Abstract：
:Information on Lyme borreliosis (LB) during pregnancy is limited. In the present study, the course and outcome of erythema migrans (EM) in 304 pregnant women, diagnosed in the period 1990-2015, was assessed and compared with that in age-matched non-pregnant women. The frequency of unfavorable outcome of pregnancies was also evaluated. The pregnant women reported constitutional symptoms less frequently than the non-pregnant women (22.4% vs. 37.2%, p < 0.001). Pregnant women diagnosed with EM later during pregnancy had a lower probability of reporting constitutional symptoms (odds ratio = 0.97 for 1-week difference in gestation week at diagnosis of EM, 95% CI: 0.94-0.99, p = 0.02). The outcome of pregnancy was unfavorable in 42/304 (13.8%) patients: preterm birth in 22/42 (52.4%), fetal/perinatal death in 10/42 (23.8%), and/or anomalies in 15/42 (35.7%). Several patients had potential explanation(s) for the unfavorable outcome. In conclusion, the course of early LB during pregnancy is milder than in age-matched non-pregnant women. The outcome of pregnancy with the treatment approach used in the present study (i.v. ceftriaxone 2 g once daily for 14 days) is favorable.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Maraspin V,Lusa L,Blejec T,Ružić-Sabljić E,Pohar Perme M,Strle Fdoi
10.3390/jcm9082364subject
Has Abstractpub_date
2020-07-24 00:00:00issue
8issn
2077-0383pii
jcm9082364journal_volume
9pub_type
杂志文章abstract：BACKGROUND:Our study aims to perform a meta-analysis of benefits and risks associated with the use of non-vitamin K oral anticoagulants (NOAC) versus vitamin K antagonists (VKA) in patients with a percutaneous coronary intervention (PCI) with a particular focus on the combination type: dual vs. dual antithrombotic ther...
journal_title：Journal of clinical medicine
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abstract：:Active vision therapy using perceptual learning and/or dichoptic or binocular environments has shown its potential effectiveness in amblyopia, but some doubts remain about the type of stimuli and the mode and sequence of presentation that should be used. A search was performed in PubMed, obtaining 143 articles with in...
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abstract：:The aim of this study is to determine the accuracy of adrenal vein sampling (AVS) with and without adrenocorticotropic hormone (ACTH) stimulation to distinguish between unilateral and bilateral primary hyperaldosteronism (PA). Retrospective analysis of a prospective database from a referral center between 1984 and 200...
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更新日期：2020-05-13 00:00:00
abstract：:Conventional 3D multicellular tumor spheroids of head and neck squamous cell carcinoma (HNSCC) consisting exclusively of cancer cells have some limitations. They are compact cell aggregates that do not interact with their extracellular milieu, thus suffering from both insufficient extracellular matrix (ECM) deposition...
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更新日期：2019-10-15 00:00:00
abstract：BACKGROUND:Hyponatraemia is associated with increased morbidity, increased mortality and is frequently hospital-acquired due to inappropriate administration of hypotonic fluids. Despite several attempts to minimise the risk, knowledge is lacking as to whether inappropriate prescribing practice continues to be a concern...
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更新日期：2020-08-29 00:00:00
abstract：:(1) Background: Focal chondral defects of the knee can significantly impair patient quality of life. Although different options are available, they are still not conclusive and have several limitations. The aim of this study was to evaluate the role of autologous cartilage micrografts in the treatment of knee chondrop...
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abstract：:Cardiovascular disease (CVD) is a major underlying cause of death, with high economic burden in most countries, including the United States. Lifestyle modifications and the use of antiplatelet therapy, such as aspirin, can contribute significantly to secondary prevention of CVD in adults. This study examined the preva...
journal_title：Journal of clinical medicine
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更新日期：2019-02-20 00:00:00
abstract：BACKGROUND:Patients with diabetic kidney disease (DKD) are at higher risk of hypoglycemia than diabetic patients without DKD. We aimed to investigate the temporal trends of severe hypoglycemia in advanced DKD patients transitioning to dialysis and examine risk factors associated with severe hypoglycemia. We also invest...
journal_title：Journal of clinical medicine
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更新日期：2019-03-27 00:00:00
abstract：:Nasal deformity is associated with congenital cleft lip and palate. Primary rhinoplasty for reconstruction of the nasal deformity at the time of bilateral cleft lip repair is a controversial issue in cleft care due to traditional teaching concerning the potential impairment of nasal growth. This study assessed long-te...
journal_title：Journal of clinical medicine
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更新日期：2019-05-01 00:00:00
abstract：:Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of several solid and hematological malignancies. ICIs are not only able to produce long and durable responses, but also very well tolerated by patients. There are several approved indications of use of ICIs in treatment of metastatic gastrointestina...
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pub_type： 杂志文章,评审
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更新日期：2020-08-06 00:00:00
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journal_title：Journal of clinical medicine
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更新日期：2020-10-11 00:00:00
abstract：:Proteasome inhibitor bortezomib has been used in the treatment of refractory cases of acute and chronic antibody-mediated rejection (AMR) in kidney transplant recipients. However, its efficacy and safety as a primary treatment for early AMR has been scarcely investigated. We herein present our preliminary experience w...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9020529
更新日期：2020-02-15 00:00:00
abstract：BACKGROUND:The heat produced during implant site osteotomy can potentially interfere with and influence the osseointegration process of a dental implant. The objective of this in vitro investigation was to measure the temperature changes during simulated osteotomies in bovine rib bone. The measurements were made at the...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9010148
更新日期：2020-01-05 00:00:00
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journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
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更新日期：2019-03-15 00:00:00
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journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9082624
更新日期：2020-08-13 00:00:00
abstract：:The core conception of sepsis-that it is a dysregulated state-is a powerful and durable idea that has inspired decades of research. But is it true that the body's response to sepsis is dysregulated? To answer that question, this review surveyed the history of trials of experimental sepsis treatments targeting the host...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm7090247
更新日期：2018-08-29 00:00:00
abstract：OBJECTIVE:To analyze the difference in the prevalence of sexually transmitted infections (STIs) between two time periods (2000⁻2007 and 2008⁻2014, with the latter period characterized by the economic crisis), as well as determine differences in sociodemographic factors, clinical care, and risk indicators. METHODS:This...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8020277
更新日期：2019-02-25 00:00:00
abstract：:Both vasculature and myocardium in the heart are excessively damaged following myocardial infarction (MI), hence therapeutic strategies for treating MI hearts should concurrently aim for true cardiac repair by introducing new cardiomyocytes to replace lost or injured ones. Of them, mesenchymal stem cells (MSCs) have l...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9051277
更新日期：2020-04-28 00:00:00
abstract：:We examined the association between self-rated health (SRH), a subjective measure of an individual's health status, and the incidence of metabolic abnormalities, as well as the effect of obesity on this association in metabolically healthy individuals. The cohort study included 85,377 metabolically healthy men and wom...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8010034
更新日期：2019-01-01 00:00:00
abstract：:Exercise has health benefits and prevents a range of chronic diseases caused by physiological and biological changes in the whole body. Generally, the metabolic regulation of skeletal muscle through exercise is known to have a protective effect on the pathogenesis of metabolic syndrome, non-alcoholic fatty liver disea...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm10030385
更新日期：2021-01-20 00:00:00
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journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9072209
更新日期：2020-07-13 00:00:00
abstract：:Antiretroviral therapy (ART) has significantly improved life expectancy of infected subjects, generating a new epidemiological setting of people aging withHuman Immunodeficiency Virus (HIV). People living with HIV (PLWH), having longer life expectancy, now face several age-related conditions as well as side effects of...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
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更新日期：2019-08-19 00:00:00
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journal_title：Journal of clinical medicine
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doi：10.3390/jcm9051478
更新日期：2020-05-14 00:00:00
abstract：:Tuberculosis (TB) remains a major health issue worldwide. In order to contain TB infections, improved vaccines as well as accurate and reliable diagnostic tools are desirable. Exosomes are employed for the diagnosis of various diseases. At present, research on exosomes in TB is still at the preliminary stage. Recent s...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
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更新日期：2021-01-04 00:00:00
abstract：:The association between tumor-associated macrophages (TAMs) and the expression of immune checkpoint molecules has not been well described in cutaneous melanoma. We evaluated the correlations between the expression of markers of TAMs, cluster of differentiation 163 (CD163), and immune checkpoint molecules, programmed c...
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更新日期：2020-08-03 00:00:00
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journal_title：Journal of clinical medicine
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doi：10.3390/jcm9082448
更新日期：2020-07-31 00:00:00
abstract：:Osteogenesis imperfecta (OI) is a connective tissue disorder that is characterized by low bone density leading to recurrent fractures. The efficacy of the anti-resorption drug denosumab for OI with osteoporosis is still largely unknown. We herein describe the clinical outcomes of eight osteoporotic cases of OI to exam...
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更新日期：2018-11-24 00:00:00
abstract：:Clinicians are significant translators and interpreters towards parents of the abundant literature on autism spectrum disorder (ASD). However, how clinicians experience and view ASD and an ASD diagnosis is not well known. Sixteen physicians working with young children with a (presumed) diagnosis of ASD participated in...
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更新日期：2018-10-12 00:00:00
abstract：:Despite extensive research and development of new treatments, acute myeloid leukemia (AML)-backbone therapy has remained essentially unchanged over the last decades and is frequently associated with poor outcomes. Eradicating the leukemic stem cells (LSCs) is the ultimate challenge in the treatment of AML. Emerging ev...
journal_title：Journal of clinical medicine
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doi：10.3390/jcm9051513
更新日期：2020-05-18 00:00:00
abstract：:High-frequency near-infrared diode laser provides a high-peak output, low-heat accumulation, and efficient biostimulation. Although these characteristics are considered suitable for osteoarthritis (OA) treatment, the effect of high-frequency near-infrared diode laser irradiation in in vitro or in vivo OA models has no...
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更新日期：2020-03-24 00:00:00
