Abstract:
:This study aimed to develop a prognosis-predicting model based on [18F]fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) and clinicopathologic factors in locally advanced cervical cancer patients treated with concurrent chemoradiotherapy (CCRT). The medical records of 270 locally advanced cervical cancer patients who were treated with CCRT were collected from three institutions and reviewed retrospectively. A nomogram was used for predicting 2-year disease-free survival (DFS) and 5-year overall survival (OS) based on Cox proportional hazards regression. Predictor variables included nodal maximum standardized uptake value (SUVmax), primary tumor SUVmax, age, tumor size, stage, serum squamous cell carcinoma antigen level, and human papillomavirus status. Internal nomogram validation was performed. A nomogram for predicting the 2-year DFS and 5-year OS was constructed using six and seven parameters, respectively. With a focus on 2-year DFS, our model found nodal SUVmax to be the highest weighted negative prognostic factor. With a focus on 5-year OS, young age was the highest weighted negative prognostic factor. The concordance index was 0.75 and 0.78 for the 2-year DFS and 5-year OS, respectively. This nomogram is a predictive tool that can be used to counsel patients for predicting survival outcomes. Moreover, our prognosis-predicting model may make it possible to personalize treatment.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Lee WK,Chong GO,Jeong SY,Lee HJ,Park SH,Ryu JM,Choi YS,Kang S,Koo YJ,Lee DH,Kong E,Lee SWdoi
10.3390/jcm9020427subject
Has Abstractpub_date
2020-02-05 00:00:00issue
2issn
2077-0383pii
jcm9020427journal_volume
9pub_type
杂志文章abstract::The main risk factor for primary open-angle glaucoma (POAG) is increased intraocular pressure (IOP). It is of interest that about half of the patients have an IOP within the normal range (normal-tension glaucoma, NTG). Additionally, there is a group of patients with a high IOP but no glaucomatous neurodegeneration (oc...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9092979
更新日期:2020-09-15 00:00:00
abstract::The investigation of the potential association between ischemic stroke and subclinical atrial fibrillation (SCAF) is important for secondary prevention. We aimed to determine whether SCAF can be predicted by atrial substrate measurement with P wave signal-averaged electrocardiography (SAECG). We recruited 125 consecut...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9041134
更新日期:2020-04-15 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate the association between large for gestational age (LGA) at birth and future risk of childhood neoplasm. STUDY DESIGN:a population-based cohort to compare the long-term risk (up to the age of 18 years) of childhood neoplasms (benign and malignant) in children that were bo...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9051336
更新日期:2020-05-04 00:00:00
abstract::The management of lymphatic malformations (LMs) is challenging, particularly for large and complex lesions involving anatomical structures in the adjacent tissue. While lymphovenous anastomosis (LVA) has been reported as an effective treatment for lymphedema, it has hardly been described as a treatment for LM. Virtual...
journal_title:Journal of clinical medicine
pub_type:
doi:10.3390/jcm8030371
更新日期:2019-03-15 00:00:00
abstract::This study proposes a method for measuring the volumetric change of alveolar bone after dental implant surgery using computed tomography (CT). A total of 40 implants in 20 patients (15 males and 5 females) were selected. The types of implants used were group 1: 24 CMI IS-II Active implants (Neobiotech Co., Seoul, Repu...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9041238
更新日期:2020-04-24 00:00:00
abstract::Survivors of colorectal cancer (CRC) may experience a range of physical, psychosocial, and practical challenges as a consequence of their diagnosis. We assessed the patterns and documented content of follow-up visits within the first three years following treatment, in comparison to survivorship care guidelines. Survi...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9092725
更新日期:2020-08-24 00:00:00
abstract::Systemic sclerosis (SSc; scleroderma) is characterized by life-threatening progressive multiorgan fibrosis orchestrated by profibrotic myofibroblasts originating from different sources. Because recent data demonstrated that the majority of myofibroblasts in a murine scleroderma model arise from adipocytic progenitors ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8081256
更新日期:2019-08-19 00:00:00
abstract::Right ventricular failure (RVF) is a major risk factor for end organ morbidity and mortality following cardiac surgery. Perioperative RVF is difficult to predict and detect, and to date, no convenient, accurate, or reproducible measure of right ventricular (RV) function is available. Few studies have examined the use ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm8040559
更新日期:2019-04-25 00:00:00
abstract:BACKGROUND:We aimed to build a model using machine learning for the prediction of survival in trauma patients and compared these model predictions to those predicted by the most commonly used algorithm, the Trauma and Injury Severity Score (TRISS). METHODS:Enrolled hospitalized trauma patients from 2009 to 2016 were d...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8060799
更新日期:2019-06-05 00:00:00
abstract::Ventilator-associated pneumonia (VAP) is a well-known complication of patients on invasive mechanical ventilation. The main cause of acute respiratory distress syndrome (ARDS) is pneumonia. ARDS can occur in patients with community-acquired or nosocomial pneumonia. Data regarding ARDS incidence, related pathogens, and...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9113508
更新日期:2020-10-29 00:00:00
abstract::The pathogenesis of an increasing number of chronic diseases is being attributed to effects of the immune system. However, its role in the development and maintenance of anorexia nervosa is seemingly under-appreciated. Yet, in examining the available research on the immune system and genetic studies in anorexia nervos...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm8111915
更新日期:2019-11-08 00:00:00
abstract::Even though the cornea is regarded as an immune-privileged tissue, transplantation always comes with the risk of rejection due to mismatches between donor and recipient. It is common sense that an alternative to corticosteroids as the current gold standard for treatment of corneal transplantation is needed. Since bloo...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9051280
更新日期:2020-04-28 00:00:00
abstract::Diabetic nephropathy patients traditionally show significant macroalbuminuria prior to the development of renal impairment. However, this clinical paradigm has recently been questioned. Epidemiological surveys confirm that chronic kidney disease (CKD) diagnosed by a low glomerular filtration rate (GFR) is more common ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm4091761
更新日期:2015-09-07 00:00:00
abstract::Focal Segmental Glomerulosclerosis (FSGS) recurrence after kidney transplantation (KTx) is relatively frequent and is associated with poor graft survival. The aim of this study was to investigate which management strategies were associated with better outcomes in our cohort of KTx recipients with primary FSGS. We retr...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm10030373
更新日期:2021-01-20 00:00:00
abstract::Early diagnosis and timely management of tooth or dental material wear is imperative to avoid extensive restorations. Previous studies suggested different methods for tooth wear assessment, but no study has developed a three-dimensional (3D) superimposition technique applicable in cases where tooth surfaces, other tha...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9123937
更新日期:2020-12-04 00:00:00
abstract::Upper gastrointestinal (GI) cancers are responsible for significant mortality and morbidity worldwide. To date, most of the studies focused on the treatments' efficacy and post-treatment survival rate. As treatments improve, more patients survive long term, and thus the accompanying complications including unintention...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm8070942
更新日期:2019-06-28 00:00:00
abstract::Due to the widespread use of ultrasound, small thyroid nodules (TNs) ≤ 10 mm are common findings. Standardized approaches for the risk stratification of TNs with Thyroid Imaging Reporting and Data Systems (TIRADS) were evaluated for the clinical routine. With TIRADS, the risk of malignancy in TNs is calculated by scor...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9010236
更新日期:2020-01-16 00:00:00
abstract:BACKGROUND:As much as there are unmet needs for brief frailty assessment in patients with chronic obstructive pulmonary disease (COPD), the lack of a simplified and comprehensive dyspnea evaluation system that focuses on the patients' perceptions of dyspnea and their COPD living disabilities remains a major challenge. ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9113580
更新日期:2020-11-06 00:00:00
abstract::Cancer cells can acquire a spectrum of stable hybrid epithelial/mesenchymal (E/M) states during epithelial-mesenchymal transition (EMT). Cells in these hybrid E/M phenotypes often combine epithelial and mesenchymal features and tend to migrate collectively commonly as small clusters. Such collectively migrating cancer...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm8050725
更新日期:2019-05-22 00:00:00
abstract::To date, studies have highlighted cross-sectional and unidirectional prospective relationships between problem gambling and mental health symptoms or substance use. The current study aims to: (1) examine the reciprocal relationships between problem gambling and mental health symptoms (depression, generalized anxiety)/...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8111888
更新日期:2019-11-06 00:00:00
abstract:BACKGROUND:The long-term stability after soft tissue graft for covering gingival recession remains a pivotal goal for both patient and periodontist. Therefore, the aim of this study was to compare the four-year outcomes of the coronally advanced flap (CAF) versus the pouch/tunnel (POT) technique, both combined with con...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9082641
更新日期:2020-08-14 00:00:00
abstract::Suprascapular neuropathy is an uncommon but increasingly recognized cause of shoulder pain and dysfunction due to nerve entrapment. The aim of this review is to summarize some important aspects of this shoulder pathology. An extensive research was performed on PubMed and Clinical Key. The goal was to collect all the a...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9082331
更新日期:2020-07-22 00:00:00
abstract:OBJECTIVES:Non-alcoholic fatty liver disease (NAFLD) is considered a well-known pathology that is determined without using alcohol and has emerged as a growing public health problem. Lipotoxicity is known to promote hepatocyte death, which, in the context of NAFLD, is termed lipoapoptosis. The severity of NAFLD correla...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9051294
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVES:To test a novel diagnostic technique to assess radial artery perfusion after transradial catheterization. BACKGROUND:Despite being mostly asymptomatic, radial artery occlusion (RAO) is not a benign complication, and its diagnosis is frequently missed because it requires time-consuming diagnostic testing. We...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm7100319
更新日期:2018-10-02 00:00:00
abstract::During surgery, ATP from damaged cells induces the release of interleukin-1β, a potent pro-inflammatory cytokine that contributes to the development of postoperative systemic inflammation, sepsis and multi-organ damage. We recently demonstrated that C-reactive protein (CRP) inhibits the ATP-induced release of monocyti...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9103340
更新日期:2020-10-18 00:00:00
abstract:INTRODUCTION:The oxytocin challenge test (OCT) used to be one of the most important tools in assessing fetal well-being before ultrasonography became prevalent. We show that, after modifying the classification of the results and the intervention algorithm, OCT can still be a useful tool in present-day obstetrics. MATE...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9010131
更新日期:2020-01-03 00:00:00
abstract:BACKGROUND:Mismatch of intramedullary nails with the bowing of femur is a frequent clinical finding. Previous studies showed inconsistent results. METHODS:We present an algorithm of region growing territory method to get the radii of the anterior bowing of femur. We also tested it on ten radiographs. Plain radiographs...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8101598
更新日期:2019-10-03 00:00:00
abstract::Patients with kidney transplantation often have a worse quality of life than the general population. One of the reasons for this, in male patients, is the high prevalence of erectile dysfunction. This is mainly due to the presence of comorbidities, surgery for kidney transplantation, adverse drug effects, psychologica...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9061991
更新日期:2020-06-25 00:00:00
abstract:BACKGROUND:Ghrelin is a 28-amino acid peptide with an orexigenic property, which is predominantly produced by the stomach. Acylated ghrelin is the active form of this hormone. Obestatin is a 23-amino acid peptide which is produced by post-translational modification of a protein precursor that also produces ghrelin. Obe...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm5070061
更新日期:2016-06-23 00:00:00
abstract::Women affected by autoimmune diseases, organ transplantation, or neoplasia need to continue immunosuppressive treatment during pregnancy. In this setting, not only a careful planning of pregnancy, but also the choice of drugs is critical to preventing maternal complications and minimizing the fetal risks. Some immunos...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm7120552
更新日期:2018-12-15 00:00:00