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Gut Microbiota: Implications in Alzheimer's Disease.

Abstract：

:Alzheimer's disease (AD), the most common cause of dementia, is a neurodegenerative disease that seriously threatens human health and life quality. The main pathological features of AD include the widespread deposition of amyloid-beta and neurofibrillary tangles in the brain. So far, the pathogenesis of AD remains elusive, and no radical treatment has been developed. In recent years, mounting evidence has shown that there is a bidirectional interaction between the gut and brain, known as the brain-gut axis, and that the intestinal microbiota are closely related to the occurrence and development of neurodegenerative diseases. In this review, we will summarize the laboratory and clinical evidence of the correlation between intestinal flora and AD, discuss its possible role in the pathogenesis, and prospect its applications in the diagnosis and treatment of AD.

journal_name

J Clin Med

journal_title

Journal of clinical medicine

authors

He Y,Li B,Sun D,Chen S

doi

10.3390/jcm9072042

subject

Has Abstract

pub_date

2020-06-29 00:00:00

issue

7

issn

2077-0383

pii

jcm9072042

journal_volume

9

pub_type

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