Abstract：
:Joint bleeding represents the most commonly reported type of hemorrhage in patients affected by hemophilia. Although the widespread use of prophylaxis has been able to significantly reduce the onset of arthropathy, it has been shown that a non-negligible percentage of patients develop degenerative changes in their joints despite this type of treatment. Thus, periodic monitoring of the joint status in hemophilia patients has been recommended to identify early arthropathic changes and prevent the development or progression of hemophilic arthropathy. Ultrasound (US) has proven able to detect and quantify the most relevant biomarkers of disease activity (i.e., joint effusion and synovial hypertrophy) and degenerative damages (i.e., osteo-chondral changes) by means of scoring scales of increasing disease severity. In the present review, we have detailed major literature evidence about the use of US to assess joint status in hemophilia patients, focusing on signs of disease activity and degenerative damages. In particular, we have discussed recent evidence about "point-of-care" use patients with hemophilia.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Di Minno MND,Pasta G,Airaldi S,Zaottini F,Storino A,Cimino E,Martinoli Cdoi
10.3390/jcm6080077subject
Has Abstractpub_date
2017-07-31 00:00:00issue
8issn
2077-0383pii
jcm6080077journal_volume
6pub_type
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