Abstract：
:For a long time, the stem cell regenerative paradigm has been based on the assumption that progenitor cells play a critical role in tissue repair by means of their plasticity and differentiation potential. However, recent works suggest that the mechanism underlying the benefits of stem cell transplantation might relate to a paracrine modulatory effect rather than the replacement of affected cells at the site of injury. Therefore, mounting evidence that stem cells may act as a reservoir of trophic signals released to modulate the surrounding tissue has led to a paradigm shift in regenerative medicine. Attention has been shifted from analysis of the stem cell genome to understanding the stem cell "secretome", which is represented by the growth factors, cytokines and chemokines produced through paracrine secretion. Insights into paracrine-mediated repair support a new approach in regenerative medicine and the isolation and administration of specific stem cell-derived paracrine factors may represent an extremely promising strategy, introducing paracrine-based therapy as a novel and feasible clinical application. In this review, we will discuss the regenerative potential of fetal and adult stem cells, with particular attention to their secretome.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Bollini S,Gentili C,Tasso R,Cancedda Rdoi
10.3390/jcm2040302subject
Has Abstractpub_date
2013-12-17 00:00:00pages
302-27issue
4issn
2077-0383pii
jcm2040302journal_volume
2pub_type
杂志文章,评审abstract：:Infected elderly people often present with signs and symptoms that differ from those in younger adults, but data on the association between patient age and presentation of early Lyme borreliosis (LB) are limited. In this study, the association between patient age (18⁻44 years, young vs. 45⁻64 years, middle-aged vs. ≥ ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7120506
更新日期：2018-12-02 00:00:00
abstract：:We have evaluated circulating miRNAs (-195-5p and -451a) in subjects with acute ischemic stroke (AIS) and in patients with transient ischemic attack (TIA). In this study, 18 subjects with AIS and 18 patients with TIA were enrolled and examined at admission (T0) and at 24 h and 48 h after admission, and compared to 20 ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8020130
更新日期：2019-01-22 00:00:00
abstract：:Postoperative ileus is one of the most important and common complications after abdominal surgery. This single-blind randomized clinical trial study was conducted with the aim of evaluating the effect of oral pyridostigmine (60 mg) on the duration and frequency of response to the treatment of ileus after abdominal sur...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7050104
更新日期：2018-05-06 00:00:00
abstract：:Chronic stress is thought to be involved in the occurrence and progression of multiple diseases, via mechanisms that still remain largely unknown. Interestingly, key regulators of the stress response, such as members of the corticotropin-releasing-hormone (CRH) family of neuropeptides and receptors, are now known to b...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8101669
更新日期：2019-10-12 00:00:00
abstract：:The limited number of available studies that examined the pathology of alcohol hangover focused on biomarkers of alcohol metabolism, oxidative stress and the inflammatory response to alcohol as potentially important determinants of hangover severity. The available literature on alcohol metabolism and oxidative stress ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9113421
更新日期：2020-10-25 00:00:00
abstract：:Apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APEX1) has been known to play key roles in DNA repair, the regulation of diverse transcriptional activity, and cellular responses to redox activity. This study aimed to examine serum APEX1 (s-APEX1) expression as a possible screening biomarker for clear cel...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8081151
更新日期：2019-08-01 00:00:00
abstract：:Current therapy of Clostridium difficile diarrhea (CDD) is problematic. Optimal treatment for CDD remains oral vancomycin, but there is little data on oral vancomycin dosing regimens. The objective of this C. difficile diarrhea study was to compare the efficacy of "high dose" vancomycin, 500 mg (PO) q6h, as sole treat...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7040075
更新日期：2018-04-10 00:00:00
abstract：:Androgens are essential for the development, differentiation, growth, and function of the prostate through epithelial-stromal interactions. However, androgen concentrations in the hypertrophic human prostate decrease significantly with age, suggesting an inverse correlation between androgen levels and proliferative di...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm7040068
更新日期：2018-04-02 00:00:00
abstract：:The factors that contribute to the development of ulcerative colitis (UC), are still not fully identified. Disruption of the colon barrier is one of the first events leading to invasion of bacteria and activation of the immune system. The colon barrier is strongly influenced by sphingolipids. Sphingolipids impact cell...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8070971
更新日期：2019-07-04 00:00:00
abstract：BACKGROUND:Heart rate variability (HRV) as an accurate, noninvasive measure of the Autonomous Nervous System (ANS) can reflect mental health (e.g., stress, depression, or anxiety). Tai Chi and Yoga (Tai Chi/Yoga), as the most widely practiced mind⁻body exercises, have shown positive outcomes of mental health. To date, ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm7110404
更新日期：2018-10-31 00:00:00
abstract：BACKGROUND:There is a need for analytical tools predicting the risk of periodontitis. The purpose of this study was to estimate and evaluate a risk score for prediction of periodontitis. MATERIALS AND METHODS:This case-cohort study included a random sample of 155 cases (with periodontitis) and 175 controls (randomly s...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8030307
更新日期：2019-03-05 00:00:00
abstract：:The aim of this article is to investigate pathological subjects from a population through different physical factors. To achieve this, particle swarm optimization (PSO) and K-means (KM) clustering algorithms have been combined (PSO-KM). Datasets provided by the literature were divided into three clusters based on age ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7040065
更新日期：2018-03-28 00:00:00
abstract：BACKGROUND:Loss of peripheral muscle oxidative phenotype, cognitive impairment, and depression are well-recognized systemic manifestations of chronic obstructive pulmonary disease (COPD). Kynurenine (KYN), known to be associated with disturbed mental health, can be metabolized in muscle by kynurenine aminotransferases ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8070915
更新日期：2019-06-26 00:00:00
abstract：:Diabetic nephropathy patients traditionally show significant macroalbuminuria prior to the development of renal impairment. However, this clinical paradigm has recently been questioned. Epidemiological surveys confirm that chronic kidney disease (CKD) diagnosed by a low glomerular filtration rate (GFR) is more common ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm4091761
更新日期：2015-09-07 00:00:00
abstract：:Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an ultra-rare autosomal recessive disorder of nucleoside metabolism that is caused by mutations in the nuclear thymidine phosphorylase gene (TYMP) gene, encoding for the enzyme thymidine phosphorylase. There are currently no approved treatments for MNGIE...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8040457
更新日期：2019-04-05 00:00:00
abstract：:The main risk factor for primary open-angle glaucoma (POAG) is increased intraocular pressure (IOP). It is of interest that about half of the patients have an IOP within the normal range (normal-tension glaucoma, NTG). Additionally, there is a group of patients with a high IOP but no glaucomatous neurodegeneration (oc...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9092979
更新日期：2020-09-15 00:00:00
abstract：:Clinically, in young immunocompetent adults, Epstein-Barr virus (EBV) usually manifests as infectious mononucleosis (IM). Typical clinical findings of EBV IM include fever, profound fatigue, pharyngitis, bilateral posterior cervical adenopathy, and splenomegaly. Respiratory involvement with EBV IM may occur, but is di...
journal_title：Journal of clinical medicine
pub_type：
doi：10.3390/jcm6090083
更新日期：2017-09-04 00:00:00
abstract：:Mitochondrial respiratory chain (MRC) disorders have a multifaceted clinical presentation and genetic origin[...]. ...
journal_title：Journal of clinical medicine
pub_type： 社论
doi：10.3390/jcm7040066
更新日期：2018-03-29 00:00:00
abstract：:(1) Background: Focal chondral defects of the knee can significantly impair patient quality of life. Although different options are available, they are still not conclusive and have several limitations. The aim of this study was to evaluate the role of autologous cartilage micrografts in the treatment of knee chondrop...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm10020322
更新日期：2021-01-17 00:00:00
abstract：:Bronchiectasis and asthma may share some characteristics and some patients may have both conditions. The present study aimed to examine the rationale of prophylactic inhaled corticosteroids (ICS) prescription in children with bronchiectasis. Data of children with radiologically established bronchiectasis were retrospe...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9124009
更新日期：2020-12-11 00:00:00
abstract：:With the expanded legalization of marijuana, its medical and recreational use have sharply increased over the past decade. A wide array of new forms of cannabis is available on the market today, and the potencies are ten times those of forms previously tested, meaning that the true impact of marijuana on the cardiovas...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9061925
更新日期：2020-06-19 00:00:00
abstract：:Sarcoidosis is a systemic disease of unknown etiology characterized by the presence of noncaseating granulomas that can occur in any organ, most commonly the lungs. Early and accurate diagnosis of sarcoidosis remains challenging because initial presentations may vary, many patients are asymptomatic, and there is no si...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9082363
更新日期：2020-07-24 00:00:00
abstract：:Bruton's tyrosine kinase (BTK) is a critical terminal enzyme in the B-cell antigen receptor (BCR) pathway. BTK activation has been implicated in the pathogenesis of certain B-cell malignancies. Targeting this pathway has emerged as a novel target in B-cell malignancies, of which ibrutinib is the first-in-class agent. ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm7040062
更新日期：2018-03-21 00:00:00
abstract：:Diabetic foot ulcers (DFUs) and diabetic foot infections (DFIs) are associated with reduced patient quality of life, lower-extremity amputation, hospitalization, and high morbidity and mortality. Diverse bacterial communities have been identified in DFUs/DFIs, playing a significant role in infection prognosis. However...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8111935
更新日期：2019-11-10 00:00:00
abstract：:In patients with Cushing's disease (CD), prompt diagnosis and treatment are essential for favorable long-term outcomes, although this remains a challenging task. The differential diagnosis of CD is still difficult in some patients, even with an organized stepwise diagnostic approach. Moreover, despite the use of high-...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8111951
更新日期：2019-11-12 00:00:00
abstract：:Minimally invasive surgery is becoming popular for treating spinal disorders. The advantages of percutaneous endoscopic debridement and drainage (PEDD) for infectious spondylitis include direct observation of the lesion, direct pus drainage, and earlier pain relief. We retrospectively reviewed 37 patients who underwen...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8091356
更新日期：2019-09-01 00:00:00
abstract：:Internet gaming disorder (IGD) is a new disease proposed by the Diagnostic and Statistical Manual of Mental Disorders-Fifth Edition (DSM-5), and has been studied extensively in relation to depression and impulsivity. The relationship between resilience and disease has been found in a variety of addictive disorders, bu...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8081102
更新日期：2019-07-25 00:00:00
abstract：:Although the use of oral administration of pharmacological all-trans retinoic acid (ATRA) concentration in acute promyelocytic leukaemia (APL) patients was approved for over 20 years and used as standard therapy still to date, the same use in solid cancers is still controversial. In the present review the literature a...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9020360
更新日期：2020-01-28 00:00:00
abstract：:To analyse the predictive ability and incremental value of left ventricular longitudinal axis strain (LAS) and late gadolinium enhancement (LGE) using standard cardiovascular magnetic resonance (CMR) imaging for the diagnosis and prognosis of severe aortic stenosis (AS) in patients with an indication for aortic valve ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8020165
更新日期：2019-02-01 00:00:00
abstract：:Attention deficit hyperactivity disorder (ADHD) is a frequent neurodevelopmental disorder that often persists into adulthood. Methylphenidate (MPH) is the first-line treatment for ADHD; however, despite its wide usage, little is known about its neurometabolic effects. Until now, no randomized and blinded clinical tria...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9082601
更新日期：2020-08-11 00:00:00
