Abstract：
:The repurposing of colchicine for the treatment of COVID-19 was suggested based in its immunomodulatory, anti-inflammatory, and anti-viral properties. We performed a single-center propensity score matched cohort study, including all consecutive COVID-19 patients admitted to a community hospital between 1 March 2020 and 30 May 2020. Patients were stratified according to the receipt of colchicine. The primary endpoint was defined as in-hospital death within 28-days follow-up. Secondary endpoints included favorable change in the Ordinal Scale for Clinical Improvement on days 14 and 28 versus baseline, proportion of patients not requiring supplemental oxygen on days 14 and 28, and proportion of patients discharged by day 28. In total data for 303 PCR positive COVID-19 patients were extracted and 66 patients were included in the 1:1 matched cohort study. At the end of the 28 day follow-up, patients receiving colchicine were approximately five times more likely to be discharged (odds ratio, 5.0; 95% confidence interval, 1.25-20.1; p = 0.023) and when comparing mortality, there were 3 deaths (9.1%) in patients receiving colchicine versus 11 deaths (33.3%) in the groups receiving standard of care (odds ratio, 0.20; 95% confidence interval, 0.05-0.80; p = 0.023). These observations warrant further investigation in large controlled clinical trials.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Brunetti L,Diawara O,Tsai A,Firestein BL,Nahass RG,Poiani G,Schlesinger Ndoi
10.3390/jcm9092961subject
Has Abstractpub_date
2020-09-14 00:00:00issue
9issn
2077-0383pii
jcm9092961journal_volume
9pub_type
杂志文章abstract：:Endometriosis concerns more than 10% of women of reproductive age, frequently leading to chronic pelvic pain. Repetitive transcranial magnetic stimulation (rTMS) over the primary motor cortex (M1) induces an analgesic effect. This effect on chronic pelvic pain is yet to be evaluated. The objective of this study was to...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8040508
更新日期：2019-04-13 00:00:00
abstract：BACKGROUND:Pyogenic liver abscess (LA) is difficult to distinguish from intrahepatic mass-forming cholangiocarcinoma (IMCC) in the emergency department (ED). We evaluated the predictive ability of white blood cells (WBC) and C-reactive protein (CRP) levels, neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte r...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9103194
更新日期：2020-10-01 00:00:00
abstract：BACKGROUND:Wolf-Hirschhorn syndrome (WHS) is a rare disease caused by deletion in the distal moiety of the short arm of chromosome 4. The objectives of this study were to report the most representative oral findings of WHS, relate them with other clinical characteristics of the disease, and establish possible phenotype...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9113556
更新日期：2020-11-04 00:00:00
abstract：:(1) Background: This study evaluated the perioperative red blood cell (RBC) transfusion need and determined predictors for transfusion in patients undergoing elective primary lumbar posterior spine fusion in a high-volume center for spine surgery. (2) Methods: Data from all patients undergoing spine surgery between 1 ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7020019
更新日期：2018-01-30 00:00:00
abstract：:Noninvasive ventilation (NIV) during exercise has been suggested to sustain higher training intensity but the type of NIV interface, patient-ventilator asynchronies (PVA) or technological limitation of the ventilator may interfere with exercise. We assessed whether these parameters affect endurance exercise capacity i...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9041054
更新日期：2020-04-08 00:00:00
abstract：:The neuropsychiatric symptoms of multiple sclerosis (MS), such as anxiety and depression, can result from disease activity itself as well as psychological reaction to an unfavorable diagnosis. Accordingly, the literature reports evidence of increased anxiety-like behavior in experimental autoimmune encephalomyelitis (...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8020162
更新日期：2019-02-01 00:00:00
abstract：:(1) Background: To evaluate women's satisfaction with the care received during childbirth undergoing labour and how this changes over time. (2) Methods: An observational, multicentre and longitudinal study in two public hospitals of Spain with a convenience sample of 248 women during the post-partum period. Satisfacti...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8040434
更新日期：2019-03-29 00:00:00
abstract：:The development of new HER2-directed therapies has resulted in a significant prolongation of survival for women with metastatic HER2-positive breast cancer. Discoveries in the laboratory inform clinical trials which are the basis for improving the standard of care and are also the backbone for quality improvement. Cli...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9061984
更新日期：2020-06-24 00:00:00
abstract：:Rheumatoid arthritis is a chronic inflammatory disease characterized by the development of osseous and cartilaginous damage. The correct differentiation between a true erosion and other entities-then often called "pseudoerosions"-is essential to avoid misdiagnosing rheumatoid arthritis and to correctly interpret the p...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8122174
更新日期：2019-12-09 00:00:00
abstract：:The aim of this study was to compare surgical and refractive outcomes between phacotrabeculectomy (P-Trab) and phaco with Ex-PRESS (P-Ex-PRESS) for glaucoma at a 6-month follow-up. This prospective randomized controlled trial included 81 eyes; 43 eyes (53%) and 38 eyes (47%) were assigned to the P-Ex-PRESS and P-Trab ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm10030424
更新日期：2021-01-22 00:00:00
abstract：:Maternal and pediatric delivery outcomes may vary in patients who underwent open fetal myelomeningocele repair and elected to deliver at the fetal center where their fetal intervention was performed versus at the referring physician's hospital. A prospective cohort study of 88 patients were evaluated following in uter...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9113443
更新日期：2020-10-27 00:00:00
abstract：:This study investigated physical activity (PA) and sedentary time (SED) in relation to hippocampal gray matter volume (GMV) in pediatric overweight/obesity. Ninety-three children (10 ± 1 year) were classified as overweight, obesity type I, or type II-III. PA was assessed with non-dominant wrist accelerometers. GMV was...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9041080
更新日期：2020-04-10 00:00:00
abstract：:Using the Taguchi method to narrow experimental parameters, the antimicrobial efficiency of a cold atmospheric plasma jet (CAPJ) treatment was investigated. An L9 array with four parameters of CAPJ treatments, including the application voltage, CAPJ-sample distance, argon (Ar) gas flow rate, and CAPJ treatment time, w...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8111930
更新日期：2019-11-09 00:00:00
abstract：:Age-related macular degeneration is the leading cause of blindness in the developed world. Since advanced glycation end products (AGEs) are implicated in the pathogenesis of AMD through various lines of evidence, we investigated the potential of fructosamine-3-kinase (FN3K) in the disruption of retinal AGEs, drusenoid...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9092869
更新日期：2020-09-04 00:00:00
abstract：:Cognitive models of pain propose that catastrophic thinking is negatively associated with chronic pain. However, pain catastrophizing is a complex phenomenon requiring a multivariate examination. This study estimates the effects of mood variables (anxiety and depression) on pain catastrophizing in older adults with ch...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9072073
更新日期：2020-07-01 00:00:00
abstract：BACKGROUND:The aim of this study was to investigate the association between acute kidney injury (AKI) and in-hospital mortality (IHM) in a large nationwide cohort of elderly subjects in Italy. METHODS:We analyzed the hospitalization data of all patients aged ≥65 years, who were discharged with a diagnosis of AKI, whic...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8091371
更新日期：2019-09-02 00:00:00
abstract：:In recent years, the genetic architecture of dilated cardiomyopathy (DCM) has been more thoroughly elucidated. However, there is still insufficient knowledge on the modifiers and regulatory principles that lead to the failure of myocardial function. The current study investigates the association of epigenome-wide DNA ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9051499
更新日期：2020-05-16 00:00:00
abstract：:Multidrug resistant Gram-Negative Bacterial Infections (MR-GNBI) are an increasing cause of mortality in acute myeloid leukemia (AML), compromising the success of antineoplastic therapy. We prospectively explored a novel strategy, including mandatory fluoroquinolone prophylaxis, weekly surveillance cultures (SC) and t...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8111985
更新日期：2019-11-15 00:00:00
abstract：:We aimed to test the association between low-density lipoprotein cholesterol (LDL-C) and cardiovascular disease (CVD), cancer, and all-cause mortality in non-statin users. A total of 347,971 subjects in Kangbuk Samsung Health Study (KSHS.57.4% men, mean follow up: 5.64 ± 3.27 years) were tested. To validate these asso...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8101571
更新日期：2019-10-01 00:00:00
abstract：:Transplant-related liver complications are a potentially fatal condition of hematopoietic stem cell transplantation (HSCT) in pediatric patients, actually representing one of the main factors involved in transplant-related mortality (TRM). The search for a specific marker capable of predicting the development of this ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8060825
更新日期：2019-06-10 00:00:00
abstract：:Intraovarian platelet-rich plasma (PRP) infusion was recently introduced in the context of addressing ovarian insufficiency. Reporting on its effectiveness prior to adopting in clinical routine practice is imperative. This study aims to provide pilot data regarding PRP application for ovarian rejuvenation. Four pilot ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9061809
更新日期：2020-06-10 00:00:00
abstract：BACKGROUND:Currently, proposed nomograms are mainly based on post-operative histopathology. The purpose of this study was to identify preoperative computed tomography (CT) and clinical information that allow prediction of disease-free (DFS) and overall survival (OS) of patients surgically treated for pancreatic head ca...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8101749
更新日期：2019-10-21 00:00:00
abstract：:Descriptive and retrospective studies without control groups have suggested a possible association between primary Sjögren's syndrome (pSS) and vitamin B12 (B12) deficiency. This is of importance because several mucosal and neurological features are common to these two conditions and could be prevented or reversed in ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9124063
更新日期：2020-12-16 00:00:00
abstract：:Limited information is available regarding interstitial lung disease (ILD) in Erdheim⁻Chester disease (ECD), a rare multisystemic non-Langerhans cell histiocytosis. Sixty-two biopsy-confirmed ECD patients were divided into those with no ILD (19.5%), minimal ILD (32%), mild ILD (29%), and moderate/severe ILD (19.5%), b...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7090243
更新日期：2018-08-28 00:00:00
abstract：:The relationship between obesity and asthma exacerbations is still under debate. The aim of our work is to analyse the relationship between obesity and hospital re-admissions in asthmatics. A review was retrospectively performed on all hospital admissions of adult patients due to asthma exacerbation occurring in our h...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9010221
更新日期：2020-01-14 00:00:00
abstract：:To date, studies have highlighted cross-sectional and unidirectional prospective relationships between problem gambling and mental health symptoms or substance use. The current study aims to: (1) examine the reciprocal relationships between problem gambling and mental health symptoms (depression, generalized anxiety)/...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8111888
更新日期：2019-11-06 00:00:00
abstract：:Our aim was to illustrate our technique of sex-sparing (SS)-robot-assisted radical cystectomy (RARC) in female patients receiving an intracorporeal neobladder (iN). From January 2013 to June 2018, 11 female patients underwent SS-RARC-iN at a single tertiary referral center. Inclusion criteria were a cT ≤ 2 N0 M0 bladd...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9020577
更新日期：2020-02-20 00:00:00
abstract：:The geographic spread of 2019 novel coronavirus (COVID-19) infections from the epicenter of Wuhan, China, has provided an opportunity to study the natural history of the recently emerged virus. Using publicly available event-date data from the ongoing epidemic, the present study investigated the incubation period and ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9020538
更新日期：2020-02-17 00:00:00
abstract：:To analyse the predictive ability and incremental value of left ventricular longitudinal axis strain (LAS) and late gadolinium enhancement (LGE) using standard cardiovascular magnetic resonance (CMR) imaging for the diagnosis and prognosis of severe aortic stenosis (AS) in patients with an indication for aortic valve ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8020165
更新日期：2019-02-01 00:00:00
abstract：:The recent advances in machine perfusion (MP) technology involve settings ranging between hypothermic, subnormothermic, and normothermic temperatures. Tissue level adenosine triphosphate (ATP) is a long-established marker of viability and functionality and is universal for all organs. In the midst of a growing number ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8091421
更新日期：2019-09-09 00:00:00
