Abstract：
:Even though the cornea is regarded as an immune-privileged tissue, transplantation always comes with the risk of rejection due to mismatches between donor and recipient. It is common sense that an alternative to corticosteroids as the current gold standard for treatment of corneal transplantation is needed. Since blood and lymphatic vessels have been identified as a severe risk factor for corneal allograft survival, much research has focused on vessel regression or inhibition of hem- and lymphangiogenesis in general. However, lymphatic vessels have been identified as required for the inflammation's resolution. Therefore, targeting other players of corneal engraftment could reveal new therapeutic strategies. The establishment of a tolerogenic microenvironment at the graft site would leave the recipient with the ability to manage pathogenic conditions independent from transplantation. Dendritic cells (DCs) as the central player of the immune system represent a target that allows the induction of tolerogenic mechanisms by many different strategies. These strategies are reviewed in this article with regard to their success in corneal transplantation.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Schönberg A,Hamdorf M,Bock Fdoi
10.3390/jcm9051280subject
Has Abstractpub_date
2020-04-28 00:00:00issue
5issn
2077-0383pii
jcm9051280journal_volume
9pub_type
杂志文章,评审abstract：:In the last decade, it has been well-established that tumor-infiltrating myeloid cells fuel not only the process of carcinogenesis through cancer-related inflammation mechanisms, but also tumor progression, invasion, and metastasis. In particular, tumor-associated macrophages (TAMs) are the most abundant leucocyte sub...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9103226
更新日期：2020-10-08 00:00:00
abstract：:Increased the incidence of prediabetes and type 2 diabetes (T2D) worldwide raises an urgent need to develop effective tools for early disease detection to facilitate future preventive interventions and improve patient's care. We evaluated the suitability of diabetes-related miR-375 and miR-9 as earlier biomarkers for ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7020012
更新日期：2018-01-26 00:00:00
abstract：BACKGROUND:There is growing evidence that non-alcoholic fatty liver disease (NAFLD) is a disease affecting not only the liver but also extrahepatic organs. AIM:To investigate whether in youths NAFLD is associated with extrahepatic complications such as subclinical atherosclerosis, cardiac abnormalities, hypertension, ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8060868
更新日期：2019-06-17 00:00:00
abstract：BACKGROUND:Deep dry needling (DDN) and ischemic compression technic (ICT) may be considered as interventions used for the treatment of Myofascial Pain Syndrome (MPS) in latent myofascial trigger points (MTrPs). The immediate effectiveness of both DDN and ICT on pressure pain threshold (PPT) and skin temperature of the ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8101632
更新日期：2019-10-05 00:00:00
abstract：:Snail1 transcriptional factor plays a key role in the control of epithelial to mesenchymal transition and fibroblast activation. As a consequence, Snail1 expression and function is regulated at multiple levels from gene transcription to protein modifications, affecting its interaction with specific cofactors. In this ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8060757
更新日期：2019-05-28 00:00:00
abstract：BACKGROUND:Ocular involvement in Psoriatic Arthritis (PsA) patients is mainly associated with uveitis but there remains a paucity of data on dry eye and retinal abnormalities. We aimed to analyze dry eye and subclinical retinal abnormalities in a cohort of PsA patients sine-psoriasis (PsO). METHODS:PsA patients sine-P...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9030719
更新日期：2020-03-06 00:00:00
abstract：INTRODUCTION:Exposure to cumulative environmental risk factors across development has been linked to a host of adverse health/functional outcomes. This perspective incorporating information regarding exposure at differing developmental periods is lacking in research surrounding individuals at Clinical High Risk (CHR) f...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8070994
更新日期：2019-07-09 00:00:00
abstract：:Pediatric Adamantinomatous Craniopharyngiomas (ACPs) are histologically benign brain tumors that often follow an aggressive clinical course. Their suprasellar location leaves them in close proximity to critical neurological and vascular structures and often results in significant neuroendocrine morbidity. Current trea...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9020519
更新日期：2020-02-14 00:00:00
abstract：:This study reports the integrated analysis of two phase III studies of meropenem-vaborbactam in the treatment of acute bacterial infections. Targeting Antibiotic Non-Susceptible Gram-Negative Organisms (TANGO) I compared the clinical efficacy and tolerability of meropenem-vaborbactam and piperacillin-tazobactam in the...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8101650
更新日期：2019-10-11 00:00:00
abstract：:Fluorescence imaging is a well-known method for both the in vivo and in vitro identification of specific cells or tissues. This imaging tool is gaining importance in the intraoperative detection and preservation of parathyroid glands during endocrine surgery owing to the intrinsic properties of parathyroid tissue. The...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9030830
更新日期：2020-03-18 00:00:00
abstract：BACKGROUND:Heart failure with preserved ejection fraction (HFpEF) remains an ongoing therapeutic and diagnostic challenge to date. In this study we aimed for an analysis of the diagnostic potential of four novel cardiovascular biomarkers, GDF-15, H-FABP, sST2, and suPAR in HFpEF patients compared to controls as well as...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9041130
更新日期：2020-04-15 00:00:00
abstract：:Drug-induced immune thrombocytopenia (DITP) is a life-threatening clinical syndrome that is under-recognized and difficult to diagnose. Many drugs can cause immune-mediated thrombocytopenia, but the most commonly implicated are abciximab, carbamazepine, ceftriaxone, eptifibatide, heparin, ibuprofen, mirtazapine, oxali...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9072212
更新日期：2020-07-13 00:00:00
abstract：INTRODUCTION:Immunoglobulin G4-related disease (IgG4-RD) is a systemic immune-mediated disease characterised pathologically by the infiltration of IgG4-bearing plasma cells into the involved organs. Autoimmune pancreatitis (AIP) is a form of chronic pancreatitis with a heavy lymphocytic infiltration and two distinct hi...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9020409
更新日期：2020-02-03 00:00:00
abstract：:The use of sugammadex can reduce post-operative residual neuromuscular blockade, which is known to increase the risk of post-operative respiratory events. However, its effect on post-operative pulmonary complications is not obvious. This study was performed to evaluate the effects of sugammadex on post-operative pulmo...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9041232
更新日期：2020-04-24 00:00:00
abstract：PURPOSE:To compare the reliability of five different intraoral scanners (IOSs) in the capture of implant scanbodies (SBs) and to verify the dimensional congruence between the meshes (MEs) of the SBs and the corresponding library file (LF). METHODS:A gypsum cast of a fully edentulous maxilla with six implant analogues ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9072174
更新日期：2020-07-09 00:00:00
abstract：:This study aimed to understand whether the effect of non-metastatic cells 1 (NME1) on recurrence-free survival (RFS) in early stage non-small cell lung cancer (NSCLC) can be modified by β-catenin overexpression and cisplatin-based adjuvant chemotherapy. Expression levels of NME1 and β-catenin were analyzed using immun...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9103067
更新日期：2020-09-23 00:00:00
abstract：BACKGROUND:The American Indian Navajo and Goshute peoples are underserved patient populations residing in the Four Corners area of the United States and Ibupah, Utah, respectively. METHODS:We conducted a cross-sectional study of epidemiological factors and lipid biomarkers that may be associated with type II diabetes,...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9113590
更新日期：2020-11-07 00:00:00
abstract：:* Correspondence: kasiajanda@op [...]. ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9061652
更新日期：2020-05-31 00:00:00
abstract：:One in every four deaths is due to cancer in Europe. In view of its increasing incidence, cancer became the leading cause of death and disease burden in Denmark, France, the Netherlands, and the UK. Without essential improvements in cancer prevention, an additional 775,000 cases of annual incidence have been prognosed...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9092749
更新日期：2020-08-25 00:00:00
abstract：BACKGROUND:Although early identification of critical illness polyneuropathy (CIP) is necessary, the established diagnostic criteria have several limitations in the intensive care unit (ICU) setting. The purpose of this study was to define simplified diagnostic criteria of CIP that best predict clinical outcomes. METHO...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9124029
更新日期：2020-12-13 00:00:00
abstract：:We aimed to evaluate the effects of ultrasound-assisted wound (UAW) debridement on cellular proliferation and dermal repair in complicated diabetic foot ulcers as compared to diabetic foot ulcers receiving surgical/sharp wound debridement. A randomized controlled trial was performed involving 51 outpatients with compl...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9124032
更新日期：2020-12-13 00:00:00
abstract：:Ovarian endometrioma are found in up to 40% of women with endometriosis and 50% of infertile women. The best surgical approach for endometrioma and its impact on pregnancy rates is still controversial. Therefore, we conducted a literature review on surgical management of ovarian endometrioma and its impact on pregnanc...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm10030414
更新日期：2021-01-22 00:00:00
abstract：:The superiority of distinct anesthesia methods for geriatric hip fracture surgery remains unclear. We evaluated high mobility group box-1 (HMGB1) and interleukin-6 (IL-6) with three different anesthesia methods in elderly patients undergoing hip fracture surgery. Routine blood test findings, postoperative morbidity, a...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9061605
更新日期：2020-05-26 00:00:00
abstract：:The application of biomarkers in medicine is evolving. Biomarkers do not only give us a better understanding of pathogenesis, but also increase treatment efficacy and safety, further enabling more precise clinical care. This paper focuses on the current use of biomarkers in atopic dermatitis, new developments and futu...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm4030479
更新日期：2015-03-16 00:00:00
abstract：:Endometrial cancer (EC) is the sixth most common cancer in women worldwide and its mortality is directly associated with the presence of poor prognostic factors driving tumor recurrence. Stratification systems are based on few molecular, and mostly clinical and pathological parameters, but these systems remain inaccur...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9061900
更新日期：2020-06-17 00:00:00
abstract：:Brain-derived neurotrophic factor (BDNF) facilitates neuronal growth and plasticity, and is crucial for learning and memory. Contactin-1 (CNTN1) is a member of the subfamily of neural immunoglobulin and is involved in the formation of axon connections in the developing nervous system. This cross-sectional study invest...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8091366
更新日期：2019-09-02 00:00:00
abstract：:Interstitial lung disease (ILD) seems to be associated with an increased risk of lung cancer (LC) and to have a poorer prognosis than LC without ILD. The frequency of ILD in an LC cohort and its prognosis implication need to be better elucidated. This retrospective, observational, cohort study evaluated the frequency ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9030700
更新日期：2020-03-05 00:00:00
abstract：:Pigmented villonodular synovitis (PVNS) of the ankle is a very rare, locally aggressive, proliferative disorder. Although surgical excision represents the standard curative treatment, the PVNS relapse rate is high. We present our study of five young athletes (range 20-36 years) with a histopathological diagnosis of PV...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9020597
更新日期：2020-02-22 00:00:00
abstract：:A recent study suggested mortality benefits using vitamin C, hydrocortisone, and thiamine combination therapy (triple therapy) in addition to standard care in patients with severe sepsis and septic shock. In order to further evaluate the effects of triple therapy in real-world clinical practice, we conducted a retrosp...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8040478
更新日期：2019-04-09 00:00:00
abstract：:Obstructive sleep apnea (OSA) is a chronic and prevalent disorder, strongly associated with cardiovascular disease (CVD). The apnea-hypopnea index (AHI), or respiratory event index (REI), and the oxygen desaturation index (ODI) are the clinical metrics of sleep apnea in terms of diagnosis and severity. However, AHI, o...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9082475
更新日期：2020-08-01 00:00:00
