Abstract:
:Osteopathic manual treatment has been recommended as a non-pharmacological therapy for Gastroesophageal Reflux Disease (GERD). However, to date, no study has supported the effectiveness of this intervention with respect to the symptoms of the disease. Our goal was to assess the effect of an osteopathic manual technique for the lower esophageal sphincter on GERD symptoms, cervical mobility and on the C4 spinous process pressure pain threshold (PPTs). METHODS:A randomized, double-blind placebo-controlled trial was performed. Sixty subjects suffering from GERD participated in this study and were randomly assigned to either an experimental group (EG) (n = 29), who received the osteopathic technique for the lower esophageal sphincter, or to a control group (CG) (n = 31), who received a manual contact, which mimicked the osteopathic technique without exerting any therapeutic force. Randomization was computer-generated, with allocation concealed by sequentially numbered, opaque, sealed envelopes. The GerdQ questionnaire was used to assess symptom changes the week after intervention. Cervical Range of Motion (CROM) and algometer were used to evaluate cervical mobility and PPTs before and after both treatments. Before-after between groups comparison (t-test) was used for statistical analysis of the outcome, with two measurement points (GerdQ), while repeated-measures ANOVA was used for those outcomes with four measurement points (CROM and PPT). RESULTS:The application of the osteopathic manual treatment in subjects with GERD produced a significant improvement in symptoms one week after the intervention (p = 0.005) with a between-groups difference of 1.49 points in GerdQ score (95% CI: 0.47-2.49). PPT C4 improved in the EG after the treatment (p = 0.034; η2 = 0.048) (between-groups difference 8.78 Newton/cm2; 95% CI: 0.48-17.09). CROM also increased in the EG compared to the CG (p < 0.001; η2 = 0.108) (between-groups difference 33.89 degrees; 95% CI: 15.17-52.61). CONCLUSIONS:The manual osteopathic technique produces an improvement in GERD symptoms one week after treatment, cervical mobility, and PPTs. This may mean that osteopathic treatment is useful for improving symptoms of GERD.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Eguaras N,Rodríguez-López ES,Lopez-Dicastillo O,Franco-Sierra MÁ,Ricard F,Oliva-Pascual-Vaca Ádoi
10.3390/jcm8101738subject
Has Abstractpub_date
2019-10-19 00:00:00issue
10issn
2077-0383pii
jcm8101738journal_volume
8pub_type
杂志文章abstract:BACKGROUND:For acute adnexal torsion of pregnant women, appropriate treatment based on an accurate diagnosis is especially important for fertility preservation and timely treatment. The 2017 American College of Obstetricians and Gynecologists (ACOG) Committee Opinion No. 723 announced its practice-changing guidelines t...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9072209
更新日期:2020-07-13 00:00:00
abstract::Acute kidney injury (AKI) is a frequent complication of hospitalized patients with infective endocarditis (IE). Further, AKI in the setting of IE is associated with high morbidity and mortality. We aimed to examine the incidence, clinical parameters, and hospital costs associated with AKI in hospitalized patients with...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm8070927
更新日期:2019-06-27 00:00:00
abstract:BACKGROUND:Profiles of amino acid metabolites (AAMs) have been linked to obesity and energy homeostasis. We investigated whether baseline obesity-related AAMs were associated with weight status in the early postoperative period after sleeve gastrectomy. METHODS:In this prospective, single-arm, longitudinal study, 27 b...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9082348
更新日期:2020-07-23 00:00:00
abstract:BACKGROUND:This retrospective study aimed to evaluate overall survival and the risk factors for mortality among Korean pediatric liver transplantation (LT) patients using data from two national registries: the Korean Network Organ Sharing (KONOS) of the Korea Centers for Disease Control and Prevention and the Korean Or...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9113435
更新日期:2020-10-26 00:00:00
abstract::Nitric oxide (NO) synthesis markers, comprising L-homoarginine, asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA), are significantly associated with cardiovascular events and mortality. Being involved in NO pathways, they may be of high importance regulating vascular tone and arterial hypertensi...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9123895
更新日期:2020-11-30 00:00:00
abstract:BACKGROUND:Heart rate variability (HRV) as an accurate, noninvasive measure of the Autonomous Nervous System (ANS) can reflect mental health (e.g., stress, depression, or anxiety). Tai Chi and Yoga (Tai Chi/Yoga), as the most widely practiced mind⁻body exercises, have shown positive outcomes of mental health. To date, ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm7110404
更新日期:2018-10-31 00:00:00
abstract:BACKGROUND:Our study aims to perform a meta-analysis of benefits and risks associated with the use of non-vitamin K oral anticoagulants (NOAC) versus vitamin K antagonists (VKA) in patients with a percutaneous coronary intervention (PCI) with a particular focus on the combination type: dual vs. dual antithrombotic ther...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9041120
更新日期:2020-04-14 00:00:00
abstract::The selection of a highly-viable single embryo in assisted reproductive technology requires an acceptable predictive method in order to reduce the multiple pregnancy rate and increase the success rate. In this study, the metabolomic profiling of growing and impaired embryos was assessed on the fifth day of fertilizati...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9124094
更新日期:2020-12-18 00:00:00
abstract:BACKGROUND:Prostate cancer (PCa) is characterized by significant heterogeneity in its molecular, genomic, and immunologic characteristics. METHODS:Whole transcriptome RNAseq data from The Cancer Genome Atlas of prostate adenocarcinomas (n = 492) was utilized. The immune microenvironment was characterized using the CIB...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9061973
更新日期:2020-06-24 00:00:00
abstract::The ongoing coronavirus disease 2019 (COVID-19) pandemic has resulted in efforts to identify therapies to ameliorate adverse clinical outcomes. The recognition of the key role for increased inflammation in COVID-19 has led to a proliferation of clinical trials targeting inflammation. The purpose of this review is to c...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9092935
更新日期:2020-09-11 00:00:00
abstract::The aim was to perform a translation, cross-cultural adaptation, and psychometric evaluation of the Spanish version of the Tampa Scale of Kinesiophobia for Temporomandibular Disorders (TSK-TMD-S). The study sample included 110 patients with TMD. We translated and cross-culturally adapted the TSK-TMD-S using standard m...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9092831
更新日期:2020-09-01 00:00:00
abstract::The endogenous PP2A inhibitor SET Nuclear Proto-Oncogene (SET) has been reported to play oncogenic roles and determines poor outcomes in colorectal cancer (CRC). Our group previously showed that miR-199b is deregulated in metastatic CRC, and reduced the cell viability and enhanced the sensitivity of CRC cells to stand...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9082419
更新日期:2020-07-28 00:00:00
abstract::The aim of this study was to investigate the prescribing cascade phenomenon of dopaminergic drugs such as levodopa in the management of gastroprokinetic drugs induced parkinsonism. Based on the Korea National Health Insurance Service (NHIS)-Senior Cohort Database, we analyzed patients aged ≥65 years, between 2009 and ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8091496
更新日期:2019-09-19 00:00:00
abstract:BACKGROUND:We aimed to build a model using machine learning for the prediction of survival in trauma patients and compared these model predictions to those predicted by the most commonly used algorithm, the Trauma and Injury Severity Score (TRISS). METHODS:Enrolled hospitalized trauma patients from 2009 to 2016 were d...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8060799
更新日期:2019-06-05 00:00:00
abstract::The outcome of patients with acute myocardial infarction (AMI) has dramatically improved over recent decades, thanks to early detection and prompt interventions to restore coronary blood flow. In contrast, the prognosis of patients with hypoxic acute kidney injury (AKI) remained unchanged over the years. Delayed diagn...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8020267
更新日期:2019-02-21 00:00:00
abstract::The widespread epidemic of obesity and type 2 diabetes (T2D), suggests that both disorders are closely linked. Several pre-clinical and clinical studies have showed that adipose-derived mesenchymal stem cells (ASC) transplantation is efficient and safe. Moreover, scientists have already highlighted the therapeutic cap...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8060765
更新日期:2019-05-30 00:00:00
abstract::This study assessed the efficacy of intraoperative high-dose intravenous iron therapy in facilitating recovery from postoperative anemia and reducing the transfusion rate in patients with total knee and total hip arthroplasty. This prospective randomized controlled study involved 58 subjects. Group F received 1000 mg ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8101674
更新日期:2019-10-13 00:00:00
abstract:BACKGROUND:Congenital factor (F) VII deficiency is a rare coagulation factor deficiency with an estimated incidence of 1 per 500,000 individuals. Patients with severe FVII deficiency present a broad range of clinical presentations. Alloimmunization against exogenous FVII, as the main challenge of replacement therapy, i...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm10020211
更新日期:2021-01-08 00:00:00
abstract:INTRODUCTION:Telemedicine is believed to be helpful in managing patients suffering from chronic diseases, in particular elderly patients with numerous accompanying conditions. This was the basis for the "GERIATRICS and e-Technology (GER-e-TEC) study", which was an experiment involving the use of the smart MyPredi™ e-pl...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9123836
更新日期:2020-11-26 00:00:00
abstract::Research examining associations between objectively-measured napping time and type 2 diabetes (T2D) is lacking. This study aimed to evaluate daytime napping in relation to T2D and adiposity measures in elderly individuals from the Mediterranean region. A cross-sectional analysis of baseline data from 2190 elderly part...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8071053
更新日期:2019-07-19 00:00:00
abstract::Mesalamine (5-ASA) is the mainstay therapy in patients with mild-to-moderate active ulcerative colitis (UC). However, non-adherence to therapy and practice variability among gastroenterologists represent long-standing barriers, leading to poor outcomes. Additionally, targets to treat in UC are increasingly evolving fr...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9092905
更新日期:2020-09-08 00:00:00
abstract::The integrated assessment of nutritional status and presence of sarcopenia would help improve clinical outcomes of in-hospital aged patients. We compared three common nutritional screening tools with the new Global Leadership Initiative on Malnutrition (GLIM) diagnostic criteria among hospitalized older patients. To t...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9061898
更新日期:2020-06-17 00:00:00
abstract::The superiority of distinct anesthesia methods for geriatric hip fracture surgery remains unclear. We evaluated high mobility group box-1 (HMGB1) and interleukin-6 (IL-6) with three different anesthesia methods in elderly patients undergoing hip fracture surgery. Routine blood test findings, postoperative morbidity, a...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9061605
更新日期:2020-05-26 00:00:00
abstract::Subthreshold micropulse laser treatment has been intensively used for selected retinal diseases in the last decade; however, the exact mechanism of the action of lasers in the subthreshold micropulse mode is not yet fully understood. This kind of treatment is safe and cheap, and contrary to classic laser photocoagulat...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm8020242
更新日期:2019-02-13 00:00:00
abstract:OBJECTIVES:Central neurological manifestations of rheumatoid arthritis (RA) like rheumatoid meningitis (RM) are rare, little known and have a high rate of morbi-mortality. METHODS:We described six cases of RM that were directly related to RA activity after exhaustive assessment. RESULTS:They were mainly women, aged o...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9061625
更新日期:2020-05-27 00:00:00
abstract::Arterial stiffness has been shown to be a subclinical marker associated with cardiovascular disease. Meanwhile, long-term exercise has been demonstrated to reduce arterial stiffness, providing a decrease in cardiovascular risk. However, the acute effect of exercise on arterial stiffness is unclear. This systematic rev...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm10020291
更新日期:2021-01-14 00:00:00
abstract::We aimed to investigate the cross-sectional and longitudinal associations of electrocardiogram (ECG)-based QT, QTc, JT, JTc, and QRS intervals with cognitive function and brain magnetic resonance imaging (MRI) measurements in a cohort of older individuals at increased risk for cardiovascular disease, but free of known...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9040911
更新日期:2020-03-26 00:00:00
abstract::Postoperative complications after pancreatic surgery are still a significant problem in clinical practice. The aim of this study was to characterize and compare the microbiomes of different body compartments (bile duct, duodenal mucosa, pancreatic tumor lesion, postoperative drainage fluid, and stool samples; preopera...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9092785
更新日期:2020-08-28 00:00:00
abstract::Tumor recurrence is now the leading cause of breast cancer-related death. These recurrences are believed to arise from residual cancer stem cells that survive initial therapeutic intervention. Therefore, a comprehensive understanding of cancer stem cell biology is needed to generate more effective therapies. Here we i...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9010087
更新日期:2019-12-29 00:00:00
abstract::In the SImplification of Medications Prescribed to Long-tErm care Residents (SIMPLER) cluster-randomized controlled trial, we evaluated the impact of structured medication regimen simplification on medication administration times, falls, hospitalization, and mortality at 8 residential aged care facilities (RACFs) at 1...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9041053
更新日期:2020-04-08 00:00:00