Abstract：
:Irritable bowel syndrome (IBS) is a disorder of the brain-gut axis; the pathophysiological mechanisms include altered colonic motility, bile acid metabolism, neurohormonal regulation, immune dysfunction, alterations in the epithelial barrier and secretory properties of the gut. This article reviews the mechanisms, efficacy, and safety of current pharmacotherapy, and medications that are in phase III trials for the treatment of IBS. There remains a significant unmet need for effective treatments-particularly for the pain component of IBS-although the introduction of drugs directed at secretion, motility and a non-absorbable antibiotic provide options for the bowel dysfunction in IBS.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Camilleri M,Ford ACdoi
10.3390/jcm6110101subject
Has Abstractpub_date
2017-10-27 00:00:00issue
11issn
2077-0383pii
jcm6110101journal_volume
6pub_type
杂志文章,评审abstract：:Paragangliomas and pheochromytomas (PPGLs) exhibit variable malignancy, advanced/hormonally active/progressive need therapy. PRRT (Peptide Receptor Radionuclide Therapy) could be an option for these patients. To evaluate the effectiveness of PRRT (90Y DOTATATE), based on overall survival (OS) and progression-free surv...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8070952
更新日期：2019-06-30 00:00:00
abstract：:Sickle cell disease (SCD) prevalence has increased rapidly in Europe as a result of an increase in the life expectancy of these patients and the arrival of SCD migrants from Africa. The aim of our study was to compare the phenotypes of adult patients born in Sub-Saharan Africa (SSA) who migrated to France with those o...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8122173
更新日期：2019-12-09 00:00:00
abstract：:Proteasome inhibitor bortezomib has been used in the treatment of refractory cases of acute and chronic antibody-mediated rejection (AMR) in kidney transplant recipients. However, its efficacy and safety as a primary treatment for early AMR has been scarcely investigated. We herein present our preliminary experience w...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
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更新日期：2020-02-15 00:00:00
abstract：:CD73, a cell-surface protein encoded by the gene NT5E, is overexpressed in glioblastoma (GBM), where it contributes to the tumor's pathophysiology via the generation of immunosuppressive adenosine. Adenosinergic signaling, in turn, drives immunosuppression of natural killer (NK) cells through metabolic and functional ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8101526
更新日期：2019-09-23 00:00:00
abstract：:This study evaluated the efficacy of Lactobacillus acidophilus YT1 (MENOLACTO) for alleviating menopausal symptoms. This study was a multi-center, randomized, double-blinded, placebo-controlled clinical trial involving female subjects (ages: 40-60 years) with menopausal symptoms and a Kupperman index (KMI) score ≥ 20....
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9072173
更新日期：2020-07-09 00:00:00
abstract：:Polycystic ovary syndrome (PCOS) is a common condition, affecting 5⁻10% of women of reproductive age worldwide. It has serious reproductive implications and causes mood disorders and metabolic disorders, such as type-2 diabetes. Because PCOS reflects multiple abnormalities, there is no single drug that can treat all i...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7070179
更新日期：2018-07-22 00:00:00
abstract：:Our aim was to illustrate our technique of sex-sparing (SS)-robot-assisted radical cystectomy (RARC) in female patients receiving an intracorporeal neobladder (iN). From January 2013 to June 2018, 11 female patients underwent SS-RARC-iN at a single tertiary referral center. Inclusion criteria were a cT ≤ 2 N0 M0 bladd...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9020577
更新日期：2020-02-20 00:00:00
abstract：:Infections with SARS-CoV-2 can result in severe clinical manifestations. As such patients present with systemic inflammation, we studied the prevalence and predictive value of anemia of inflammation (AI) or functional iron deficiency (FID), originating from immune-mediated alterations of iron homeostasis. Within this ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9082429
更新日期：2020-07-29 00:00:00
abstract：:Reprogramming somatic cells to induced pluripotent stem cells (iPSCs) or direct reprogramming to desired cell types are powerful and new in vitro methods for the study of human disease, cell replacement therapy, and drug development. Both methods to reprogram cells are unconstrained by the ethical and social questions...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
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更新日期：2014-04-04 00:00:00
abstract：:The focus of the presented work was to isolate and characterize circulating endometrial cells (CECs) enriched from peripheral blood (PB) of patients with diagnosed endometriosis. The molecular characteristics of CECs could be supportive for an understanding of endometriosis pathogenesis and treatment decisions in the ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8111938
更新日期：2019-11-11 00:00:00
abstract：BACKGROUND:Recent research has shown an increased risk of accidents and injuries in ADHD patients, which could potentially be reduced by stimulant treatment. Therefore, the first aim of our study was to evaluate the prevalence of adult ADHD in a trauma surgery population. The second aim was to investigate accident mech...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8101643
更新日期：2019-10-08 00:00:00
abstract：:This study assessed the efficacy of intraoperative high-dose intravenous iron therapy in facilitating recovery from postoperative anemia and reducing the transfusion rate in patients with total knee and total hip arthroplasty. This prospective randomized controlled study involved 58 subjects. Group F received 1000 mg ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8101674
更新日期：2019-10-13 00:00:00
abstract：:Purpose: This study aimed to evaluate the effects of a child-centered exergaming program and a traditional teacher-led physical activity (PA) program on preschoolers' executive functions and perceived competence. Methods: Sixty children aged 4⁻5 years from an urban childcare center in China completed an 8-week exergam...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8040469
更新日期：2019-04-06 00:00:00
abstract：BACKGROUND:Amino acid metabolites (AAMs) have been linked to glucose homeostasis and type 2 diabetes (T2D). We investigated whether (1) baseline AAMs predict T2D remission 12 months after bariatric surgery and (2) whether AAMs are superior for predicting T2D remission postoperatively compared with existing prediction m...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9123897
更新日期：2020-12-01 00:00:00
abstract：:The management of lymphatic malformations (LMs) is challenging, particularly for large and complex lesions involving anatomical structures in the adjacent tissue. While lymphovenous anastomosis (LVA) has been reported as an effective treatment for lymphedema, it has hardly been described as a treatment for LM. Virtual...
journal_title：Journal of clinical medicine
pub_type：
doi：10.3390/jcm8030371
更新日期：2019-03-15 00:00:00
abstract：:Oral diseases are considered the most common noncommunicable diseases and are related to serious local and systemic disorders. Oral pathogens can grow and spread in the oral mucosae and frequently in biomaterials (e.g., dentures or prostheses) under polymicrobial biofilms, leading to several disorders such as dental c...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9020517
更新日期：2020-02-14 00:00:00
abstract：OBJECTIVE:To review the current published literature on the use of procalcitonin as a diagnostic and prognostic marker in adult patients with meningitis. METHODS:We conducted a PubMed search to identify all relevant publications regarding the diagnostic and prognostic value of serum procalcitonin in patients with a kn...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm7060148
更新日期：2018-06-11 00:00:00
abstract：:This study investigated associations of perceived environmental factors with leisure-time physical activity (LTPA) and screen time (ST) among older adults. A cross-sectional study was conducted by administering computer-assisted telephone interviews to 1028 older Taiwanese adults in November 2016. Data on personal fac...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7030056
更新日期：2018-03-13 00:00:00
abstract：:Sleep bruxism (SB) is a masticatory muscle activity during sleep that is characterized as rhythmic (phasic) or non-rhythmic (tonic). The recent hypothesis on the etiology of SB supports the role of the central and autonomic nervous systems. Therefore, in this study, we aimed to assess the intensity of SB in patients w...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7100327
更新日期：2018-10-05 00:00:00
abstract：BACKGROUND:Currently, proposed nomograms are mainly based on post-operative histopathology. The purpose of this study was to identify preoperative computed tomography (CT) and clinical information that allow prediction of disease-free (DFS) and overall survival (OS) of patients surgically treated for pancreatic head ca...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8101749
更新日期：2019-10-21 00:00:00
abstract：:Limited information is available regarding interstitial lung disease (ILD) in Erdheim⁻Chester disease (ECD), a rare multisystemic non-Langerhans cell histiocytosis. Sixty-two biopsy-confirmed ECD patients were divided into those with no ILD (19.5%), minimal ILD (32%), mild ILD (29%), and moderate/severe ILD (19.5%), b...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7090243
更新日期：2018-08-28 00:00:00
abstract：:Drug-induced immune thrombocytopenia (DITP) is a life-threatening clinical syndrome that is under-recognized and difficult to diagnose. Many drugs can cause immune-mediated thrombocytopenia, but the most commonly implicated are abciximab, carbamazepine, ceftriaxone, eptifibatide, heparin, ibuprofen, mirtazapine, oxali...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9072212
更新日期：2020-07-13 00:00:00
abstract：BACKGROUND:The long-term stability after soft tissue graft for covering gingival recession remains a pivotal goal for both patient and periodontist. Therefore, the aim of this study was to compare the four-year outcomes of the coronally advanced flap (CAF) versus the pouch/tunnel (POT) technique, both combined with con...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9082641
更新日期：2020-08-14 00:00:00
abstract：:Patients with chronic lymphocytic leukemia (CLL) have defects in both humoral and cellular immunity as a result of their underlying malignancy, as well as chemotherapy-related immune suppression. Upper respiratory tract (URT) colonization can be regarded as a major contributor to infection, so the relationship between...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8060861
更新日期：2019-06-16 00:00:00
abstract：:The relationship between serum uric acid (SUA) and hypertension has been a subject of increasing interest since the 1870 discovery by Frederick Akbar Mahomed. Several epidemiological studies have shown a strong association between high SUA levels and the presence or the development of hypertension. Genetic analyses ha...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm10030448
更新日期：2021-01-24 00:00:00
abstract：OBJECTIVES:We systematically reviewed the literature to address the question of which of the three hemodynamic factors predicts prognosis best in heart failure patients when directly compared to each other: cardiac output, preload or afterload. METHODS:Prognostic studies in heart failure (HF) were searched that includ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8101757
更新日期：2019-10-22 00:00:00
abstract：:Limb length discrepancy (LLD) is a common problem after joint-preserving hip surgeries, hip dysplasia, and hip deformities. Limping, pain, sciatica, paresthesia, and hip instability are common clinical findings and may necessitate limb-lengthening procedures. The study included five patients (two female and three male...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9124104
更新日期：2020-12-19 00:00:00
abstract：:The future hope of generated induced pluripotent stem cells (iPS cells) from Alzheimer's disease patients is multifold. Firstly, they may help to uncover novel mechanisms of the disease, which could lead to the development of new and unprecedented drugs for patients and secondly, they could also be directly used for s...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm3041402
更新日期：2014-12-12 00:00:00
abstract：:Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of several solid and hematological malignancies. ICIs are not only able to produce long and durable responses, but also very well tolerated by patients. There are several approved indications of use of ICIs in treatment of metastatic gastrointestina...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9082533
更新日期：2020-08-06 00:00:00
abstract：:The aim of this paper was to provide insights into alcohol misuse within UK veterans to inform as to whether their presentations differ from the general public. This was done by exploring differences in the severity of alcohol misuse between UK veterans and the general public admitted to a general NHS hospital over an...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm5110095
更新日期：2016-11-02 00:00:00
