Abstract：
:One in every four deaths is due to cancer in Europe. In view of its increasing incidence, cancer became the leading cause of death and disease burden in Denmark, France, the Netherlands, and the UK. Without essential improvements in cancer prevention, an additional 775,000 cases of annual incidence have been prognosed until 2040. Between 1995 and 2018, the direct costs of cancer doubled from EUR 52 billion to EUR 103 billion in Europe, and per capita health spending on cancer increased by 86% from EUR 105 to EUR 195 in general, whereby Austria, Germany, Switzerland, Benelux, and France spend the most on cancer care compared to other European countries. In view of the consequent severe socio-economic burden on society, the paradigm change from a reactive to a predictive, preventive, and personalized medical approach in the overall cancer management is essential. Concepts of predictive, preventive, and personalized medicine (3PM) demonstrate a great potential to revise the above presented trends and to implement cost-effective healthcare that benefits the patient and society as a whole. At any stage, application of early and predictive diagnostics, targeted prevention, and personalization of medical services are basic pillars making 3PM particularly attractive for the patients as well as ethical and cost-effective healthcare. Optimal 3PM approach requires novel instruments such as well-designed liquid biopsy application. This review article highlights current achievements and details liquid biopsy approaches specifically in cancer management. 3PM-relevant expert recommendations are provided.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Liskova A,Samec M,Koklesova L,Giordano FA,Kubatka P,Golubnitschaja Odoi
10.3390/jcm9092749subject
Has Abstractpub_date
2020-08-25 00:00:00issue
9issn
2077-0383pii
jcm9092749journal_volume
9pub_type
杂志文章,评审abstract：:Electrical enabling motor control (eEmc) through transcutaneous spinal cord stimulation is a non-invasive method that can modify the functional state of the sensory-motor system. We hypothesize that eEmc delivery, together with hand training, improves hand function in healthy subjects more than either intervention alo...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
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abstract：BACKGROUND:The clinical practice shows that many low-dose ACTH-stimulation tests have a false positive result. The aim of the study was to determine the diagnostic accuracy of a low-dose ACTH-stimulation test in the diagnosis of adrenal insufficiency and to define its optimal cut-off. METHODS:We analyzed data from 103...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8060806
更新日期：2019-06-05 00:00:00
abstract：:Bronchiectasis and asthma may share some characteristics and some patients may have both conditions. The present study aimed to examine the rationale of prophylactic inhaled corticosteroids (ICS) prescription in children with bronchiectasis. Data of children with radiologically established bronchiectasis were retrospe...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
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更新日期：2020-12-11 00:00:00
abstract：:Background: Urinary calprotectin is a novel biomarker that distinguishes between intrinsic or prerenal acute kidney injury (AKI) in different studies. However, these studies were based on different populations and different AKI criteria. We evaluated the diagnostic accuracy of urinary calprotectin and compared its dia...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
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更新日期：2019-01-10 00:00:00
abstract：:The purpose of this study was to compare the thickness of all inner and outer macular layers between ocular hypertension (OHT) and early primary open-angle glaucoma (POAG) using spectral domain optical coherence tomography (SD-OCT) 8 × 8 posterior pole algorithm (8 × 8 PPA). Fifty-seven eyes of 57 OHT individuals and ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9051503
更新日期：2020-05-16 00:00:00
abstract：:This study aimed at evaluating the clinical relevance of glycoprotein profiles during the earliest phases of rheumatoid arthritis (RA) as biomarkers of cardiovascular (CV) risk and treatment response. Then, GlycA and GlycB serum levels were measured using 1H-nuclear magnetic resonance in 82 early RA patients, 14 clini...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9082472
更新日期：2020-08-01 00:00:00
abstract：:A major challenge of cell-based therapy for cartilage lesions is the preservation of the chondrogenic phenotype during ex vivo cell cultivation. In this in vitro study, the chondro-inductive capacity of two different hyaline cartilage-conditioned cell culture media on human chondrocytes in 3D spheroids was determined....
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9092798
更新日期：2020-08-30 00:00:00
abstract：BACKGROUND:Wolf-Hirschhorn syndrome (WHS) is a rare disease caused by deletion in the distal moiety of the short arm of chromosome 4. The objectives of this study were to report the most representative oral findings of WHS, relate them with other clinical characteristics of the disease, and establish possible phenotype...
journal_title：Journal of clinical medicine
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更新日期：2020-11-04 00:00:00
abstract：:In the statin era, the incidence of atherosclerotic cardiovascular diseases (ASCVD) in patients with familial hypercholesterolemia (FH) has not been updated. We aimed to determine the incidence of ASCVD in patients with FH-phenotype (FH-P) and to compare it with that of normal low-density lipoprotein cholesterol (LDL-...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8071080
更新日期：2019-07-23 00:00:00
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journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm6050054
更新日期：2017-05-19 00:00:00
abstract：:Inflammatory bowel diseases (IBDs) may be associated with extra-intestinal manifestations. Among these, mucocutaneous manifestations are relatively frequent, often difficult to diagnose and treat, and may complicate the course of the underlying disease. In the present review, a summary of the most relevant literature ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
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更新日期：2021-01-19 00:00:00
abstract：:Decompensated cirrhosis predisposes to infectious diseases and acute-on-chronic liver failure (ACLF) in critically ill patients. Infections like spontaneous bacterial peritonitis (SBP) are frequently associated with multi-organ failure and increased mortality. Consequently, reliable predictors of outcome and early dia...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9092865
更新日期：2020-09-04 00:00:00
abstract：:Increased the incidence of prediabetes and type 2 diabetes (T2D) worldwide raises an urgent need to develop effective tools for early disease detection to facilitate future preventive interventions and improve patient's care. We evaluated the suitability of diabetes-related miR-375 and miR-9 as earlier biomarkers for ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7020012
更新日期：2018-01-26 00:00:00
abstract：:Diabetic nephropathy (DN) often develops in patients suffering from type 1 or type 2 diabetes mellitus. DN is characterized by renal injury resulting in proteinuria. Neuropilin-1 (NRP-1) is a single-pass transmembrane receptor protein devoid of enzymatic activity. Its large extracellular tail is structured in several ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm4061293
更新日期：2015-06-17 00:00:00
abstract：:Mixed neuroendocrine non-neuroendocrine neoplasms (MiNENs) represent a rare diagnosis of the gastro-entero-pancreatic tract. Evidence from the current literature regarding their epidemiology, biology, and management is of variable quality and conflicting. Based on available data, the MiNEN has an aggressive biological...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9010273
更新日期：2020-01-19 00:00:00
abstract：:Sodium glucose co-transporter 2 (SGLT2) inhibitors reduce the risk of heart and kidney failure in patients with type 2 diabetes, possibly due to diuretic effects. Previous non-placebo-controlled studies with SGLT2 inhibitors observed changes in volume markers in healthy individuals and in patients with type 2 diabetes...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8060779
更新日期：2019-05-31 00:00:00
abstract：:Background: Due to the higher frequency of ischemic stroke in men compared to women, we aimed to determine if gender differences exist regarding periodontal status and several plasma biomarkers in patients with a recent large artery atherosclerosis ischemic stroke (IS). Material and methods: Patients with their first ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9061744
更新日期：2020-06-04 00:00:00
abstract：:Purpose: This study aimed to evaluate the effects of a child-centered exergaming program and a traditional teacher-led physical activity (PA) program on preschoolers' executive functions and perceived competence. Methods: Sixty children aged 4⁻5 years from an urban childcare center in China completed an 8-week exergam...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8040469
更新日期：2019-04-06 00:00:00
abstract：:This study aimed to develop a prognosis-predicting model based on [18F]fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) and clinicopathologic factors in locally advanced cervical cancer patients treated with concurrent chemoradiotherapy (CCRT). The medical records of 270 locally adv...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9020427
更新日期：2020-02-05 00:00:00
abstract：:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causal agent of coronavirus disease 2019 (COVID-19), first emerged in Wuhan, China. The clinical manifestations of patients infected with COVID-19 include fever, cough, and dyspnea, up to acute respiratory distress syndrome (ARDS) and acute cardiac inju...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9124057
更新日期：2020-12-15 00:00:00
abstract：:Pancreatic ductal adenocarcinoma (PDA) is notorious for its poor prognosis. The current mainstay of treatment for PDA is surgical resection followed by adjuvant chemotherapy. However, it is difficult to predict the post-operative outcome because of the lack of reliable markers. The single-nucleotide polymorphism (SNP)...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8122225
更新日期：2019-12-16 00:00:00
abstract：OBJECTIVES:The purpose of this study was to evaluate the effectiveness of the intraoral use of subperiosteally placed self-inflating tissue expanders for subsequent bone augmentation and implant integrity. MATERIAL AND METHODS:A prospective, multicenter, randomized controlled trial was performed on patients requiring ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9041143
更新日期：2020-04-16 00:00:00
abstract：:Ticagrelor, an antiplatelet adenosine diphosphate (ADP)-P2Y12 receptor antagonist, increases the risk of bleeding. Its management is challenging because platelet transfusion is ineffective and no specific antidote is currently available. Epinephrine, a vasopressor catecholamine prescribed during shock, restores platel...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9030809
更新日期：2020-03-16 00:00:00
abstract：:Recent advances in molecular genetic technologies have facilitated non-invasive prenatal testing (NIPT) through the analysis of cell-free fetal DNA in maternal plasma. NIPT can be used to identify monogenic disorders including the identification of autosomal recessive disorders where the maternally inherited mutation ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm3020537
更新日期：2014-05-21 00:00:00
abstract：:Background: We performed this prospective double-blind randomized controlled trial to identify the effect of a preoperative prophylactic transdermal scopolamine (TDS) patch on postoperative nausea and vomiting (PONV) after retromastoid craniectomy with microvascular decompression (RMC-MVD). Methods: We recruited 38 pa...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9010156
更新日期：2020-01-07 00:00:00
abstract：:We aimed to examine the usefulness of serum glutathione peroxidase 3 (GPx3) as a biomarker of lung cancer recurrence after complete resection. We prospectively collected serial serum samples at the baseline, as well as 3, 6 and 12 months after surgery from complete resection cases in 2013. GPx3 levels were measured by...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9123801
更新日期：2020-11-24 00:00:00
abstract：:Cardiovascular disease (CVD) is the number one cause of deaths worldwide, with yearly deaths due to atherothrombosis-i [...]. ...
journal_title：Journal of clinical medicine
pub_type： 社论
doi：10.3390/jcm8111895
更新日期：2019-11-06 00:00:00
abstract：:Background The use of computed tomography (CT) for coronavirus disease 2019 (COVID-19) diagnosis in an area of northern Italy with a high incidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may have identified more patients with this disease than RT-PCR in the very early onset of the CO...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9123935
更新日期：2020-12-04 00:00:00
abstract：:Coronary artery calcification (CAC) is a feature of coronary atherosclerosis and a well-known risk factor for cardiovascular disease (CVD). As the absence of CAC is associated with a lower incidence rate of CVD, measurement of a CAC score is helpful for risk stratification when the risk decision is uncertain. This was...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm10030457
更新日期：2021-01-25 00:00:00
abstract：:: Protein-bound uremic toxin is a cardiovascular (CV) risk factor for patients with end-stage renal disease. Indole-3-acetic acid (IAA) was found to be associated with CV disease but the detailed pathophysiology remains unknown. Moreover, mitogen-activated protein kinase (MAPK) signaling cascades play an important rol...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9010124
更新日期：2020-01-02 00:00:00
