Abstract：
:The triple-negative breast tumor boundary is made of aligned, linear collagen. The pro-oncogenic impact of linear collagen is well established; however, its mechanism of formation is unknown. An in vitro analogue of the tumor border is created by a co-culture of MDA-MB-231 cells, adipose derived stem cells, and dermal fibroblasts. Decellularization of this co-culture after seven days reveals an extracellular matrix that is linear in fashion, high in pro-oncogenic collagen type VI, and able to promote invasion of reseeded cells. Further investigation revealed linear collagen VI is produced by fibroblasts in response to a paracrine co-culture of adipose derived stem cells and MDA-MB-231, which together secrete high levels of the chemokine CCL5. The addition of monoclonal antibody against CCL5 to the co-culture results in an unorganized matrix with dramatically decreased collagen VI. Importantly, reseeded cells do not exhibit pro-oncogenic behavior. These data illustrate a cellular mechanism, which creates linear extracellular matrix (ECM) in vitro, and highlight a potential role of CCL5 for building striated tumor collagen in vivo.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Brett E,Sauter M,Timmins É,Azimzadeh O,Rosemann M,Merl-Pham J,Hauck SM,Nelson PJ,Becker KF,Schunn I,Lowery A,Kerin MJ,Atkinson M,Krüger A,Machens HG,Duscher Ddoi
10.3390/jcm9040991subject
Has Abstractpub_date
2020-04-02 00:00:00issue
4issn
2077-0383pii
jcm9040991journal_volume
9pub_type
杂志文章abstract：:The aim of this study was to assess the efficacy of anti-endomysium antibodies (EMA) as a serological marker for celiac disease (CD) diagnosis in a pediatric population. A retrospective study of pediatric patients who underwent a CD serological markers study: EMA and anti-tissue transglutaminase antibodies (anti-TG2)....
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8122179
更新日期：2019-12-11 00:00:00
abstract：:Disrupting the process of memory reconsolidation could be a promising treatment for addiction. However, its application may be constrained by the intensity of addiction memory. This study aimed to develop and initially validate a new measure, the Addiction Memory Intensity Scale (AMIS), for assessing the intensity of ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7120467
更新日期：2018-11-22 00:00:00
abstract：:Objective: To determine blood transfusion practices, risk factors, and outcomes associated with the use of blood products in the setting of the acute management of burn patients at the Victorian Adult Burn Service. Background: Patients with burn injuries have variable transfusion requirements, based on a multitude of ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm10030476
更新日期：2021-01-27 00:00:00
abstract：:With the improvement in survival rate, cardiotoxicity has emerged as a significant adverse effect of cancer therapy. Early diagnosis of subclinical cardiac injury may allow the initiation of cardioprotective therapy and preventing the interruption of optimal cancer therapy and the development of irreversible cardiac d...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm10010154
更新日期：2021-01-05 00:00:00
abstract：INTRODUCTION:Immunoglobulin G4-related disease (IgG4-RD) is a systemic immune-mediated disease characterised pathologically by the infiltration of IgG4-bearing plasma cells into the involved organs. Autoimmune pancreatitis (AIP) is a form of chronic pancreatitis with a heavy lymphocytic infiltration and two distinct hi...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9020409
更新日期：2020-02-03 00:00:00
abstract：:Rhinosinusitis (RS) is a common disease in children, significantly affecting their quality of life. Chronic rhinosinusitis (CRS) is frequently linked to other respiratory diseases, including asthma. Children affected by CRS may be candidates for surgery in the case of failure of maximal medical therapy comprising thre...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8050684
更新日期：2019-05-15 00:00:00
abstract：:The relationship between serum uric acid (SUA) and hypertension has been a subject of increasing interest since the 1870 discovery by Frederick Akbar Mahomed. Several epidemiological studies have shown a strong association between high SUA levels and the presence or the development of hypertension. Genetic analyses ha...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm10030448
更新日期：2021-01-24 00:00:00
abstract：:We aimed to determine if low body weight (LBW) status (<50 kg) is independently associated with increased risk of ischemic stroke and bleeding in Thai patients with non-valvular atrial fibrillation (NVAF). (1) Background: It has been unclear whether LBW influence clinical outcome of patients with NVAF. (2) Methods: Th...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9092713
更新日期：2020-08-22 00:00:00
abstract：BACKGROUND:To determine the validity of the Quick Sepsis-Related Organ Failure Assessment (qSOFA) in the prediction of outcome (in-hospital and 1-month mortality, intensive care unit (ICU) admission, and hospital and ICU length of stay) in adult patients with or without suspected infections where qSOFA was calculated a...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8010061
更新日期：2019-01-08 00:00:00
abstract：BACKGROUND:Gut microbiota-related metabolites, trimethylamine-N-oxide (TMAO), choline, and betaine, have been shown to be associated with cardiovascular disease (CVD) risk. Moreover, lower plasma betaine concentrations have been reported in subjects with type 2 diabetes mellitus (T2DM). However, few studies have explor...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8111813
更新日期：2019-11-01 00:00:00
abstract：:Actinic cheilitis (AC) is one of the most frequent pathologies to affect the lips. Studies show that the most commonplace oral malignancy, squamous cell carcinoma (SCC), often emerges from AC lesions. Invasive diagnostic techniques performed on the lips carry a high risk of complications, but reflectance confocal micr...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9061987
更新日期：2020-06-25 00:00:00
abstract：BACKGROUND:Several comparison studies have suggested that kidney transplantation (KT) could reduce mortality in patients with end-stage renal disease (ESRD). Selection criteria bias is common in the selection of dialysis patients for control groups. In this study, we compared the survival outcome between KT recipients ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7110388
更新日期：2018-10-26 00:00:00
abstract：:Research examining associations between objectively-measured napping time and type 2 diabetes (T2D) is lacking. This study aimed to evaluate daytime napping in relation to T2D and adiposity measures in elderly individuals from the Mediterranean region. A cross-sectional analysis of baseline data from 2190 elderly part...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8071053
更新日期：2019-07-19 00:00:00
abstract：:Photodynamic therapy (PDT) has become an effective treatment for certain types of solid tumors. The combination of PDT with other therapies has been extensively investigated in recent years to improve its effectiveness and expand its applications. This focused review summarizes the development of a prodrug system in w...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8122198
更新日期：2019-12-13 00:00:00
abstract：OBJECTIVES:To test a novel diagnostic technique to assess radial artery perfusion after transradial catheterization. BACKGROUND:Despite being mostly asymptomatic, radial artery occlusion (RAO) is not a benign complication, and its diagnosis is frequently missed because it requires time-consuming diagnostic testing. We...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7100319
更新日期：2018-10-02 00:00:00
abstract：BACKGROUND:Residual coronary artery disease (CAD) has been associated with worsened prognosis in patients undergoing percutaneous coronary intervention (PCI) for acute coronary syndromes (ACS). The residual SYNTAX Score (rSS) aims to assess residual CAD after PCI. The association between kidney function and rSS has not...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8060810
更新日期：2019-06-06 00:00:00
abstract：:The worldwide epidemiology of inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), still shows an increasing trend in Asia and Iran. Despite an improvement in the treatment landscape focused on symptomatic control, long-term colectomies have not decreased over the last 10-year ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9123922
更新日期：2020-12-03 00:00:00
abstract：:Examination of the corneal surface by in vivo confocal microscopy (IVCM) allows for objective identification of corneal and conjunctival cell phenotypes to evaluate different epithelialization patterns. Detection of a corneal-conjunctival epithelial transition could be considered as a sign of restored epithelial funct...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9113574
更新日期：2020-11-06 00:00:00
abstract：:Amiodarone is recommended for shock-refractory ventricular arrhythmia during resuscitation; however, it is unknown whether amiodarone is effective for preventing ventricular arrhythmia recurrence in out-of-hospital cardiac arrest (OHCA) survivors treated with targeted temperature management (TTM). We investigated the ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8020244
更新日期：2019-02-13 00:00:00
abstract：:The main risk factor for primary open-angle glaucoma (POAG) is increased intraocular pressure (IOP). It is of interest that about half of the patients have an IOP within the normal range (normal-tension glaucoma, NTG). Additionally, there is a group of patients with a high IOP but no glaucomatous neurodegeneration (oc...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9092979
更新日期：2020-09-15 00:00:00
abstract：:This study evaluated whether inter-hospital transfer (IHT) after the return of spontaneous circulation (ROSC) was associated with poor neurological outcomes after 6 months in post-cardiac-arrest patients treated with targeted temperature management (TTM). We used data from the Korean Hypothermia Network prospective re...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9061979
更新日期：2020-06-24 00:00:00
abstract：BACKGROUND:The Dyskinesia Impairment Scale (DIS) is a new assessment scale for dystonia and choreoathetosis in children and youth with dyskinetic cerebral palsy. Today, the Burke-Fahn-Marsden Dystonia Rating Scale (BFM) is mostly used to assess dystonia in children with inherited dystonia. The aim of this study was to ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9082597
更新日期：2020-08-11 00:00:00
abstract：:Neuroendocrine breast cancer (NEBC) is a rare histotype of breast carcinoma that presents, in most cases, positive hormone receptors and negative HER2. Indeed, the analysis of gene expression profiles revealed that NEBC belongs mainly to the luminal subtype. Cases of HER2-positive and triple-negative NEBC are rare. Th...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9051452
更新日期：2020-05-13 00:00:00
abstract：:Despite extensive research and development of new treatments, acute myeloid leukemia (AML)-backbone therapy has remained essentially unchanged over the last decades and is frequently associated with poor outcomes. Eradicating the leukemic stem cells (LSCs) is the ultimate challenge in the treatment of AML. Emerging ev...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9051513
更新日期：2020-05-18 00:00:00
abstract：:Duchenne muscular dystrophy (DMD), the most severe form of dystrophinopathy, is quite homogeneous with regards to its causative biochemical defect, i.e., complete dystrophin deficiency, but not so much with regards to its phenotype. For instance, muscle weakness progresses to the loss of independent ambulation at a va...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8050649
更新日期：2019-05-10 00:00:00
abstract：BACKGROUND AND AIMS:Endoscopic resection (ER) for submucosal invasive colorectal cancer (T1 CRC) can be grouped as curative ER (C-ER) and non-curative ER (NC-ER). Little is known about the long-term outcomes of patients in these two groups. Therefore, we have evaluated the long-term outcomes in endoscopically resected ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9082451
更新日期：2020-07-31 00:00:00
abstract：:CANTOS reported reduced secondary atherothrombotic events in patients with residual inflammatory risk treated with the inhibitory anti-IL-1β antibody, Canakinumab. Yet, mechanisms that underlie this benefit remain elusive. Recent work has implicated formation of neutrophil extracellular traps (NETosis) in arterial thr...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8122072
更新日期：2019-11-26 00:00:00
abstract：:The use of sugammadex can reduce post-operative residual neuromuscular blockade, which is known to increase the risk of post-operative respiratory events. However, its effect on post-operative pulmonary complications is not obvious. This study was performed to evaluate the effects of sugammadex on post-operative pulmo...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9041232
更新日期：2020-04-24 00:00:00
abstract：:Androgen/androgen receptor (AR) signaling is a significant driver of prostate cancer progression, therefore androgen-deprivation therapy (ADT) is often used as a standard form of treatment for advanced and metastatic prostate cancer patients. However, after several years of ADT, prostate cancer progresses to castratio...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8030354
更新日期：2019-03-13 00:00:00
abstract：:This study aimed to develop a prognosis-predicting model based on [18F]fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) and clinicopathologic factors in locally advanced cervical cancer patients treated with concurrent chemoradiotherapy (CCRT). The medical records of 270 locally adv...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9020427
更新日期：2020-02-05 00:00:00
