Abstract：
:The use of targeted agents and immunotherapy for the treatment of advanced non-small-cell lung cancer (NSCLC) has made it mandatory to characterize tumor tissue for patient selection. Moreover, the development of agents that are active against specific resistance mechanisms arising during treatment make it equally important to characterize the tumor tissue at progression by performing tissue re-biopsy. Given that tumor tissue is not always available for molecular characterization due to the paucity of diagnostic specimens or problems relating to the carrying out of invasive procedures, the use of liquid biopsy represents a valid approach to overcoming these difficulties. The most common material used for liquid biopsy in this setting is plasma-derived cell free DNA (cfDNA), which originates from cells undergoing apoptosis or necrosis. However, other sources of tumor material can be considered, such as extracellular vesicle (EV)-derived nucleic acids, which are actively secreted from living cells and closely correspond to tumor dynamics. In this review, we discuss the role of liquid biopsy in the therapeutic management of NSCLC with particular regard to targeted therapy and immunotherapy, and analyze the pros and cons of the different types of samples used in this context.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Pasini L,Ulivi Pdoi
10.3390/jcm8070998subject
Has Abstractpub_date
2019-07-09 00:00:00issue
7issn
2077-0383pii
jcm8070998journal_volume
8pub_type
杂志文章,评审abstract：:Interstitial lung disease (ILD) seems to be associated with an increased risk of lung cancer (LC) and to have a poorer prognosis than LC without ILD. The frequency of ILD in an LC cohort and its prognosis implication need to be better elucidated. This retrospective, observational, cohort study evaluated the frequency ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9030700
更新日期：2020-03-05 00:00:00
abstract：:Pancreatic pathology, comprising acute and chronic pancreatitis, autoimmune pancreatitis and pancreatic neoplasms, primarily presents with gastrointestinal symptoms and signs; however, it is well recognized that it can also associate a wide range of extra-digestive features. Among these systemic manifestations, cutane...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9082611
更新日期：2020-08-12 00:00:00
abstract：BACKGROUND:The purpose of this prospective study was to evaluate the role of 18F-Fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) for assessing treatment response in patients with pulmonary multidrug-resistant tuberculosis (MDR-TB). METHODS:The study subjects were four patients di...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7120559
更新日期：2018-12-17 00:00:00
abstract：:(1) Background: To evaluate women's satisfaction with the care received during childbirth undergoing labour and how this changes over time. (2) Methods: An observational, multicentre and longitudinal study in two public hospitals of Spain with a convenience sample of 248 women during the post-partum period. Satisfacti...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8040434
更新日期：2019-03-29 00:00:00
abstract：:The worldwide epidemiology of inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), still shows an increasing trend in Asia and Iran. Despite an improvement in the treatment landscape focused on symptomatic control, long-term colectomies have not decreased over the last 10-year ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9123922
更新日期：2020-12-03 00:00:00
abstract：:Molecular mechanisms and pathological features of p-Cresyl sulfate (PCS)-induced uremic lung injury (ULI) in chronic kidney disease (CKD) remain unclear. We analyzed pleural effusions (PE) from CKD and non-CKD patients for uremic toxins, reactive oxygen species (ROS), and chemotactic cytokines. Correlations between PE...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7090266
更新日期：2018-09-09 00:00:00
abstract：:Tens of millions of patients are affected by liver disease worldwide. Many of these patients can benefit from cell therapy involving living metabolically active cells, either by treatment of their liver disease, or by prevention of their disease phenotype. Cell therapies, including hepatocyte transplantation and bioar...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm3030997
更新日期：2014-09-05 00:00:00
abstract：:Irritable bowel syndrome (IBS) is a disorder of the brain-gut axis; the pathophysiological mechanisms include altered colonic motility, bile acid metabolism, neurohormonal regulation, immune dysfunction, alterations in the epithelial barrier and secretory properties of the gut. This article reviews the mechanisms, eff...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm6110101
更新日期：2017-10-27 00:00:00
abstract：:The vasodilator-associated stimulated phosphoprotein (VASP) phosphorylation level is a highly specific method to assess P2Y12 receptor inhibition. Traditionally, VASP phosphorylation is analyzed by flow cytometry, which is laborious and restricted to specialized laboratories. Recently, a simple ELISA kit has been comm...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9020332
更新日期：2020-01-24 00:00:00
abstract：BACKGROUND:Neoadjuvant therapy (NAT) represents a paradigm shift in the management of patients with pancreatic ductal adenocarcinoma (PDAC) with perceived benefits including a higher R0 rate. However, it is unclear whether NAT affects the sites and patterns of recurrence after surgery. This review seeks to compare site...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9072132
更新日期：2020-07-06 00:00:00
abstract：:Polycystic ovary syndrome (PCOS) is a common condition, affecting 5⁻10% of women of reproductive age worldwide. It has serious reproductive implications and causes mood disorders and metabolic disorders, such as type-2 diabetes. Because PCOS reflects multiple abnormalities, there is no single drug that can treat all i...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7070179
更新日期：2018-07-22 00:00:00
abstract：:The detection of rare mutational targets in plasma (liquid biopsy) has emerged as a promising tool for the assessment of patients with cancer. We determined the presence of cell-free DNA containing the BRAFV600E mutations (cfBRAFV600E) in plasma samples from 57 patients with papillary thyroid cancer (PTC) with somatic...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9082481
更新日期：2020-08-02 00:00:00
abstract：:Although the use of oral administration of pharmacological all-trans retinoic acid (ATRA) concentration in acute promyelocytic leukaemia (APL) patients was approved for over 20 years and used as standard therapy still to date, the same use in solid cancers is still controversial. In the present review the literature a...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9020360
更新日期：2020-01-28 00:00:00
abstract：:In emergency departments, the most common cause of death associated with suspected infected patients is sepsis. In this study, deep learning algorithms were used to predict the mortality of suspected infected patients in a hospital emergency department. During January 2007 and December 2013, 42,220 patients considered...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8111906
更新日期：2019-11-07 00:00:00
abstract：:To assess neck disability with respect to jaw disability, craniocervical position, cervical alignment, and sensorimotor impairments in patients with temporomandibular disorders (TMD), a systematic review and meta-analysis of observational studies trials were conducted. The meta-analysis showed statistically significan...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9092806
更新日期：2020-08-30 00:00:00
abstract：:Social media enables the public sharing of information. With the recent emphasis on transparency and the open sharing of information between doctors and patients, the intersection of social media and healthcare is of particular interest. Twitter is currently the most popular form of social media used for healthcare co...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm7060121
更新日期：2018-05-28 00:00:00
abstract：:Two doses of propiverine ER (30 and 45 mg/d) are available for the treatment of overactive bladder (OAB) syndrome. We have explored factors associated with the initial dosing choice (allocation bias), the decision to adapt dosing (escalation bias) and how dosing relative to other factors affects treatment outcomes. Da...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm10020311
更新日期：2021-01-15 00:00:00
abstract：:The prognostic significance of sarcopenia in unresectable advanced esophageal cancer remains unclear. Our study retrospectively evaluated 176 consecutive Japanese patients with esophageal squamous cell carcinoma who had been diagnosed with unresectable advanced cancer in Aichi Cancer Center Hospital between January 20...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8101647
更新日期：2019-10-09 00:00:00
abstract：:The abnormal activation of the tryptophan catabolites pathway (TRYCATs) is observed in patients suffering from cerebrovascular disease, including stroke. A previous study confirmed that lower bioavailability of tryptophan for serotonin synthesis was characterized in the patients during the acute stroke phase. Interest...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8122133
更新日期：2019-12-03 00:00:00
abstract：:Pulmonary vein (PV) enlargement is associated with atrial fibrillation (AF). However, the predictive value of PV volume for new-onset AF has not been determined. We retrospectively assessed and enrolled non-AF subjects who underwent echocardiography and cardiac CT angiography (CCTA) around the same time and evaluated ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9020401
更新日期：2020-02-02 00:00:00
abstract：BACKGROUND:The results of several studies have suggested that infections and sepsis, either bacterial or viral, might be associated with elevated plasma proprotein convertase subtilisin/kexin type 9 (PCSK9) levels. Since there are no data on PCSK9 levels and antibiotic resistance or the severity of disease in patients ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8101742
更新日期：2019-10-20 00:00:00
abstract：:This study was conducted to determine whether overcrowding in the emergency department (ED) affects the occurrence of a return visit (RV) within 72 hours. The crowding indicator of index visit was the average number of total patients, patients under observation, and boarding patients during the first 1 and 4 hours fro...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9051406
更新日期：2020-05-09 00:00:00
abstract：BACKGROUND:To investigate insulin sensitivity and glucose metabolism in pregnant lean and overweight polycystic ovary syndrome (PCOS) patients vs. lean and overweight controls without PCOS. METHODS:Prospective cohort study on 67 pregnant women (31 with PCOS and 36 controls, subdivided into overweight or obese and norm...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm10010035
更新日期：2020-12-24 00:00:00
abstract：CONTEXT:As the food industry is continually involved in the development of new attractive alternative therapeutic agents, the evaluation of the beneficial impact of (poly)phenols on cognitive and brain function during aging has gained increasing interest. OBJECTIVE:This systematic review and meta-analysis aimed to eva...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9030835
更新日期：2020-03-19 00:00:00
abstract：:Androgens are essential for the development, differentiation, growth, and function of the prostate through epithelial-stromal interactions. However, androgen concentrations in the hypertrophic human prostate decrease significantly with age, suggesting an inverse correlation between androgen levels and proliferative di...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm7040068
更新日期：2018-04-02 00:00:00
abstract：:Graves' orbitopathy (GO) is the most common extrathyroidal manifestation of Graves' disease (GD). Our aim was to assess the efficacy and safety of Tocilizumab (TCZ) in GO refractory to conventional therapy. This was an open-label multicenter study of glucocorticoid-resistant GO treated with TCZ. The main outcomes were...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9092816
更新日期：2020-08-31 00:00:00
abstract：:In the SImplification of Medications Prescribed to Long-tErm care Residents (SIMPLER) cluster-randomized controlled trial, we evaluated the impact of structured medication regimen simplification on medication administration times, falls, hospitalization, and mortality at 8 residential aged care facilities (RACFs) at 1...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9041053
更新日期：2020-04-08 00:00:00
abstract：BACKGROUND:To study the impact of MRI characteristics and of targeted biopsy (TB) core number on the final grade group (GG) prediction. MATERIALS AND METHODS:The cohort was 478 consecutive patients who underwent radical prostatectomy (RP) after positive mpMRI (multiparametric magnetic resonance imaging) followed by fu...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9010225
更新日期：2020-01-15 00:00:00
abstract：:Paravalvular leak (PVL) is an important complication of transcatheter aortic valve implantation (TAVI) and is associated with poor prognosis. We aimed to identify the risk factors for PVL after TAVI including patient (calcium amount or location), device (leakage-proof or not), and procedural (oversizing index (OI)) fa...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9123936
更新日期：2020-12-04 00:00:00
abstract：:Acute kidney injury and renal failure are common after heart transplantation. We retrospectively reviewed a national cohort and identified 1129 heart transplant patients. Patients receiving renal replacement therapy after heart transplantation were grouped into the dialysis cohort. The long-term survival and risk fact...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9082455
更新日期：2020-07-31 00:00:00
