Abstract:
:Pediatric Adamantinomatous Craniopharyngiomas (ACPs) are histologically benign brain tumors that often follow an aggressive clinical course. Their suprasellar location leaves them in close proximity to critical neurological and vascular structures and often results in significant neuroendocrine morbidity. Current treatment paradigms, involving surgical resection and radiotherapy, confer significant morbidity to patients and there is an obvious need to discover effective and safe alternative treatments. Recent years have witnessed significant efforts to fully detail the genomic, transcriptomic and proteomic make-up of these tumors, in an attempt to identify potential therapeutic targets. These studies have resulted in ever mounting evidence that inflammatory processes and the immune response play a critical role in the pathogenesis of both the solid and cystic portion of ACPs. Several inflammatory and immune markers have been identified in both the cyst fluid and solid tumor tissue of ACP. Due to the existence of effective agents that target them, IL-6 and immune checkpoint inhibitors seem to present the most likely immediate candidates for clinical trials of targeted immune-related therapy in ACP. If effective, such agents may result in a paradigm shift in treatment that ultimately reduces morbidity and results in better outcomes for our patients.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Whelan R,Prince E,Gilani A,Hankinson Tdoi
10.3390/jcm9020519subject
Has Abstractpub_date
2020-02-14 00:00:00issue
2issn
2077-0383pii
jcm9020519journal_volume
9pub_type
杂志文章,评审abstract:BACKGROUND:There is a need for analytical tools predicting the risk of periodontitis. The purpose of this study was to estimate and evaluate a risk score for prediction of periodontitis. MATERIALS AND METHODS:This case-cohort study included a random sample of 155 cases (with periodontitis) and 175 controls (randomly s...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8030307
更新日期:2019-03-05 00:00:00
abstract::Immune thrombocytopenia (ITP) is an acquired autoimmune disorder characterized by isolated thrombocytopenia defined as platelet count in peripheral blood <100 × 109/L. Hypovitaminosis D is very common in children with autoimmune diseases. To analyze whether hypovitaminosis D is associated with the clinical presentatio...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8111861
更新日期:2019-11-03 00:00:00
abstract::This study sought to determine whether the implementation of regular and structured follow-up of patients with chronic heart failure (CHF), combined with therapeutic education and remote monitoring solution, leads to better management. This was a single-center retrospective study conducted in a cohort of patients with...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9103106
更新日期:2020-09-25 00:00:00
abstract::Cholangiocarcinoma (CCA) arises from the biliary tract epithelium and accounts for 10-15% of all hepatobiliary malignancies. Depending on anatomic location, CCA is classified as intrahepatic (iCCA), perihilar (pCCA) and distal (dCCA). The best treatment option for pCCA is liver resection and when a radical oncological...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9051353
更新日期:2020-05-05 00:00:00
abstract::Propionibacterium are anaerobic/aero-tolerant rod Gram-positive bacteria, and numerous studies are associated with primary and secondary endodontic infections. The data in the literature on the prevalence of Propionibacterium are conflicting, and there are studies that report conflicting data on the prevalence in prim...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9030739
更新日期:2020-03-09 00:00:00
abstract::Background. Accumulating evidence suggests that inflammation plays a key role in acute kidney injury (AKI) pathogenesis. We explored the relationship between high-sensitivity C-reactive protein (hs-CRP) and AKI in acute myocardial infarction (AMI). Methods. We prospectively included 2,063 AMI patients in whom hs-CRP w...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8122192
更新日期:2019-12-12 00:00:00
abstract::Proteasome inhibitor bortezomib has been used in the treatment of refractory cases of acute and chronic antibody-mediated rejection (AMR) in kidney transplant recipients. However, its efficacy and safety as a primary treatment for early AMR has been scarcely investigated. We herein present our preliminary experience w...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9020529
更新日期:2020-02-15 00:00:00
abstract::We aimed to report an update of the systematic review by Petrén et al. (2003). The objective was to evaluate how orthodontic treatments can affect unilateral posterior crossbite (UPXB) in primary and early mixed dentition. Several databases were consulted, and articles published between January 2002 and March 2020 wer...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm10010033
更新日期:2020-12-24 00:00:00
abstract::We aimed to develop a mathematical model to predict the progression of aortic stenosis (AS) and aortic dilatation (AD) in bicuspid aortic valve patients. Bicuspid AS patients who underwent at least two serial echocardiograms from 2005 to 2017 were enrolled. Mathematical modeling was undertaken to assess (1) the non-li...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8091302
更新日期:2019-08-24 00:00:00
abstract::Tadalafil 5 mg represents the standard for men with Erectile dysfunction (ED) and lower urinary tract symptoms (LUTS)/benign prostatic enlargement (BPE). We carried out an observational trial aiming to assess the efficacy and safety of Tadalafil compared with Tadalafil plus Tamsulosin. Seventy-five patients complainin...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8081126
更新日期:2019-07-29 00:00:00
abstract:BACKGROUND:Mismatch of intramedullary nails with the bowing of femur is a frequent clinical finding. Previous studies showed inconsistent results. METHODS:We present an algorithm of region growing territory method to get the radii of the anterior bowing of femur. We also tested it on ten radiographs. Plain radiographs...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8101598
更新日期:2019-10-03 00:00:00
abstract:BACKGROUND:There is a lack of evidence regarding the link between apolipoproteins and cancer mortality. By using two nationally representative samples of US adults, we prospectively evaluated the associations between apolipoprotein B (apoB) levels and apoB/apoA-I ratio with cancer mortality. We also examined the role o...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9010170
更新日期:2020-01-08 00:00:00
abstract::Epistaxis is a common debilitating manifestation in hereditary hemorrhagic telangiectasia (HHT), due to mucocutaneous telangiectases. The epistaxis can be difficult to control despite available treatments. Dysregulated angiogenesis has been shown to be associated with telangiectases formation. Topical propranolol has ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9103130
更新日期:2020-09-28 00:00:00
abstract::To analyse the predictive ability and incremental value of left ventricular longitudinal axis strain (LAS) and late gadolinium enhancement (LGE) using standard cardiovascular magnetic resonance (CMR) imaging for the diagnosis and prognosis of severe aortic stenosis (AS) in patients with an indication for aortic valve ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8020165
更新日期:2019-02-01 00:00:00
abstract::Clinical trials in attention-deficit/hyperactivity disorder (ADHD) have typically measured outcome using clinician ratings on the Attention-Deficit/Hyperactivity Disorder Rating Scale, Fourth Edition (ADHD-RS-IV) and the Clinical Global Impression-Improvement (CGI-I) scale. Remission has been defined as an endpoint sc...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8040461
更新日期:2019-04-05 00:00:00
abstract::Adenomyosis is used to be called endometriosis interna, and deep endometriosis is now called adenomyosis externa. Thus, there is a question as to whether adenomyosis is simply endometriosis of the uterus, either from the perspective of pathogenesis or pathophysiology. In this manuscript, a comprehensive review was per...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9020485
更新日期:2020-02-10 00:00:00
abstract::The detection of rare mutational targets in plasma (liquid biopsy) has emerged as a promising tool for the assessment of patients with cancer. We determined the presence of cell-free DNA containing the BRAFV600E mutations (cfBRAFV600E) in plasma samples from 57 patients with papillary thyroid cancer (PTC) with somatic...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9082481
更新日期:2020-08-02 00:00:00
abstract::: Protein-bound uremic toxin is a cardiovascular (CV) risk factor for patients with end-stage renal disease. Indole-3-acetic acid (IAA) was found to be associated with CV disease but the detailed pathophysiology remains unknown. Moreover, mitogen-activated protein kinase (MAPK) signaling cascades play an important rol...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9010124
更新日期:2020-01-02 00:00:00
abstract::The aim of this study was to investigate whether early intermittent electroencephalography (EEG) could be used to predict neurological prognosis of patients who underwent extracorporeal cardiopulmonary resuscitation (ECPR). This was a retrospective and observational study of adult patients who were evaluated by EEG sc...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9061745
更新日期:2020-06-04 00:00:00
abstract::Prolonged oligohydramnios following extreme preterm prelabour rupture of membranes (EPPROM) is traditionally associated with a high morbidity and mortality to both the mother and the baby. The clinical maternal evaluation and fetal ultrasound assessment may provide important prognostic information for the clinicians a...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm3010025
更新日期:2014-01-09 00:00:00
abstract::There are differences in the incidence, clinical presentation, molecular pathogenesis, and outcome of colorectal cancer (CRC) based on tumor location. Emerging research suggests that the perioperative carcinoembryonic antigen (CEA) ratio (post-op/pre-op CEA) is a prognostic factor for CRC patients. We aimed to determi...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9123848
更新日期:2020-11-27 00:00:00
abstract::Osteopathic manual treatment has been recommended as a non-pharmacological therapy for Gastroesophageal Reflux Disease (GERD). However, to date, no study has supported the effectiveness of this intervention with respect to the symptoms of the disease. Our goal was to assess the effect of an osteopathic manual techniqu...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8101738
更新日期:2019-10-19 00:00:00
abstract::(1) Background: L-arginine is a complex modulator of immune functions, and its levels are known to decrease under septic conditions. L-arginine may suppress leukocyte recruitment in vivo; however, little is known about the gestational age-specific effects of L-arginine on leukocyte recruitment in preterm infants. We n...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9092772
更新日期:2020-08-27 00:00:00
abstract::Treatment with immune checkpoint inhibitors has shown efficacy against a variety of cancer types. The effects of nivolumab and pembrolizumab on lung cancer have been reported, and further therapeutic advances are ongoing. The side effects of immune checkpoint inhibitors are very different from those of conventional cy...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9072033
更新日期:2020-06-29 00:00:00
abstract::The idea of right heart catheterization (RHC) grew in the milieu of modern thinking about the cardiovascular system, influenced by the experiments of William Harvey, which were inspired by the treatises of Greek philosophers like Aristotle and Gallen, who made significant contributions to the subject. RHC was first di...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm8091331
更新日期:2019-08-28 00:00:00
abstract::Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder, with the characteristic symptoms of chronic abdominal pain and altered bowel habits (diarrhea, constipation, or both). IBS is a highly prevalent condition, which negatively affects quality of life and is a significant burden on global healthcare...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm6110104
更新日期:2017-11-03 00:00:00
abstract::Minimal residual disease evaluation refers to a series of molecular and immunophenotypical techniques aimed at detecting submicroscopic disease after therapy. As such, its application in acute myeloid leukemia has greatly increased our ability to quantify treatment response, and to determine the chemosensitivity of th...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm6060057
更新日期:2017-06-03 00:00:00
abstract:BACKGROUND:This study aims to evaluate if children with temporal arachnoid cysts (AC) have cognitive symptoms and if neurosurgery improves these. METHODS:A prospective case series study including consecutive pediatric patients with temporal AC. The children underwent neuroradiology, neuroopthalmologic evaluation, and ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9030850
更新日期:2020-03-20 00:00:00
abstract::Paravalvular leak (PVL) is an important complication of transcatheter aortic valve implantation (TAVI) and is associated with poor prognosis. We aimed to identify the risk factors for PVL after TAVI including patient (calcium amount or location), device (leakage-proof or not), and procedural (oversizing index (OI)) fa...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9123936
更新日期:2020-12-04 00:00:00
abstract::Despite extensive research and development of new treatments, acute myeloid leukemia (AML)-backbone therapy has remained essentially unchanged over the last decades and is frequently associated with poor outcomes. Eradicating the leukemic stem cells (LSCs) is the ultimate challenge in the treatment of AML. Emerging ev...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9051513
更新日期:2020-05-18 00:00:00