Abstract：
:Elevated distractibility is one of the major contributors to alcohol hangover-induced behavioral deficits. Yet, the basic mechanisms driving increased distractibility during hangovers are still not very well understood. Aside from impairments in attention and psychomotor functions, changes in stimulus-response bindings may also increase responding to distracting information, as suggested by the theory of event coding (TEC). Yet, this has never been investigated in the context of alcohol hangover. Therefore, we investigated whether alcohol hangover has different effects on target-response bindings and distractor-response bindings using a task that allows to differentiate these two phenomena. A total of n = 35 healthy males aged 19 to 28 were tested once sober and once hungover after being intoxicated in a standardized experimental drinking setting the night before (2.64 gr of alcohol per estimated liter of body water). We found that alcohol hangover reduced distractor-response bindings, while no such impairment was found for target-response bindings, which appeared to be unaffected. Our findings imply that the processing of distracting information is most likely not increased, but in fact decreased by hangover. This suggests that increased distractibility during alcohol hangover is most likely not caused by modulations in distractor-response bindings.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Opitz A,Beste C,Stock AKdoi
10.3390/jcm9030778subject
Has Abstractpub_date
2020-03-12 00:00:00issue
3issn
2077-0383pii
jcm9030778journal_volume
9pub_type
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journal_title：Journal of clinical medicine
pub_type： 杂志文章
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更新日期：2019-11-15 00:00:00
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更新日期：2020-04-10 00:00:00
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更新日期：2019-12-19 00:00:00
abstract：:The authors wish to make the following corrections to this paper [...]. ...
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pub_type： 已发布勘误
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更新日期：2019-03-20 00:00:00
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更新日期：2020-06-26 00:00:00
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更新日期：2019-04-06 00:00:00
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更新日期：2020-04-07 00:00:00
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更新日期：2018-06-11 00:00:00
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更新日期：2020-05-04 00:00:00
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更新日期：2018-11-22 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2020-06-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2019-08-19 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2019-12-13 00:00:00
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更新日期：2019-10-13 00:00:00
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pub_type： 杂志文章
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更新日期：2019-11-01 00:00:00
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pub_type： 杂志文章
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更新日期：2021-01-14 00:00:00
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pub_type： 杂志文章
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更新日期：2020-03-30 00:00:00
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更新日期：2020-04-15 00:00:00
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更新日期：2020-09-08 00:00:00
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更新日期：2017-10-27 00:00:00
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更新日期：2020-01-05 00:00:00
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更新日期：2020-11-26 00:00:00
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更新日期：2020-05-14 00:00:00
abstract：:Hepatocellular carcinoma (HCC) is a poor-prognosis cancer due to its high rate of recurrence. microRNAs (miRNAs) are a class of small non-coding RNA molecules that affect crucial processes in cancer development. The objective of this study is to identify the role of miRNAs in patient bone marrow (BM) and explore the f...
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更新日期：2015-08-14 00:00:00
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更新日期：2019-12-16 00:00:00
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更新日期：2019-06-01 00:00:00
