Abstract：
:The factors that contribute to the development of ulcerative colitis (UC), are still not fully identified. Disruption of the colon barrier is one of the first events leading to invasion of bacteria and activation of the immune system. The colon barrier is strongly influenced by sphingolipids. Sphingolipids impact cell-cell contacts and function as second messengers. We collected blood and colon tissue samples from UC patients and healthy controls and investigated the sphingolipids and other lipids by LC-MS/MS or LC-QTOFMS. The expression of enzymes of the sphingolipid pathway were determined by RT-PCR and immunohistochemistry. In inflamed colon tissue, the de novo-synthesis of sphingolipids is reduced, whereas lactosylceramides are increased. Reduction of dihydroceramides was due to posttranslational inhibition rather than altered serine palmitoyl transferase or ceramide synthase expression in inflamed colon tissue. Furthermore, in human plasma from UC-patients, several sphinglipids change significantly in comparison to healthy controls. Beside sphingolipids free fatty acids, lysophosphatidylcholines and triglycerides changed significantly in the blood of colitis patients dependent on the disease severity. Our data indicate that detraction of the sphingolipid de novo synthesis in colon tissue might be an important trigger for UC. Several lipids changed significantly in the blood, which might be used as biomarkers for disease control; however, diet-related variabilities need to be considered.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Bazarganipour S,Hausmann J,Oertel S,El-Hindi K,Brachtendorf S,Blumenstein I,Kubesch A,Sprinzl K,Birod K,Hahnefeld L,Trautmann S,Thomas D,Herrmann E,Geisslinger G,Schiffmann S,Grösch Sdoi
10.3390/jcm8070971subject
Has Abstractpub_date
2019-07-04 00:00:00issue
7issn
2077-0383pii
jcm8070971journal_volume
8pub_type
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