Abstract：
:Cardiovascular disease (CVD) is the number one cause of deaths worldwide, with yearly deaths due to atherothrombosis-i [...].
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Di Minno A,Stornaiuolo M,Novellino Edoi
10.3390/jcm8111895subject
Has Abstractpub_date
2019-11-06 00:00:00issue
11issn
2077-0383pii
jcm8111895journal_volume
8pub_type
社论abstract：:The endogenous PP2A inhibitor SET Nuclear Proto-Oncogene (SET) has been reported to play oncogenic roles and determines poor outcomes in colorectal cancer (CRC). Our group previously showed that miR-199b is deregulated in metastatic CRC, and reduced the cell viability and enhanced the sensitivity of CRC cells to stand...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9082419
更新日期：2020-07-28 00:00:00
abstract：:The repurposing of colchicine for the treatment of COVID-19 was suggested based in its immunomodulatory, anti-inflammatory, and anti-viral properties. We performed a single-center propensity score matched cohort study, including all consecutive COVID-19 patients admitted to a community hospital between 1 March 2020 an...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9092961
更新日期：2020-09-14 00:00:00
abstract：:Despite the excellent overall survival (OS) of patients with chronic myeloid leukemia (CML), a significant proportion will not achieve optimal response to imatinib or second-generation tyrosine kinase inhibitors (2GTKI). For patients with inadequate response to 2GTKIs, alternative 2GTKIs or ponatinib are widely availa...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9072251
更新日期：2020-07-15 00:00:00
abstract：:The aim of this study was to investigate whether early intermittent electroencephalography (EEG) could be used to predict neurological prognosis of patients who underwent extracorporeal cardiopulmonary resuscitation (ECPR). This was a retrospective and observational study of adult patients who were evaluated by EEG sc...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9061745
更新日期：2020-06-04 00:00:00
abstract：:In the United States, one out of every 500 African American children have sickle cell disease (SCD), and SCD affects approximately 100,000 Americans. Significant advances in the treatment of this monogenetic disorder have failed to substantially extend the life expectancy of adults with SCD over the past two decades. ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8111997
更新日期：2019-11-15 00:00:00
abstract：:The investigation of the potential association between ischemic stroke and subclinical atrial fibrillation (SCAF) is important for secondary prevention. We aimed to determine whether SCAF can be predicted by atrial substrate measurement with P wave signal-averaged electrocardiography (SAECG). We recruited 125 consecut...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9041134
更新日期：2020-04-15 00:00:00
abstract：:Several conditions can lead to the development of a subchondral cyst. The mechanism by which the cysts form, their location, and their severity depend on the underlying pathology, although the exact pathogenesis is not fully elucidated. Treatment options vary according to the location of the cyst, with less invasive p...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9051358
更新日期：2020-05-06 00:00:00
abstract：:We aim to examine how season and temperature levels affect physical activity using a wearable device among patients scheduled to undergo surgical resection of lung cancer. Physical activity (PA) data from the wearable device were analyzed by seasons for 555 preoperative lung cancer patients from the CATCH-LUNG cohort ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9020349
更新日期：2020-01-27 00:00:00
abstract：:The clinical use of virtual reality (VR) has proven its efficacy, especially when used as an exposure technique. A prominent property of VR's utility is its equivalence with the reality it represents. In this study, we explored this equivalence in a clinical context using neuroimaging. A sample of 32 adults with speci...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8122139
更新日期：2019-12-04 00:00:00
abstract：:Schizophrenia is a multifactorial disease associated with widespread cognitive impairment. Although cognitive deficits are one of the factors most strongly associated with functional impairment in schizophrenia (SZ), current treatment strategies hardly tackle these impairments. To develop more efficient treatment stra...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9020341
更新日期：2020-01-25 00:00:00
abstract：BACKGROUND:The heat produced during implant site osteotomy can potentially interfere with and influence the osseointegration process of a dental implant. The objective of this in vitro investigation was to measure the temperature changes during simulated osteotomies in bovine rib bone. The measurements were made at the...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9010148
更新日期：2020-01-05 00:00:00
abstract：:Acute kidney injury and renal failure are common after heart transplantation. We retrospectively reviewed a national cohort and identified 1129 heart transplant patients. Patients receiving renal replacement therapy after heart transplantation were grouped into the dialysis cohort. The long-term survival and risk fact...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9082455
更新日期：2020-07-31 00:00:00
abstract：:Although the use of oral administration of pharmacological all-trans retinoic acid (ATRA) concentration in acute promyelocytic leukaemia (APL) patients was approved for over 20 years and used as standard therapy still to date, the same use in solid cancers is still controversial. In the present review the literature a...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9020360
更新日期：2020-01-28 00:00:00
abstract：:Photodynamic therapy (PDT) is an anticancer strategy utilizing light-mediated activation of a photosensitizer (PS) which has accumulated in tumor and/or surrounding vasculature. Upon activation, the PS mediates tumor destruction through the generation of reactive oxygen species and tumor-associated vasculature damage,...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9020333
更新日期：2020-01-24 00:00:00
abstract：BACKGROUND:The aim of this study was to investigate the association between acute kidney injury (AKI) and in-hospital mortality (IHM) in a large nationwide cohort of elderly subjects in Italy. METHODS:We analyzed the hospitalization data of all patients aged ≥65 years, who were discharged with a diagnosis of AKI, whic...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8091371
更新日期：2019-09-02 00:00:00
abstract：:Epileptic seizures in critically ill patients represent a major source of concern, because they are associated with significant mortality and morbidity rates. Despite recent advances that have enabled a better understanding of the global epidemiology of this entity, epileptic seizures in critically ill patients remain...
journal_title：Journal of clinical medicine
pub_type： 社论
doi：10.3390/jcm9072218
更新日期：2020-07-13 00:00:00
abstract：:Epistaxis is a common debilitating manifestation in hereditary hemorrhagic telangiectasia (HHT), due to mucocutaneous telangiectases. The epistaxis can be difficult to control despite available treatments. Dysregulated angiogenesis has been shown to be associated with telangiectases formation. Topical propranolol has ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9103130
更新日期：2020-09-28 00:00:00
abstract：:Thyroid follicular cells, as well as adrenocortical cells, are endowed by an intrinsic heterogeneity regarding their growth potential, in response to various stimuli. This heterogeneity appears to constitute the underlying cause for the focal cell hyperplasia and eventually the formation of thyroid and adrenal nodules...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm7030037
更新日期：2018-02-26 00:00:00
abstract：:Abnormalities in body composition are associated with poor prognosis in cancer patients. We investigated the association between body composition and 90-day mortality in cancer patients who developed septic shock. We included consecutive septic shock patients with active cancer from 2010 to 2017. The muscle area at th...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8101583
更新日期：2019-10-02 00:00:00
abstract：PURPOSE:Evasion of the immune system by cancer cells allows for the progression of tumors. Antitumor immunotherapy has shown remarkable effects in a diverse range of cancers. The aim of this study was to determine the clinicopathological significance of human epidermal growth factor receptor 2 (HER2), indoleamine 2,3-d...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9051265
更新日期：2020-04-27 00:00:00
abstract：:Metabolic Syndrome (MetS) contributes to the development of cardiovascular disease (CVD) and type II diabetes mellitus (T2DM). Few studies have investigated the MetS risk of young adults (18⁻24 years old). This study aims to determine the prevalence of MetS in Appalachian and non-Appalachian students attending West Vi...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7120487
更新日期：2018-11-27 00:00:00
abstract：:The vasodilator-associated stimulated phosphoprotein (VASP) phosphorylation level is a highly specific method to assess P2Y12 receptor inhibition. Traditionally, VASP phosphorylation is analyzed by flow cytometry, which is laborious and restricted to specialized laboratories. Recently, a simple ELISA kit has been comm...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9020332
更新日期：2020-01-24 00:00:00
abstract：:Microbial contamination could compromise the stability of dental implants increasing the risk of inflammatory reactions in the surrounding soft tissues. In this human, randomized, double-blind, clinical study, the presence of Porphyromonas gingivalis on the healing abutment and the inflammatory infiltrate surrounding ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9010284
更新日期：2020-01-20 00:00:00
abstract：:(1) Background: To evaluate women's satisfaction with the care received during childbirth undergoing labour and how this changes over time. (2) Methods: An observational, multicentre and longitudinal study in two public hospitals of Spain with a convenience sample of 248 women during the post-partum period. Satisfacti...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8040434
更新日期：2019-03-29 00:00:00
abstract：:The nociceptive withdrawal reflex (NWR) is used to probe spinal cord excitability in chronic pain states. Here, we used an automated and unbiased procedure for determining the NWR threshold and compared the reflex thresholds and corresponding pain ratings in a well-characterized cohort of fibromyalgia (n = 29) and mat...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9061992
更新日期：2020-06-25 00:00:00
abstract：:Improving transgender people's quality of life (QoL) is the most important goal of gender-affirming care. Prospective changes in affect can influence QoL. We aim to assess the impact of initiating gender-affirming hormonal treatment (HT) on affect. In the European Network for the Investigation of Gender Incongruence (...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm10020296
更新日期：2021-01-14 00:00:00
abstract：:To demonstrate the association of the serum creatinine/serum cystatin C ratio (sarcopenia index, SI) with clinical outcomes including cardiovascular and bleeding risk in older patients who underwent percutaneous coronary intervention (PCI), we analyzed a multicenter nation-wide pooled registry. A total of 1086 older p...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9103121
更新日期：2020-09-27 00:00:00
abstract：:TPK1 mutations are a rare, but potentially treatable, cause of thiamine deficiency. Diagnosis is challenging given the phenotypic overlap that exists with other metabolic and neurological disorders. We report a case of TPK1-related disease presenting with Leigh-like syndrome and review the diagnostic utility of thiami...
journal_title：Journal of clinical medicine
pub_type：
doi：10.3390/jcm8070991
更新日期：2019-07-08 00:00:00
abstract：:(1) Background: This study evaluated the perioperative red blood cell (RBC) transfusion need and determined predictors for transfusion in patients undergoing elective primary lumbar posterior spine fusion in a high-volume center for spine surgery. (2) Methods: Data from all patients undergoing spine surgery between 1 ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7020019
更新日期：2018-01-30 00:00:00
abstract：:Elevated distractibility is one of the major contributors to alcohol hangover-induced behavioral deficits. Yet, the basic mechanisms driving increased distractibility during hangovers are still not very well understood. Aside from impairments in attention and psychomotor functions, changes in stimulus-response binding...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9030778
更新日期：2020-03-12 00:00:00
