Abstract:
BACKGROUND AND AIMS:Data from clinical trials suggest that biological drugs may improve the outcomes in Crohn's disease (CD) by reducing the need for surgery or hospitalization. The aim of this study is to evaluate the time-trends of the use of biological drugs and other treatments for CD, and its relationship with outcomes in Catalonia. MATERIALS AND METHODS:All patients with CD included in the Catalan Health Surveillance System (containing data on a population of more than 7.5 million) from 2011 to 2017 were identified. The exposures to different treatments for inflammatory bowel disease were retrieved from electronic invoicing records. RESULTS:Between 2011 and 2017, the use of salicylates, corticosteroids and immunosuppressive treatment fell from 28.8% to 17.1%, 15.8% to 13.7%, and 32.9% to 29.6%, respectively (p < 0.001). Biological treatment use rose from 15.0% to 18.7% (p < 0.001). Ostomy rates per 1000 patients/year fell from 13.2 in 2011 to 9.8 in 2017 (p = 0.003), and surgical resection rates from 24.1 to 18.0 (p < 0.001). The rate of CD-related hospitalizations per 1000 patients/year also fell, from 92.7 to 72.2 (p < 0.001). CONCLUSIONS:Biological drug use rose from 15.0% to 18.7% between 2011 and 2017. During this period, we observed an improvement in the outcomes of CD patients.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Brunet E,Vela E,Melcarne L,Clèries M,Pontes C,Llovet LP,García-Iglesias P,Gallach M,Villòria A,Vergara M,Calvet Xdoi
10.3390/jcm9092896subject
Has Abstractpub_date
2020-09-08 00:00:00issue
9issn
2077-0383pii
jcm9092896journal_volume
9pub_type
杂志文章abstract::Low skeletal muscle mass (LSMM) is increasingly recognized for its predictive value for adverse events in cancer patients. In specific, the predictive value of LSMM has been demonstrated for anti-cancer drug toxicity in a variety of cancer types and anti-cancer drugs. However, due to the limited sample size and study ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9113780
更新日期:2020-11-23 00:00:00
abstract::It is now widely established that management of lung cancer is much more complex and cannot be centered on the binary classification of small-cell versus non-small cell lung cancer (NSCLC). Lung cancer is now recognized as a highly heterogeneous disease that develops from genetic mutations and gene expression patterns...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm7060153
更新日期:2018-06-15 00:00:00
abstract::Epistaxis is a common debilitating manifestation in hereditary hemorrhagic telangiectasia (HHT), due to mucocutaneous telangiectases. The epistaxis can be difficult to control despite available treatments. Dysregulated angiogenesis has been shown to be associated with telangiectases formation. Topical propranolol has ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9103130
更新日期:2020-09-28 00:00:00
abstract::Conventional angiography is used to evaluate and treat possible sources of intraabdominal bleeding, though it may cause complications such as contrast-induced nephropathy (CIN). The study's purpose was to identify factors predicting active extravasation and complications during angiography for acute intraabdominal ble...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm6040047
更新日期:2017-04-18 00:00:00
abstract::Immune checkpoint inhibitors (ICI) have revolutionised cancer therapy. However, they have been effective in only a small subset of patients and a principal mechanism underlying immune-refractoriness is a 'cold' tumour microenvironment, that is, lack of a T-cell-rich, spontaneously inflamed phenotype. As such, there is...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9103323
更新日期:2020-10-16 00:00:00
abstract:BACKGROUND:Deep dry needling (DDN) and ischemic compression technic (ICT) may be considered as interventions used for the treatment of Myofascial Pain Syndrome (MPS) in latent myofascial trigger points (MTrPs). The immediate effectiveness of both DDN and ICT on pressure pain threshold (PPT) and skin temperature of the ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8101632
更新日期:2019-10-05 00:00:00
abstract::Hybrid transplantation of skeletal muscle-derived multipotent stem cells (Sk-MSCs) and bioabsorbable polyglyconate (PGA) felt was studied as a novel regeneration therapy for the transected recurrent laryngeal nerve (RLN). Sk-MSCs were isolated from green fluorescence protein transgenic mice and then expanded and trans...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm7090276
更新日期:2018-09-12 00:00:00
abstract::Histological evaluation of renal biopsies is currently the gold standard for acquiring important diagnostic and prognostic information in diabetic nephropathy (DN) patients. Nevertheless, there is an unmet clinical need for new biomarkers that allow earlier diagnosis and risk stratification. As biochemical changes in ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8071022
更新日期:2019-07-12 00:00:00
abstract::Patients with kidney transplantation often have a worse quality of life than the general population. One of the reasons for this, in male patients, is the high prevalence of erectile dysfunction. This is mainly due to the presence of comorbidities, surgery for kidney transplantation, adverse drug effects, psychologica...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9061991
更新日期:2020-06-25 00:00:00
abstract:BACKGROUND:Research findings regarding the association between tricyclic antidepressant (TCA) treatment and the risk of fracture are not consistent; we aimed to assess whether people who take TCAs are at an increased fracture risk. METHODS:Relevant studies published through June 2020 were identified through database s...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9082584
更新日期:2020-08-10 00:00:00
abstract::Chronification of inflammation is the process that lies at the basis of several human diseases that make up to 80% of morbidity and mortality worldwide. It can also explain a great deal of processes related to aging. Atherosclerosis is an example of the most important chronic inflammatory pathology in terms of public ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9040978
更新日期:2020-04-01 00:00:00
abstract::The exact roles of adipokines in the pathogenesis of type 2 diabetes and obesity are still unclear. The aim of the study was to evaluate fatty acid binding protein 4 (FABP4) concentrations in the serum and urine of women with excessive gestational weight gain (EGWG) and gestational diabetes mellitus (GDM) in the early...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm7120505
更新日期:2018-12-02 00:00:00
abstract::Non-steroidal anti-inflammatory drugs (NSAIDs) can be used as opioid alternatives for patient-controlled analgesia (PCA). However, their use after nephrectomy has raised concerns regarding possible nephrotoxicity. This study compared postoperative renal function and postoperative outcomes between patients using NSAID ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9092959
更新日期:2020-09-13 00:00:00
abstract::The aim of this paper was to provide insights into alcohol misuse within UK veterans to inform as to whether their presentations differ from the general public. This was done by exploring differences in the severity of alcohol misuse between UK veterans and the general public admitted to a general NHS hospital over an...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm5110095
更新日期:2016-11-02 00:00:00
abstract::OCT (optical coherence tomography) is widely used in ophthalmology and pediatric ophthalmology, but limited research has been done on the use of OCT in strabismus. This study investigates the use of different OCT machines to image rectus muscle insertions pre-, intra-, and post-operatively in pediatric strabismus pati...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8101732
更新日期:2019-10-19 00:00:00
abstract::(1) Introduction: Several surgical therapy options for the treatment of pathologies of the long biceps tendon (LHB) have been established. However, tenotomy, as well as established tenodesis techniques, has disadvantages, such as cosmetic deformities, functional impairments and residual shoulder pain. This study prese...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm10030432
更新日期:2021-01-23 00:00:00
abstract::Ly75 (also known as DEC-205 or CD205) is expressed in immune cells and cancers and involved in tumor immunity. However, clinical relevance of Ly75 expression in skin cutaneous melanoma (SKCM) have not been comprehensively studied. This study analyzed the correlation between Ly75 mRNA expression and patient survival us...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9051383
更新日期:2020-05-08 00:00:00
abstract::The purpose of this study was to compare the thickness of all inner and outer macular layers between ocular hypertension (OHT) and early primary open-angle glaucoma (POAG) using spectral domain optical coherence tomography (SD-OCT) 8 × 8 posterior pole algorithm (8 × 8 PPA). Fifty-seven eyes of 57 OHT individuals and ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9051503
更新日期:2020-05-16 00:00:00
abstract::Hepatobiliary complications in children with sickle cell disease (SCD) are rarely reported but can be life-threatening. We retrospectively assessed their prevalence in a cohort of 616 children followed in a French university-hospital SCD reference center. Eligibility criteria were the following: age <18 years, seen at...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8091481
更新日期:2019-09-18 00:00:00
abstract:INTRODUCTION:Immunoglobulin G4-related disease (IgG4-RD) is a systemic immune-mediated disease characterised pathologically by the infiltration of IgG4-bearing plasma cells into the involved organs. Autoimmune pancreatitis (AIP) is a form of chronic pancreatitis with a heavy lymphocytic infiltration and two distinct hi...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9020409
更新日期:2020-02-03 00:00:00
abstract::Molecular mechanisms and pathological features of p-Cresyl sulfate (PCS)-induced uremic lung injury (ULI) in chronic kidney disease (CKD) remain unclear. We analyzed pleural effusions (PE) from CKD and non-CKD patients for uremic toxins, reactive oxygen species (ROS), and chemotactic cytokines. Correlations between PE...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm7090266
更新日期:2018-09-09 00:00:00
abstract::Although skin manifestations are quite common in systemic sclerosis (SSc), a link between SSc and psoriasis (PsO) has been poorly investigated. We assessed the Clalit medical database in a cohort study to compare the prevalence of PsO between SSc-patients and SSc-free controls. We also evaluated the SSc-related autoan...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8040521
更新日期:2019-04-16 00:00:00
abstract::Pancreatic pathology, comprising acute and chronic pancreatitis, autoimmune pancreatitis and pancreatic neoplasms, primarily presents with gastrointestinal symptoms and signs; however, it is well recognized that it can also associate a wide range of extra-digestive features. Among these systemic manifestations, cutane...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9082611
更新日期:2020-08-12 00:00:00
abstract::Previous studies have shown better clinical outcomes after total hip arthroplasty (THA) compared to hemiarthroplasty (HA) for displaced femoral neck fracture. However, few studies have focused on the surgical risks of the two procedures. Therefore, we investigated the perioperative complications of HA and THA in femor...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9103203
更新日期:2020-10-03 00:00:00
abstract::We aim to examine how season and temperature levels affect physical activity using a wearable device among patients scheduled to undergo surgical resection of lung cancer. Physical activity (PA) data from the wearable device were analyzed by seasons for 555 preoperative lung cancer patients from the CATCH-LUNG cohort ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9020349
更新日期:2020-01-27 00:00:00
abstract::Thyroid follicular cells, as well as adrenocortical cells, are endowed by an intrinsic heterogeneity regarding their growth potential, in response to various stimuli. This heterogeneity appears to constitute the underlying cause for the focal cell hyperplasia and eventually the formation of thyroid and adrenal nodules...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm7030037
更新日期:2018-02-26 00:00:00
abstract::Mesalamine (5-ASA) is the mainstay therapy in patients with mild-to-moderate active ulcerative colitis (UC). However, non-adherence to therapy and practice variability among gastroenterologists represent long-standing barriers, leading to poor outcomes. Additionally, targets to treat in UC are increasingly evolving fr...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9092905
更新日期:2020-09-08 00:00:00
abstract:BACKGROUND:The management of Helicobacter pylori (H. pylori) infection raises important challenges, still being the most common chronic infection worldwide in all age groups. In high-prevalence regions, paediatric patients need a specific focus, as the acquisition of the infection takes place in childhood. The objectiv...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9030784
更新日期:2020-03-13 00:00:00
abstract::Adipokines are powerful agents involved in the development of obesity-dependent cancers. This prospective study aimed to investigate the association between pre-treatment body mass index (BMI) and serum YKL-40, leptin, and adiponectin concentrations as well as the plasma activity of tissue factor (TF) and the future p...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9061742
更新日期:2020-06-04 00:00:00
abstract:BACKGROUND:To determine the validity of the Quick Sepsis-Related Organ Failure Assessment (qSOFA) in the prediction of outcome (in-hospital and 1-month mortality, intensive care unit (ICU) admission, and hospital and ICU length of stay) in adult patients with or without suspected infections where qSOFA was calculated a...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm8010061
更新日期:2019-01-08 00:00:00