Abstract:
BACKGROUND:Ghrelin is a 28-amino acid peptide with an orexigenic property, which is predominantly produced by the stomach. Acylated ghrelin is the active form of this hormone. Obestatin is a 23-amino acid peptide which is produced by post-translational modification of a protein precursor that also produces ghrelin. Obestatin has the opposite effect of ghrelin on food intake. The aim of this study was to evaluate acylated ghrelin and obestatin levels and their ratio in obese and normal-weight children and adolescents, and their association with metabolic syndrome (MetS) parameters. METHODS:Serum acyl-ghrelin, obestatin, leptin, insulin, fasting plasma glucose (FPG), lipid profile, and malondialdehyde (MDA) were evaluated in 73 children and adolescents (42 obese and 31 control). Insulin resistance was calculated by a homeostasis model assessment of insulin resistance (HOMA-IR). MetS was determined according to IDF criteria. RESULTS:Acyl-ghrelin levels were significantly lower in obese subjects compared to the control group and lower in obese children with MetS compared to obese subjects without MetS. Obestatin was significantly higher in obese subjects compared to that of the control, but it did not differ significantly among those with or without MetS. Acyl-ghrelin to obestatin ratio was significantly lower in obese subjects compared to that in normal subjects. Acyl-ghrelin showed significant negative and obestatin showed significant positive correlations with body mass index (BMI), BMI Z-score, leptin, insulin, and HOMA-IR. Acyl-ghrelin had a significant negative correlation with MDA as an index of oxidative stress. CONCLUSION:Ghrelin is decreased and obestatin is elevated in obesity. Both of these hormones are associated with insulin resistance, and ghrelin is associated with oxidative stress. The balance between ghrelin and obestatin seems to be disturbed in obesity.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Razzaghy-Azar M,Nourbakhsh M,Pourmoteabed A,Nourbakhsh M,Ilbeigi D,Khosravi Mdoi
10.3390/jcm5070061subject
Has Abstractpub_date
2016-06-23 00:00:00issue
7issn
2077-0383pii
jcm5070061journal_volume
5pub_type
杂志文章abstract::We investigated the prognostic value of standard electroencephalography, a 30-min recording using 21 electrodes on the scalp, during the early post-cardiac arrest period, and evaluated the performance of electroencephalography findings combined with other clinical features for predicting favourable outcomes in comatos...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9041113
更新日期:2020-04-13 00:00:00
abstract::This study aimed to investigate the cross-sectional association between arthritis and migraine in a large representative sample of the US adult population. The study used data from adults who participated in the RAND American Life Panel (ALP). Arthritis (excluding rheumatoid arthritis) and migraine were self-reported....
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm10020342
更新日期:2021-01-18 00:00:00
abstract::Alzheimer's disease (AD), the most common cause of dementia, is a neurodegenerative disease that seriously threatens human health and life quality. The main pathological features of AD include the widespread deposition of amyloid-beta and neurofibrillary tangles in the brain. So far, the pathogenesis of AD remains elu...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9072042
更新日期:2020-06-29 00:00:00
abstract::A higher incidence rate of nocturia in patients with obstructive sleep apnea (OSA) has been observed. We investigated the differences in clinical examinations between OSA patients with and without nocturia, and further compared those with successful and unsuccessful uvulopalatopharyngoplasty (UPPP). This retrospective...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9103089
更新日期:2020-09-25 00:00:00
abstract::Two doses of propiverine ER (30 and 45 mg/d) are available for the treatment of overactive bladder (OAB) syndrome. We have explored factors associated with the initial dosing choice (allocation bias), the decision to adapt dosing (escalation bias) and how dosing relative to other factors affects treatment outcomes. Da...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm10020311
更新日期:2021-01-15 00:00:00
abstract::Ongoing outbreak of pneumonia caused by novel coronavirus (2019-nCoV) began in December 2019 in Wuhan, China, and the number of new patients continues to increase. Even though it began to spread to many other parts of the world, such as other Asian countries, the Americas, Europe, and the Middle East, the impact of se...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9040944
更新日期:2020-03-30 00:00:00
abstract::Endometriosis concerns more than 10% of women of reproductive age, frequently leading to chronic pelvic pain. Repetitive transcranial magnetic stimulation (rTMS) over the primary motor cortex (M1) induces an analgesic effect. This effect on chronic pelvic pain is yet to be evaluated. The objective of this study was to...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8040508
更新日期:2019-04-13 00:00:00
abstract::(1) Objective: To compare the accuracy of different indexes of adiposity and/or body composition in identifying metabolic syndrome (MetS) in adult patients suffering from Prader‒Willi syndrome (PWS). (2) Study Design: One hundred and twenty PWS patients (69 females and 51 males), aged 29.1 ± 9.4 years, body mass index...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9061646
更新日期:2020-05-30 00:00:00
abstract:BACKGROUND:The thyroid plays a key role in development and homeostasis, but it has been difficult to establish causality with diseases and phenotypic traits because of several potential confounders. METHODS:To determine the causal effect of euthyroid function, we conducted a two-sample Mendelian randomization study of...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm7100296
更新日期:2018-09-21 00:00:00
abstract::In the past, numerous non-operative treatments for adolescent idiopathic scoliosis (AIS), including exercise, physical therapy, electrical stimulation, and brace treatment, have been tried to delay or prevent the curve progression. Of these, brace treatment is the only option that is widely accepted and has demonstrat...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm7060136
更新日期:2018-06-04 00:00:00
abstract::The relation between vitamin-D (VD) status and healing after hip fracture had not been sufficiently addressed. Currently serum total 25-hydroxy-VD (t-25OHD) is the most widely used indicator of VD status. It is unclear whether free or bioavailable VD are better markers of 25OHD availability for tissues. Validity of ov...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm7080193
更新日期:2018-08-01 00:00:00
abstract::This study of parents in Romania explores how perceptions of their couple relationship quality and of factors associated with it (such as sexual communication anxiety and sexual perfectionism) were related to their perception of aspects describing parenting dimensions relevant to the sexual education and sexual health...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8030386
更新日期:2019-03-19 00:00:00
abstract:OBJECTIVE:Clinical presentation of patients with mitral paravalvular leakage (PVL) varies from asymptomatic to heart failure related with hemolytic anemia or pulmonary hypertension. We aimed to investigate the structural and functional characteristics of mitral PVL by multimodal imaging and their association with the s...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm10020222
更新日期:2021-01-10 00:00:00
abstract::Decompensated cirrhosis predisposes to infectious diseases and acute-on-chronic liver failure (ACLF) in critically ill patients. Infections like spontaneous bacterial peritonitis (SBP) are frequently associated with multi-organ failure and increased mortality. Consequently, reliable predictors of outcome and early dia...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9092865
更新日期:2020-09-04 00:00:00
abstract::Irritable bowel syndrome (IBS) is a disorder of the brain-gut axis; the pathophysiological mechanisms include altered colonic motility, bile acid metabolism, neurohormonal regulation, immune dysfunction, alterations in the epithelial barrier and secretory properties of the gut. This article reviews the mechanisms, eff...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm6110101
更新日期:2017-10-27 00:00:00
abstract::Overactivated osteoclasts lead to many bone diseases, including osteoporosis and rheumatoid arthritis. The p38 MAPK (p38) is an essential regulator of the receptor activator of nuclear factor-κB ligand (RANKL)-mediated osteoclastogenesis and bone loss. We previously reported TAT conjugated thioredoxin-interacting prot...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8040431
更新日期:2019-03-29 00:00:00
abstract:BACKGROUND:Inflammation is often considered relating to pediatric obstructive sleep apnea (OSA). We conducted a study investigating cytokines, including Il-17 and Il-23, in children with OSA before and after adenotonsillectomy (T&A), compared with controls. METHODS:Children with OSA between age 4 and 12 receiving T&A ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9041028
更新日期:2020-04-05 00:00:00
abstract::The aim of this study was to assess the efficacy of anti-endomysium antibodies (EMA) as a serological marker for celiac disease (CD) diagnosis in a pediatric population. A retrospective study of pediatric patients who underwent a CD serological markers study: EMA and anti-tissue transglutaminase antibodies (anti-TG2)....
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8122179
更新日期:2019-12-11 00:00:00
abstract::Once thought to be uncommon, celiac disease has now become a common disease globally. While avoidance of the gluten-containing diet is the only effective treatment so far, many new targets are being explored for the development of new drugs for its treatment. The endpoints of therapy include not only reversal of sympt...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm8060885
更新日期:2019-06-21 00:00:00
abstract:BACKGROUND:Abdominal trauma, leading to intra-abdominal bleeding, is a life-threatening condition that might need emergency surgical intervention. Sonography and Computed Tomography (CT) are most commonly used to detect free intra-abdominal fluid. This study investigates the accuracy of CT to distinguish between ascite...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm10010076
更新日期:2020-12-28 00:00:00
abstract:BACKGROUND:The assessment of ovarian reserve in the case of endometrioma is of pivotal importance for planning a tailored management. However, both the antral follicle count (AFC) and the antimüllerian hormone (AMH) dosage are subject to a fair degree of variability in ovarian endometriosis. This study aimed to identif...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9124076
更新日期:2020-12-17 00:00:00
abstract::The number of healthy and frail older adults is increasing worldwide, especially in industrialized countries, as a result of the increase in life expectancy [...]. ...
journal_title:Journal of clinical medicine
pub_type: 社论
doi:10.3390/jcm10020166
更新日期:2021-01-06 00:00:00
abstract:BACKGROUND:Compared to typically developing individuals, individuals with attention-deficit-hyperactivity disorder (ADHD) are on average more often exposed to stressful conditions (e.g., school failure, family conflicts, financial problems). We hypothesized that high exposure to stress relates to a more persistent and ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8111824
更新日期:2019-11-01 00:00:00
abstract::Coronavirus disease 2019 (COVID-19) is a pandemic viral disease originated in Wuhan, China, in December 2019, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The severe form of the disease is often associated with acute respiratory distress syndrome (ARDS), and most critically ill patients ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9092762
更新日期:2020-08-26 00:00:00
abstract:BACKGROUND:Postoperative Acute Kidney Injury (AKI) is a common and serious complication associated with significant morbidity and mortality. While several pre- and intra-operative risk factors for AKI have been recognized in cardiac surgery patients, relatively few data are available regarding the incidence and risk fa...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm7110431
更新日期:2018-11-09 00:00:00
abstract::Branched-chain amino acid (BCAA) and insulin-like growth factor 1 (IGF-1) are essential for muscle protein synthesis. We investigated the association of serum BCAA and IGF-1 levels with sarcopenia and gait speed in 192 patients with liver cirrhosis (LC). Sarcopenia was diagnosed according to the Japan Society of Hepat...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9103239
更新日期:2020-10-10 00:00:00
abstract::There are differences in the incidence, clinical presentation, molecular pathogenesis, and outcome of colorectal cancer (CRC) based on tumor location. Emerging research suggests that the perioperative carcinoembryonic antigen (CEA) ratio (post-op/pre-op CEA) is a prognostic factor for CRC patients. We aimed to determi...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9123848
更新日期:2020-11-27 00:00:00
abstract:BACKGROUND:Hand osteoarthritis (OA) is one of the most common joint diseases, but studies on biomarkers are rare. The aim of this explorative study was (a) to evaluate potential biomarkers of hand OA, (b) to identify an optimal time point to sample venous blood, and (c) to correlate biomarker levels with radiological a...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8101545
更新日期:2019-09-26 00:00:00
abstract::Photodynamic therapy (PDT) is an anticancer strategy utilizing light-mediated activation of a photosensitizer (PS) which has accumulated in tumor and/or surrounding vasculature. Upon activation, the PS mediates tumor destruction through the generation of reactive oxygen species and tumor-associated vasculature damage,...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9020333
更新日期:2020-01-24 00:00:00
abstract::Hyponatremia is the most common electrolyte disorder in clinical practice and is associated with increased morbidity and mortality. It is frequently encountered in hematologic patients with either benign or malignant diseases. Several underlying mechanisms, such as hypovolemia, infections, toxins, renal, endocrine, ca...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9113721
更新日期:2020-11-19 00:00:00