Abstract：
:The recent advances in machine perfusion (MP) technology involve settings ranging between hypothermic, subnormothermic, and normothermic temperatures. Tissue level adenosine triphosphate (ATP) is a long-established marker of viability and functionality and is universal for all organs. In the midst of a growing number of complex clinical parameters for the quality assessment of graft prior to transplantation, a revisit of ATP may shed light on the underlying reconditioning mechanisms of different perfusion temperatures in the form of restoration of metabolic and energy status. This article aims to review and critically analyse animal and preclinical human studies (discarded grafts) during MP of three abdominal organs (liver, kidney, and pancreas) in which ATP was a primary endpoint. A selective review of recent novel reconditioning approaches relevant to mitigation of graft ischaemia-reperfusion injury via MP and for different perfusion temperatures was also conducted. With a current reiterated interest for oxygenation during MP, a re-introduction of tissue ATP levels may be valuable for graft viability assessment prior to transplantation. Further studies may help delineate the benefits of selective perfusion temperatures on organs viability.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Bellini MI,Yiu J,Nozdrin M,Papalois Vdoi
10.3390/jcm8091421subject
Has Abstractpub_date
2019-09-09 00:00:00issue
9issn
2077-0383pii
jcm8091421journal_volume
8pub_type
杂志文章,评审abstract：:Previous studies exploring the association between arterial stiffness and prediabetes remain controversial. This study aimed to investigate the association of the different domains of prediabetes categorized by glycated hemoglobin A1c (A1c) 5.7-6.4%, impaired fasting glucose (IFG), fasting plasma glucose of 5.6-6.9 mm...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8050603
更新日期：2019-05-01 00:00:00
abstract：:The aim of this study was to evaluate the ability of a PIPS (photon-induced photoacoustic streaming) Er:YAG laser to reduce the root canal system bacterial count in vivo in comparison to the traditional irrigation technique. The post-operative patients' quality of life (QoL) after endodontic therapy was evaluated thro...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9123915
更新日期：2020-12-02 00:00:00
abstract：:Congenital lactic acidosis (CLA) is a rare condition in most instances due to a range of inborn errors of metabolism that result in defective mitochondrial function. Even though the implementation of next generation sequencing has been rapid, the diagnosis rate for this highly heterogeneous allelic condition remains l...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8111811
更新日期：2019-11-01 00:00:00
abstract：BACKGROUND:The assessment of ovarian reserve in the case of endometrioma is of pivotal importance for planning a tailored management. However, both the antral follicle count (AFC) and the antimüllerian hormone (AMH) dosage are subject to a fair degree of variability in ovarian endometriosis. This study aimed to identif...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9124076
更新日期：2020-12-17 00:00:00
abstract：:Intravenous lipid emulsions are an essential component of parenteral nutrition regimens. Originally employed as an efficient non-glucose energy source to reduce the adverse effects of high glucose intake and provide essential fatty acids, lipid emulsions have assumed a larger therapeutic role due to research demonstra...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm5030034
更新日期：2016-03-07 00:00:00
abstract：:Androgen/androgen receptor (AR) signaling is a significant driver of prostate cancer progression, therefore androgen-deprivation therapy (ADT) is often used as a standard form of treatment for advanced and metastatic prostate cancer patients. However, after several years of ADT, prostate cancer progresses to castratio...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8030354
更新日期：2019-03-13 00:00:00
abstract：:MicroRNAs (miRNAs) can provide insight into the pathophysiological states of ocular tissues such as proliferative diabetic retinopathy (PDR). In this study, differences in miRNA expression in vitreous from PDR patients with and without incidence of recurrent vitreous hemorrhage (RVH) after the initial pars-plana vitre...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8122217
更新日期：2019-12-15 00:00:00
abstract：:This study explored the perspectives and experiences of breast cancer patients and medical oncologists with regards to participation in a lifestyle intervention at a tertiary cancer treatment center. A thematic approach was used to understand the context within which a lifestyle intervention was recommended and experi...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9092815
更新日期：2020-08-31 00:00:00
abstract：:Patients with kidney transplantation often have a worse quality of life than the general population. One of the reasons for this, in male patients, is the high prevalence of erectile dysfunction. This is mainly due to the presence of comorbidities, surgery for kidney transplantation, adverse drug effects, psychologica...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9061991
更新日期：2020-06-25 00:00:00
abstract：:We have evaluated circulating miRNAs (-195-5p and -451a) in subjects with acute ischemic stroke (AIS) and in patients with transient ischemic attack (TIA). In this study, 18 subjects with AIS and 18 patients with TIA were enrolled and examined at admission (T0) and at 24 h and 48 h after admission, and compared to 20 ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8020130
更新日期：2019-01-22 00:00:00
abstract：:Two doses of propiverine ER (30 and 45 mg/d) are available for the treatment of overactive bladder (OAB) syndrome. We have explored factors associated with the initial dosing choice (allocation bias), the decision to adapt dosing (escalation bias) and how dosing relative to other factors affects treatment outcomes. Da...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm10020311
更新日期：2021-01-15 00:00:00
abstract：:Von Hippel-Lindau (VHL), is a rare autosomal dominant inherited cancer in which the lack of VHL protein triggers the development of multisystemic tumors such us retinal hemangioblastomas (HB), CNS-HB, and clear cell renal cell carcinoma (ccRCC). ccRCC ranks third in terms of incidence and first in cause of death. Stan...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9092740
更新日期：2020-08-25 00:00:00
abstract：:With the expanded legalization of marijuana, its medical and recreational use have sharply increased over the past decade. A wide array of new forms of cannabis is available on the market today, and the potencies are ten times those of forms previously tested, meaning that the true impact of marijuana on the cardiovas...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9061925
更新日期：2020-06-19 00:00:00
abstract：:Epistaxis is a common debilitating manifestation in hereditary hemorrhagic telangiectasia (HHT), due to mucocutaneous telangiectases. The epistaxis can be difficult to control despite available treatments. Dysregulated angiogenesis has been shown to be associated with telangiectases formation. Topical propranolol has ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9103130
更新日期：2020-09-28 00:00:00
abstract：:Pediatric Adamantinomatous Craniopharyngiomas (ACPs) are histologically benign brain tumors that often follow an aggressive clinical course. Their suprasellar location leaves them in close proximity to critical neurological and vascular structures and often results in significant neuroendocrine morbidity. Current trea...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9020519
更新日期：2020-02-14 00:00:00
abstract：:The use of targeted agents and immunotherapy for the treatment of advanced non-small-cell lung cancer (NSCLC) has made it mandatory to characterize tumor tissue for patient selection. Moreover, the development of agents that are active against specific resistance mechanisms arising during treatment make it equally imp...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8070998
更新日期：2019-07-09 00:00:00
abstract：:Patients diagnosed with traumatic or non-traumatic spinal pain and idiopathic scoliosis frequently suffer from imbalance. The evaluation of the perception of verticality by means of visual tests emerges as a quick and easy tool for clinical management of the balance disorders. Several studies have assessed the visual ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9061725
更新日期：2020-06-03 00:00:00
abstract：:The purpose of the present systematic review and meta-analysis was to explore the effects of transcranial direct current stimulation (tDCS) on endurance (i.e., time to task failure (TTF)) and maximal voluntary contraction (MVC). Furthermore, we aimed to analyze whether the duration of stimulation, the brain region tar...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8040536
更新日期：2019-04-18 00:00:00
abstract：:This study aimed to investigate the cross-sectional association between arthritis and migraine in a large representative sample of the US adult population. The study used data from adults who participated in the RAND American Life Panel (ALP). Arthritis (excluding rheumatoid arthritis) and migraine were self-reported....
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm10020342
更新日期：2021-01-18 00:00:00
abstract：:Suprascapular neuropathy is an uncommon but increasingly recognized cause of shoulder pain and dysfunction due to nerve entrapment. The aim of this review is to summarize some important aspects of this shoulder pathology. An extensive research was performed on PubMed and Clinical Key. The goal was to collect all the a...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9082331
更新日期：2020-07-22 00:00:00
abstract：:A 37 year-old man presented to the Emergency Department (ED) with new onset seizure and fall from standing.[...]. ...
journal_title：Journal of clinical medicine
pub_type：
doi：10.3390/jcm5040046
更新日期：2016-04-12 00:00:00
abstract：:Topical application of vascular endothelial growth factor A (VEGFA) inhibitors including Bevacizumab is used for antiangiogenic therapy at the ocular surface. While clinical studies have suggested that this approach is well-tolerated, the effect of the drug on limbal epithelial stem cells has not been studied. In this...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8111925
更新日期：2019-11-09 00:00:00
abstract：:Numerous studies have previously evaluated the marginal and internal fit of fixed prostheses; however, few reports have performed an objective comparison of the various methods used for their assessment. The purpose of this study was to compare five marginal and internal fit assessment methods for fixed prostheses. A ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8060785
更新日期：2019-06-01 00:00:00
abstract：:Pancreatic ductal adenocarcinoma (PDA) is notorious for its poor prognosis. The current mainstay of treatment for PDA is surgical resection followed by adjuvant chemotherapy. However, it is difficult to predict the post-operative outcome because of the lack of reliable markers. The single-nucleotide polymorphism (SNP)...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8122225
更新日期：2019-12-16 00:00:00
abstract：:The type of fixation used in primary total knee replacement (TKR) may influence the risk of prosthetic joint infection (PJI). We conducted a systematic review and meta-analysis to assess published evidence linking type of fixation (cemented, uncemented, or hybrid) with the risk of PJI following primary TKR. Randomised...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8060828
更新日期：2019-06-11 00:00:00
abstract：BACKGROUND AND PURPOSE:The aim of the study was to determine the effects of post-traumatically released High Mobility Group Box-1 protein (HMGB1) and extracellular histones on cardiomyocytes (CM). We also evaluated a therapeutic option to capture circulating histones after trauma, using a hemadsorption filter to treat ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9051421
更新日期：2020-05-11 00:00:00
abstract：:Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder, with the characteristic symptoms of chronic abdominal pain and altered bowel habits (diarrhea, constipation, or both). IBS is a highly prevalent condition, which negatively affects quality of life and is a significant burden on global healthcare...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm6110104
更新日期：2017-11-03 00:00:00
abstract：:Liver transplantation remains an essential procedure for many patients suffering from alcoholic liver disease. Alcohol use monitoring remains paramount all through the stages of this complex process. Direct alcohol biomarkers, with improved specificity and sensibility, should replace traditional indirect markers. Phos...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9093060
更新日期：2020-09-22 00:00:00
abstract：:Atopic dermatitis (AD) is characterized by chronic, relapsing, pruritic skin inflammation and does not have a well-understood pathogenesis. In this study, we addressed the contribution of adipokines to AD eczema based on the assessment of blood levels of adiponectin, resistin, leptin, lipocalin-2, and vaspin in adult ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9092858
更新日期：2020-09-04 00:00:00
abstract：:Access to in vitro fertilization (IVF) for obese women varies across centers, and the impact of obesity on IVF outcomes is widely discussed. We assessed the impact of obesity and its severity on live birth rate (LBR) after IVF. We included women treated for IVF in our center. Data were prospectively collected in the B...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9082414
更新日期：2020-07-28 00:00:00
