Abstract:
:Permanent hypoparathyroidism, a feared thyroidectomy complication, leads to significant patient morbidity, medical treatment, and monitoring. This study explores whether preoperative high-dose vitamin D loading decreases the incidence of permanent hypoparathyroidism. In a subgroup analysis, the study examines the predictive utility of day 1 parathyroid hormone (PTH) in permanent hypoparathyroidism. Patients (n = 150) were previously recruited in the VItamin D In Thyroidectomy (VIDIT) trial, a multicentre, randomised, double blind, placebo-controlled trial evaluating the role of 300,000 IU cholecalciferol administered orally a week before total thyroidectomy. Patients were contacted postoperatively beyond six months through a telephonic questionnaire. The primary outcome was permanent hypoparathyroidism, strictly defined as the need for activated vitamin D six months postoperatively. Out of 150 patients, 130 (86.7%) were contactable. Permanent hypoparathyroidism occurred in 11/130 (8.5%) patients, with a lower incidence of 5.3% (3/57) in the cholecalciferol group compared to 11% (8/73) in the placebo group; however, this was non-significant (p = 0.34). In a subgroup analysis, no relationship between day 1 PTH level and the incidence of permanent hypoparathyroidism was found (p ≥ 0.99). There was a lower rate of permanent hypoparathyroidism in the cholecalciferol group, which was not significant. The predictive utility of day 1 postoperative PTH levels may be limited to transient hypoparathyroidism.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Kannan T,Foster Y,Ho DJ,Gelzinnis SJ,Merakis M,Balogh ZJ,Wynne K,Bendinelli Cdoi
10.3390/jcm10030442subject
Has Abstractpub_date
2021-01-24 00:00:00issue
3issn
2077-0383pii
jcm10030442journal_volume
10pub_type
杂志文章abstract::Computer-aided diagnosis (CAD) and other risk stratification systems may improve ultrasound image interpretation. This prospective study aimed to compare the diagnostic performance of CAD and the European Thyroid Imaging Reporting and Data System (EU-TIRADS) classification applied by physicians with S-Detect 2 softwar...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9082495
更新日期:2020-08-03 00:00:00
abstract::Sarcopenia is related to adverse outcomes in various populations. However, little is known about the prevalence of sarcopenia in polytrauma patients. Identifying the number of patients at risk of adverse outcome will increase awareness to prevent further loss of muscle mass. We utilized data from a regional prospectiv...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9072046
更新日期:2020-06-29 00:00:00
abstract:BACKGROUND:Ocular involvement in Psoriatic Arthritis (PsA) patients is mainly associated with uveitis but there remains a paucity of data on dry eye and retinal abnormalities. We aimed to analyze dry eye and subclinical retinal abnormalities in a cohort of PsA patients sine-psoriasis (PsO). METHODS:PsA patients sine-P...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9030719
更新日期:2020-03-06 00:00:00
abstract:BACKGROUND AND PURPOSE:The aim of the study was to determine the effects of post-traumatically released High Mobility Group Box-1 protein (HMGB1) and extracellular histones on cardiomyocytes (CM). We also evaluated a therapeutic option to capture circulating histones after trauma, using a hemadsorption filter to treat ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9051421
更新日期:2020-05-11 00:00:00
abstract::The use of targeted agents and immunotherapy for the treatment of advanced non-small-cell lung cancer (NSCLC) has made it mandatory to characterize tumor tissue for patient selection. Moreover, the development of agents that are active against specific resistance mechanisms arising during treatment make it equally imp...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm8070998
更新日期:2019-07-09 00:00:00
abstract:OBJECTIVE:To review the current published literature on the use of procalcitonin as a diagnostic and prognostic marker in adult patients with meningitis. METHODS:We conducted a PubMed search to identify all relevant publications regarding the diagnostic and prognostic value of serum procalcitonin in patients with a kn...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm7060148
更新日期:2018-06-11 00:00:00
abstract:BACKGROUND:To determine the validity of the Quick Sepsis-Related Organ Failure Assessment (qSOFA) in the prediction of outcome (in-hospital and 1-month mortality, intensive care unit (ICU) admission, and hospital and ICU length of stay) in adult patients with or without suspected infections where qSOFA was calculated a...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm8010061
更新日期:2019-01-08 00:00:00
abstract:BACKGROUND:To investigate insulin sensitivity and glucose metabolism in pregnant lean and overweight polycystic ovary syndrome (PCOS) patients vs. lean and overweight controls without PCOS. METHODS:Prospective cohort study on 67 pregnant women (31 with PCOS and 36 controls, subdivided into overweight or obese and norm...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm10010035
更新日期:2020-12-24 00:00:00
abstract::The 2018 update of the Global Strategy for Asthma Management and Prevention does not mention fatigue-related symptoms. Nevertheless, patients with asthma frequently report tiredness, lack of energy, and daytime sleepiness. Quantitative research regarding the prevalence of fatigue in asthmatic patients is lacking. This...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm7120471
更新日期:2018-11-23 00:00:00
abstract::Uric acid urolithiasis constitutes approximately 7-10% of all urinary stones. Previous studies have revealed that patients with gout do not equally have uric acid stones. Instead, the risk of gout in patients with uric acid stones remains controversial. This study aimed to investigate whether there is different associ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8101536
更新日期:2019-09-25 00:00:00
abstract:BACKGROUND:Amino acid metabolites (AAMs) have been linked to glucose homeostasis and type 2 diabetes (T2D). We investigated whether (1) baseline AAMs predict T2D remission 12 months after bariatric surgery and (2) whether AAMs are superior for predicting T2D remission postoperatively compared with existing prediction m...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9123897
更新日期:2020-12-01 00:00:00
abstract::Mitochondrial respiratory chain (MRC) disorders have a multifaceted clinical presentation and genetic origin[...]. ...
journal_title:Journal of clinical medicine
pub_type: 社论
doi:10.3390/jcm7040066
更新日期:2018-03-29 00:00:00
abstract::Aim: This study aimed to compare mortality risks across uric acid (UA) levels between non-diabetes adults and participants with diabetes and to investigate the association between hyperuricemia and mortality risks in low-risk adults. Methods: We analyzed data from adults aged >18 years without coronary heart disease a...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8122127
更新日期:2019-12-03 00:00:00
abstract::Subthreshold micropulse laser treatment has been intensively used for selected retinal diseases in the last decade; however, the exact mechanism of the action of lasers in the subthreshold micropulse mode is not yet fully understood. This kind of treatment is safe and cheap, and contrary to classic laser photocoagulat...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm8020242
更新日期:2019-02-13 00:00:00
abstract::The association between tumor-associated macrophages (TAMs) and the expression of immune checkpoint molecules has not been well described in cutaneous melanoma. We evaluated the correlations between the expression of markers of TAMs, cluster of differentiation 163 (CD163), and immune checkpoint molecules, programmed c...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9082500
更新日期:2020-08-03 00:00:00
abstract::To assess neck disability with respect to jaw disability, craniocervical position, cervical alignment, and sensorimotor impairments in patients with temporomandibular disorders (TMD), a systematic review and meta-analysis of observational studies trials were conducted. The meta-analysis showed statistically significan...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9092806
更新日期:2020-08-30 00:00:00
abstract:AIM:This study examined the fertility performance of women after combined hysterolaparoscopic surgical management of endometriosis. Design: This study is a hospital-based retrospective review. MATERIALS AND METHODS:Data collected from the records of all patients presented with endometriosis-related infertility using a...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9020507
更新日期:2020-02-13 00:00:00
abstract::Staphylococcus aureus bloodstream infection (SA-BSI) is an infection with increasing morbidity and mortality. Concomitant Staphylococcus aureus bacteriuria (SABU) frequently occurs in patients with SA-BSI. It is considered as either a sign of exacerbation of SA-BSI or a primary source in terms of urosepsis. The clinic...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9020508
更新日期:2020-02-13 00:00:00
abstract:OBJECTIVES:To test a novel diagnostic technique to assess radial artery perfusion after transradial catheterization. BACKGROUND:Despite being mostly asymptomatic, radial artery occlusion (RAO) is not a benign complication, and its diagnosis is frequently missed because it requires time-consuming diagnostic testing. We...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm7100319
更新日期:2018-10-02 00:00:00
abstract::In excess of three quarters of patients with psoriatic arthritis (PsA) have preceding psoriasis (PsO), which offers a clinical biomarker for the recognition of early PsA. Numerous surveys have shown a remarkably high frequency of clinically occult musculoskeletal symptoms in psoriasis patients. Imaging studies, partic...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9103262
更新日期:2020-10-12 00:00:00
abstract::We aimed to test the association between low-density lipoprotein cholesterol (LDL-C) and cardiovascular disease (CVD), cancer, and all-cause mortality in non-statin users. A total of 347,971 subjects in Kangbuk Samsung Health Study (KSHS.57.4% men, mean follow up: 5.64 ± 3.27 years) were tested. To validate these asso...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8101571
更新日期:2019-10-01 00:00:00
abstract::Healthcare systems in the developed world are struggling with the demand of emergency room presentations; the study of the factors driving such demand is of fundamental importance. From a database of all emergency medical admissions (66,933 episodes in 36,271 patients) to St James' Hospital, Dublin, Ireland, over 12 y...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm3041220
更新日期:2014-10-29 00:00:00
abstract::Clinicians are significant translators and interpreters towards parents of the abundant literature on autism spectrum disorder (ASD). However, how clinicians experience and view ASD and an ASD diagnosis is not well known. Sixteen physicians working with young children with a (presumed) diagnosis of ASD participated in...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm7100348
更新日期:2018-10-12 00:00:00
abstract::Adenomyosis is used to be called endometriosis interna, and deep endometriosis is now called adenomyosis externa. Thus, there is a question as to whether adenomyosis is simply endometriosis of the uterus, either from the perspective of pathogenesis or pathophysiology. In this manuscript, a comprehensive review was per...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9020485
更新日期:2020-02-10 00:00:00
abstract::T-cell-depleted (TCD) human leukocyte antigen (HLA) haploidentical (haplo) hematopoietic stem cell transplantation (HSCT) (TCD-haplo-HSCT) has had a huge impact on the treatment of many haematological diseases. The adoptive transfer of a titrated number of T cells genetically modified with a gene suicide can improve i...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8111904
更新日期:2019-11-07 00:00:00
abstract::Internet gaming disorder (IGD) is a new disease proposed by the Diagnostic and Statistical Manual of Mental Disorders-Fifth Edition (DSM-5), and has been studied extensively in relation to depression and impulsivity. The relationship between resilience and disease has been found in a variety of addictive disorders, bu...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8081102
更新日期:2019-07-25 00:00:00
abstract::Irritable bowel syndrome (IBS) is one of the most common of all medical disorders worldwide and, while for some it represents no more than a nuisance, for others it imposes significant negative impacts on daily life and activities. IBS is a heterogeneous disorder and may well have a number of causes which may lie anyw...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm7010006
更新日期:2018-01-03 00:00:00
abstract:BACKGROUND:It can be hypothetically assumed that maternal and perinatal factors influence the intestinal barrier. METHODS:The study was conducted with 100 healthy, full-term newborns breastfed in the first week of life, with similar analyses for their mothers. Zonulin and calprotectin levels were used as intestinal pe...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8040473
更新日期:2019-04-07 00:00:00
abstract::(1) Background: Intravitreal anti-vascular endothelial growth factor (anti-VEGF) is an established treatment for center-involving diabetic macular edema (ci-DME). However, the clinical response is heterogeneous. This study investigated miRNAs as a biomarker to predict treatment response to anti-VEGF in DME. (2) Method...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9092920
更新日期:2020-09-10 00:00:00
abstract::Paraneoplastic neurological syndromes (PNSs) are a heterogeneous group of rare immune-mediated diseases associated with cancer. The aim of this study was to investigate the prevalence of PNSs in the province of Brescia. PNS prevalence was calculated using the Lombardy regional hospital admission records from 1998 to 2...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9103105
更新日期:2020-09-25 00:00:00