当前位置： SCI文献检索 > Journal of Clinical Medicine期刊下所有文献 > Second-Line Gemcitabine Plus Nab-Paclitaxel for Patients with Unresectable Advanced Pancreatic Cancer after First-Line FOLFIRINOX Failure.

Second-Line Gemcitabine Plus Nab-Paclitaxel for Patients with Unresectable Advanced Pancreatic Cancer after First-Line FOLFIRINOX Failure.

Abstract：

:FOLFIRINOX (FX) and gemcitabine (GEM) plus nab-paclitaxel (GnP) have been reported as effective regimens for unresectable advanced pancreatic cancer (APC). FX may be more effective but is also associated with more adverse events (AEs). Therefore, first-line treatment with FX followed by second-line GnP may be appropriate. AIMS:To assess the safety and efficacy of second-line GnP for patients with APC after first-line FX failure. METHODS:This study was a multicenter prospective phase II study evaluating second-line GnP in patients with APC after failed first-line FX. The primary endpoint was response rate (RR), and the secondary endpoints were overall survival (OS), progression free survival (PFS), and the frequency and degree of adverse events (AEs). RESULTS:Thirty patients (14 male; median age, 64 years) were enrolled. The RR was 13.3%, with a median follow-up time of 9.3 months. The median OS and PFS were 7.6 and 3.8 months, respectively. From the beginning of first-line treatment, the median OS and PFS were 14.2 and 9.3 months, respectively. Grade 3 or 4 AEs were seen in 70% of patients. CONCLUSION:Second-line GnP after FX failure for patients with APC could be more effective than GEM alone. Further comparison studies are warranted.

journal_name

J Clin Med

journal_title

Journal of clinical medicine

authors

Mita N,Iwashita T,Uemura S,Yoshida K,Iwasa Y,Ando N,Iwata K,Okuno M,Mukai T,Shimizu M

doi

10.3390/jcm8060761

subject

Has Abstract

pub_date

2019-05-29 00:00:00

issue

6

issn

2077-0383

pii

jcm8060761

journal_volume

8

pub_type

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