当前位置： SCI文献检索 > Journal of Clinical Medicine期刊下所有文献 > Drop of Butyrylcholinesterase Activity after Cyclophosphamide Conditioning as a Predictive Marker of Liver Transplant-Related Complications and Its Correlation with Transplant-Related Mortality in Pediatric Hematopoietic Stem Cell Recipients.

Drop of Butyrylcholinesterase Activity after Cyclophosphamide Conditioning as a Predictive Marker of Liver Transplant-Related Complications and Its Correlation with Transplant-Related Mortality in Pediatric Hematopoietic Stem Cell Recipients.

Abstract：

:Transplant-related liver complications are a potentially fatal condition of hematopoietic stem cell transplantation (HSCT) in pediatric patients, actually representing one of the main factors involved in transplant-related mortality (TRM). The search for a specific marker capable of predicting the development of this condition is a relevant clinical issue. We have observed a variable reduction in serum butyrylcholinesterase (BChE) activity after a cyclophosphamide-containing conditioning regimen. This study aims to determine the cutoff of BChE activity reduction that might be a specific prognostic marker for liver complications after HSCT. Our results show that the reduction of BChE values below 2000 U/L the day before the transplantation is an indicator strongly associated with the transplant-related liver complications (p < 0.0001). The incidence of overall survival at 1 year was significantly higher in the BChE > 2000 U/L group compared to the BChE < 2000 U/L group (84.7% versus 58.5%, p < 0.001), while the TRM rate was significantly lower (8.1% versus 23.1%, p < 0.05). None of the patients undergoing prophylaxis with defibrotide developed severe liver complications. Starting defibrotide treatment at the first signs of hepatic dysfunction in patients with particularly low BChE activity levels reduces severe liver transplant-related complications.

journal_name

J Clin Med

journal_title

Journal of clinical medicine

authors

Maximova N,Caddeo G,Zanon D,Maestro A,Simeone R

doi

10.3390/jcm8060825

subject

Has Abstract

pub_date

2019-06-10 00:00:00

issue

6

issn

2077-0383

pii

jcm8060825

journal_volume

8

pub_type

杂志文章

相关文献

Journal of Clinical Medicine文献大全
  • Gender Differences in the Levels of Periodontal Destruction, Behavioral Risk Factors and Systemic Oxidative Stress in Ischemic Stroke Patients: A Cohort Pilot Study.

    abstract：:Background: Due to the higher frequency of ischemic stroke in men compared to women, we aimed to determine if gender differences exist regarding periodontal status and several plasma biomarkers in patients with a recent large artery atherosclerosis ischemic stroke (IS). Material and methods: Patients with their first ...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9061744

    authors： Stănescu I,Bulboacă AE,Micu IC,Bolboacă SD,Feștilă DG,Bulboacă AC,Bodizs G,Dogaru G,Boarescu PM,Popa-Wagner A,Roman A

    更新日期：2020-06-04 00:00:00

  • Bortezomib Treatment Modulates Autophagy in Multiple Myeloma.

    abstract：:Although the introduction of bortezomib as a therapeutic strategy has improved the overall survival of multiple myeloma (MM) patients, 15-20% of high-risk patients do not respond to bortezomib over time or become resistant to treatment. Therefore, the development of new therapeutic strategies, such as combination ther...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9020552

    authors： Di Lernia G,Leone P,Solimando AG,Buonavoglia A,Saltarella I,Ria R,Ditonno P,Silvestris N,Crudele L,Vacca A,Racanelli V

    更新日期：2020-02-18 00:00:00

  • Intra-Vitreal Administration of Microvesicles Derived from Human Adipose-Derived Multipotent Stromal Cells Improves Retinal Functionality in Dogs with Retinal Degeneration.

    abstract：:This study was designed to determine the influence of microvesicles (MVs) derived from multipotent stromal cells isolated from human adipose tissue (hASCs) on retinal functionality in dogs with various types of retinal degeneration. The biological properties of hASC-MVs were first determined using an in vitro model of...

    journal_title：Journal of clinical medicine

    pub_type：

    doi：10.3390/jcm8040510

    authors： Cislo-Pakuluk A,Smieszek A,Kucharczyk N,Bedford PGC,Marycz K

    更新日期：2019-04-13 00:00:00

  • Patient and Medical Oncologists' Perspectives on Prescribed Lifestyle Intervention-Experiences of Women with Breast Cancer and Providers.

    abstract：:This study explored the perspectives and experiences of breast cancer patients and medical oncologists with regards to participation in a lifestyle intervention at a tertiary cancer treatment center. A thematic approach was used to understand the context within which a lifestyle intervention was recommended and experi...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9092815

    authors： Balneaves LG,Truant TLO,Van Patten C,Kirkham AA,Waters E,Campbell KL

    更新日期：2020-08-31 00:00:00

  • Impact of Medication Regimen Simplification on Medication Administration Times and Health Outcomes in Residential Aged Care: 12 Month Follow Up of the SIMPLER Randomized Controlled Trial.

    abstract：:In the SImplification of Medications Prescribed to Long-tErm care Residents (SIMPLER) cluster-randomized controlled trial, we evaluated the impact of structured medication regimen simplification on medication administration times, falls, hospitalization, and mortality at 8 residential aged care facilities (RACFs) at 1...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9041053

    authors： Sluggett JK,Hopkins RE,Chen EY,Ilomäki J,Corlis M,Van Emden J,Hogan M,Caporale T,Ooi CE,Hilmer SN,Bell JS

    更新日期：2020-04-08 00:00:00

  • Predictions of Preterm Birth from Early Pregnancy Characteristics: Born in Guangzhou Cohort Study.

    abstract：:Preterm birth (PTB, <37 weeks) is the leading cause of death in children <5 years of age. Early risk prediction for PTB would enable early monitoring and intervention. However, such prediction models have been rarely reported, especially in low- and middle-income areas. We used data on a number of easily accessible pr...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm7080185

    authors： He JR,Ramakrishnan R,Lai YM,Li WD,Zhao X,Hu Y,Chen NN,Hu F,Lu JH,Wei XL,Yuan MY,Shen SY,Qiu L,Chen QZ,Hu CY,Cheng KK,Mol BWJ,Xia HM,Qiu X

    更新日期：2018-07-27 00:00:00

  • Impact of the Total Number of Carotid Plaques on the Outcome of Ischemic Stroke Patients with Atrial Fibrillation.

    abstract：BACKGROUND:Atrial fibrillation (AF) shares several risk factors with atherosclerosis. We investigated the association between total carotid plaque number (TPN) and long-term prognosis in ischemic stroke patients with AF. METHODS:A total of 392 ischemic stroke patients with AF who underwent carotid ultrasonography were...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm8111897

    authors： Park H,Han M,Kim YD,Yoo J,Lee HS,Choi JK,Heo JH,Nam HS

    更新日期：2019-11-07 00:00:00

  • Surgical Treatment on Subungual Osteochondromas in Paediatric Feet: A Case Series Study.

    abstract：:Subungual osteochondroma (SO) is an infrequent and non-malignant bone tumour of the distal phalanx, especially prominent in paediatric populations. The aim of this research was to describe a case series of paediatric feet with SO which received surgical treatments. The secondary purpose was to compare these descriptiv...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9041122

    authors： Navarro-Flores E,López-López D,Becerro-de-Bengoa-Vallejo R,Losa-Iglesias ME,Romero-Morales C,San-Antolín-Gil M,Calvo-Lobo C,Bautista-Casasnovas AL

    更新日期：2020-04-14 00:00:00

  • Preclinical and Clinical Evidence of Immune Responses Triggered in Oncologic Photodynamic Therapy: Clinical Recommendations.

    abstract：:Photodynamic therapy (PDT) is an anticancer strategy utilizing light-mediated activation of a photosensitizer (PS) which has accumulated in tumor and/or surrounding vasculature. Upon activation, the PS mediates tumor destruction through the generation of reactive oxygen species and tumor-associated vasculature damage,...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章,评审

    doi：10.3390/jcm9020333

    authors： Beltrán Hernández I,Yu Y,Ossendorp F,Korbelik M,Oliveira S

    更新日期：2020-01-24 00:00:00

  • SOX2 Expression Is an Independent Predictor of Oral Cancer Progression.

    abstract：:Potentially malignant oral lesions, mainly leukoplakia, are common. Malignant transformation varies widely, even in the absence of histological features such as dysplasia. Hence, there is a need for novel biomarker-based systems to more accurately predict the risk of cancer progression. The pluripotency transcription ...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm8101744

    authors： de Vicente JC,Donate-Pérez Del Molino P,Rodrigo JP,Allonca E,Hermida-Prado F,Granda-Díaz R,Rodríguez Santamarta T,García-Pedrero JM

    更新日期：2019-10-21 00:00:00

  • Pathophysiology and Diagnosis of Drug-Induced Immune Thrombocytopenia.

    abstract：:Drug-induced immune thrombocytopenia (DITP) is a life-threatening clinical syndrome that is under-recognized and difficult to diagnose. Many drugs can cause immune-mediated thrombocytopenia, but the most commonly implicated are abciximab, carbamazepine, ceftriaxone, eptifibatide, heparin, ibuprofen, mirtazapine, oxali...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章,评审

    doi：10.3390/jcm9072212

    authors： Vayne C,Guéry EA,Rollin J,Baglo T,Petermann R,Gruel Y

    更新日期：2020-07-13 00:00:00

  • Mobile Application-Based Interventions for Chronic Pain Patients: A Systematic Review and Meta-Analysis of Effectiveness.

    abstract：:Chronic pain is one of the major causes of disability in the general population. Even though there are effective treatment options available for reducing symptoms, these treatments often do not have consistent lasting effects. As the usage of mobile devices has increased enormously during the last few years, mobile ap...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章,评审

    doi：10.3390/jcm9113557

    authors： Pfeifer AC,Uddin R,Schröder-Pfeifer P,Holl F,Swoboda W,Schiltenwolf M

    更新日期：2020-11-05 00:00:00

  • Low Intracellular Water, Overhydration, and Mortality in Hemodialysis Patients.

    abstract：BACKGROUND:In hemodialysis patients, extracellular water (ECW) overload predicts all-cause and cardiovascular mortality. The primary aim of the present study was to analyze changes in post-dialysis (i.e., following removal of excess ECW) ECW, intracellular water (ICW), and the overhydration (OH) parameter over time. Ad...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9113616

    authors： Gracia-Iguacel C,González-Parra E,Mahillo I,Ortiz A

    更新日期：2020-11-10 00:00:00

  • Enhancement of Antiviral CD8+ T-Cell Responses and Complete Remission of Metastatic Melanoma in an HIV-1-Infected Subject Treated with Pembrolizumab.

    abstract：BACKGROUND:Pembrolizumab is an immune checkpoint inhibitor against programmed cell death protein-1 (PD-1) approved for therapy in metastatic melanoma. PD-1 expression is associated with a diminished functionality in HIV-1 specific-CD8+ T cells. It is thought that PD-1 blockade could contribute to reinvigorate antiviral...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm8122089

    authors： Blanch-Lombarte O,Gálvez C,Revollo B,Jiménez-Moyano E,Llibre JM,Manzano JL,Boada A,Dalmau J,E Speiser D,Clotet B,Prado JG,Martinez-Picado J

    更新日期：2019-12-01 00:00:00

  • The Effect of Aspirin on Preventing Vascular Access Dysfunction in Incident Hemodialysis Patients: A Prospective Cohort Study in Korean Clinical Research Centers for End-Stage Renal Disease (CRC for ESRD).

    abstract：:Background: Aspirin is often prescribed empirically to improve the patency of hemodialysis (HD) vascular access. Therefore, this study aimed to investigate the impact of aspirin on the survival of vascular access in incident HD patients with arteriovenous fistula (AVF) or arteriovenous graft (AVG). Methods: A prospect...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm8050677

    authors： Kim CH,Oh HJ,Kim YS,Kim YL,Chang JH,Ryu DR

    更新日期：2019-05-14 00:00:00

  • How the Results of a Randomized Trial of Catheter-Directed Thrombolysis Versus Anticoagulation alone for Submassive Pulmonary Embolism Would Affect Patient and Physician Decision Making: Report of an Online Survey.

    abstract：:Keywords: pulmonary embolism; submassive; survey. ...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm8020215

    authors： Taslakian B,Li C,Goldhaber SZ,Mikkelsen KZ,Horowitz JM,Kabrhel C,Barnes GD,Sista AK

    更新日期：2019-02-07 00:00:00

  • Translational Medicine in Pulmonary-Renal Crosstalk: Therapeutic Targeting of p-Cresyl Sulfate Triggered Nonspecific ROS and Chemoattractants in Dyspneic Patients with Uremic Lung Injury.

    abstract：:Molecular mechanisms and pathological features of p-Cresyl sulfate (PCS)-induced uremic lung injury (ULI) in chronic kidney disease (CKD) remain unclear. We analyzed pleural effusions (PE) from CKD and non-CKD patients for uremic toxins, reactive oxygen species (ROS), and chemotactic cytokines. Correlations between PE...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm7090266

    authors： Chang JF,Liang SS,Thanasekaran P,Chang HW,Wen LL,Chen CH,Liou JC,Yeh JC,Liu SH,Dai HM,Lin WN

    更新日期：2018-09-09 00:00:00

  • Increased Arterial Stiffness in Prediabetic Subjects Recognized by Hemoglobin A1c with Postprandial Glucose but Not Fasting Glucose Levels.

    abstract：:Previous studies exploring the association between arterial stiffness and prediabetes remain controversial. This study aimed to investigate the association of the different domains of prediabetes categorized by glycated hemoglobin A1c (A1c) 5.7-6.4%, impaired fasting glucose (IFG), fasting plasma glucose of 5.6-6.9 mm...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm8050603

    authors： Li CH,Lu FH,Yang YC,Wu JS,Chang CJ

    更新日期：2019-05-01 00:00:00

  • Propensity Score-Matched Analysis of the Survival Benefit from Kidney Transplantation in Patients with End-Stage Renal Disease.

    abstract：BACKGROUND:Several comparison studies have suggested that kidney transplantation (KT) could reduce mortality in patients with end-stage renal disease (ESRD). Selection criteria bias is common in the selection of dialysis patients for control groups. In this study, we compared the survival outcome between KT recipients ...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm7110388

    authors： Wu MJ,Yu TM,Lin CL,Kao CH

    更新日期：2018-10-26 00:00:00

  • Reduced Kidney Function and Relative Hypocalciuria-Observational, Cross-Sectional, Population-Based Data.

    abstract：:This observational, cross-sectional, epidemiological analysis investigated relationships of kidney function to urine calcium and other variables. The analyses targeted two population-based samples of adults (Gubbio study and Moli-sani study: n = 3508 and 955, respectively). Kidney function was assessed as estimated gl...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9124133

    authors： Cirillo M,Bilancio G,Cavallo P,Giordano F,Iesce G,Costanzo S,De Curtis A,Di Castelnuovo A,Iacoviello L

    更新日期：2020-12-21 00:00:00

  • Differences in Sexually Transmitted Infections between the Precrisis Period (2000⁻2007) and the Crisis Period (2008⁻2014) in Granada, Spain.

    abstract：OBJECTIVE:To analyze the difference in the prevalence of sexually transmitted infections (STIs) between two time periods (2000⁻2007 and 2008⁻2014, with the latter period characterized by the economic crisis), as well as determine differences in sociodemographic factors, clinical care, and risk indicators. METHODS:This...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm8020277

    authors： Pérez-Morente MÁ,Sánchez-Ocón MT,Martínez-García E,Martín-Salvador A,Hueso-Montoro C,García-García I

    更新日期：2019-02-25 00:00:00

  • NT5E/CD73 as Correlative Factor of Patient Survival and Natural Killer Cell Infiltration in Glioblastoma.

    abstract：:CD73, a cell-surface protein encoded by the gene NT5E, is overexpressed in glioblastoma (GBM), where it contributes to the tumor's pathophysiology via the generation of immunosuppressive adenosine. Adenosinergic signaling, in turn, drives immunosuppression of natural killer (NK) cells through metabolic and functional ...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm8101526

    authors： Wang J,Matosevic S

    更新日期：2019-09-23 00:00:00

  • Platelet Rich Fibrin (PRF) and Its Related Products: Biomolecular Characterization of the Liquid Fibrinogen.

    abstract：:Liquid fibrinogen is an injectable platelet concentrate rich in platelets, leukocytes, and fibrinogen obtained by blood centrifugation. The aim of this study was to analyze the release of different growth factors in the liquid fibrinogen at different times and to assess possible correlations between growth factors and...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9041099

    authors： Serafini G,Lopreiato M,Lollobrigida M,Lamazza L,Mazzucchi G,Fortunato L,Mariano A,Scotto d'Abusco A,Fontana M,De Biase A

    更新日期：2020-04-12 00:00:00

  • Effectiveness of Approaches to Increase Physical Activity Behavior to Prevent Chronic Disease in Adults: A Brief Commentary.

    abstract：:Effective behavior change approaches are necessary to help individuals avoid or mitigate risk factors, engage in behavioral patterns that lead to better health, and consequently, prevent several chronic diseases. Physical inactivity is considered one of the most harmful risk factors for chronic medical conditions, and...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm8030295

    authors： Schwartz J,Rhodes R,Bredin SSD,Oh P,Warburton DER

    更新日期：2019-03-01 00:00:00

  • Time Trends of Crohn's Disease in Catalonia from 2011 to 2017. Increasing Use of Biologics Correlates with a Reduced Need for Surgery.

    abstract：BACKGROUND AND AIMS:Data from clinical trials suggest that biological drugs may improve the outcomes in Crohn's disease (CD) by reducing the need for surgery or hospitalization. The aim of this study is to evaluate the time-trends of the use of biological drugs and other treatments for CD, and its relationship with out...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9092896

    authors： Brunet E,Vela E,Melcarne L,Clèries M,Pontes C,Llovet LP,García-Iglesias P,Gallach M,Villòria A,Vergara M,Calvet X

    更新日期：2020-09-08 00:00:00

  • Comment from the Editor to the Special Issue: "Big Data and Precision Medicine Series I: Lung Cancer Early Diagnosis".

    abstract：:With this Editorial we want to present the Special Issue "Big Data and Precision Medicine Series I: Lung Cancer Early Diagnosis" to the scientific community, which aims to gather experts on the early detection of lung cancer in order to implement common efforts in the fight against cancer. ...

    journal_title：Journal of clinical medicine

    pub_type： 社论

    doi：10.3390/jcm7020028

    authors： Gasparri R,Sedda G,Spaggiari L

    更新日期：2018-02-09 00:00:00

  • Acute Kidney Injury and In-Hospital Mortality: A Retrospective Analysis of a Nationwide Administrative Database of Elderly Subjects in Italy.

    abstract：BACKGROUND:The aim of this study was to investigate the association between acute kidney injury (AKI) and in-hospital mortality (IHM) in a large nationwide cohort of elderly subjects in Italy. METHODS:We analyzed the hospitalization data of all patients aged ≥65 years, who were discharged with a diagnosis of AKI, whic...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm8091371

    authors： Fabbian F,Savriè C,De Giorgi A,Cappadona R,Di Simone E,Boari B,Storari A,Gallerani M,Manfredini R

    更新日期：2019-09-02 00:00:00

  • Sex-Specific Prognostic Implications in Dilated Cardiomyopathy After Left Ventricular Reverse Remodeling.

    abstract：BACKGROUND:Women affected by Dilated Cardiomyopathy (DCM) experience better outcomes compared to men. Whether a more pronounced Left Ventricular Reverse Remodelling (LVRR) might explain this is still unknown. AIM:We investigated the relationship between LVRR and sex and its long-term outcomes. METHODS:A cohort of 605...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9082426

    authors： Cannata A,Manca P,Nuzzi V,Gregorio C,Artico J,Gentile P,Pio Loco C,Ramani F,Barbati G,Merlo M,Sinagra G

    更新日期：2020-07-29 00:00:00

  • Dilated Cardiomyopathy: A Paradigm of Revolution in Medicine.

    abstract：:Dilated Cardiomyopathy (DCM) has a straightforward and apparently "simple" definition: a heart muscle disease characterized by left ventricular (LV) or biventricular dilation and systolic dysfunction in the absence of either pressure or volume overload or coronary artery disease sufficient enough to explain the dysfun...

    journal_title：Journal of clinical medicine

    pub_type： 社论

    doi：10.3390/jcm9113385

    authors： Merlo M,Cannatà A,Sinagra G

    更新日期：2020-10-22 00:00:00

  • Systematic Review of Primary Outcome Measurements for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) in Randomized Controlled Trials.

    abstract：BACKGROUND:Due to its unknown etiology, the objective diagnosis and therapeutics of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) are still challenging. Generally, the patient-reported outcome (PRO) is the major strategy driving treatment response because the patient is the most important judge of whether...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章,评审

    doi：10.3390/jcm9113463

    authors： Kim DY,Lee JS,Son CG

    更新日期：2020-10-28 00:00:00