Abstract：
:In patients with Cushing's disease (CD), prompt diagnosis and treatment are essential for favorable long-term outcomes, although this remains a challenging task. The differential diagnosis of CD is still difficult in some patients, even with an organized stepwise diagnostic approach. Moreover, despite the use of high-resolution magnetic resonance imaging (MRI) combined with advanced fine sequences, some tumors remain invisible. Surgery, using various surgical approaches for safe maximum tumor removal, still remains the first-line treatment for most patients with CD. Persistent or recurrent CD after unsuccessful surgery requires further treatment, including repeat surgery, medical therapy, radiotherapy, or sometimes, bilateral adrenalectomy. These treatments have their own advantages and disadvantages. However, the most important thing is that this complex disease should be managed by a multidisciplinary team with collaborating experts. In addition, a personalized and individual-based approach is paramount to achieve high success rates while minimizing the occurrence of adverse events and improving the patients' quality of life. Finally, the recent new insights into the pathophysiology of CD at the molecular level are highly anticipated to lead to the introduction of more accurate diagnostic tests and efficacious therapies for this devastating disease in the near future.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Nishioka H,Yamada Sdoi
10.3390/jcm8111951subject
Has Abstractpub_date
2019-11-12 00:00:00issue
11issn
2077-0383pii
jcm8111951journal_volume
8pub_type
杂志文章,评审abstract：:We aimed to test the association between low-density lipoprotein cholesterol (LDL-C) and cardiovascular disease (CVD), cancer, and all-cause mortality in non-statin users. A total of 347,971 subjects in Kangbuk Samsung Health Study (KSHS.57.4% men, mean follow up: 5.64 ± 3.27 years) were tested. To validate these asso...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8101571
更新日期：2019-10-01 00:00:00
abstract：:Tadalafil 5 mg represents the standard for men with Erectile dysfunction (ED) and lower urinary tract symptoms (LUTS)/benign prostatic enlargement (BPE). We carried out an observational trial aiming to assess the efficacy and safety of Tadalafil compared with Tadalafil plus Tamsulosin. Seventy-five patients complainin...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8081126
更新日期：2019-07-29 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Elderly and/or frail women with ovarian cancer are often undertreated. The aim of the study is to compare the effects of age and frailty on surgical approaches, postoperative complications, and prognosis in elderly women with ovarian cancer. METHODS:A retrospective multicenter study of women ≥...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9051339
更新日期：2020-05-04 00:00:00
abstract：:To investigate the clinicopathological features and treatment outcomes in patients with stage I, high-risk endometrial cancer. Patients with International Federation of Gynecology and Obstetrics stage I, papillary serous, clear cell, or grade 3 endometrioid carcinoma treated between 2000 and 2012 were analyzed for the...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7090254
更新日期：2018-09-04 00:00:00
abstract：:This Special Issue on lung diseases is aimed at giving emergent researchers and clinicians an important forum to share their original research and expert reviews on key topics within respiratory diseases. This Special Issue will be of interest to general physicians and respiratory specialist and will equip the reader ...
journal_title：Journal of clinical medicine
pub_type： 社论
doi：10.3390/jcm8122060
更新日期：2019-11-23 00:00:00
abstract：:Conventional 3D multicellular tumor spheroids of head and neck squamous cell carcinoma (HNSCC) consisting exclusively of cancer cells have some limitations. They are compact cell aggregates that do not interact with their extracellular milieu, thus suffering from both insufficient extracellular matrix (ECM) deposition...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8101686
更新日期：2019-10-15 00:00:00
abstract：:Since an association between myocardial infarction (MI) and respiratory infections has been described for influenza viruses and other respiratory viral agents, understanding possible physiopathological links between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and acute coronary syndromes (ACS) is of t...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9061683
更新日期：2020-06-02 00:00:00
abstract：:Arteriogenesis supplies oxygen and nutrients in the tumor microenvironment (TME), which may play an important role in tumor growth and metastasis. Pancreatic neuroendocrine tumors (pNETs) are the second most common pancreatic malignancy and are frequently metastatic on presentation. Nearly a third of pNETs secrete bio...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8111980
更新日期：2019-11-14 00:00:00
abstract：:We aimed to develop a mathematical model to predict the progression of aortic stenosis (AS) and aortic dilatation (AD) in bicuspid aortic valve patients. Bicuspid AS patients who underwent at least two serial echocardiograms from 2005 to 2017 were enrolled. Mathematical modeling was undertaken to assess (1) the non-li...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8091302
更新日期：2019-08-24 00:00:00
abstract：:The pathophysiology of cardiogenic shock (CS) varies depending on its etiology, which may lead to different hemodynamic profiles (HP) and may help tailor therapy. We aimed to assess the HP of CS patients according to their etiologies of acute myocardial infarction (AMI) and acute decompensated chronic heart failure (A...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9113384
更新日期：2020-10-22 00:00:00
abstract：BACKGROUND:There is a paucity of head-to-head comparisons of the efficacy and harms of pharmacological treatments for systemic sclerosis-related interstitial lung disease (SSc-ILD). METHODS:We conducted a network meta-analysis (NMA) in order to compare the effects of different treatments with the placebo on change in ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9082560
更新日期：2020-08-07 00:00:00
abstract：:A 37 year-old man presented to the Emergency Department (ED) with new onset seizure and fall from standing.[...]. ...
journal_title：Journal of clinical medicine
pub_type：
doi：10.3390/jcm5040046
更新日期：2016-04-12 00:00:00
abstract：BACKGROUND:Loss of peripheral muscle oxidative phenotype, cognitive impairment, and depression are well-recognized systemic manifestations of chronic obstructive pulmonary disease (COPD). Kynurenine (KYN), known to be associated with disturbed mental health, can be metabolized in muscle by kynurenine aminotransferases ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8070915
更新日期：2019-06-26 00:00:00
abstract：:The aim of our study was to evaluate redox status, enzymatic and non-enzymatic antioxidant barriers, oxidative damage of proteins, lipids and DNA, as well as concentration of coenzyme Q10 and vitamins A and E in patients with chronic granulomatous disease (CGD). The study was performed on fifteen Caucasian individuals...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9051397
更新日期：2020-05-09 00:00:00
abstract：BACKGROUND:Deep dry needling (DDN) and ischemic compression technic (ICT) may be considered as interventions used for the treatment of Myofascial Pain Syndrome (MPS) in latent myofascial trigger points (MTrPs). The immediate effectiveness of both DDN and ICT on pressure pain threshold (PPT) and skin temperature of the ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8101632
更新日期：2019-10-05 00:00:00
abstract：:The idea of right heart catheterization (RHC) grew in the milieu of modern thinking about the cardiovascular system, influenced by the experiments of William Harvey, which were inspired by the treatises of Greek philosophers like Aristotle and Gallen, who made significant contributions to the subject. RHC was first di...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8091331
更新日期：2019-08-28 00:00:00
abstract：:There is a lack of evidence or societal guidelines regarding the utility of fibrinogen monitoring during thrombolysis. The purpose of our study was to investigate the current use of monitoring fibrinogen levels during thrombolysis. A voluntary, anonymous online survey was sent to all physician members of the Society o...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7050111
更新日期：2018-05-10 00:00:00
abstract：:Periprosthetic joint infection in total knee arthroplasty is a significant complication that is a common reason for revision surgery. The current standard of care is two-stage revision surgery. There is however increasing evidence to support the use of single-stage revision surgery. We conducted a PRISMA systematic re...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8020174
更新日期：2019-02-02 00:00:00
abstract：:Background: We decided to investigate whether aneurysm wall enhancement (AWE) on high-resolution vessel wall magnetic resonance imaging (HR VW-MRI) coexists with the conventional risk factors for aneurysm rupture. Methods: We performed HR VW-MRI in 46 patients with 64 unruptured small intracranial aneurysms. Patient d...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm10020225
更新日期：2021-01-10 00:00:00
abstract：:There is a large body of research showing that psychological treatment can be effectively delivered via the internet, and Digital Mental Health Services (DMHS) are now delivering those interventions in routine care. However, not all attempts to translate these research outcomes into routine care have been successful. ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8081239
更新日期：2019-08-17 00:00:00
abstract：:C-reactive protein (CRP) and myxovirus resistance protein A (MxA) are associated with bacterial and viral infections, respectively. We conducted a prospective, multicenter, cross-sectional study of adults and children with febrile upper respiratory tract infections (URIs) to evaluate the diagnostic accuracy of a rapid...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm6100094
更新日期：2017-10-07 00:00:00
abstract：:Exercise has health benefits and prevents a range of chronic diseases caused by physiological and biological changes in the whole body. Generally, the metabolic regulation of skeletal muscle through exercise is known to have a protective effect on the pathogenesis of metabolic syndrome, non-alcoholic fatty liver disea...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm10030385
更新日期：2021-01-20 00:00:00
abstract：:Disrupting the process of memory reconsolidation could be a promising treatment for addiction. However, its application may be constrained by the intensity of addiction memory. This study aimed to develop and initially validate a new measure, the Addiction Memory Intensity Scale (AMIS), for assessing the intensity of ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7120467
更新日期：2018-11-22 00:00:00
abstract：:Eosinophilic granulomatosis with polyangiitis (EGPA) is a type of systemic vasculitis with eosinophilia in the peripheral blood, which is preceded by bronchial asthma or allergic disease. EGPA is pathologically characterized by microangiopathy granulomatosis vasculitis. Vasculitis can be exacerbated and cause central ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9123890
更新日期：2020-11-30 00:00:00
abstract：:Endometrial cancer (EC) is the sixth most common cancer in women worldwide and its mortality is directly associated with the presence of poor prognostic factors driving tumor recurrence. Stratification systems are based on few molecular, and mostly clinical and pathological parameters, but these systems remain inaccur...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9061900
更新日期：2020-06-17 00:00:00
abstract：BACKGROUND:'Gaming Disorder' (GD) has received increased medical attention and official recognition from both the American Psychiatric Association (APA) and the World Health Organization (WHO). Although these two medical organizations have independently developed promising clinical diagnostic frameworks to assess disor...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8101691
更新日期：2019-10-15 00:00:00
abstract：:Multiple myeloma (MM) is a hematological malignancy with a poor prognosis, characterized by clonal proliferation of plasma cells in the bone marrow (BM). Relapse due to undetected minimal residual disease (MRD) is the leading cause of death among patients with MM. This review summarizes the methods and prognostic valu...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm6100091
更新日期：2017-09-25 00:00:00
abstract：:For a long time, the stem cell regenerative paradigm has been based on the assumption that progenitor cells play a critical role in tissue repair by means of their plasticity and differentiation potential. However, recent works suggest that the mechanism underlying the benefits of stem cell transplantation might relat...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm2040302
更新日期：2013-12-17 00:00:00
abstract：:(1) Background: Little is known about the impact of pathophysiological mechanisms that underlie the enhancement of excitotoxicity and the neuronal consequences of status epilepticus (SE), as well as the clinical consequences of secondary brain insults (SBI) in patients with SE on outcome; (2) Methods: Electronic searc...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9082521
更新日期：2020-08-05 00:00:00
abstract：:Corneal grafts interact with their hosts via complex immunobiological processes that sometimes lead to graft failure. Prediction of graft failure is often a tedious task due to the genetic and nongenetic heterogeneity of patients. As in other areas of medicine, a reliable prediction method would impact therapeutic dec...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9020586
更新日期：2020-02-21 00:00:00
