Abstract:
:The neuropsychiatric symptoms of multiple sclerosis (MS), such as anxiety and depression, can result from disease activity itself as well as psychological reaction to an unfavorable diagnosis. Accordingly, the literature reports evidence of increased anxiety-like behavior in experimental autoimmune encephalomyelitis (EAE), an accepted MS model. Due to the recently described critical role of platelets in inflammation and autoimmune disease, we examined the relationship between platelets, inflammation, and anxiety-like behavior in EAE. In the elevated plus maze, EAE-induced C57BL/6J mice showed decreased time spent in the open arms relative to vehicle-only controls, demonstrating an increase in anxiety-like behavior. This effect occurred in the presence of platelet⁻neuron association, but absence of lymphocytic infiltration, in the hippocampal parenchyma. Platelet depletion at the pre-clinical disease stage, using antibody-mediated lysis prevented the EAE-induced increase in anxiety-like behavior, while no significant difference in distance moved was recorded. Furthermore, platelet depletion was also associated with reduction of the pro-inflammatory environment to control levels in the hippocampus and prevention of EAE disease symptomology. These studies demonstrate the high efficacy of a platelet-targeting approach in preventing anxiety-like symptoms and clinical manifestations of EAE and have implications for the treatment of neuropsychiatric symptoms in MS.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Kocovski P,Jiang X,D'Souza CS,Li Z,Dang PT,Wang X,Chen W,Peter K,Hale MW,Orian JMdoi
10.3390/jcm8020162subject
Has Abstractpub_date
2019-02-01 00:00:00issue
2issn
2077-0383pii
jcm8020162journal_volume
8pub_type
杂志文章abstract::Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the global coronavirus disease 2019 (COVID-19) outbreak. Along with the respiratory tract, the gastrointestinal (GI) tract is one of the main extra-pulmonary targets of SARS-CoV-2 with respect to symptom occurrence and is a potential route fo...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9113630
更新日期:2020-11-11 00:00:00
abstract:OBJECTIVE:To investigate the risk and risk factors for suicide attempt by patients with regular migraines (RM) and status migrainosus (SM) in Taiwan. METHODS:We analyzed a subset of the National Health Insurance Research Database of Taiwan and enrolled patients (≥20 years old) who had ever received a diagnosis of RM o...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm7090269
更新日期:2018-09-11 00:00:00
abstract::Reprogramming somatic cells to induced pluripotent stem cells (iPSCs) or direct reprogramming to desired cell types are powerful and new in vitro methods for the study of human disease, cell replacement therapy, and drug development. Both methods to reprogram cells are unconstrained by the ethical and social questions...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
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更新日期:2014-04-04 00:00:00
abstract::Diabetic foot ulcers (DFUs) and diabetic foot infections (DFIs) are associated with reduced patient quality of life, lower-extremity amputation, hospitalization, and high morbidity and mortality. Diverse bacterial communities have been identified in DFUs/DFIs, playing a significant role in infection prognosis. However...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm8111935
更新日期:2019-11-10 00:00:00
abstract::Microbial contamination could compromise the stability of dental implants increasing the risk of inflammatory reactions in the surrounding soft tissues. In this human, randomized, double-blind, clinical study, the presence of Porphyromonas gingivalis on the healing abutment and the inflammatory infiltrate surrounding ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9010284
更新日期:2020-01-20 00:00:00
abstract::We aimed to evaluate the effects of ultrasound-assisted wound (UAW) debridement on cellular proliferation and dermal repair in complicated diabetic foot ulcers as compared to diabetic foot ulcers receiving surgical/sharp wound debridement. A randomized controlled trial was performed involving 51 outpatients with compl...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
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更新日期:2020-12-13 00:00:00
abstract::Non-steroidal anti-inflammatory drugs (NSAIDs) can be used as opioid alternatives for patient-controlled analgesia (PCA). However, their use after nephrectomy has raised concerns regarding possible nephrotoxicity. This study compared postoperative renal function and postoperative outcomes between patients using NSAID ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9092959
更新日期:2020-09-13 00:00:00
abstract:BACKGROUND:There is growing evidence that non-alcoholic fatty liver disease (NAFLD) is a disease affecting not only the liver but also extrahepatic organs. AIM:To investigate whether in youths NAFLD is associated with extrahepatic complications such as subclinical atherosclerosis, cardiac abnormalities, hypertension, ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
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更新日期:2019-06-17 00:00:00
abstract::With this Editorial we want to present the Special Issue "Big Data and Precision Medicine Series I: Lung Cancer Early Diagnosis" to the scientific community, which aims to gather experts on the early detection of lung cancer in order to implement common efforts in the fight against cancer. ...
journal_title:Journal of clinical medicine
pub_type: 社论
doi:10.3390/jcm7020028
更新日期:2018-02-09 00:00:00
abstract::Liver transplantation is increasingly dependent on the use of extended criteria donors (ECD) to increase the organ donor pool and address rising demand. This has necessitated the adoption of innovative technologies and strategies to protect these higher-risk grafts from the deleterious effects of traditional preservat...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9041046
更新日期:2020-04-07 00:00:00
abstract::The relationship between bruxism and tooth wear is contentious in the literature. The pathophysiological processes of tooth wear may be complicated by the relationship between bruxism and gastroesophageal reflux disease (GERD). The objective of this study was to evaluate the associations among bruxism, GERD, and tooth...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm7110417
更新日期:2018-11-06 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Elderly and/or frail women with ovarian cancer are often undertreated. The aim of the study is to compare the effects of age and frailty on surgical approaches, postoperative complications, and prognosis in elderly women with ovarian cancer. METHODS:A retrospective multicenter study of women ≥...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9051339
更新日期:2020-05-04 00:00:00
abstract::Multidrug resistant Gram-Negative Bacterial Infections (MR-GNBI) are an increasing cause of mortality in acute myeloid leukemia (AML), compromising the success of antineoplastic therapy. We prospectively explored a novel strategy, including mandatory fluoroquinolone prophylaxis, weekly surveillance cultures (SC) and t...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8111985
更新日期:2019-11-15 00:00:00
abstract::FOLFIRINOX (FX) and gemcitabine (GEM) plus nab-paclitaxel (GnP) have been reported as effective regimens for unresectable advanced pancreatic cancer (APC). FX may be more effective but is also associated with more adverse events (AEs). Therefore, first-line treatment with FX followed by second-line GnP may be appropri...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8060761
更新日期:2019-05-29 00:00:00
abstract::Systemic sclerosis (SSc) is a connective tissue disease that is characterized by widespread skin and internal organ fibrosis vasculopathy and immune response abnormalities, including T, B, natural killer (NK), and natural killer T (NKT) cell involvement. The aim of the study was to investigate the immune cell profile ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8050625
更新日期:2019-05-08 00:00:00
abstract::Seizures are defined as a transient occurrence of signs and symptoms due to the abnormal, excessive, or synchronous neuronal activity in the brain characterized by abrupt and involuntary skeletal muscle activity. An early diagnosis, treatment, and specific medical support must be performed to prevent Status Epilepticu...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm8010039
更新日期:2019-01-02 00:00:00
abstract:BACKGROUND:Acute respiratory distress syndrome (ARDS) is associated with both high morbidity and mortality in intensive care units worldwide. Patients with ARDS often require parenteral nutrition with lipid emulsions as essential components. In the present study, we assessed the immunomodulatory and apoptotic effects o...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9072048
更新日期:2020-06-29 00:00:00
abstract::We prospectively evaluated the relationship between meibomian gland dysfunction (MGD) and Graves' ophthalmopathy (GO) in 19 patients (38 eyes) with subjective dry eye symptoms, compared to 14 age-matched normal participants (14 eyes). Extraocular muscle and lacrimal gland enlargement were evaluated by magnetic resonan...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9092814
更新日期:2020-08-31 00:00:00
abstract::Noninvasive ventilation (NIV) during exercise has been suggested to sustain higher training intensity but the type of NIV interface, patient-ventilator asynchronies (PVA) or technological limitation of the ventilator may interfere with exercise. We assessed whether these parameters affect endurance exercise capacity i...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9041054
更新日期:2020-04-08 00:00:00
abstract::Due to the widespread use of ultrasound, small thyroid nodules (TNs) ≤ 10 mm are common findings. Standardized approaches for the risk stratification of TNs with Thyroid Imaging Reporting and Data Systems (TIRADS) were evaluated for the clinical routine. With TIRADS, the risk of malignancy in TNs is calculated by scor...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9010236
更新日期:2020-01-16 00:00:00
abstract::Acute kidney injury and renal failure are common after heart transplantation. We retrospectively reviewed a national cohort and identified 1129 heart transplant patients. Patients receiving renal replacement therapy after heart transplantation were grouped into the dialysis cohort. The long-term survival and risk fact...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9082455
更新日期:2020-07-31 00:00:00
abstract::Fetal exposure to particulate matter (PM) is associated with infant developmental delay likely via neuroinflammation and prefrontal cortex lesions; however, whether air-purifier usage, which can reduce indoor PM levels, is related to infant developmental delay remains unknown. We therefore examined the prospective rel...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9061924
更新日期:2020-06-19 00:00:00
abstract:BACKGROUND:To investigate insulin sensitivity and glucose metabolism in pregnant lean and overweight polycystic ovary syndrome (PCOS) patients vs. lean and overweight controls without PCOS. METHODS:Prospective cohort study on 67 pregnant women (31 with PCOS and 36 controls, subdivided into overweight or obese and norm...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm10010035
更新日期:2020-12-24 00:00:00
abstract::Inflammatory bowel diseases (IBDs) may be associated with extra-intestinal manifestations. Among these, mucocutaneous manifestations are relatively frequent, often difficult to diagnose and treat, and may complicate the course of the underlying disease. In the present review, a summary of the most relevant literature ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm10020364
更新日期:2021-01-19 00:00:00
abstract::To demonstrate the association of the serum creatinine/serum cystatin C ratio (sarcopenia index, SI) with clinical outcomes including cardiovascular and bleeding risk in older patients who underwent percutaneous coronary intervention (PCI), we analyzed a multicenter nation-wide pooled registry. A total of 1086 older p...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9103121
更新日期:2020-09-27 00:00:00
abstract::A major challenge of cell-based therapy for cartilage lesions is the preservation of the chondrogenic phenotype during ex vivo cell cultivation. In this in vitro study, the chondro-inductive capacity of two different hyaline cartilage-conditioned cell culture media on human chondrocytes in 3D spheroids was determined....
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9092798
更新日期:2020-08-30 00:00:00
abstract::Endometriosis concerns more than 10% of women of reproductive age, frequently leading to chronic pelvic pain. Repetitive transcranial magnetic stimulation (rTMS) over the primary motor cortex (M1) induces an analgesic effect. This effect on chronic pelvic pain is yet to be evaluated. The objective of this study was to...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8040508
更新日期:2019-04-13 00:00:00
abstract::Chronic stress is thought to be involved in the occurrence and progression of multiple diseases, via mechanisms that still remain largely unknown. Interestingly, key regulators of the stress response, such as members of the corticotropin-releasing-hormone (CRH) family of neuropeptides and receptors, are now known to b...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm8101669
更新日期:2019-10-12 00:00:00
abstract::Recurrent high-grade glioma (HGG) remains incurable with inevitable evolution of resistance and high inter-patient heterogeneity in time to progression (TTP). Here, we evaluate if early tumor volume response dynamics can calibrate a mathematical model to predict patient-specific resistance to develop opportunities for...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9072019
更新日期:2020-06-27 00:00:00
abstract::We sought to clarify the correlation between non-protein respiratory quotient (npRQ) in indirect calorimetry and serum zinc (Zn) level in chronic liver diseases (CLDs, n = 586, 309 liver cirrhosis (LC) patients, median age = 63 years). Clinical parameters potentially linked to npRQ <0.85 (best cutoff point for the pro...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9010255
更新日期:2020-01-17 00:00:00