Abstract:
:Antiretroviral therapy (ART) has significantly improved life expectancy of infected subjects, generating a new epidemiological setting of people aging withHuman Immunodeficiency Virus (HIV). People living with HIV (PLWH), having longer life expectancy, now face several age-related conditions as well as side effects of long-term exposure of ART. Chronic kidney disease (CKD) is a common comorbidity in this population. CKD is a relentlessly progressive disease that may evolve toward end-stage renal disease (ESRD) and significantly affect quality of life and risk of death. Herein, we review current understanding of renal involvement in PLWH, mechanisms and risk factors for CKD as well as strategies for early recognition of renal dysfunction and best care of CKD.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Alfano G,Cappelli G,Fontana F,Di Lullo L,Di Iorio B,Bellasi A,Guaraldi Gdoi
10.3390/jcm8081254subject
Has Abstractpub_date
2019-08-19 00:00:00issue
8issn
2077-0383pii
jcm8081254journal_volume
8pub_type
杂志文章,评审abstract:INTRODUCTION:The inherent immunosuppression of uremia increases the susceptibility of hemodialysis patients to infection. There is still limited evidence on hemodialysis patients and COVID-19. The clinical and analytical spectrum and treatment responses and mortality are poorly characterized. MATERIAL AND METHODS:Clin...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9072264
更新日期:2020-07-16 00:00:00
abstract::FOLFIRINOX (FX) and gemcitabine (GEM) plus nab-paclitaxel (GnP) have been reported as effective regimens for unresectable advanced pancreatic cancer (APC). FX may be more effective but is also associated with more adverse events (AEs). Therefore, first-line treatment with FX followed by second-line GnP may be appropri...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8060761
更新日期:2019-05-29 00:00:00
abstract:BACKGROUND:Thyroid hormone modulation of cardiovascular function has been associated with cardiovascular disease. Recent evidence suggests that free thyroxine (FT4) levels are associated with an increase in systemic arterial stiffness, but little is known about the effects of FT4 at the local level of the common caroti...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm10030420
更新日期:2021-01-22 00:00:00
abstract::Osteoarthritis is a highly prevalent and disabling disease, causing a significant individual and socioeconomic burden worldwide. Until now, there has been a dearth of research exploring the impact of osteoarthritis in global Indigenous communities. Osteoarthritis has a similar risk factor profile to many chronic disea...
journal_title:Journal of clinical medicine
pub_type: 社论
doi:10.3390/jcm9082393
更新日期:2020-07-27 00:00:00
abstract::Radiation chorioretinopathy, radiation maculopathy, and radiation optic neuropathy are the major complications of ophthalmic radiotherapy. Optical coherence tomography (OCT) and OCT angiography (OCTA) are revolutionary imaging methods, allowing the visualization of the retinal cellular architecture and the retinal vas...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9113496
更新日期:2020-10-29 00:00:00
abstract::This study proposes a method for measuring the volumetric change of alveolar bone after dental implant surgery using computed tomography (CT). A total of 40 implants in 20 patients (15 males and 5 females) were selected. The types of implants used were group 1: 24 CMI IS-II Active implants (Neobiotech Co., Seoul, Repu...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9041238
更新日期:2020-04-24 00:00:00
abstract::We sought to clarify the correlation between non-protein respiratory quotient (npRQ) in indirect calorimetry and serum zinc (Zn) level in chronic liver diseases (CLDs, n = 586, 309 liver cirrhosis (LC) patients, median age = 63 years). Clinical parameters potentially linked to npRQ <0.85 (best cutoff point for the pro...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9010255
更新日期:2020-01-17 00:00:00
abstract::The purpose of this study was to compare the thickness of all inner and outer macular layers between ocular hypertension (OHT) and early primary open-angle glaucoma (POAG) using spectral domain optical coherence tomography (SD-OCT) 8 × 8 posterior pole algorithm (8 × 8 PPA). Fifty-seven eyes of 57 OHT individuals and ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9051503
更新日期:2020-05-16 00:00:00
abstract::Coronavirus disease 2019 (COVID-19), due to the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has become an epidemiological threat and a worldwide concern. SARS-CoV-2 has spread to 210 countries worldwide and more than 6,500,000 confirmed cases and 384,643 deaths have been reported, while the number of...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9061753
更新日期:2020-06-05 00:00:00
abstract::Mutations in the protein DJ-1 cause autosomal recessive forms of Parkinson's disease (PD) and oxidized DJ-1 is found in the brains of idiopathic PD individuals. While several functions have been ascribed to DJ-1 (most notably protection from oxidative stress), its contribution to PD pathogenesis is not yet clear. Here...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm8091377
更新日期:2019-09-03 00:00:00
abstract::Multidisciplinary interventions have been developed for patients with atopic dermatitis (AD) and their families, with the aim of improving outcomes such as disease control, adherence, and quality of life. We reviewed the content of different multidisciplinary approaches to intervention for AD and evidence for their im...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm4051156
更新日期:2015-05-21 00:00:00
abstract::Minimally invasive surgery is becoming popular for treating spinal disorders. The advantages of percutaneous endoscopic debridement and drainage (PEDD) for infectious spondylitis include direct observation of the lesion, direct pus drainage, and earlier pain relief. We retrospectively reviewed 37 patients who underwen...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8091356
更新日期:2019-09-01 00:00:00
abstract:CONTEXT:As the food industry is continually involved in the development of new attractive alternative therapeutic agents, the evaluation of the beneficial impact of (poly)phenols on cognitive and brain function during aging has gained increasing interest. OBJECTIVE:This systematic review and meta-analysis aimed to eva...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9030835
更新日期:2020-03-19 00:00:00
abstract::Inflammatory bowel diseases (IBDs) may be associated with extra-intestinal manifestations. Among these, mucocutaneous manifestations are relatively frequent, often difficult to diagnose and treat, and may complicate the course of the underlying disease. In the present review, a summary of the most relevant literature ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm10020364
更新日期:2021-01-19 00:00:00
abstract:BACKGROUND:Ghrelin is a 28-amino acid peptide with an orexigenic property, which is predominantly produced by the stomach. Acylated ghrelin is the active form of this hormone. Obestatin is a 23-amino acid peptide which is produced by post-translational modification of a protein precursor that also produces ghrelin. Obe...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm5070061
更新日期:2016-06-23 00:00:00
abstract::The relationship between obesity and asthma exacerbations is still under debate. The aim of our work is to analyse the relationship between obesity and hospital re-admissions in asthmatics. A review was retrospectively performed on all hospital admissions of adult patients due to asthma exacerbation occurring in our h...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9010221
更新日期:2020-01-14 00:00:00
abstract::Hepatobiliary complications in children with sickle cell disease (SCD) are rarely reported but can be life-threatening. We retrospectively assessed their prevalence in a cohort of 616 children followed in a French university-hospital SCD reference center. Eligibility criteria were the following: age <18 years, seen at...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8091481
更新日期:2019-09-18 00:00:00
abstract::The nociceptive withdrawal reflex (NWR) is used to probe spinal cord excitability in chronic pain states. Here, we used an automated and unbiased procedure for determining the NWR threshold and compared the reflex thresholds and corresponding pain ratings in a well-characterized cohort of fibromyalgia (n = 29) and mat...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9061992
更新日期:2020-06-25 00:00:00
abstract:BACKGROUND:Prescribing medications is one of the most common medical decisions that is made by primary care providers (PCPs). In the Republic of Croatia, PCPs hold a key position in prescribing and evaluating the medications that are provided for patients. Accordingly, providing advice for patients regarding the potent...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm7090231
更新日期:2018-08-22 00:00:00
abstract:BACKGROUND:Congenital factor (F) VII deficiency is a rare coagulation factor deficiency with an estimated incidence of 1 per 500,000 individuals. Patients with severe FVII deficiency present a broad range of clinical presentations. Alloimmunization against exogenous FVII, as the main challenge of replacement therapy, i...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm10020211
更新日期:2021-01-08 00:00:00
abstract::Cardiovascular disease (CVD) is the number one cause of deaths worldwide, with yearly deaths due to atherothrombosis-i [...]. ...
journal_title:Journal of clinical medicine
pub_type: 社论
doi:10.3390/jcm8111895
更新日期:2019-11-06 00:00:00
abstract::The future hope of generated induced pluripotent stem cells (iPS cells) from Alzheimer's disease patients is multifold. Firstly, they may help to uncover novel mechanisms of the disease, which could lead to the development of new and unprecedented drugs for patients and secondly, they could also be directly used for s...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm3041402
更新日期:2014-12-12 00:00:00
abstract::Pain in Sickle Cell Disease (SCD) is a major comorbidity and unique with acute pain due to recurrent and episodic vaso-occlusive crises as well as chronic pain, which can span an individual's entire life. Opioids are the mainstay treatment for pain in SCD. Due to recent health crises raised by adverse effects includin...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9123902
更新日期:2020-12-01 00:00:00
abstract:INTRODUCTION:Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are an increasing tumor entity. Since many patients are diagnosed at an advanced stage, treatment is still challenging and dependent on many tumor and patient specific factors. Therefore, the aim of the present study was to elucidate the expression...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9103368
更新日期:2020-10-21 00:00:00
abstract::We report a case of a pregnant woman with nephrotic syndrome due to biopsy-proven focal segmental glomerulosclerosis (FSGS) whose fetus developed echogenic kidneys and severe oligohydramnios by 27 weeks of gestation. Maternal treatment with prednisone resulted in normalization of the amniotic fluid indices and resolut...
journal_title:Journal of clinical medicine
pub_type:
doi:10.3390/jcm7100324
更新日期:2018-10-04 00:00:00
abstract::Primary Sjögren's syndrome (pSS) is a chronic systemic autoimmune rheumatic disease characterized by lymphoplasmacytic infiltration of the salivary and lacrimal glands, whereby sicca syndrome and/or systemic manifestations are the clinical hallmarks, associated with a particular autoantibody profile. pSS is the most f...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9072299
更新日期:2020-07-20 00:00:00
abstract::The use of targeted agents and immunotherapy for the treatment of advanced non-small-cell lung cancer (NSCLC) has made it mandatory to characterize tumor tissue for patient selection. Moreover, the development of agents that are active against specific resistance mechanisms arising during treatment make it equally imp...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm8070998
更新日期:2019-07-09 00:00:00
abstract::Acute kidney injury and renal failure are common after heart transplantation. We retrospectively reviewed a national cohort and identified 1129 heart transplant patients. Patients receiving renal replacement therapy after heart transplantation were grouped into the dialysis cohort. The long-term survival and risk fact...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9082455
更新日期:2020-07-31 00:00:00
abstract::Antibiotic treatment in paediatric rhinosinusitis is still a matter of debate, as the current guidelines have been drafted mainly based on clinical studies published before 2013. Recent modifications in the epidemiological basis of the disease might mean that current treatments are not completely adequate considering ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm8081162
更新日期:2019-08-03 00:00:00
abstract:BACKGROUND:Anemia of Chronic Disease (ACD) can negatively influence the clinical course of Inflammatory Bowel Disease (IBD) patients. The aim of this study was to evaluate the effect of Vedolizumab on ACD in IBD. METHODS:Clinical data of 75 IBD patients (25 Crohn's disease (CD) and 50 Ulcerative Colitis (UC)) receivin...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9072126
更新日期:2020-07-06 00:00:00