Abstract:
:Previous studies exploring the association between arterial stiffness and prediabetes remain controversial. This study aimed to investigate the association of the different domains of prediabetes categorized by glycated hemoglobin A1c (A1c) 5.7-6.4%, impaired fasting glucose (IFG), fasting plasma glucose of 5.6-6.9 mmol/L, and impaired glucose tolerance (IGT), two-hour post-load glucose of 7.8-11.0 mmol/L, on arterial stiffness. These were measured by brachial-ankle pulse-wave velocity (baPWV). We enrolled 4938 eligible subjects and divided them into the following nine groups: (1) normoglycemic; (2) isolated A1c 5.7-6.4%; (3) isolated IFG; (4) IFG with A1c 5.7-6.4%; (5) isolated IGT; (6) combined IGT and IFG with A1c <5.7%; (7) IGT with A1c 5.7-6.4%; (8) combined IGT and IFG with A1c 5.7-6.4%; and (9) newly diagnosed diabetes (NDD). The baPWV values were significantly high in subjects with NDD (β = 47.69, 95% confidence interval (CI) = 29.02-66.37, p < 0.001), those with IGT with A1c 5.7-6.4% (β = 36.02, 95% CI = 19.08-52.95, p < 0.001), and those with combined IGT and IFG with A1c 5.7-6.4% (β = 27.72, 95% CI = 0.68-54.76, p = 0.044), but not in the other subgroups. These findings suggest that increased arterial stiffness was found in prediabetes individuals having an A1c 5.7-6.4% with IGT, but not IFG. Isolated A1c 5.7-6.4% and isolated IGT were not associated with elevated arterial stiffness.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Li CH,Lu FH,Yang YC,Wu JS,Chang CJdoi
10.3390/jcm8050603subject
Has Abstractpub_date
2019-05-01 00:00:00issue
5issn
2077-0383pii
jcm8050603journal_volume
8pub_type
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