当前位置： SCI文献检索 > Journal of Clinical Medicine期刊下所有文献 > Efficacy and Safety of Denosumab Therapy for Osteogenesis Imperfecta Patients with Osteoporosis-Case Series.

Efficacy and Safety of Denosumab Therapy for Osteogenesis Imperfecta Patients with Osteoporosis-Case Series.

Abstract：

:Osteogenesis imperfecta (OI) is a connective tissue disorder that is characterized by low bone density leading to recurrent fractures. The efficacy of the anti-resorption drug denosumab for OI with osteoporosis is still largely unknown. We herein describe the clinical outcomes of eight osteoporotic cases of OI to examine the effects and safety of denosumab. This retrospective, consecutive case series included eight patients respectively aged 42, 40, 14, 22, 3, 51, 37, and 9 years. We measured the bone mineral density (BMD) of the lumbar 1⁻4 spine (L-BMD) and bilateral hips (H-BMD), bone-specific alkaline phosphatase, urinary type I collagen amino-terminal telopeptide, and tartrate-resistant acid phosphatase 5b before and during denosumab therapy. Despite multiple pretreatment fractures in the cohort, no fractures or severe side effects, such as hypocalcemia, were observed during the observational period apart from a fracture in a young pediatric girl. Both L-BMD and H-BMD were increased by denosumab in seven of eight cases. Bone turnover markers were inhibited in most cases by denosumab therapy. Denosumab treatment could generally raise BMD without any adverse effects. The agent therefore represents a good therapeutic option for OI with osteoporosis.

journal_name

J Clin Med

journal_title

Journal of clinical medicine

authors

Kobayashi T,Nakamura Y,Suzuki T,Yamaguchi T,Takeda R,Takagi M,Hasegawa T,Kosho T,Kato H

doi

10.3390/jcm7120479

subject

Has Abstract

pub_date

2018-11-24 00:00:00

issue

12

issn

2077-0383

pii

jcm7120479

journal_volume

7

pub_type

杂志文章

相关文献

Journal of Clinical Medicine文献大全
  • Drop of Butyrylcholinesterase Activity after Cyclophosphamide Conditioning as a Predictive Marker of Liver Transplant-Related Complications and Its Correlation with Transplant-Related Mortality in Pediatric Hematopoietic Stem Cell Recipients.

    abstract：:Transplant-related liver complications are a potentially fatal condition of hematopoietic stem cell transplantation (HSCT) in pediatric patients, actually representing one of the main factors involved in transplant-related mortality (TRM). The search for a specific marker capable of predicting the development of this ...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm8060825

    authors： Maximova N,Caddeo G,Zanon D,Maestro A,Simeone R

    更新日期：2019-06-10 00:00:00

  • Effect of Prophylactic Amiodarone Infusion on the Recurrence of Ventricular Arrhythmias in Out-of-Hospital Cardiac Arrest Survivors: A Propensity-Matched Analysis.

    abstract：:Amiodarone is recommended for shock-refractory ventricular arrhythmia during resuscitation; however, it is unknown whether amiodarone is effective for preventing ventricular arrhythmia recurrence in out-of-hospital cardiac arrest (OHCA) survivors treated with targeted temperature management (TTM). We investigated the ...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm8020244

    authors： Lee BK,Youn CS,Kim YJ,Ryoo SM,Lim KS,Nam GB,Kim SJ,Kim WY

    更新日期：2019-02-13 00:00:00

  • Pulmonary Vein Enlargement as an Independent Predictor for New-Onset Atrial Fibrillation.

    abstract：:Pulmonary vein (PV) enlargement is associated with atrial fibrillation (AF). However, the predictive value of PV volume for new-onset AF has not been determined. We retrospectively assessed and enrolled non-AF subjects who underwent echocardiography and cardiac CT angiography (CCTA) around the same time and evaluated ...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9020401

    authors： Kim S,Kim YH,Lee SH,Kim JS

    更新日期：2020-02-02 00:00:00

  • Pain Catastrophizing in Older Adults with Chronic Pain: The Mediator Effect of Mood Using a Path Analysis Approach.

    abstract：:Cognitive models of pain propose that catastrophic thinking is negatively associated with chronic pain. However, pain catastrophizing is a complex phenomenon requiring a multivariate examination. This study estimates the effects of mood variables (anxiety and depression) on pain catastrophizing in older adults with ch...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9072073

    authors： Dong HJ,Gerdle B,Bernfort L,Levin LÅ,Dragioti E

    更新日期：2020-07-01 00:00:00

  • The GALNT14 Genotype Predicts Postoperative Outcome of Pancreatic Ductal Adenocarcinoma.

    abstract：:Pancreatic ductal adenocarcinoma (PDA) is notorious for its poor prognosis. The current mainstay of treatment for PDA is surgical resection followed by adjuvant chemotherapy. However, it is difficult to predict the post-operative outcome because of the lack of reliable markers. The single-nucleotide polymorphism (SNP)...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm8122225

    authors： Chiang CC,Yeh CT,Hwang TL,Chu YD,Lim SN,Chen CW,Kuo CJ,Le PH,Chen TH,Lin WR

    更新日期：2019-12-16 00:00:00

  • Real-World Data on Clinical Features, Outcomes, and Prognostic Factors in Multiple Myeloma from Miyazaki Prefecture, Japan.

    abstract：:The prognosis of multiple myeloma (MM) has improved with the introduction of novel agents. These data are largely derived from clinical trials and might not reflect real-world patient outcomes accurately. We surveyed real-world data from 284 patients newly diagnosed with MM between 2010 and 2018 in Miyazaki Prefecture...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm10010105

    authors： Akizuki K,Matsuoka H,Toyama T,Kamiunten A,Sekine M,Shide K,Kameda T,Kawano N,Maeda K,Takeuchi M,Kawano H,Sato S,Ishizaki J,Tahira Y,Shimoda H,Hidaka T,Yamashita K,Kubuki Y,Shimoda K

    更新日期：2020-12-30 00:00:00

  • Intramedullary Bone Lengthening Following Preceding Hip Surgery-A Case Series.

    abstract：:Limb length discrepancy (LLD) is a common problem after joint-preserving hip surgeries, hip dysplasia, and hip deformities. Limping, pain, sciatica, paresthesia, and hip instability are common clinical findings and may necessitate limb-lengthening procedures. The study included five patients (two female and three male...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9124104

    authors： Zak L,Tiefenboeck TM,Wozasek GE

    更新日期：2020-12-19 00:00:00

  • Outcomes after In Utero Myelomeningocele Repair Based on Delivery Location.

    abstract：:Maternal and pediatric delivery outcomes may vary in patients who underwent open fetal myelomeningocele repair and elected to deliver at the fetal center where their fetal intervention was performed versus at the referring physician's hospital. A prospective cohort study of 88 patients were evaluated following in uter...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9113443

    authors： Bergh EP,Tsao K,Austin MT,Fletcher SA,Lopez SM,Moise KJ Jr,Johnson A,Papanna R

    更新日期：2020-10-27 00:00:00

  • Uses of Inflammatory Markers for Differentiation of Intrahepatic Mass-Forming Cholangiocarcinoma from Liver Abscess: Case-Control Study.

    abstract：BACKGROUND:Pyogenic liver abscess (LA) is difficult to distinguish from intrahepatic mass-forming cholangiocarcinoma (IMCC) in the emergency department (ED). We evaluated the predictive ability of white blood cells (WBC) and C-reactive protein (CRP) levels, neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte r...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9103194

    authors： Lee SC,Kim SJ,Yu MH,Lee KJ,Cha YS

    更新日期：2020-10-01 00:00:00

  • Oral Fluid Biomarkers for Diagnosing Gingivitis in Human: A Cross-Sectional Study.

    abstract：:Diagnoses based on oral fluid biomarkers have been introduced to overcome limitations of periodontal probe-based diagnoses. Diagnostic ability of certain biomarkers for periodontitis have been identified and widely studied, however, such studies targeting gingivitis is scarce. The aims of this study were to determine ...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9061720

    authors： Hong I,Pae HC,Song YW,Cha JK,Lee JS,Paik JW,Choi SH

    更新日期：2020-06-03 00:00:00

  • Inhibition of Osteoclastogenesis by Thioredoxin-Interacting Protein-Derived Peptide (TN13).

    abstract：:Overactivated osteoclasts lead to many bone diseases, including osteoporosis and rheumatoid arthritis. The p38 MAPK (p38) is an essential regulator of the receptor activator of nuclear factor-κB ligand (RANKL)-mediated osteoclastogenesis and bone loss. We previously reported TAT conjugated thioredoxin-interacting prot...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm8040431

    authors： Kim MJ,Kim WS,Byun JE,Choi JH,Yoon SR,Choi I,Jung H

    更新日期：2019-03-29 00:00:00

  • Validation and Adaptation of the Multidimensional Prognostic Index in an Older Australian Cohort.

    abstract：BACKGROUND AND AIMS:The Multidimensional Prognostic Index (MPI), an objective and quantifiable tool based on the Comprehensive Geriatric Assessment, has been shown to predict adverse outcomes in European cohorts. We conducted a validation study of the original MPI, and of adapted versions that accounted for the use of ...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm8111820

    authors： Bryant K,Sorich MJ,Woodman RJ,Mangoni AA

    更新日期：2019-11-01 00:00:00

  • Special Issue "Saliva and Oral Diseases".

    abstract：:The discovery of microbial, immunological or molecular markers in saliva offers unique opportunities, and has caused our view of saliva to change drastically in recent years [...]. ...

    journal_title：Journal of clinical medicine

    pub_type： 社论

    doi：10.3390/jcm9061955

    authors： López Jornet P

    更新日期：2020-06-23 00:00:00

  • The Enhanced Adhesion of Eosinophils Is Associated with Their Prolonged Viability and Pro-Proliferative Effect in Asthma.

    abstract：:Before eosinophils migrate into the bronchial lumen, they promote airway structural changes after contact with pulmonary cells and extracellular matrix components. We aimed to investigate the impact of eosinophil adhesion to their viability and pro-proliferative effect on airway smooth muscle (ASM) cells and pulmonary...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm8091274

    authors： Januskevicius A,Janulaityte I,Kalinauskaite-Zukauske V,Gosens R,Malakauskas K

    更新日期：2019-08-22 00:00:00

  • Mortality Prediction of Septic Patients in the Emergency Department Based on Machine Learning.

    abstract：:In emergency departments, the most common cause of death associated with suspected infected patients is sepsis. In this study, deep learning algorithms were used to predict the mortality of suspected infected patients in a hospital emergency department. During January 2007 and December 2013, 42,220 patients considered...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm8111906

    authors： Perng JW,Kao IH,Kung CT,Hung SC,Lai YH,Su CM

    更新日期：2019-11-07 00:00:00

  • Combining Novel Biomarkers for Risk Stratification of Two-Year Cardiovascular Mortality in Patients with ST-Elevation Myocardial Infarction.

    abstract：:ST-elevation myocardial infarction (STEMI) is one of the main reasons for morbidity and mortality worldwide. In addition to the classic biomarker NT-proBNP, new biomarkers like ST2 and Pentraxin-3 (Ptx-3) have emerged as potential tools in stratifying risk in cardiac patients. Indeed, multimarker approaches to estimat...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9020550

    authors： Zagidullin N,Motloch LJ,Gareeva D,Hamitova A,Lakman I,Krioni I,Popov D,Zulkarneev R,Paar V,Kopp K,Jirak P,Ishmetov V,Hoppe UC,Tulbaev E,Pavlov V

    更新日期：2020-02-18 00:00:00

  • Tunnel/Pouch versus Coronally Advanced Flap Combined with a Connective Tissue Graft for the Treatment of Maxillary Gingival Recessions: Four-Year Follow-Up of a Randomized Controlled Trial.

    abstract：BACKGROUND:The long-term stability after soft tissue graft for covering gingival recession remains a pivotal goal for both patient and periodontist. Therefore, the aim of this study was to compare the four-year outcomes of the coronally advanced flap (CAF) versus the pouch/tunnel (POT) technique, both combined with con...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9082641

    authors： Salem S,Salhi L,Seidel L,Lecloux G,Rompen E,Lambert F

    更新日期：2020-08-14 00:00:00

  • Associations among Bruxism, Gastroesophageal Reflux Disease, and Tooth Wear.

    abstract：:The relationship between bruxism and tooth wear is contentious in the literature. The pathophysiological processes of tooth wear may be complicated by the relationship between bruxism and gastroesophageal reflux disease (GERD). The objective of this study was to evaluate the associations among bruxism, GERD, and tooth...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm7110417

    authors： Li Y,Yu F,Niu L,Hu W,Long Y,Tay FR,Chen J

    更新日期：2018-11-06 00:00:00

  • A Method for the Prediction of Clinical Outcome Using Diffusion Magnetic Resonance Imaging: Application on Parkinson's Disease.

    abstract：:Robust early prediction of clinical outcomes in Parkinson's disease (PD) is paramount for implementing appropriate management interventions. We propose a method that uses the baseline MRI, measuring diffusion parameters from multiple parcellated brain regions, to predict the 2-year clinical outcome in Parkinson's dise...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9030647

    authors： Tsai CC,Lin YC,Ng SH,Chen YL,Cheng JS,Lu CS,Weng YH,Lin SH,Chen PY,Wu YM,Wang JJ

    更新日期：2020-02-28 00:00:00

  • Outcomes of Inhaled Amikacin and Clofazimine-Containing Regimens for Treatment of Refractory Mycobacterium avium Complex Pulmonary Disease.

    abstract：:Limited data are available regarding optimal treatment for refractory Mycobacterium avium complex-pulmonary disease (MAC-PD). We evaluated outcomes of inhaled amikacin (AMK) with clofazimine (CFZ) regimens as an add-on salvage therapy for refractory MAC-PD. We retrospectively analyzed 52 patients with refractory MAC-P...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9092968

    authors： Kim BG,Kim H,Kwon OJ,Huh HJ,Lee NY,Baek SY,Sohn I,Jhun BW

    更新日期：2020-09-14 00:00:00

  • Long Daytime Napping Is Associated with Increased Adiposity and Type 2 Diabetes in an Elderly Population with Metabolic Syndrome.

    abstract：:Research examining associations between objectively-measured napping time and type 2 diabetes (T2D) is lacking. This study aimed to evaluate daytime napping in relation to T2D and adiposity measures in elderly individuals from the Mediterranean region. A cross-sectional analysis of baseline data from 2190 elderly part...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm8071053

    authors： Papandreou C,Díaz-López A,Babio N,Martínez-González MA,Bulló M,Corella D,Fitó M,Romaguera D,Vioque J,Alonso-Gómez ÁM,Wärnberg J,Martínez AJ,Serra-Majem L,Estruch R,Fernández-García JC,Lapetra J,Pintó X,Tur JA,Garcia-R

    更新日期：2019-07-19 00:00:00

  • Texture Analysis of Multi-Shot Echo-planar Diffusion-Weighted Imaging in Head and Neck Squamous Cell Carcinoma: The Diagnostic Value for Nodal Metastasis.

    abstract：:Accurate assessment of nodal metastasis in head and neck squamous cell carcinoma (SCC) is important, and diffusion-weighted imaging (DWI) has emerged as a potential technique in differentiating benign from malignant lymph nodes (LNs). This study aims to evaluate the diagnostic performance of texture analysis using app...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm8111767

    authors： Park JH,Bae YJ,Choi BS,Jung YH,Jeong WJ,Kim H,Sunwoo L,Jung C,Kim JH

    更新日期：2019-10-23 00:00:00

  • Impact of Remote Ischemic Preconditioning Conducted in Living Kidney Donors on Renal Function in Donors and Recipients Following Living Donor Kidney Transplantation: A Randomized Clinical Trial.

    abstract：:Although remote ischemic preconditioning (RIPC) has been shown to have renoprotective effects, few studies have assessed the effects of RIPC on renal function in living kidney donors. This study investigated whether RIPC performed in living kidney donors could improve residual renal function in donors and outcomes in ...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm8050713

    authors： Bang JY,Kim SG,Oh J,Kim SO,Go YJ,Hwang GS,Song JG

    更新日期：2019-05-20 00:00:00

  • Tumor Volume Dynamics as an Early Biomarker for Patient-Specific Evolution of Resistance and Progression in Recurrent High-Grade Glioma.

    abstract：:Recurrent high-grade glioma (HGG) remains incurable with inevitable evolution of resistance and high inter-patient heterogeneity in time to progression (TTP). Here, we evaluate if early tumor volume response dynamics can calibrate a mathematical model to predict patient-specific resistance to develop opportunities for...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9072019

    authors： Glazar DJ,Grass GD,Arrington JA,Forsyth PA,Raghunand N,Yu HM,Sahebjam S,Enderling H

    更新日期：2020-06-27 00:00:00

  • Correlation between Speech Perception Outcomes after Cochlear Implantation and Postoperative Acoustic and Electric Hearing Thresholds.

    abstract：:The reliable prediction of cochlear implant (CI) speech perception outcomes is highly relevant and can facilitate the monitoring of postoperative hearing performance. To date, multiple audiometric, demographic, and surgical variables have shown some degree of correlation with CI speech perception outcomes. In the pres...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm10020324

    authors： Rüegg U,Dalbert A,Veraguth D,Röösli C,Huber A,Pfiffner F

    更新日期：2021-01-17 00:00:00

  • Effectiveness of the Botulinum Toxin for Treating Sialorrhea in Patients with Parkinson's Disease: A Systematic Review.

    abstract：:The main objective was to assess the efficacy of botulinum toxin-based treatment for sialorrhea in adult patients with Parkinson's disease. The search was performed by using the Medline-PubMed, EMBASE and Cochrane Library databases from January 2000⁻December 2017, in English/Spanish in patients with Parkinson's diseas...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章,评审

    doi：10.3390/jcm8030317

    authors： Ruiz-Roca JA,Pons-Fuster E,Lopez-Jornet P

    更新日期：2019-03-06 00:00:00

  • Fetal Renal Echogenicity Associated with Maternal Focal Segmental Glomerulosclerosis: The Effect of Transplacental Transmission of Permeability Factor suPAR.

    abstract：:We report a case of a pregnant woman with nephrotic syndrome due to biopsy-proven focal segmental glomerulosclerosis (FSGS) whose fetus developed echogenic kidneys and severe oligohydramnios by 27 weeks of gestation. Maternal treatment with prednisone resulted in normalization of the amniotic fluid indices and resolut...

    journal_title：Journal of clinical medicine

    pub_type：

    doi：10.3390/jcm7100324

    authors： Shuster S,Ankawi G,Licht C,Reiser J,Wang X,Wei C,Chitayat D,Hladunewich M

    更新日期：2018-10-04 00:00:00

  • Long-Term Evolution of Quality of Life and Symptoms Following Surgical Treatment for Endometriosis: Different Trajectories for Which Patients?

    abstract：:Many studies have shown a global efficacy of laparoscopic surgery for patients with endometriosis in reducing painful symptoms and improving quality of life (QoL) in the short and long-term. The aim of this study was to analyze the different trajectories of long-term evolution in QoL and symptoms following surgical tr...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9082461

    authors： Comptour A,Lambert C,Chauvet P,Figuier C,Gremeau AS,Canis M,Pereira B,Bourdel N

    更新日期：2020-07-31 00:00:00

  • NK Cell Reconstitution in Paediatric Leukemic Patients after T-Cell-Depleted HLA-Haploidentical Haematopoietic Stem Cell Transplantation Followed by the Reinfusion of iCasp9-Modified Donor T Cells.

    abstract：:T-cell-depleted (TCD) human leukocyte antigen (HLA) haploidentical (haplo) hematopoietic stem cell transplantation (HSCT) (TCD-haplo-HSCT) has had a huge impact on the treatment of many haematological diseases. The adoptive transfer of a titrated number of T cells genetically modified with a gene suicide can improve i...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm8111904

    authors： Stabile H,Nisti P,Fionda C,Pagliara D,Gaspari S,Locatelli F,Santoni A,Gismondi A

    更新日期：2019-11-07 00:00:00

  • Effect of Bladder Neck Preservation on Long-Term Urinary Continence after Robot-Assisted Laparoscopic Prostatectomy: A Systematic Review and Meta-Analysis.

    abstract：:This study aimed to evaluate the effect of bladder neck preservation (BNP) on long-term urinary continence after robot-assisted laparoscopic prostatectomy (RALP). We systematically searched the PubMed, Embase, and Cochrane Library databases to identify studies that assessed the difference in urinary continence and onc...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章,评审

    doi：10.3390/jcm8122068

    authors： Kim JW,Kim DK,Ahn HK,Jung HD,Lee JY,Cho KS

    更新日期：2019-11-24 00:00:00