Abstract：
:The relationship between serum uric acid (SUA) and hypertension has been a subject of increasing interest since the 1870 discovery by Frederick Akbar Mahomed. Several epidemiological studies have shown a strong association between high SUA levels and the presence or the development of hypertension. Genetic analyses have found that xanthine oxidoreductase (XOR) genetic polymorphisms are associated with hypertension. However, genetic studies on urate transporters and Mendelian randomization studies failed to demonstrate a causal relationship between SUA and hypertension. Results from clinical trials on the role of urate-lowering therapy in the management of patients with hypertension are not uniform. Our study sought to analyze the prognostic and therapeutic role of SUA in the hypertensive disease, from uric acid (UA) biology to clinical trials on urate-lowering therapies.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Piani F,Cicero AFG,Borghi Cdoi
10.3390/jcm10030448subject
Has Abstractpub_date
2021-01-24 00:00:00issue
3issn
2077-0383pii
jcm10030448journal_volume
10pub_type
杂志文章,评审abstract：BACKGROUND:Hand osteoarthritis (OA) is one of the most common joint diseases, but studies on biomarkers are rare. The aim of this explorative study was (a) to evaluate potential biomarkers of hand OA, (b) to identify an optimal time point to sample venous blood, and (c) to correlate biomarker levels with radiological a...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8101545
更新日期：2019-09-26 00:00:00
abstract：:Information on Lyme borreliosis (LB) during pregnancy is limited. In the present study, the course and outcome of erythema migrans (EM) in 304 pregnant women, diagnosed in the period 1990-2015, was assessed and compared with that in age-matched non-pregnant women. The frequency of unfavorable outcome of pregnancies wa...
journal_title：Journal of clinical medicine
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abstract：BACKGROUND:This study aimed to investigate the outcome of therapeutic penetrating keratoplasty (TPK) for medically-uncontrolled infectious keratitis, and to determine the factors associated with the recurrence of infection after TPK. METHODS:A 10-year retrospective study of medically-uncontrolled infectious keratitis ...
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pub_type： 杂志文章
doi：10.3390/jcm9113696
更新日期：2020-11-18 00:00:00
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pub_type： 杂志文章
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更新日期：2020-01-11 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2020-01-15 00:00:00
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journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
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更新日期：2020-06-17 00:00:00
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pub_type： 杂志文章
doi：10.3390/jcm8071045
更新日期：2019-07-17 00:00:00
abstract：:The authors wish to make the following corrections to this paper [...]. ...
journal_title：Journal of clinical medicine
pub_type： 已发布勘误
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更新日期：2019-04-26 00:00:00
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journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm10030423
更新日期：2021-01-22 00:00:00
abstract：:Hypothermic machine perfusion (HMP) has been introduced as an alternative to static cold storage (SCS) in kidney transplantation, but its true benefit in the clinical routine remains incompletely understood. The aim of this study was to assess the effect of HMP vs. SCS in kidney transplantation. All kidney transplants...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9072311
更新日期：2020-07-21 00:00:00
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journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
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更新日期：2019-07-31 00:00:00
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journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9040953
更新日期：2020-03-30 00:00:00
abstract：:The authors wish to make the following corrections to this paper [...]. ...
journal_title：Journal of clinical medicine
pub_type： 已发布勘误
doi：10.3390/jcm9020569
更新日期：2020-02-19 00:00:00
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journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm10020311
更新日期：2021-01-15 00:00:00
abstract：:Uric acid urolithiasis constitutes approximately 7-10% of all urinary stones. Previous studies have revealed that patients with gout do not equally have uric acid stones. Instead, the risk of gout in patients with uric acid stones remains controversial. This study aimed to investigate whether there is different associ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8101536
更新日期：2019-09-25 00:00:00
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journal_title：Journal of clinical medicine
pub_type：
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更新日期：2018-10-04 00:00:00
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journal_title：Journal of clinical medicine
pub_type： 杂志文章
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更新日期：2019-11-06 00:00:00
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journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
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更新日期：2019-09-22 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2020-09-08 00:00:00
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journal_title：Journal of clinical medicine
pub_type： 杂志文章
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更新日期：2020-07-31 00:00:00
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更新日期：2018-06-11 00:00:00
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更新日期：2020-11-27 00:00:00
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更新日期：2020-09-17 00:00:00
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更新日期：2015-05-21 00:00:00
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abstract：:Current therapy of Clostridium difficile diarrhea (CDD) is problematic. Optimal treatment for CDD remains oral vancomycin, but there is little data on oral vancomycin dosing regimens. The objective of this C. difficile diarrhea study was to compare the efficacy of "high dose" vancomycin, 500 mg (PO) q6h, as sole treat...
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