLC) can be modified by β-catenin overexpression and cisplatin-based adjuvant chemotherapy. Expression levels of NME1 and β-catenin were analyzed using immun...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9103067
更新日期：2020-09-23 00:00:00
abstract：BACKGROUND:There is growing evidence that non-alcoholic fatty liver disease (NAFLD) is a disease affecting not only the liver but also extrahepatic organs. AIM:To investigate whether in youths NAFLD is associated with extrahepatic complications such as subclinical atherosclerosis, cardiac abnormalities, hypertension, ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8060868
更新日期：2019-06-17 00:00:00
abstract：:Research examining associations between objectively-measured napping time and type 2 diabetes (T2D) is lacking. This study aimed to evaluate daytime napping in relation to T2D and adiposity measures in elderly individuals from the Mediterranean region. A cross-sectional analysis of baseline data from 2190 elderly part...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8071053
更新日期：2019-07-19 00:00:00
abstract：:Infections with SARS-CoV-2 can result in severe clinical manifestations. As such patients present with systemic inflammation, we studied the prevalence and predictive value of anemia of inflammation (AI) or functional iron deficiency (FID), originating from immune-mediated alterations of iron homeostasis. Within this ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9082429
更新日期：2020-07-29 00:00:00
abstract：:Primary Sjögren's syndrome (pSS) is a chronic systemic autoimmune rheumatic disease characterized by lymphoplasmacytic infiltration of the salivary and lacrimal glands, whereby sicca syndrome and/or systemic manifestations are the clinical hallmarks, associated with a particular autoantibody profile. pSS is the most f...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9072299
更新日期：2020-07-20 00:00:00
abstract：:Neovascular age related macular degeneration (nAMD) leads to severe vision loss worldwide and is characterized by the formation of choroidal neovascularization (CNV) and fibrosis. In the current study, we aimed to investigate the effect of blockade for platelet derived growth factor receptor-β (PDGFR-β) on the formati...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9072242
更新日期：2020-07-15 00:00:00
