Abstract：
:We report a case of a pregnant woman with nephrotic syndrome due to biopsy-proven focal segmental glomerulosclerosis (FSGS) whose fetus developed echogenic kidneys and severe oligohydramnios by 27 weeks of gestation. Maternal treatment with prednisone resulted in normalization of the amniotic fluid indices and resolution of fetal renal echogenicity. The newborn was noted to have transient renal dysfunction and proteinuria, resolving by 6 weeks postpartum. The transplacental passage of permeability factors is postulated to have caused both the fetal and newborn renal presentation, with significantly elevated levels of soluble urokinase-type plasminogen activator receptor (suPAR) noted in the cord blood. This case documents the transplacental maternal-fetal transmission of suPAR, demonstrating the potential for maternal-fetal transmission of deleterious, disease-causing entities, and adds to the differential diagnosis of fetal echogenic kidneys. Further, this is the first documentation of a fetal response to maternal systemic therapy.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Shuster S,Ankawi G,Licht C,Reiser J,Wang X,Wei C,Chitayat D,Hladunewich Mdoi
10.3390/jcm7100324subject
Has Abstractpub_date
2018-10-04 00:00:00issue
10issn
2077-0383pii
jcm7100324journal_volume
7pub_type
abstract：:Diagnoses based on oral fluid biomarkers have been introduced to overcome limitations of periodontal probe-based diagnoses. Diagnostic ability of certain biomarkers for periodontitis have been identified and widely studied, however, such studies targeting gingivitis is scarce. The aims of this study were to determine ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
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更新日期：2020-06-03 00:00:00
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journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
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更新日期：2020-09-14 00:00:00
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更新日期：2018-05-10 00:00:00
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更新日期：2020-12-13 00:00:00
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更新日期：2020-12-17 00:00:00
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更新日期：2020-01-15 00:00:00
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更新日期：2018-01-26 00:00:00
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journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9123805
更新日期：2020-11-25 00:00:00
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更新日期：2019-09-20 00:00:00
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journal_title：Journal of clinical medicine
pub_type： 杂志文章
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更新日期：2019-12-01 00:00:00
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journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8060785
更新日期：2019-06-01 00:00:00
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journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9020592
更新日期：2020-02-21 00:00:00
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journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
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更新日期：2019-01-07 00:00:00
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journal_title：Journal of clinical medicine
pub_type： 杂志文章
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更新日期：2019-09-26 00:00:00
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journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8101519
更新日期：2019-09-21 00:00:00
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journal_title：Journal of clinical medicine
pub_type： 杂志文章
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更新日期：2019-10-23 00:00:00
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journal_title：Journal of clinical medicine
pub_type： 杂志文章
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更新日期：2018-05-06 00:00:00
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更新日期：2015-05-18 00:00:00
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pub_type： 社论
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更新日期：2019-11-23 00:00:00
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更新日期：2020-02-27 00:00:00
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更新日期：2020-05-22 00:00:00
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更新日期：2019-03-05 00:00:00
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