Abstract：
:Ly75 (also known as DEC-205 or CD205) is expressed in immune cells and cancers and involved in tumor immunity. However, clinical relevance of Ly75 expression in skin cutaneous melanoma (SKCM) have not been comprehensively studied. This study analyzed the correlation between Ly75 mRNA expression and patient survival using systematic multiomic analysis tools. Ly75 mRNA expression level was significantly lower in SKCM tissues than in normal tissues. Survival analysis showed that Ly75 expression significantly correlated with good patient survival. To determine possible mechanisms, the association between Ly75 expression and immune cell infiltration was analyzed. Ly75 expression was positively correlated with various infiltrated immune cells, particularly with natural killer (NK) cell infiltration and activation in SKCM. Moreover, analysis of Ly75-co-altered gene expression revealed that Ptprc (CD45) was most significantly correlated with Ly75. Gene ontology analysis of Ly75-co-altered genes indicated the relation to lymphocyte activation, including NK cell activation. Overall, our study provides the first clinical evidence that Ly75 expression is significantly associated with melanoma patient survival and NK cell infiltration, suggesting that Ly75 could be a useful prognostic factor.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Gil M,Kim KEdoi
10.3390/jcm9051383subject
Has Abstractpub_date
2020-05-08 00:00:00issue
5issn
2077-0383pii
jcm9051383journal_volume
9pub_type
杂志文章abstract：:Intraovarian platelet-rich plasma (PRP) infusion was recently introduced in the context of addressing ovarian insufficiency. Reporting on its effectiveness prior to adopting in clinical routine practice is imperative. This study aims to provide pilot data regarding PRP application for ovarian rejuvenation. Four pilot ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9061809
更新日期：2020-06-10 00:00:00
abstract：:Objectives: One of the challenges of spine surgery is the need for adequate exposure of the anterolateral spinal column. Improved retractor systems with integrated lighting minimize the need for large thoracotomy, flank, or abdominal incisions. In 2013, we began using the NuVasive MaXcess® system via a minimal-access ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9103119
更新日期：2020-09-27 00:00:00
abstract：BACKGROUND:In mildly to moderately malnourished adolescent patients with anorexia nervosa (AN), accelerated refeeding protocols using higher initial calory supply coupled with phosphate supplements were not associated with a higher incidence of refeeding syndrome (RS). It is unclear whether this is also a feasible appr...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9051535
更新日期：2020-05-19 00:00:00
abstract：BACKGROUND:We investigated the associations between v-Raf murine sarcoma viral oncogene homolog B1 (BRAFV600E, henceforth BRAF) and v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations and colorectal cancer (CRC) prognosis, using The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GSE39582)...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8010111
更新日期：2019-01-17 00:00:00
abstract：:This study investigated associations of perceived environmental factors with leisure-time physical activity (LTPA) and screen time (ST) among older adults. A cross-sectional study was conducted by administering computer-assisted telephone interviews to 1028 older Taiwanese adults in November 2016. Data on personal fac...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7030056
更新日期：2018-03-13 00:00:00
abstract：:The outcome of patients with hepatocellular carcinoma (HCC) is still poor. Decorin is a small leucine-rich proteoglycan, which exerts antiproliferative and antiangiogenic properties in vitro. We aimed to investigate the associations of decorin with physical function and prognosis in patients with HCC. We enrolled 65 p...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9040936
更新日期：2020-03-28 00:00:00
abstract：:Rheumatoid arthritis is a chronic inflammatory disease characterized by the development of osseous and cartilaginous damage. The correct differentiation between a true erosion and other entities-then often called "pseudoerosions"-is essential to avoid misdiagnosing rheumatoid arthritis and to correctly interpret the p...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8122174
更新日期：2019-12-09 00:00:00
abstract：:Contemporary minimally invasive surgical (MIS) treatment options of patients with male Lower Urinary Tract Symptoms (LUTS) in men with prostate glands >80 mL include Holmium Laser Enucleation Prostate (HoLEP), Thulium laser VapoEnucleation Prostate (ThuVEP), and Laparoscopic (LSP) or Robotic-Assisted Simple Prostatect...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9061798
更新日期：2020-06-09 00:00:00
abstract：:The aim of this study is to determine the accuracy of adrenal vein sampling (AVS) with and without adrenocorticotropic hormone (ACTH) stimulation to distinguish between unilateral and bilateral primary hyperaldosteronism (PA). Retrospective analysis of a prospective database from a referral center between 1984 and 200...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9051447
更新日期：2020-05-13 00:00:00
abstract：:Elevated distractibility is one of the major contributors to alcohol hangover-induced behavioral deficits. Yet, the basic mechanisms driving increased distractibility during hangovers are still not very well understood. Aside from impairments in attention and psychomotor functions, changes in stimulus-response binding...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9030778
更新日期：2020-03-12 00:00:00
abstract：BACKGROUND:Oral and enteral mucositis due to high-dose cytostatic treatment administered during autologous and allogeneic stem-cell transplantation increases mortality. Salivary secretory immunoglobulin A (sIgA) is a basic pillar of local immunity in the first line of defense. Altered salivary sialoglycoprotein carbohy...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9061747
更新日期：2020-06-05 00:00:00
abstract：:Prolonged oligohydramnios following extreme preterm prelabour rupture of membranes (EPPROM) is traditionally associated with a high morbidity and mortality to both the mother and the baby. The clinical maternal evaluation and fetal ultrasound assessment may provide important prognostic information for the clinicians a...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm3010025
更新日期：2014-01-09 00:00:00
abstract：:This study aims to evaluate clinical and ulcer characteristics as well the outcomes of patients with diabetic foot ulcers (DFUs). The study group was composed of DFUs patients managed by a limb salvage protocol according to guidance. Clinical and ulcers findings were described, and 1-year outcomes defined as limb salv...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9061780
更新日期：2020-06-08 00:00:00
abstract：BACKGROUND:Although aldosterone has been demonstrated to induce left ventricular (LV) hypertrophy not only in primary aldosteronism but also in primary hypertension (HT), it can be affected by multiple factors, including age, and the effect of aldosterone on LV function is controversial. This study was to investigate t...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8071045
更新日期：2019-07-17 00:00:00
abstract：:The triple-negative breast tumor boundary is made of aligned, linear collagen. The pro-oncogenic impact of linear collagen is well established; however, its mechanism of formation is unknown. An in vitro analogue of the tumor border is created by a co-culture of MDA-MB-231 cells, adipose derived stem cells, and dermal...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9040991
更新日期：2020-04-02 00:00:00
abstract：:Mesalamine (5-ASA) is the mainstay therapy in patients with mild-to-moderate active ulcerative colitis (UC). However, non-adherence to therapy and practice variability among gastroenterologists represent long-standing barriers, leading to poor outcomes. Additionally, targets to treat in UC are increasingly evolving fr...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9092905
更新日期：2020-09-08 00:00:00
abstract：:Metabolic Syndrome (MetS) contributes to the development of cardiovascular disease (CVD) and type II diabetes mellitus (T2DM). Few studies have investigated the MetS risk of young adults (18⁻24 years old). This study aims to determine the prevalence of MetS in Appalachian and non-Appalachian students attending West Vi...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7120487
更新日期：2018-11-27 00:00:00
abstract：:Attention deficit hyperactivity disorder (ADHD) is a frequent neurodevelopmental disorder that often persists into adulthood. Methylphenidate (MPH) is the first-line treatment for ADHD; however, despite its wide usage, little is known about its neurometabolic effects. Until now, no randomized and blinded clinical tria...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9082601
更新日期：2020-08-11 00:00:00
abstract：:In excess of three quarters of patients with psoriatic arthritis (PsA) have preceding psoriasis (PsO), which offers a clinical biomarker for the recognition of early PsA. Numerous surveys have shown a remarkably high frequency of clinically occult musculoskeletal symptoms in psoriasis patients. Imaging studies, partic...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9103262
更新日期：2020-10-12 00:00:00
abstract：:Sodium glucose co-transporter 2 (SGLT2) inhibitors reduce the risk of heart and kidney failure in patients with type 2 diabetes, possibly due to diuretic effects. Previous non-placebo-controlled studies with SGLT2 inhibitors observed changes in volume markers in healthy individuals and in patients with type 2 diabetes...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8060779
更新日期：2019-05-31 00:00:00
abstract：:Helicobacter pylori, responsible for chronic ulcers and most stomach cancers, infects half of the world's population. The Urea Breath Test (UBT) is one of the most accurate and reliable non-invasive methods for diagnosing active H. pylori infection. The objective was to use longitudinal, population-wide UBT data for W...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8111821
更新日期：2019-11-01 00:00:00
abstract：:This study evaluated whether inter-hospital transfer (IHT) after the return of spontaneous circulation (ROSC) was associated with poor neurological outcomes after 6 months in post-cardiac-arrest patients treated with targeted temperature management (TTM). We used data from the Korean Hypothermia Network prospective re...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9061979
更新日期：2020-06-24 00:00:00
abstract：:To analyse the predictive ability and incremental value of left ventricular longitudinal axis strain (LAS) and late gadolinium enhancement (LGE) using standard cardiovascular magnetic resonance (CMR) imaging for the diagnosis and prognosis of severe aortic stenosis (AS) in patients with an indication for aortic valve ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8020165
更新日期：2019-02-01 00:00:00
abstract：:(1) Introduction: Several surgical therapy options for the treatment of pathologies of the long biceps tendon (LHB) have been established. However, tenotomy, as well as established tenodesis techniques, has disadvantages, such as cosmetic deformities, functional impairments and residual shoulder pain. This study prese...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm10030432
更新日期：2021-01-23 00:00:00
abstract：:The idea of right heart catheterization (RHC) grew in the milieu of modern thinking about the cardiovascular system, influenced by the experiments of William Harvey, which were inspired by the treatises of Greek philosophers like Aristotle and Gallen, who made significant contributions to the subject. RHC was first di...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8091331
更新日期：2019-08-28 00:00:00
abstract：BACKGROUND:When a rescuer walks alongside a stretcher and compresses the patient's chest, the rescuer produces low-quality chest compressions. We hypothesized that a stretcher equipped with wing boards allows for better chest compressions than the conventional method. METHODS:In this prospective, randomized, crossover...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9051584
更新日期：2020-05-23 00:00:00
abstract：:Staphylococcus aureus bloodstream infection (SA-BSI) is an infection with increasing morbidity and mortality. Concomitant Staphylococcus aureus bacteriuria (SABU) frequently occurs in patients with SA-BSI. It is considered as either a sign of exacerbation of SA-BSI or a primary source in terms of urosepsis. The clinic...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9020508
更新日期：2020-02-13 00:00:00
abstract：:Keywords: pulmonary embolism; submassive; survey. ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8020215
更新日期：2019-02-07 00:00:00
abstract：AIM:Our aim was to investigate the characteristics, treatment and prognosis of patients with myocardial infarction (MI) treated outside a cardiology department (CD), compared with MI patients treated at a CD. METHODS:A cohort of 1310 patients diagnosed with MI at eight Swedish hospitals in 2011 were included in this o...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm10010106
更新日期：2020-12-30 00:00:00
abstract：:Children are susceptible to a variety of respiratory infections. Wheezing is a common sign presented by children with respiratory infections. Asthma, bronchiolitis, and bronchitis are common causes of childhood wheezing disease (CWD) and are regarded as overlapping disease spectra. Macrolides are common antimicrobial ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7110432
更新日期：2018-11-09 00:00:00
