Abstract：
:Atopic dermatitis (AD) is characterized by chronic, relapsing, pruritic skin inflammation and does not have a well-understood pathogenesis. In this study, we addressed the contribution of adipokines to AD eczema based on the assessment of blood levels of adiponectin, resistin, leptin, lipocalin-2, and vaspin in adult non-obese patients suffering from chronic extrinsic childhood-onset AD. We investigated 49 AD patients with a median age of 37 years. The control group consisted of 30 age-matched healthy subjects. Adipokines were assessed in the serum by ELISA assays and the severity of AD with the SCORing Atopic Dermatitis (SCORAD) index. We found that adiponectin and resistin decreased and leptin appreciably increased in AD patients when compared to those in healthy subjects. Further, the levels of adiponectin and resistin were inversely related to the intensity of eczema. In conclusion, apart from the formerly investigated role of leptin in AD, this study points to adiponectin and resistin as the potential candidate adipokine biomarkers involved in shaping eczema intensity and severity, which may help predict disease exacerbations and enable the development of effective targeted therapeutic interventions.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Jaworek AK,Szepietowski JC,Szafraniec K,Jaworek M,Hałubiec P,Wojas-Pelc A,Pokorski Mdoi
10.3390/jcm9092858subject
Has Abstractpub_date
2020-09-04 00:00:00issue
9issn
2077-0383pii
jcm9092858journal_volume
9pub_type
杂志文章abstract：:CD73, a cell-surface protein encoded by the gene NT5E, is overexpressed in glioblastoma (GBM), where it contributes to the tumor's pathophysiology via the generation of immunosuppressive adenosine. Adenosinergic signaling, in turn, drives immunosuppression of natural killer (NK) cells through metabolic and functional ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8101526
更新日期：2019-09-23 00:00:00
abstract：:Histological evaluation of renal biopsies is currently the gold standard for acquiring important diagnostic and prognostic information in diabetic nephropathy (DN) patients. Nevertheless, there is an unmet clinical need for new biomarkers that allow earlier diagnosis and risk stratification. As biochemical changes in ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
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更新日期：2019-07-12 00:00:00
abstract：:Additive manufacturing (AM) of patient-specific implants (PSIs) is gradually moving towards in-house or point-of-care (POC) manufacturing. Polyetheretherketone (PEEK) has been used in cranioplasty cases as a reliable alternative to other alloplastic materials. As only a few fused filament fabrication (FFF) printers ar...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9092818
更新日期：2020-08-31 00:00:00
abstract：:Elevated distractibility is one of the major contributors to alcohol hangover-induced behavioral deficits. Yet, the basic mechanisms driving increased distractibility during hangovers are still not very well understood. Aside from impairments in attention and psychomotor functions, changes in stimulus-response binding...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9030778
更新日期：2020-03-12 00:00:00
abstract：BACKGROUND:The Dyskinesia Impairment Scale (DIS) is a new assessment scale for dystonia and choreoathetosis in children and youth with dyskinetic cerebral palsy. Today, the Burke-Fahn-Marsden Dystonia Rating Scale (BFM) is mostly used to assess dystonia in children with inherited dystonia. The aim of this study was to ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9082597
更新日期：2020-08-11 00:00:00
abstract：:Background: Aspirin is often prescribed empirically to improve the patency of hemodialysis (HD) vascular access. Therefore, this study aimed to investigate the impact of aspirin on the survival of vascular access in incident HD patients with arteriovenous fistula (AVF) or arteriovenous graft (AVG). Methods: A prospect...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8050677
更新日期：2019-05-14 00:00:00
abstract：:Polycystic ovary syndrome (PCOS) is a common condition, affecting 5⁻10% of women of reproductive age worldwide. It has serious reproductive implications and causes mood disorders and metabolic disorders, such as type-2 diabetes. Because PCOS reflects multiple abnormalities, there is no single drug that can treat all i...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7070179
更新日期：2018-07-22 00:00:00
abstract：:Descriptive and retrospective studies without control groups have suggested a possible association between primary Sjögren's syndrome (pSS) and vitamin B12 (B12) deficiency. This is of importance because several mucosal and neurological features are common to these two conditions and could be prevented or reversed in ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9124063
更新日期：2020-12-16 00:00:00
abstract：:Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an ultra-rare autosomal recessive disorder of nucleoside metabolism that is caused by mutations in the nuclear thymidine phosphorylase gene (TYMP) gene, encoding for the enzyme thymidine phosphorylase. There are currently no approved treatments for MNGIE...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8040457
更新日期：2019-04-05 00:00:00
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journal_title：Journal of clinical medicine
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更新日期：2020-01-11 00:00:00
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journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9051280
更新日期：2020-04-28 00:00:00
abstract：PURPOSE:Multidisciplinary approach is widely advised for an effective care of patients with neuroendocrine neoplasia (NEN). Since data on efficacy of multidisciplinary management of NENs patients in referral centers are scanty, this study aimed at analyzing the modality of presentation and clinical outcome of patients ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8060910
更新日期：2019-06-25 00:00:00
abstract：:The purpose of this study was to investigate the relationship between the retinal pigment epithelium (RPE) and outer retina changes, expressed in terms of sub-RPE illumination (SRI) on optical-coherence tomography (OCT), and central retinal function, measured by visual acuity and focal electroretinogram (fERG), in pat...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9092973
更新日期：2020-09-15 00:00:00
abstract：:In emergency departments, the most common cause of death associated with suspected infected patients is sepsis. In this study, deep learning algorithms were used to predict the mortality of suspected infected patients in a hospital emergency department. During January 2007 and December 2013, 42,220 patients considered...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8111906
更新日期：2019-11-07 00:00:00
abstract：PURPOSE:The aim of this study is to record material- and surface-dependent heat dissipation during the process of inserting implants into native animal bone. MATERIALS AND METHODS:Implants made of titanium and zirconium that were identical in macrodesign were inserted under controlled conditions into a bovine rib temp...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8101541
更新日期：2019-09-25 00:00:00
abstract：:Recent advances in molecular genetic technologies have facilitated non-invasive prenatal testing (NIPT) through the analysis of cell-free fetal DNA in maternal plasma. NIPT can be used to identify monogenic disorders including the identification of autosomal recessive disorders where the maternally inherited mutation ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm3020537
更新日期：2014-05-21 00:00:00
abstract：:The widely varying therapeutic response of patients with inflammatory bowel disease (IBD) continues to raise questions regarding the unclarified heterogeneity of pathological mechanisms promoting disease progression. While biomarkers for the differentiation of Crohn's disease (CD) versus ulcerative colitis (UC) have b...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9051360
更新日期：2020-05-06 00:00:00
abstract：:Right ventricular failure (RVF) is a major risk factor for end organ morbidity and mortality following cardiac surgery. Perioperative RVF is difficult to predict and detect, and to date, no convenient, accurate, or reproducible measure of right ventricular (RV) function is available. Few studies have examined the use ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8040559
更新日期：2019-04-25 00:00:00
abstract：BACKGROUND:For acute adnexal torsion of pregnant women, appropriate treatment based on an accurate diagnosis is especially important for fertility preservation and timely treatment. The 2017 American College of Obstetricians and Gynecologists (ACOG) Committee Opinion No. 723 announced its practice-changing guidelines t...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9072209
更新日期：2020-07-13 00:00:00
abstract：:We aimed to determine if low body weight (LBW) status (<50 kg) is independently associated with increased risk of ischemic stroke and bleeding in Thai patients with non-valvular atrial fibrillation (NVAF). (1) Background: It has been unclear whether LBW influence clinical outcome of patients with NVAF. (2) Methods: Th...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9092713
更新日期：2020-08-22 00:00:00
abstract：:Surgery, including minimally invasive surgery, and radiotherapy are key modalities in the treatment of gynecological malignancies. The aim of this review is to offer the multidisciplinary care team a comprehensive summary of the intersections of surgery and radiotherapy in the local treatment of gynecological malignan...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm10010093
更新日期：2020-12-29 00:00:00
abstract：BACKGROUND:Current therapeutic options in the course of metastatic castration-resistant prostate cancers (mCRPC) reinforce the need for reliable tools to characterize the tumor in a dynamic way. Circulating tumor cells (CTCs) have emerged as a viable solution to the problem, whereby patients with a variety of solid tum...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9072066
更新日期：2020-07-01 00:00:00
abstract：:Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE-MTDPS1) is a devastating autosomal recessive disorder due to mutations in TYMP, which cause a loss of function of thymidine phosphorylase (TP), nucleoside accumulation in plasma and tissues, and mitochondrial dysfunction. The clinical picture includes progre...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm7110389
更新日期：2018-10-26 00:00:00
abstract：:Numerous studies over the years have shown that oxidative stress plays a major role in the development of the disease. Oxidative stress involvement in COPD opens up the possibility of using antioxidant therapies in the treatment of the disease. However, so far, these therapies have shown no clinical benefit indicating...
journal_title：Journal of clinical medicine
pub_type： 社论
doi：10.3390/jcm8111953
更新日期：2019-11-13 00:00:00
abstract：:This study aimed to understand whether the effect of non-metastatic cells 1 (NME1) on recurrence-free survival (RFS) in early stage non-small cell lung cancer (NSCLC) can be modified by β-catenin overexpression and cisplatin-based adjuvant chemotherapy. Expression levels of NME1 and β-catenin were analyzed using immun...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9103067
更新日期：2020-09-23 00:00:00
abstract：:(1) Background: L-arginine is a complex modulator of immune functions, and its levels are known to decrease under septic conditions. L-arginine may suppress leukocyte recruitment in vivo; however, little is known about the gestational age-specific effects of L-arginine on leukocyte recruitment in preterm infants. We n...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9092772
更新日期：2020-08-27 00:00:00
abstract：:microRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by either blocking translation or inducing degradation of target mRNA. miRNAs play essential roles in diverse biological and pathological processes, including development of hepatic fibrosis. Hepatic stellate cells (HSCs) play a central role in...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm5030038
更新日期：2016-03-16 00:00:00
abstract：:Nocturnal (night) eating syndrome and sleep-related eating disorder have common characteristics, but are considered to differ in their level of consciousness during eating behavior and recallability. To date, there have been no large population-based studies determining their similarities and differences. We conducted...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9041243
更新日期：2020-04-24 00:00:00
abstract：BACKGROUND:Peri-interventional myocardial injury occurs frequently during transcatheter aortic valve implantation (TAVI). We assessed the effect of remote ischemic preconditioning (RIPC) on myocardial injury, acute kidney injury (AKIN) and 6-month mortality in patients undergoing TAVI. METHODS:We performed a prospecti...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9010160
更新日期：2020-01-07 00:00:00
abstract：:The burden of illness related to diabetes and its complications is exceedingly high and growing globally. Systematic approaches to managing chronic care are needed to address the complex nature of the disease, taking into account health system structures. This study presents data collected from interviews with physici...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7110451
更新日期：2018-11-20 00:00:00
