Abstract:
:Eosinophilic granulomatosis with polyangiitis (EGPA) is a type of systemic vasculitis with eosinophilia in the peripheral blood, which is preceded by bronchial asthma or allergic disease. EGPA is pathologically characterized by microangiopathy granulomatosis vasculitis. Vasculitis can be exacerbated and cause central nervous system and cardiovascular disorders and gastrointestinal perforation. Histological examination reveals eosinophil infiltration and granulomas in lesions in areas such as the lung, nervous system, and skin. Laboratory tests show inflammatory findings such as C-reactive protein (CRP) elevation, increased eosinophils, elevated serum IgE, and elevated myeloperoxidase-anti-neutrophil cytoplasmic antibodies (MPO-ANCA). MPO-ANCA is positive in approximately 40-70% of cases of this disease. EGPA is a necrotizing vasculitis that affects small- and medium-sized blood vessels; however, it differs from other types of ANCA-related vasculitis (such as microscopic polyangiitis and granulomatosis) because it is preceded by bronchial asthma and eosinophilia in the blood and tissues. Treatment with immunosuppressive agents such as steroids or cyclophosphamide depends on the Five Factor Score, which predicts the prognosis and severity of the condition. If the effect of appropriate treatment with steroids is insufficient, the anti-interleukin-5 antibody mepolizumab can be administered. The combination of mepolizumab with standard treatment leads to a significantly longer duration of remission, a higher proportion of patients who achieve sustained remission, and less steroid use than with a placebo.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Isozaki T,Homma T,Sagara H,Kasama Tdoi
10.3390/jcm9123890subject
Has Abstractpub_date
2020-11-30 00:00:00issue
12issn
2077-0383pii
jcm9123890journal_volume
9pub_type
杂志文章,评审abstract::This study aimed to understand whether the effect of non-metastatic cells 1 (NME1) on recurrence-free survival (RFS) in early stage non-small cell lung cancer (NSCLC) can be modified by β-catenin overexpression and cisplatin-based adjuvant chemotherapy. Expression levels of NME1 and β-catenin were analyzed using immun...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9103067
更新日期:2020-09-23 00:00:00
abstract::Recently, proton pump inhibitor (PPI) intake has been linked to acute kidney injury and chronic kidney disease. The objective of this study was to assess the effect of PPIs on renal function and rejection rate in kidney transplant patients. We performed a single center, retrospective analysis of 455 patients who recei...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9010258
更新日期:2020-01-18 00:00:00
abstract::Coronavirus disease 2019 (COVID-19) is a pandemic viral disease originated in Wuhan, China, in December 2019, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The severe form of the disease is often associated with acute respiratory distress syndrome (ARDS), and most critically ill patients ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9092762
更新日期:2020-08-26 00:00:00
abstract::Molecular monitoring of minimal residual disease (MRD) and BCR-ABL1 kinase domain (KD) mutation testing have a well consolidated role in the routine management of chronic myeloid leukemia (CML) patients, as they provide precious information for therapeutic decision-making. Molecular response levels are used to define ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9123865
更新日期:2020-11-27 00:00:00
abstract:BACKGROUND:We investigated the associations between v-Raf murine sarcoma viral oncogene homolog B1 (BRAFV600E, henceforth BRAF) and v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations and colorectal cancer (CRC) prognosis, using The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GSE39582)...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8010111
更新日期:2019-01-17 00:00:00
abstract::Periprosthetic joint infection in total knee arthroplasty is a significant complication that is a common reason for revision surgery. The current standard of care is two-stage revision surgery. There is however increasing evidence to support the use of single-stage revision surgery. We conducted a PRISMA systematic re...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm8020174
更新日期:2019-02-02 00:00:00
abstract:BACKGROUND:Postoperative Acute Kidney Injury (AKI) is a common and serious complication associated with significant morbidity and mortality. While several pre- and intra-operative risk factors for AKI have been recognized in cardiac surgery patients, relatively few data are available regarding the incidence and risk fa...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm7110431
更新日期:2018-11-09 00:00:00
abstract::Due to the widespread use of ultrasound, small thyroid nodules (TNs) ≤ 10 mm are common findings. Standardized approaches for the risk stratification of TNs with Thyroid Imaging Reporting and Data Systems (TIRADS) were evaluated for the clinical routine. With TIRADS, the risk of malignancy in TNs is calculated by scor...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9010236
更新日期:2020-01-16 00:00:00
abstract:BACKGROUND:Profiles of amino acid metabolites (AAMs) have been linked to obesity and energy homeostasis. We investigated whether baseline obesity-related AAMs were associated with weight status in the early postoperative period after sleeve gastrectomy. METHODS:In this prospective, single-arm, longitudinal study, 27 b...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9082348
更新日期:2020-07-23 00:00:00
abstract::Secretogranin III (SCG3) plays a crucial role in the biogenesis of secretory granules in endocrine cells, and thus affects glucose homeostasis by regulating insulin secretion by pancreatic beta cells. Insulin resistance and compensatory hyperinsulinemia are hallmarks of metabolic syndrome (MetS). However, the role of ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8091436
更新日期:2019-09-11 00:00:00
abstract:BACKGROUND:The aim of this systematic review and meta-analysis was to determine the fracture resistance and survival rate of partial indirect restorations inlays, onlays, and overlays fabricated using computer-aided design and computer-aided manufacturing (CAD-CAM) technology from ceramics, composite resin, resin nanoc...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm8111932
更新日期:2019-11-09 00:00:00
abstract::Sarcopenia is defined as a syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength. It has been identified as one of the most common comorbidities associated with femoral neck fracture (FNF). The aim of this review was to evaluate the impact of physical therapy on FNF patients' ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9103115
更新日期:2020-09-26 00:00:00
abstract::Molecular mechanisms and pathological features of p-Cresyl sulfate (PCS)-induced uremic lung injury (ULI) in chronic kidney disease (CKD) remain unclear. We analyzed pleural effusions (PE) from CKD and non-CKD patients for uremic toxins, reactive oxygen species (ROS), and chemotactic cytokines. Correlations between PE...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm7090266
更新日期:2018-09-09 00:00:00
abstract::microRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by either blocking translation or inducing degradation of target mRNA. miRNAs play essential roles in diverse biological and pathological processes, including development of hepatic fibrosis. Hepatic stellate cells (HSCs) play a central role in...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm5030038
更新日期:2016-03-16 00:00:00
abstract::Permanent hypoparathyroidism, a feared thyroidectomy complication, leads to significant patient morbidity, medical treatment, and monitoring. This study explores whether preoperative high-dose vitamin D loading decreases the incidence of permanent hypoparathyroidism. In a subgroup analysis, the study examines the pred...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm10030442
更新日期:2021-01-24 00:00:00
abstract:BACKGROUND:The results of several studies have suggested that infections and sepsis, either bacterial or viral, might be associated with elevated plasma proprotein convertase subtilisin/kexin type 9 (PCSK9) levels. Since there are no data on PCSK9 levels and antibiotic resistance or the severity of disease in patients ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8101742
更新日期:2019-10-20 00:00:00
abstract::Ventilator-associated pneumonia (VAP) is a well-known complication of patients on invasive mechanical ventilation. The main cause of acute respiratory distress syndrome (ARDS) is pneumonia. ARDS can occur in patients with community-acquired or nosocomial pneumonia. Data regarding ARDS incidence, related pathogens, and...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9113508
更新日期:2020-10-29 00:00:00
abstract::The nociceptive withdrawal reflex (NWR) is used to probe spinal cord excitability in chronic pain states. Here, we used an automated and unbiased procedure for determining the NWR threshold and compared the reflex thresholds and corresponding pain ratings in a well-characterized cohort of fibromyalgia (n = 29) and mat...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9061992
更新日期:2020-06-25 00:00:00
abstract::Pulmonary hypertension (PH) in patients with heart failure (HF) contributes to a poorer prognosis. However, in those with dilated cardiomyopathy (DCM), the true prevalence and role of PH is unclear. Therefore, this study aimed to analyze the profile of DCM patients at various levels of PH risk, determined via echocard...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9061660
更新日期:2020-06-01 00:00:00
abstract:INTRODUCTION:Exposure to cumulative environmental risk factors across development has been linked to a host of adverse health/functional outcomes. This perspective incorporating information regarding exposure at differing developmental periods is lacking in research surrounding individuals at Clinical High Risk (CHR) f...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8070994
更新日期:2019-07-09 00:00:00
abstract::Studies have reported controversial findings on the association between fetal growth restriction (FGR) or intertwin weight discordance and the risk of hypertensive disorders of pregnancy (HDP) in twin pregnancies. The aim of this study was to investigate the association between twin growth disorders and HDP. Twin preg...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9103276
更新日期:2020-10-13 00:00:00
abstract::Mixed neuroendocrine non-neuroendocrine neoplasms (MiNENs) represent a rare diagnosis of the gastro-entero-pancreatic tract. Evidence from the current literature regarding their epidemiology, biology, and management is of variable quality and conflicting. Based on available data, the MiNEN has an aggressive biological...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9010273
更新日期:2020-01-19 00:00:00
abstract::Limited data are available regarding optimal treatment for refractory Mycobacterium avium complex-pulmonary disease (MAC-PD). We evaluated outcomes of inhaled amikacin (AMK) with clofazimine (CFZ) regimens as an add-on salvage therapy for refractory MAC-PD. We retrospectively analyzed 52 patients with refractory MAC-P...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9092968
更新日期:2020-09-14 00:00:00
abstract::The outcome of coronavirus disease 2019 (COVID-19) is associated with organ damage; however, the information about the relationship between acute kidney injury (AKI) and COVID-19 is still rare. We evaluated the clinical features and prognosis of COVID-19 patients with AKI according to the AKI severity. Medical data of...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9061718
更新日期:2020-06-03 00:00:00
abstract:BACKGROUND:Metabolic syndrome is associated with low-grade systemic inflammation, which is a key driver of premature atherosclerosis. We characterized immune cell behavior in metabolic syndrome, its consequences, and the potential involvement of the CX3CL1/CX3CR1 and CCL2/CCR2 chemokine axes. METHODS:Whole blood from ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8050708
更新日期:2019-05-18 00:00:00
abstract::Hemophilia is the most common of the severe bleeding disorders and if not properly managed since early infancy can lead to chronic disease and lifelong disabilities. However, it enjoys the most efficacious and safe treatment among the most prevalent monogenic disorders. Hemophilia should be considered in the neonatal ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm6050054
更新日期:2017-05-19 00:00:00
abstract::Recurrent high-grade glioma (HGG) remains incurable with inevitable evolution of resistance and high inter-patient heterogeneity in time to progression (TTP). Here, we evaluate if early tumor volume response dynamics can calibrate a mathematical model to predict patient-specific resistance to develop opportunities for...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9072019
更新日期:2020-06-27 00:00:00
abstract::Methotrexate (MTX) is a remarkable drug with a key role in the management of rheumatoid arthritis (RA) at every stage of its evolution. Its attributes include good overall efficacy for signs and symptoms, inhibition of structural damage and preservation of function with acceptable and manageable safety, a large dose-t...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8040515
更新日期:2019-04-15 00:00:00
abstract:BACKGROUND:Pyogenic liver abscess (LA) is difficult to distinguish from intrahepatic mass-forming cholangiocarcinoma (IMCC) in the emergency department (ED). We evaluated the predictive ability of white blood cells (WBC) and C-reactive protein (CRP) levels, neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte r...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9103194
更新日期:2020-10-01 00:00:00
abstract::Ocular surgery is one of the most performed medical procedures in the world. Its limitation or suspension, recursively extended over time, could be associated with a significant increase in the number of blind people worldwide. Indeed, cataract causes more than half of all cases of visual impairment in those countries...
journal_title:Journal of clinical medicine
pub_type: 社论
doi:10.3390/jcm9051403
更新日期:2020-05-09 00:00:00